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The map label for this gene is cobA1 [H]

Identifier: 119897236

GI number: 119897236

Start: 1014601

End: 1015365

Strand: Direct

Name: cobA1 [H]

Synonym: azo0945

Alternate gene names: 119897236

Gene position: 1014601-1015365 (Clockwise)

Preceding gene: 119897235

Following gene: 119897237

Centisome position: 23.19

GC content: 72.55

Gene sequence:

>765_bases
ATGGCCAAGGTAACGCTTGTCGGGGCAGGGCCCGGCGCGGCTGATCTGCTGACTGTTCGTGCGGTGCGCGCCATTGGCCA
GGCCGATGTGCTGCTTGCCGATGCGCTGGTGACCGAGGAAGTGCTGGCACTCGCCAAGCCGGGTGCGCGCGTGCTGCGCG
TCGGCAAGCGCGGCGGCATGAAGTCCACCGCGCAGGACTTCATCCACCGCGTGATGGCGCGCTACGCCCGCCGCGGCTGC
GCGGTGGCGCGCGTCAAGGGCGGCGACCCCTTCCTGTTCGGCCGCGGCGGTGAAGAGGCCGAATACCTCGAAGCGCTCGG
CATCGAGGTCGAGGTGGTGCCGGGTCTCACCTCCGGCATCGCGGTGCCGGCGGCGGTCGGCATTCCGGTCACCCACCGCG
CCCATACCCACGGCGTCACGCTGGTTACCGGCACCGCCGGCGACGGCCGCGACGAGCCAAACTGGGCGGCGCTGGCCAAG
TGCGGCACCACGCTGGTGATCTACATGGGGCTGGGCCGGCTGCTCAACATCGTTGCGCGCCTGATCGCCGCCGGCATGCC
GCCGGACACCCCGGCCGCGGCGATCGCCTCGGGCACGCTGCCGGGCCAGCGCCACGTCAAGGGCACGCTGGCCGACCTGC
CGCTGCGCGTCACTGCCGAAGGCCTCAGCTCGCCGGCCATCATCGTCGTCGGCGAGGTCGCCGCGCTTGCCCGAGTGCCC
GGACTGGCGATGGATGAGTCCGACGTGCGCGCGCTCGCCGCGTGA

Upstream 100 bases:

>100_bases
GCGGACAACGGCGTCCGCCGTTTCCCGGTTCTGCGGAACCTGTGGAAACGGCGAGACGCCGTTTTTTTTCGCCTCAAGTT
TGATGTTGGAGGGTTCGATC

Downstream 100 bases:

>100_bases
GCCAGGAGAGCGCAATGCGCAAACAGAAACTCGTCATGGTCGGCAACGGCATGGCCGGCGTGAAGACGCTGGAAGAGCTG
CTCAAGCACGCGCCGGATGC

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MAKVTLVGAGPGAADLLTVRAVRAIGQADVLLADALVTEEVLALAKPGARVLRVGKRGGMKSTAQDFIHRVMARYARRGC
AVARVKGGDPFLFGRGGEEAEYLEALGIEVEVVPGLTSGIAVPAAVGIPVTHRAHTHGVTLVTGTAGDGRDEPNWAALAK
CGTTLVIYMGLGRLLNIVARLIAAGMPPDTPAAAIASGTLPGQRHVKGTLADLPLRVTAEGLSSPAIIVVGEVAALARVP
GLAMDESDVRALAA

Sequences:

>Translated_254_residues
MAKVTLVGAGPGAADLLTVRAVRAIGQADVLLADALVTEEVLALAKPGARVLRVGKRGGMKSTAQDFIHRVMARYARRGC
AVARVKGGDPFLFGRGGEEAEYLEALGIEVEVVPGLTSGIAVPAAVGIPVTHRAHTHGVTLVTGTAGDGRDEPNWAALAK
CGTTLVIYMGLGRLLNIVARLIAAGMPPDTPAAAIASGTLPGQRHVKGTLADLPLRVTAEGLSSPAIIVVGEVAALARVP
GLAMDESDVRALAA
>Mature_253_residues
AKVTLVGAGPGAADLLTVRAVRAIGQADVLLADALVTEEVLALAKPGARVLRVGKRGGMKSTAQDFIHRVMARYARRGCA
VARVKGGDPFLFGRGGEEAEYLEALGIEVEVVPGLTSGIAVPAAVGIPVTHRAHTHGVTLVTGTAGDGRDEPNWAALAKC
GTTLVIYMGLGRLLNIVARLIAAGMPPDTPAAAIASGTLPGQRHVKGTLADLPLRVTAEGLSSPAIIVVGEVAALARVPG
LAMDESDVRALAA

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=234, Percent_Identity=43.5897435897436, Blast_Score=182, Evalue=1e-47,
Organism=Saccharomyces cerevisiae, GI6322922, Length=248, Percent_Identity=34.2741935483871, Blast_Score=121, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 25849; Mature: 25717

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS00839 SUMT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVTLVGAGPGAADLLTVRAVRAIGQADVLLADALVTEEVLALAKPGARVLRVGKRGGM
CCEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHEEECCCCCC
KSTAQDFIHRVMARYARRGCAVARVKGGDPFLFGRGGEEAEYLEALGIEVEVVPGLTSGI
CHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCHHHHHHHHCCEEEEECCCCCCC
AVPAAVGIPVTHRAHTHGVTLVTGTAGDGRDEPNWAALAKCGTTLVIYMGLGRLLNIVAR
CCCHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHH
LIAAGMPPDTPAAAIASGTLPGQRHVKGTLADLPLRVTAEGLSSPAIIVVGEVAALARVP
HHHCCCCCCCCHHHHHCCCCCCCHHCCCHHHHCCEEEEECCCCCCEEEEEECHHHHHHCC
GLAMDESDVRALAA
CCCCCHHHHHHHCC
>Mature Secondary Structure 
AKVTLVGAGPGAADLLTVRAVRAIGQADVLLADALVTEEVLALAKPGARVLRVGKRGGM
CEEEEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHEEECCCCCC
KSTAQDFIHRVMARYARRGCAVARVKGGDPFLFGRGGEEAEYLEALGIEVEVVPGLTSGI
CHHHHHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCHHHHHHHHCCEEEEECCCCCCC
AVPAAVGIPVTHRAHTHGVTLVTGTAGDGRDEPNWAALAKCGTTLVIYMGLGRLLNIVAR
CCCHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHH
LIAAGMPPDTPAAAIASGTLPGQRHVKGTLADLPLRVTAEGLSSPAIIVVGEVAALARVP
HHHCCCCCCCCHHHHHCCCCCCCHHCCCHHHHCCEEEEECCCCCCEEEEEECHHHHHHCC
GLAMDESDVRALAA
CCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]