Click here to switch to the map view.

The map label for this gene is pntAA [H]

Identifier: 119897294

GI number: 119897294

Start: 1077900

End: 1079021

Strand: Direct

Name: pntAA [H]

Synonym: azo1003

Alternate gene names: 119897294

Gene position: 1077900-1079021 (Clockwise)

Preceding gene: 119897293

Following gene: 119897295

Centisome position: 24.63

GC content: 68.98

Gene sequence:

>1122_bases
ATGCCATTGACGATCGGAGTGCCGGCCGAACGGATACCCGGCGAACGCCGGCTGCCCGTGGTGCCGGATGTGGTGAAGAA
GTATCTGGGCCTGGGTGCCCGGGTCGTGATCGAGTCCGGCGCGGGCGTGCCCGCGCACTACCGCGACGAAACCTTTGGCG
ACGTGACCTTGGGCGCCGCCGCCGAGGTGTTCGCGCAGTCGGACATCGTGCTGTGCGTGCAGCCGCCGTCGGCCGAGCAT
CTGGCTACGATGAAGCCGGGCGCGCTGCTGATCGGCCTGCTGCAGCCGTGGTCTGACCCCGAGCGCATCAAGCTGCTGCA
AGACAAGCAGATCACCGCGTTCGCGATGGAACTGCTGCCGCGCATCTCGCGCGCGCAGAGCATGGACGTGCTCTCCAGCC
AGGCGGCCGTCGCGGGCTACGAGTGCGCGCTGATCGCCGCCGACCATTCGCCGAAGTTCTTCCCCATGCTCACCTACGCC
GCCGGCACCATCCGCCCGGCCAAGGTGCTGGTGATCGGCGCCGGCGTCGCCGGGCTGCAGGCCATCGCCACCGCGCGCCG
CATCGGCGCCATGGTGGAAGCCTATGACGTGCGCCCCGAAACCCGTGAGCAGATCGAGTCGCTCGGGGCCAAGTTCGTCG
ATACCGGCGTGTCGGCGGCGGGCTCGGGCGGCTACGCCCGCGAACTGACCGACGAAGAAAAGGCGAAGCAGGCCGAGCGG
CTGGCCAAGGCGGTCGCGCAGTGCGATGCGCTGATCACCACCGCGGCGATCCCCGGCAAGAAGGCGCCGAAGATCATCAC
CGCCGACATGATCGCGCGCATGAAGCCGGGCGCGGTCGTCGTCGATATGGCCGCCGAGACCGGTGGCAACGTCGAGGGCA
CCGTCGCCGGGGAAAAGACCTGGATCAACGACGTGCTGGTGATCGGCCCCACCCACATCGCCAGCCGCATGCCGGTGCAC
GCGGCCGAGATGCTCGCCAAGAACCTCTTCAACTTCATCGGCCCCTTCATCAAGGACGGCGCGCTCACGCTCGACTGGGA
CGACGAAGTGCTGGCGGGCACCTGCCTCACCCACGCCGGCGAGCTGCGCCACGCCGGCGTCAAAGCCGCCCTCGGCCTGT
AA

Upstream 100 bases:

>100_bases
GCAATGCGCGCCGCATCGTCGGAGTCGGGAACAGCAATACCTAACGATCCGATCCGACTGGCGCGCTTCTTATTTTGAAT
AAGACCTCCAGGGAGGAGTC

Downstream 100 bases:

>100_bases
CGGAGACGCTGCCATGGATGGATTTACCGCAATCTACATCTTCATGCTCGCCGCCTTCACCGGCTACGAGGTCATCTCGC
GGGTGCCGGTGATCCTTCAC

Product: NAD(P) transhydrogenase subunit alpha part 1

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MPLTIGVPAERIPGERRLPVVPDVVKKYLGLGARVVIESGAGVPAHYRDETFGDVTLGAAAEVFAQSDIVLCVQPPSAEH
LATMKPGALLIGLLQPWSDPERIKLLQDKQITAFAMELLPRISRAQSMDVLSSQAAVAGYECALIAADHSPKFFPMLTYA
AGTIRPAKVLVIGAGVAGLQAIATARRIGAMVEAYDVRPETREQIESLGAKFVDTGVSAAGSGGYARELTDEEKAKQAER
LAKAVAQCDALITTAAIPGKKAPKIITADMIARMKPGAVVVDMAAETGGNVEGTVAGEKTWINDVLVIGPTHIASRMPVH
AAEMLAKNLFNFIGPFIKDGALTLDWDDEVLAGTCLTHAGELRHAGVKAALGL

Sequences:

>Translated_373_residues
MPLTIGVPAERIPGERRLPVVPDVVKKYLGLGARVVIESGAGVPAHYRDETFGDVTLGAAAEVFAQSDIVLCVQPPSAEH
LATMKPGALLIGLLQPWSDPERIKLLQDKQITAFAMELLPRISRAQSMDVLSSQAAVAGYECALIAADHSPKFFPMLTYA
AGTIRPAKVLVIGAGVAGLQAIATARRIGAMVEAYDVRPETREQIESLGAKFVDTGVSAAGSGGYARELTDEEKAKQAER
LAKAVAQCDALITTAAIPGKKAPKIITADMIARMKPGAVVVDMAAETGGNVEGTVAGEKTWINDVLVIGPTHIASRMPVH
AAEMLAKNLFNFIGPFIKDGALTLDWDDEVLAGTCLTHAGELRHAGVKAALGL
>Mature_372_residues
PLTIGVPAERIPGERRLPVVPDVVKKYLGLGARVVIESGAGVPAHYRDETFGDVTLGAAAEVFAQSDIVLCVQPPSAEHL
ATMKPGALLIGLLQPWSDPERIKLLQDKQITAFAMELLPRISRAQSMDVLSSQAAVAGYECALIAADHSPKFFPMLTYAA
GTIRPAKVLVIGAGVAGLQAIATARRIGAMVEAYDVRPETREQIESLGAKFVDTGVSAAGSGGYARELTDEEKAKQAERL
AKAVAQCDALITTAAIPGKKAPKIITADMIARMKPGAVVVDMAAETGGNVEGTVAGEKTWINDVLVIGPTHIASRMPVHA
AEMLAKNLFNFIGPFIKDGALTLDWDDEVLAGTCLTHAGELRHAGVKAALGL

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=363, Percent_Identity=37.7410468319559, Blast_Score=221, Evalue=9e-58,
Organism=Homo sapiens, GI122939153, Length=363, Percent_Identity=37.7410468319559, Blast_Score=221, Evalue=9e-58,
Organism=Escherichia coli, GI1787887, Length=370, Percent_Identity=42.7027027027027, Blast_Score=278, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI17550456, Length=365, Percent_Identity=41.3698630136986, Blast_Score=267, Evalue=5e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 39226; Mature: 39095

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLTIGVPAERIPGERRLPVVPDVVKKYLGLGARVVIESGAGVPAHYRDETFGDVTLGAA
CCEEECCCHHHCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEHHHH
AEVFAQSDIVLCVQPPSAEHLATMKPGALLIGLLQPWSDPERIKLLQDKQITAFAMELLP
HHHHCCCCEEEEECCCCCHHHCCCCCCCEEEEECCCCCCHHHHHHHCCCCHHHHHHHHHH
RISRAQSMDVLSSQAAVAGYECALIAADHSPKFFPMLTYAAGTIRPAKVLVIGAGVAGLQ
HHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEHHHHCCCCCCEEEEEEECCHHHHH
AIATARRIGAMVEAYDVRPETREQIESLGAKFVDTGVSAAGSGGYARELTDEEKAKQAER
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHH
LAKAVAQCDALITTAAIPGKKAPKIITADMIARMKPGAVVVDMAAETGGNVEGTVAGEKT
HHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHCCCCEEEEEEECCCCCCCEEEECCCCE
WINDVLVIGPTHIASRMPVHAAEMLAKNLFNFIGPFIKDGALTLDWDDEVLAGTCLTHAG
ECCCEEEECCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHH
ELRHAGVKAALGL
HHHHCCCHHHCCC
>Mature Secondary Structure 
PLTIGVPAERIPGERRLPVVPDVVKKYLGLGARVVIESGAGVPAHYRDETFGDVTLGAA
CEEECCCHHHCCCCCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEHHHH
AEVFAQSDIVLCVQPPSAEHLATMKPGALLIGLLQPWSDPERIKLLQDKQITAFAMELLP
HHHHCCCCEEEEECCCCCHHHCCCCCCCEEEEECCCCCCHHHHHHHCCCCHHHHHHHHHH
RISRAQSMDVLSSQAAVAGYECALIAADHSPKFFPMLTYAAGTIRPAKVLVIGAGVAGLQ
HHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCEEEEHHHHCCCCCCEEEEEEECCHHHHH
AIATARRIGAMVEAYDVRPETREQIESLGAKFVDTGVSAAGSGGYARELTDEEKAKQAER
HHHHHHHHHHHHHHHCCCCHHHHHHHHHCHHHHHCCCCCCCCCCCHHHCCCHHHHHHHHH
LAKAVAQCDALITTAAIPGKKAPKIITADMIARMKPGAVVVDMAAETGGNVEGTVAGEKT
HHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHCCCCEEEEEEECCCCCCCEEEECCCCE
WINDVLVIGPTHIASRMPVHAAEMLAKNLFNFIGPFIKDGALTLDWDDEVLAGTCLTHAG
ECCCEEEECCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHH
ELRHAGVKAALGL
HHHHCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]