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The map label for this gene is gyrA [H]

Identifier: 119897357

GI number: 119897357

Start: 1146520

End: 1149153

Strand: Direct

Name: gyrA [H]

Synonym: azo1066

Alternate gene names: 119897357

Gene position: 1146520-1149153 (Clockwise)

Preceding gene: 119897356

Following gene: 119897358

Centisome position: 26.2

GC content: 65.49

Gene sequence:

>2634_bases
ATGACACAGTTCGCCAAGGAAACGCTGCCGATCAGCCTCGAGGAGGAAATGCGCCACTCCTACCTGGATTACGCCATGAG
CGTGATCGTGGGGCGGGCGCTGCCCGATGCGCGCGACGGCCTGAAGCCGGTGCACCGCCGGGTGCTGTACGCGATGCACG
AGCTTTCCAACGACTGGAACCGCGCCTACAAGAAGTCGGCGCGTATCGTCGGCGACGTCATCGGTAAGTACCACCCGCAT
GGCGACTCGGCGGTGTACGACACCATCGTGCGCATGGCGCAGGATTTCTCGCTGCGCTACATGCTGGTCGACGGCCAGGG
CAACTTCGGCTCGGTCGACGGCGACAACGCCGCGGCGATGCGTTACACCGAAATCCGCATGGCGCGCATCGGTCACGAAC
TGCTGGCCGACATCGACAAGGAAACGGTGGATTTCGGGCCGAACTACGACGGCTCGGAAAAAGAGCCGCTGATCCTGCCG
GCCCGCATCCCCAATCTGCTGATCAACGGTTCCTCCGGTATCGCGGTCGGCATGGCGACCAACATCCCGCCGCACAACCT
GGGCGAAGTGGTCGATGCCTGTCTCAAGCTGCTCGAAGATCCGGAAACCGACCTCGAAGCGCTGATCGAAATCGTCAAGG
CGCCCGACTTCCCCACCGCGGGTCTGATCTACGGCCTGCACGGCGTGCACGAAGGCTATCGCACCGGCCGCGGCCGGGTG
GTGATGCGCGCCCGCACCCATATCGAGCCGATCGGCAAGAACAGCGACCGCGAAGCCATCATCGTCGACGAGCTGCCCTA
CCAGGTGAACAAGCGCACCCTGCTGGAGCGCATCGCCGAGCTGGTCAACGAAAAGAAGGTCGAGGGCATCAGCGAGATCC
GCGACGAGTCGGACAAGTCCGGCATGCGCGTGGTGATCGAACTGAAGCGCAACGAAATGCCCGAGGTGGTGCTCAACAAC
CTGTACAAGCACACCCAGCTGCAGGACACCTTCGGCATGAACATGGTGGCGCTGGTGGACGGCAAGCCCCGCCTGCTCAA
CCTCAAGCAGATGCTGGTGTGCTTCCTCGAGCACCGCCGCGAGGTCGTCACCCGCCGCACCATCTTCGAACTGAAGAAGG
CGCGCGACCGCGGCCACATCCTCGAAGGCCTGGCGGTGGCGCTGTCCAACGTGGACGAGATCATCGCCCTGATCAAGGCC
GCGCCGACGCCGGCGGATGCCAAGCGCGGCCTGATGGAACGCACGTGGCGCTCGCCGCTGGTGGAAGAAATGCTGTCGCG
CGCGCTCGCCGACAGCTACCGCCCGGAAGGGCTGGACCCCGAGTTCGGCTTCTCGGCCCAGGGTTACAAGCTGTCCGACG
CCCAGGCCCAGGCCATCCTGGAACTGCGCCTGCAGCGCCTGACCGGCCTCGAACAGGACAAGATCGTCGGCGAGTACCGC
GAGGTGATGGATCTCATCACCGACCTGCTCGACATCCTGGCCCGTCCCGAGCGCATCACCGCGATCATCGTCGAGGAGCT
GACCGCGATCCGCAACCAGTTCGGCGACCCGCGCCGTTCCGAGATCGTGCTCAGCACCGCCGAGATCAACATCGAGGACC
TGATCACGCCGGAAGACATGGTGGTGACGCTGTCGCACACCGGTTACTTCAAGCGCCAGCCGCTCGCCGACTACCGCGCC
CAGCGTCGCGGCGGCCGCGGCAAGCAGGCCACCTCGATGAAGGACGAGGACTTCATCGACCACCTCTTCGTCGCCAATAC
CCACGACACCGTGCTGTGCTTCTCCAGCCGCGGCCGCGCCTACTGGCTGAAGGTGTACGAGGTGCCCGAAGGCACCCGCA
ACTCGCGCGGCAAGCCGATCGTGAACCTGTTCCCGTTGATCGAGGGCGAGAAGATCACCGCGGTGCTGCCGGTGCAGACC
TTCGATGAAGAGCATTTCGTGTTCATGGCGACTTCGGAAGGCACGGTCAAGAAGACTGCGCTCACCGCTTTCGCCAACCC
GCGCAAGGCCGGCATCATCGCGGTCAACCTCGATGACGGCGACCACCTGATCGGCGTCGCGATCACCGACGGTGAGTGCG
ACGTGATGCTGTTCTCCGACGCCGGCAAGGCCGTGCGCTTTGCCGAGAGCGACGTGCGCCCGATGGGCCGCGAAGCGCGC
GGCGTGCGCGGCATGACGCTGGAAGACGGCCAGCGCGTGATCGCGATGCTGGTCGCCAAGGGCGAAACCCAGTCGGTGTT
GACGGCTACCGAAAACGGTTATGGCAAGCGCACCCCGGTGGCGGAATACACCCGCCACGGCCGCGGCACCAAGGGCATGA
TCGCGATCCAGACCTCGGACCGCAACGGCAAGCTGGTCGGCGCGGTGCTGGTCGATCCGACCGACGAGGTGATGCTGATC
TCCACCGGTGCGGTGCTGATCCGCACCAAGGTGCAGGACATCCGCGAGCTTGGCCGCGCCACCCAGGGCGTGACGCTGAT
CAACCTCGATGAGGGCACGTACCTGGCCGGGATCGAGAAGGTGGCCGAGTCCGGCGCCGAGGCGGACGAACTGGTGGAAG
GTGGCGAAGAGGGCGCCGCGGACGGCGAGGATGCCGGCGCGCCGGGCGCCGCGGGTGAAGGAGAACAGGAATGA

Upstream 100 bases:

>100_bases
TTGACGGCGGGCCTGTCAGCGACCCGCCGACCGGAATGGCGCAAGGGGGCGTGGTAACATCTCTCCCTTTTGGGTTACGC
GGGTCTGACCGCCTTCGAGC

Downstream 100 bases:

>100_bases
CACGCGTCTGGAATTTCGCGGCCGGTCCGGCCGCGCTGCCCGCCGAGGTGCTGCAGCAGGCCGCCGAGGAGATGCTCGAC
TGGCGCGGTGCCGGCGTCGG

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 877; Mature: 876

Protein sequence:

>877_residues
MTQFAKETLPISLEEEMRHSYLDYAMSVIVGRALPDARDGLKPVHRRVLYAMHELSNDWNRAYKKSARIVGDVIGKYHPH
GDSAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDNAAAMRYTEIRMARIGHELLADIDKETVDFGPNYDGSEKEPLILP
ARIPNLLINGSSGIAVGMATNIPPHNLGEVVDACLKLLEDPETDLEALIEIVKAPDFPTAGLIYGLHGVHEGYRTGRGRV
VMRARTHIEPIGKNSDREAIIVDELPYQVNKRTLLERIAELVNEKKVEGISEIRDESDKSGMRVVIELKRNEMPEVVLNN
LYKHTQLQDTFGMNMVALVDGKPRLLNLKQMLVCFLEHRREVVTRRTIFELKKARDRGHILEGLAVALSNVDEIIALIKA
APTPADAKRGLMERTWRSPLVEEMLSRALADSYRPEGLDPEFGFSAQGYKLSDAQAQAILELRLQRLTGLEQDKIVGEYR
EVMDLITDLLDILARPERITAIIVEELTAIRNQFGDPRRSEIVLSTAEINIEDLITPEDMVVTLSHTGYFKRQPLADYRA
QRRGGRGKQATSMKDEDFIDHLFVANTHDTVLCFSSRGRAYWLKVYEVPEGTRNSRGKPIVNLFPLIEGEKITAVLPVQT
FDEEHFVFMATSEGTVKKTALTAFANPRKAGIIAVNLDDGDHLIGVAITDGECDVMLFSDAGKAVRFAESDVRPMGREAR
GVRGMTLEDGQRVIAMLVAKGETQSVLTATENGYGKRTPVAEYTRHGRGTKGMIAIQTSDRNGKLVGAVLVDPTDEVMLI
STGAVLIRTKVQDIRELGRATQGVTLINLDEGTYLAGIEKVAESGAEADELVEGGEEGAADGEDAGAPGAAGEGEQE

Sequences:

>Translated_877_residues
MTQFAKETLPISLEEEMRHSYLDYAMSVIVGRALPDARDGLKPVHRRVLYAMHELSNDWNRAYKKSARIVGDVIGKYHPH
GDSAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDNAAAMRYTEIRMARIGHELLADIDKETVDFGPNYDGSEKEPLILP
ARIPNLLINGSSGIAVGMATNIPPHNLGEVVDACLKLLEDPETDLEALIEIVKAPDFPTAGLIYGLHGVHEGYRTGRGRV
VMRARTHIEPIGKNSDREAIIVDELPYQVNKRTLLERIAELVNEKKVEGISEIRDESDKSGMRVVIELKRNEMPEVVLNN
LYKHTQLQDTFGMNMVALVDGKPRLLNLKQMLVCFLEHRREVVTRRTIFELKKARDRGHILEGLAVALSNVDEIIALIKA
APTPADAKRGLMERTWRSPLVEEMLSRALADSYRPEGLDPEFGFSAQGYKLSDAQAQAILELRLQRLTGLEQDKIVGEYR
EVMDLITDLLDILARPERITAIIVEELTAIRNQFGDPRRSEIVLSTAEINIEDLITPEDMVVTLSHTGYFKRQPLADYRA
QRRGGRGKQATSMKDEDFIDHLFVANTHDTVLCFSSRGRAYWLKVYEVPEGTRNSRGKPIVNLFPLIEGEKITAVLPVQT
FDEEHFVFMATSEGTVKKTALTAFANPRKAGIIAVNLDDGDHLIGVAITDGECDVMLFSDAGKAVRFAESDVRPMGREAR
GVRGMTLEDGQRVIAMLVAKGETQSVLTATENGYGKRTPVAEYTRHGRGTKGMIAIQTSDRNGKLVGAVLVDPTDEVMLI
STGAVLIRTKVQDIRELGRATQGVTLINLDEGTYLAGIEKVAESGAEADELVEGGEEGAADGEDAGAPGAAGEGEQE
>Mature_876_residues
TQFAKETLPISLEEEMRHSYLDYAMSVIVGRALPDARDGLKPVHRRVLYAMHELSNDWNRAYKKSARIVGDVIGKYHPHG
DSAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDNAAAMRYTEIRMARIGHELLADIDKETVDFGPNYDGSEKEPLILPA
RIPNLLINGSSGIAVGMATNIPPHNLGEVVDACLKLLEDPETDLEALIEIVKAPDFPTAGLIYGLHGVHEGYRTGRGRVV
MRARTHIEPIGKNSDREAIIVDELPYQVNKRTLLERIAELVNEKKVEGISEIRDESDKSGMRVVIELKRNEMPEVVLNNL
YKHTQLQDTFGMNMVALVDGKPRLLNLKQMLVCFLEHRREVVTRRTIFELKKARDRGHILEGLAVALSNVDEIIALIKAA
PTPADAKRGLMERTWRSPLVEEMLSRALADSYRPEGLDPEFGFSAQGYKLSDAQAQAILELRLQRLTGLEQDKIVGEYRE
VMDLITDLLDILARPERITAIIVEELTAIRNQFGDPRRSEIVLSTAEINIEDLITPEDMVVTLSHTGYFKRQPLADYRAQ
RRGGRGKQATSMKDEDFIDHLFVANTHDTVLCFSSRGRAYWLKVYEVPEGTRNSRGKPIVNLFPLIEGEKITAVLPVQTF
DEEHFVFMATSEGTVKKTALTAFANPRKAGIIAVNLDDGDHLIGVAITDGECDVMLFSDAGKAVRFAESDVRPMGREARG
VRGMTLEDGQRVIAMLVAKGETQSVLTATENGYGKRTPVAEYTRHGRGTKGMIAIQTSDRNGKLVGAVLVDPTDEVMLIS
TGAVLIRTKVQDIRELGRATQGVTLINLDEGTYLAGIEKVAESGAEADELVEGGEEGAADGEDAGAPGAAGEGEQE

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=331, Percent_Identity=25.6797583081571, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI19913406, Length=320, Percent_Identity=26.5625, Blast_Score=83, Evalue=1e-15,
Organism=Escherichia coli, GI1788562, Length=869, Percent_Identity=61.5650172612198, Blast_Score=1087, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=711, Percent_Identity=36.0056258790436, Blast_Score=392, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI212645845, Length=375, Percent_Identity=25.0666666666667, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI212645657, Length=353, Percent_Identity=24.929178470255, Blast_Score=76, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17535065, Length=324, Percent_Identity=25.6172839506173, Blast_Score=76, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=354, Percent_Identity=25.9887005649718, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI17136538, Length=424, Percent_Identity=24.5283018867925, Blast_Score=81, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 96918; Mature: 96787

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQFAKETLPISLEEEMRHSYLDYAMSVIVGRALPDARDGLKPVHRRVLYAMHELSNDWN
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCHHH
RAYKKSARIVGDVIGKYHPHGDSAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDNAAAM
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEE
RYTEIRMARIGHELLADIDKETVDFGPNYDGSEKEPLILPARIPNLLINGSSGIAVGMAT
EHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCEEEECCCCEEEEECCCCEEEEEEC
NIPPHNLGEVVDACLKLLEDPETDLEALIEIVKAPDFPTAGLIYGLHGVHEGYRTGRGRV
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEE
VMRARTHIEPIGKNSDREAIIVDELPYQVNKRTLLERIAELVNEKKVEGISEIRDESDKS
EEEECCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCC
GMRVVIELKRNEMPEVVLNNLYKHTQLQDTFGMNMVALVDGKPRLLNLKQMLVCFLEHRR
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECHHHHHHHHHHHHH
EVVTRRTIFELKKARDRGHILEGLAVALSNVDEIIALIKAAPTPADAKRGLMERTWRSPL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHH
VEEMLSRALADSYRPEGLDPEFGFSAQGYKLSDAQAQAILELRLQRLTGLEQDKIVGEYR
HHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHH
EVMDLITDLLDILARPERITAIIVEELTAIRNQFGDPRRSEIVLSTAEINIEDLITPEDM
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECHHHCCCCCCE
VVTLSHTGYFKRQPLADYRAQRRGGRGKQATSMKDEDFIDHLFVANTHDTVLCFSSRGRA
EEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHEEECCCCEEEEECCCCCE
YWLKVYEVPEGTRNSRGKPIVNLFPLIEGEKITAVLPVQTFDEEHFVFMATSEGTVKKTA
EEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEEECEECCCCCEEEEEECCCCEEHHH
LTAFANPRKAGIIAVNLDDGDHLIGVAITDGECDVMLFSDAGKAVRFAESDVRPMGREAR
HHHHCCCCCCCEEEEEECCCCEEEEEEEECCCEEEEEECCCCCEEEECCCCCCCCCHHHC
GVRGMTLEDGQRVIAMLVAKGETQSVLTATENGYGKRTPVAEYTRHGRGTKGMIAIQTSD
CCCCCCHHCHHHEEHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCEEEEEECC
RNGKLVGAVLVDPTDEVMLISTGAVLIRTKVQDIRELGRATQGVTLINLDEGTYLAGIEK
CCCCEEEEEEECCCCCEEEEECCEEEEHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHH
VAESGAEADELVEGGEEGAADGEDAGAPGAAGEGEQE
HHHCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TQFAKETLPISLEEEMRHSYLDYAMSVIVGRALPDARDGLKPVHRRVLYAMHELSNDWN
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCHHH
RAYKKSARIVGDVIGKYHPHGDSAVYDTIVRMAQDFSLRYMLVDGQGNFGSVDGDNAAAM
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEE
RYTEIRMARIGHELLADIDKETVDFGPNYDGSEKEPLILPARIPNLLINGSSGIAVGMAT
EHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCEEEECCCCEEEEECCCCEEEEEEC
NIPPHNLGEVVDACLKLLEDPETDLEALIEIVKAPDFPTAGLIYGLHGVHEGYRTGRGRV
CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCEE
VMRARTHIEPIGKNSDREAIIVDELPYQVNKRTLLERIAELVNEKKVEGISEIRDESDKS
EEEECCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCC
GMRVVIELKRNEMPEVVLNNLYKHTQLQDTFGMNMVALVDGKPRLLNLKQMLVCFLEHRR
CCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECHHHHHHHHHHHHH
EVVTRRTIFELKKARDRGHILEGLAVALSNVDEIIALIKAAPTPADAKRGLMERTWRSPL
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHH
VEEMLSRALADSYRPEGLDPEFGFSAQGYKLSDAQAQAILELRLQRLTGLEQDKIVGEYR
HHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHH
EVMDLITDLLDILARPERITAIIVEELTAIRNQFGDPRRSEIVLSTAEINIEDLITPEDM
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECHHHCCCCCCE
VVTLSHTGYFKRQPLADYRAQRRGGRGKQATSMKDEDFIDHLFVANTHDTVLCFSSRGRA
EEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHEEECCCCEEEEECCCCCE
YWLKVYEVPEGTRNSRGKPIVNLFPLIEGEKITAVLPVQTFDEEHFVFMATSEGTVKKTA
EEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEEECEECCCCCEEEEEECCCCEEHHH
LTAFANPRKAGIIAVNLDDGDHLIGVAITDGECDVMLFSDAGKAVRFAESDVRPMGREAR
HHHHCCCCCCCEEEEEECCCCEEEEEEEECCCEEEEEECCCCCEEEECCCCCCCCCHHHC
GVRGMTLEDGQRVIAMLVAKGETQSVLTATENGYGKRTPVAEYTRHGRGTKGMIAIQTSD
CCCCCCHHCHHHEEHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHCCCCCCCEEEEEECC
RNGKLVGAVLVDPTDEVMLISTGAVLIRTKVQDIRELGRATQGVTLINLDEGTYLAGIEK
CCCCEEEEEEECCCCCEEEEECCEEEEHHHHHHHHHHHHHHCCEEEEEECCCCHHHHHHH
VAESGAEADELVEGGEEGAADGEDAGAPGAAGEGEQE
HHHCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7811002; 10984043 [H]