Click here to switch to the map view.

The map label for this gene is aroA [H]

Identifier: 119897362

GI number: 119897362

Start: 1153344

End: 1155305

Strand: Direct

Name: aroA [H]

Synonym: azo1071

Alternate gene names: 119897362

Gene position: 1153344-1155305 (Clockwise)

Preceding gene: 119897361

Following gene: 119897363

Centisome position: 26.36

GC content: 67.84

Gene sequence:

>1962_bases
ATGACCATGGAATTTCTCGATCTGCCGCCCATGCTCGCCGCGCGCGGGCAGGTGCGTTTGCCCGGCTCGAAGAGCATCTC
GAACCGCAGCCTGCTGCTCGCCGCGCTCGCCGAGGGCGAAACCGACATCCGCGACCTGCTTGCCTCCGACGACGTCGAGC
GCATGCTGGAAGCGCTGCAGGCGCTCGGCGTGCGCTGGTCGCGCGAGGAAGGCACGGACAACTACCGTGTGCACGGCGTC
GGCGGCCCGTTTCCGGTCAAGAAGGGCGATCTTTTCCTCGGCAATGCCGGCACCGCCTTCCGTCCCTTGACCGCAGCGCT
GGCGCTGTCGGGGGGCGACTATCGCCTGTCCGGTGTGGCCCGGATGCATGAGCGCCCGATCGGTGACCTGGTGGATGCGC
TGCGCCAGGCCGGGGCCGATATCGAATACGTCGGCAACGAGGGCTTTCCGCCGCTGCACATCCGTCCGGCCACGATCCGG
CCGGGGGGCGTGCTGAAGGTCAGGGGCGATGTTTCCAGCCAGTTCCTGACCGCACTGCTGATGGCCTTGCCGCTGACCGG
GGTCGAGACGACGATCGAGGTGGTCGGCGAACTGATTTCCAAGCCGTATATCGCGATCACGCTCGACCTGATGGCGCGCT
TCGGGGTCGATGTCGTGCGCGAGGACTGGCAGCGTTTCACCGTTCCCGGCGGGGCGCGCTACCGCAGCCCCGGCGTCTTG
TACGTCGAAGGCGACGCGTCCTCGGCATCCTATTTCCTCGCTGCCGGTGCGATCGGCGGTGGGCCGGTCCGCGTCGAAGG
GGTAGGCCGGGACAGCATCCAGGGCGACGTCCGCTTCGCCGACGCGCTGGCTCAGCTCGGCGCGGTCATTACCGTGGGCG
ACAACTGGATCGAGGCGGCCGCGCCGGCGGGCGGCCGCTTGCGTGCATTCGATCTCGACCTCAACCACATCCCCGATGCG
GCGATGACGCTGGCCGTGGCCGCGCTGTTCGCCGACGGGCCGTGCACGCTGCGCAATATCGCCAGCTGGCGGGTCAAGGA
GACCGATCGCATCGCTGCGATGGCGACCGAGTTGCGCAAGGTTGGGGCGGAAGTGGAAGAGGGGGCGGACTACCTGCGGA
TCATGCCGCCTGCGGTGTTGCGTCCGGCCGCAATCGACACCTACGACGATCACCGCATGGCGATGTGCTTTTCGCTCGTC
AGCCTCGGCGGCTGCCGCGTCCGCATCAACGATCCGCGCTGCGTGAACAAGACCTTTCCGTCCTACTTCGAGGCCTTCGC
CACCGTGGCCGCGCCGGTTCCCGTTGTGGCGATCGACGGGCCGTCGGCGTCGGGCAAGGGGACGGTTGGTGCGCGTGTCG
CGGCCGCCCTCGGCTGGCATCACCTCGACAGCGGATCGCTCTACCGGCTAGTGGCTCTGAGCGCGGAGCGCGGCGGCATC
GACCTGGACGACGAGGTGGCGCTGGCCGCCATCGCCGGCGATCTTCCTGCGCGTTTCGAAGGCGAACGCGTCTGGCTGGG
CACCGACGACGTCACCGACGCGATCCGCAGCGAGCAGTGTTCCGCCGGCGCGTCCAAGGTCGCGGTCCTTCCCGCGGTGC
GTGCCGCCTTGCTCGGCCGTCAGCGCGACTATCGCCAGGGCCCCGGGCTGGTTGCGGAAGGTCGCGACATCGGTTCGGTG
ATCTTTCCCGACGCGAGCGTCAAGATCTTCCTCACCGCCTCAGTGGAAGCCCGTGCCGAACGCCGCTATAAGCAGTTGAT
CGGCAAGGGTTTGGCTGCTAACATGGAAAGCCTTATGCAGGATCTGCGGGAGCGGGACGCGCGCGACGCGGCCCGGACCG
TGGCGCCCTTGCAGAAGTTGCCTGACGCCGCGCTGCTTGATACGACCGACAGGGACGTCGAGCAGGCCGTGACTTTCGTG
CTCGATCTTGTTCGGGATCACGGGTTGCGGGGAGCAAATTAA

Upstream 100 bases:

>100_bases
TGCTGGCGGGCGACGGCACCCGGCTGGAACAGCTGTTCGGCGAGGCGCGACGCGCGCGCGACGCATGGGCCGCGCAGTTC
CCGCCCCCTTCTACCGCGGA

Downstream 100 bases:

>100_bases
CCGCTGAAGGCTGCAGCCGCATACCGGAGCAAATGCTCCGCGTGTGCGTTTTTTCAATTTCCACTTAACGCCGTCCTTCG
GGCCGGTGCCGGGTTTTTTC

Product: bifunctional 3-phosphoshikimate 1-carboxyvinyltransferase/cytidine monophosphate kinase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS [H]

Number of amino acids: Translated: 653; Mature: 652

Protein sequence:

>653_residues
MTMEFLDLPPMLAARGQVRLPGSKSISNRSLLLAALAEGETDIRDLLASDDVERMLEALQALGVRWSREEGTDNYRVHGV
GGPFPVKKGDLFLGNAGTAFRPLTAALALSGGDYRLSGVARMHERPIGDLVDALRQAGADIEYVGNEGFPPLHIRPATIR
PGGVLKVRGDVSSQFLTALLMALPLTGVETTIEVVGELISKPYIAITLDLMARFGVDVVREDWQRFTVPGGARYRSPGVL
YVEGDASSASYFLAAGAIGGGPVRVEGVGRDSIQGDVRFADALAQLGAVITVGDNWIEAAAPAGGRLRAFDLDLNHIPDA
AMTLAVAALFADGPCTLRNIASWRVKETDRIAAMATELRKVGAEVEEGADYLRIMPPAVLRPAAIDTYDDHRMAMCFSLV
SLGGCRVRINDPRCVNKTFPSYFEAFATVAAPVPVVAIDGPSASGKGTVGARVAAALGWHHLDSGSLYRLVALSAERGGI
DLDDEVALAAIAGDLPARFEGERVWLGTDDVTDAIRSEQCSAGASKVAVLPAVRAALLGRQRDYRQGPGLVAEGRDIGSV
IFPDASVKIFLTASVEARAERRYKQLIGKGLAANMESLMQDLRERDARDAARTVAPLQKLPDAALLDTTDRDVEQAVTFV
LDLVRDHGLRGAN

Sequences:

>Translated_653_residues
MTMEFLDLPPMLAARGQVRLPGSKSISNRSLLLAALAEGETDIRDLLASDDVERMLEALQALGVRWSREEGTDNYRVHGV
GGPFPVKKGDLFLGNAGTAFRPLTAALALSGGDYRLSGVARMHERPIGDLVDALRQAGADIEYVGNEGFPPLHIRPATIR
PGGVLKVRGDVSSQFLTALLMALPLTGVETTIEVVGELISKPYIAITLDLMARFGVDVVREDWQRFTVPGGARYRSPGVL
YVEGDASSASYFLAAGAIGGGPVRVEGVGRDSIQGDVRFADALAQLGAVITVGDNWIEAAAPAGGRLRAFDLDLNHIPDA
AMTLAVAALFADGPCTLRNIASWRVKETDRIAAMATELRKVGAEVEEGADYLRIMPPAVLRPAAIDTYDDHRMAMCFSLV
SLGGCRVRINDPRCVNKTFPSYFEAFATVAAPVPVVAIDGPSASGKGTVGARVAAALGWHHLDSGSLYRLVALSAERGGI
DLDDEVALAAIAGDLPARFEGERVWLGTDDVTDAIRSEQCSAGASKVAVLPAVRAALLGRQRDYRQGPGLVAEGRDIGSV
IFPDASVKIFLTASVEARAERRYKQLIGKGLAANMESLMQDLRERDARDAARTVAPLQKLPDAALLDTTDRDVEQAVTFV
LDLVRDHGLRGAN
>Mature_652_residues
TMEFLDLPPMLAARGQVRLPGSKSISNRSLLLAALAEGETDIRDLLASDDVERMLEALQALGVRWSREEGTDNYRVHGVG
GPFPVKKGDLFLGNAGTAFRPLTAALALSGGDYRLSGVARMHERPIGDLVDALRQAGADIEYVGNEGFPPLHIRPATIRP
GGVLKVRGDVSSQFLTALLMALPLTGVETTIEVVGELISKPYIAITLDLMARFGVDVVREDWQRFTVPGGARYRSPGVLY
VEGDASSASYFLAAGAIGGGPVRVEGVGRDSIQGDVRFADALAQLGAVITVGDNWIEAAAPAGGRLRAFDLDLNHIPDAA
MTLAVAALFADGPCTLRNIASWRVKETDRIAAMATELRKVGAEVEEGADYLRIMPPAVLRPAAIDTYDDHRMAMCFSLVS
LGGCRVRINDPRCVNKTFPSYFEAFATVAAPVPVVAIDGPSASGKGTVGARVAAALGWHHLDSGSLYRLVALSAERGGID
LDDEVALAAIAGDLPARFEGERVWLGTDDVTDAIRSEQCSAGASKVAVLPAVRAALLGRQRDYRQGPGLVAEGRDIGSVI
FPDASVKIFLTASVEARAERRYKQLIGKGLAANMESLMQDLRERDARDAARTVAPLQKLPDAALLDTTDRDVEQAVTFVL
DLVRDHGLRGAN

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1787137, Length=429, Percent_Identity=58.041958041958, Blast_Score=465, Evalue=1e-132,
Organism=Escherichia coli, GI1787139, Length=221, Percent_Identity=47.5113122171946, Blast_Score=191, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6320332, Length=521, Percent_Identity=36.852207293666, Blast_Score=259, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792 [H]

Pfam domain/function: PF00275 EPSP_synthase [H]

EC number: =2.5.1.19 [H]

Molecular weight: Translated: 69579; Mature: 69448

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00104 EPSP_SYNTHASE_1 ; PS00885 EPSP_SYNTHASE_2 ; PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMEFLDLPPMLAARGQVRLPGSKSISNRSLLLAALAEGETDIRDLLASDDVERMLEALQ
CCCCCCCCCHHHHCCCCEECCCCCCCCCCCEEEEEECCCCHHHHHHHCCCCHHHHHHHHH
ALGVRWSREEGTDNYRVHGVGGPFPVKKGDLFLGNAGTAFRPLTAALALSGGDYRLSGVA
HHCCEECCCCCCCCEEEEECCCCCCCCCCCEEECCCCCCHHHHHHHHEECCCCEEEHHHH
RMHERPIGDLVDALRQAGADIEYVGNEGFPPLHIRPATIRPGGVLKVRGDVSSQFLTALL
HHHCCCHHHHHHHHHHCCCCEEECCCCCCCCEEEECCEECCCCEEEEECCCHHHHHHHHH
MALPLTGVETTIEVVGELISKPYIAITLDLMARFGVDVVREDWQRFTVPGGARYRSPGVL
HHHCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCEE
YVEGDASSASYFLAAGAIGGGPVRVEGVGRDSIQGDVRFADALAQLGAVITVGDNWIEAA
EEECCCCCCEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCEEEEECCCHHHHC
APAGGRLRAFDLDLNHIPDAAMTLAVAALFADGPCTLRNIASWRVKETDRIAAMATELRK
CCCCCCEEEEECCHHHCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHH
VGAEVEEGADYLRIMPPAVLRPAAIDTYDDHRMAMCFSLVSLGGCRVRINDPRCVNKTFP
HCCHHHCCCCEEEECCHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCH
SYFEAFATVAAPVPVVAIDGPSASGKGTVGARVAAALGWHHLDSGSLYRLVALSAERGGI
HHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCC
DLDDEVALAAIAGDLPARFEGERVWLGTDDVTDAIRSEQCSAGASKVAVLPAVRAALLGR
CCCCCHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
QRDYRQGPGLVAEGRDIGSVIFPDASVKIFLTASVEARAERRYKQLIGKGLAANMESLMQ
CCHHHCCCCCEECCCCCCEEECCCCCEEEEEEECHHHHHHHHHHHHHHCCHHHHHHHHHH
DLRERDARDAARTVAPLQKLPDAALLDTTDRDVEQAVTFVLDLVRDHGLRGAN
HHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TMEFLDLPPMLAARGQVRLPGSKSISNRSLLLAALAEGETDIRDLLASDDVERMLEALQ
CCCCCCCCHHHHCCCCEECCCCCCCCCCCEEEEEECCCCHHHHHHHCCCCHHHHHHHHH
ALGVRWSREEGTDNYRVHGVGGPFPVKKGDLFLGNAGTAFRPLTAALALSGGDYRLSGVA
HHCCEECCCCCCCCEEEEECCCCCCCCCCCEEECCCCCCHHHHHHHHEECCCCEEEHHHH
RMHERPIGDLVDALRQAGADIEYVGNEGFPPLHIRPATIRPGGVLKVRGDVSSQFLTALL
HHHCCCHHHHHHHHHHCCCCEEECCCCCCCCEEEECCEECCCCEEEEECCCHHHHHHHHH
MALPLTGVETTIEVVGELISKPYIAITLDLMARFGVDVVREDWQRFTVPGGARYRSPGVL
HHHCCCCHHHHHHHHHHHHCCCEEEEEHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCCEE
YVEGDASSASYFLAAGAIGGGPVRVEGVGRDSIQGDVRFADALAQLGAVITVGDNWIEAA
EEECCCCCCEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCEEEEECCCHHHHC
APAGGRLRAFDLDLNHIPDAAMTLAVAALFADGPCTLRNIASWRVKETDRIAAMATELRK
CCCCCCEEEEECCHHHCCHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHHHH
VGAEVEEGADYLRIMPPAVLRPAAIDTYDDHRMAMCFSLVSLGGCRVRINDPRCVNKTFP
HCCHHHCCCCEEEECCHHHHCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCH
SYFEAFATVAAPVPVVAIDGPSASGKGTVGARVAAALGWHHLDSGSLYRLVALSAERGGI
HHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCC
DLDDEVALAAIAGDLPARFEGERVWLGTDDVTDAIRSEQCSAGASKVAVLPAVRAALLGR
CCCCCHHHHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
QRDYRQGPGLVAEGRDIGSVIFPDASVKIFLTASVEARAERRYKQLIGKGLAANMESLMQ
CCHHHCCCCCEECCCCCCEEECCCCCEEEEEEECHHHHHHHHHHHHHHCCHHHHHHHHHH
DLRERDARDAARTVAPLQKLPDAALLDTTDRDVEQAVTFVLDLVRDHGLRGAN
HHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA