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The map label for this gene is argH

Identifier: 119897280

GI number: 119897280

Start: 1061310

End: 1062752

Strand: Reverse

Name: argH

Synonym: azo0989

Alternate gene names: 119897280

Gene position: 1062752-1061310 (Counterclockwise)

Preceding gene: 119897283

Following gene: 119897279

Centisome position: 24.29

GC content: 67.91

Gene sequence:

>1443_bases
ATGACAGACACCACCCCGTCGGCCGACCTCGGCGCCTCTTCCCAGCAACCCGCCAAGGCTTGGTCCGGCCGCTTCTCGGA
ACCGGTTTCCGATCTGGTCAAGCGCTACACCGCGTCGGTGTTCTTCGACAACCGCATGGCCGAACAGGACATCCGCGGCT
CGCTCGCGCACGCCAAGATGCTCGCCCGCCAGGGCATCATCGGCGCGCAGGACCTCGCCGACATCGAGCGCGGCATGGCG
CAGATCAAGGGCGAGATCGAACGCGGCGAGTTCAACTGGAACCTCGACGACGAGGACGTCCACCTCAACATCGAGAAGCG
CCTCACCGCGCTGGTCGGCGACGCCGGCAAGCGCCTGCACACCGGCCGCAGCCGCAACGACCAGGTCGCCACCGACATCC
GCCTGTGGCTGCGCGACGCGATCGACCAGATCCTCGCGCTGATCGGCGACTTCCAGAAGAACCTGCTCGACGTCGCCGAA
GCCAACGCGGCCACGCCGATGCCCGGCTTCACCCACCTGCAGGTCGCCCAGCCGGTCACCTTCGGCCACCACCTGATGGC
CTATTTCGAGATGACCCGGCGCGACGCCGAGCGCTTCGCCGACTGCCGCAAGCGGGTCAACCGCCTGCCGCTGGGCAGCG
CCGCGCTGGCCGGCACCAGCTACCCGATCGACCGCGAGTTCGTCGCCCGCGAACTCGGCTTCGACGAGGTCTGCTACAAC
TCGCTCGACGCCGTCAGCGACCGCGACTTCGCGATCGAATTCTGCGCCGCGTCCTCGCTGCTGATGACGCACCTGTCGCG
CTTCTCCGAGGAACTCATCCTGTGGATGAGCCCGCGCTTCGGCTTCATCGACCTCGCCGACCGCTTCTGCACCGGCAGCT
CGATCATGCCGCAGAAGAAGAACCCGGACGTGCCGGAACTTGTGCGTGGCAAGACCGGCCGGGTGAACGGCAGCCTGATC
GCACTGCTGACCCTGATGAAAGGCCAGCCCCTGGCCTACAACAAGGACAACCAGGAAGACAAGGAGCCGCTGTTCGACAC
CGCCGACACGGTGATCGACACCCTGCGCATCTATGCCGACATGATCACCGGCATCCGCGTCAAGGCCGACAACATGCGCG
GCGCGCTCACCCAGGGCTACGCCACCGCCACCGACCTCGCCGACTACCTGGTCAAGAAGGGCCTGCCCTTCCGCGACGCC
CACGAAGCAGTCGCACTGGCCGTGCGTGCCGCCGAAGTGCGCGGCTGCGACCTGCCGCAGTTCTCGCTCGACGAGCTGCG
GGCGGCGATGGCGCACGTGCCCGGCGCAGCCGACAAGCTCGCTGACGACATCTTCGGCGTGCTGACCGTGGAAGGCTCGC
TCGACTCGCGCAATCACATCGGCGGAACCGCGCCCGCCCAGGTCCTGGCAGCGGTCGCGCACGCCCGCACCCGCCTCGGC
TGA

Upstream 100 bases:

>100_bases
TATACTTTTCATGGTTTACGCAGGCGCCAAGGCGACCTGCCGCCTCATACAGACGCGGCCCCGGCACAGGCGGGCCGGTT
TTTCCTCAGCAACGGACATT

Downstream 100 bases:

>100_bases
GCAACGATGAGCGGCGGACGAATCGGCAAGTACGAGATTCGCCGCCTGCTCGGCGAAGGGGCCACCAGCGCCGTCCATCT
TGCCTGGGACCCCTTCAACC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MTDTTPSADLGASSQQPAKAWSGRFSEPVSDLVKRYTASVFFDNRMAEQDIRGSLAHAKMLARQGIIGAQDLADIERGMA
QIKGEIERGEFNWNLDDEDVHLNIEKRLTALVGDAGKRLHTGRSRNDQVATDIRLWLRDAIDQILALIGDFQKNLLDVAE
ANAATPMPGFTHLQVAQPVTFGHHLMAYFEMTRRDAERFADCRKRVNRLPLGSAALAGTSYPIDREFVARELGFDEVCYN
SLDAVSDRDFAIEFCAASSLLMTHLSRFSEELILWMSPRFGFIDLADRFCTGSSIMPQKKNPDVPELVRGKTGRVNGSLI
ALLTLMKGQPLAYNKDNQEDKEPLFDTADTVIDTLRIYADMITGIRVKADNMRGALTQGYATATDLADYLVKKGLPFRDA
HEAVALAVRAAEVRGCDLPQFSLDELRAAMAHVPGAADKLADDIFGVLTVEGSLDSRNHIGGTAPAQVLAAVAHARTRLG

Sequences:

>Translated_480_residues
MTDTTPSADLGASSQQPAKAWSGRFSEPVSDLVKRYTASVFFDNRMAEQDIRGSLAHAKMLARQGIIGAQDLADIERGMA
QIKGEIERGEFNWNLDDEDVHLNIEKRLTALVGDAGKRLHTGRSRNDQVATDIRLWLRDAIDQILALIGDFQKNLLDVAE
ANAATPMPGFTHLQVAQPVTFGHHLMAYFEMTRRDAERFADCRKRVNRLPLGSAALAGTSYPIDREFVARELGFDEVCYN
SLDAVSDRDFAIEFCAASSLLMTHLSRFSEELILWMSPRFGFIDLADRFCTGSSIMPQKKNPDVPELVRGKTGRVNGSLI
ALLTLMKGQPLAYNKDNQEDKEPLFDTADTVIDTLRIYADMITGIRVKADNMRGALTQGYATATDLADYLVKKGLPFRDA
HEAVALAVRAAEVRGCDLPQFSLDELRAAMAHVPGAADKLADDIFGVLTVEGSLDSRNHIGGTAPAQVLAAVAHARTRLG
>Mature_479_residues
TDTTPSADLGASSQQPAKAWSGRFSEPVSDLVKRYTASVFFDNRMAEQDIRGSLAHAKMLARQGIIGAQDLADIERGMAQ
IKGEIERGEFNWNLDDEDVHLNIEKRLTALVGDAGKRLHTGRSRNDQVATDIRLWLRDAIDQILALIGDFQKNLLDVAEA
NAATPMPGFTHLQVAQPVTFGHHLMAYFEMTRRDAERFADCRKRVNRLPLGSAALAGTSYPIDREFVARELGFDEVCYNS
LDAVSDRDFAIEFCAASSLLMTHLSRFSEELILWMSPRFGFIDLADRFCTGSSIMPQKKNPDVPELVRGKTGRVNGSLIA
LLTLMKGQPLAYNKDNQEDKEPLFDTADTVIDTLRIYADMITGIRVKADNMRGALTQGYATATDLADYLVKKGLPFRDAH
EAVALAVRAAEVRGCDLPQFSLDELRAAMAHVPGAADKLADDIFGVLTVEGSLDSRNHIGGTAPAQVLAAVAHARTRLG

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=466, Percent_Identity=41.4163090128755, Blast_Score=374, Evalue=1e-104,
Organism=Homo sapiens, GI68303542, Length=466, Percent_Identity=41.4163090128755, Blast_Score=374, Evalue=1e-104,
Organism=Homo sapiens, GI68303547, Length=466, Percent_Identity=39.2703862660944, Blast_Score=345, Evalue=4e-95,
Organism=Homo sapiens, GI68303549, Length=466, Percent_Identity=38.8412017167382, Blast_Score=336, Evalue=3e-92,
Organism=Escherichia coli, GI1790398, Length=461, Percent_Identity=46.4208242950108, Blast_Score=409, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6321806, Length=463, Percent_Identity=41.6846652267819, Blast_Score=352, Evalue=7e-98,
Organism=Drosophila melanogaster, GI221473854, Length=451, Percent_Identity=39.2461197339246, Blast_Score=323, Evalue=1e-88,
Organism=Drosophila melanogaster, GI78706858, Length=451, Percent_Identity=39.2461197339246, Blast_Score=323, Evalue=1e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_AZOSB (A1K451)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_932493.1
- ProteinModelPortal:   A1K451
- SMR:   A1K451
- STRING:   A1K451
- GeneID:   4606660
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo0989
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- PhylomeDB:   A1K451
- ProtClustDB:   PRK00855
- BioCyc:   ASP62928:AZO0989-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 52723; Mature: 52592

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTTPSADLGASSQQPAKAWSGRFSEPVSDLVKRYTASVFFDNRMAEQDIRGSLAHAKM
CCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LARQGIIGAQDLADIERGMAQIKGEIERGEFNWNLDDEDVHLNIEKRLTALVGDAGKRLH
HHHCCCCCHHHHHHHHHHHHHHHCCHHCCEECCCCCCCCEEEEHHHHHHHHHHHHHHHHH
TGRSRNDQVATDIRLWLRDAIDQILALIGDFQKNLLDVAEANAATPMPGFTHLQVAQPVT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCHH
FGHHLMAYFEMTRRDAERFADCRKRVNRLPLGSAALAGTSYPIDREFVARELGFDEVCYN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHCCHHHHHHH
SLDAVSDRDFAIEFCAASSLLMTHLSRFSEELILWMSPRFGFIDLADRFCTGSSIMPQKK
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHCCCCCCCCCCC
NPDVPELVRGKTGRVNGSLIALLTLMKGQPLAYNKDNQEDKEPLFDTADTVIDTLRIYAD
CCCHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
MITGIRVKADNMRGALTQGYATATDLADYLVKKGLPFRDAHEAVALAVRAAEVRGCDLPQ
HHHCCEEEECCCCCHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCC
FSLDELRAAMAHVPGAADKLADDIFGVLTVEGSLDSRNHIGGTAPAQVLAAVAHARTRLG
CCHHHHHHHHHHCCCHHHHHHHHHHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDTTPSADLGASSQQPAKAWSGRFSEPVSDLVKRYTASVFFDNRMAEQDIRGSLAHAKM
CCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LARQGIIGAQDLADIERGMAQIKGEIERGEFNWNLDDEDVHLNIEKRLTALVGDAGKRLH
HHHCCCCCHHHHHHHHHHHHHHHCCHHCCEECCCCCCCCEEEEHHHHHHHHHHHHHHHHH
TGRSRNDQVATDIRLWLRDAIDQILALIGDFQKNLLDVAEANAATPMPGFTHLQVAQPVT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCHH
FGHHLMAYFEMTRRDAERFADCRKRVNRLPLGSAALAGTSYPIDREFVARELGFDEVCYN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCHHHHHHHCCHHHHHHH
SLDAVSDRDFAIEFCAASSLLMTHLSRFSEELILWMSPRFGFIDLADRFCTGSSIMPQKK
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHCCCCCCCCCCC
NPDVPELVRGKTGRVNGSLIALLTLMKGQPLAYNKDNQEDKEPLFDTADTVIDTLRIYAD
CCCHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
MITGIRVKADNMRGALTQGYATATDLADYLVKKGLPFRDAHEAVALAVRAAEVRGCDLPQ
HHHCCEEEECCCCCHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCC
FSLDELRAAMAHVPGAADKLADDIFGVLTVEGSLDSRNHIGGTAPAQVLAAVAHARTRLG
CCHHHHHHHHHHCCCHHHHHHHHHHEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA