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The map label for this gene is hflC [H]

Identifier: 119897226

GI number: 119897226

Start: 1001389

End: 1002270

Strand: Direct

Name: hflC [H]

Synonym: azo0935

Alternate gene names: 119897226

Gene position: 1001389-1002270 (Clockwise)

Preceding gene: 119897225

Following gene: 119897227

Centisome position: 22.88

GC content: 61.34

Gene sequence:

>882_bases
ATGCGCGACAAGCTTTCCGTGATTGCCGGTGTTGTGCTCTTTGCCATCGTGCTGGCGTCGATGTCGCTGTTTACCGTCGA
TCAGCGCCAGTACGCGATCGTGTTCCAGCTCGGCCAGGTCAAGGAGGTCATCGACGCCCCGGGCCTGAACTTCAAGCTGC
CGCTGATCCAGAACGTGCGCTATTTCGAGAAGCGCATCCTGACGATGGACACGCCGGAGCCGGAGCGTTTCATCACGTCG
GAGAAAAAGAACGTGCTGGTCGACCACTTCGTGAAGTGGCGCATCATTGATCCGCGGCTGTATTACGAATCCGTGGCGGG
TGACGAAACCCGCGCCAGGACGCGGCTTAACCAGACGGTCAATTCCGGTCTGCGCGAAGAGTTCGGCAAGCGCACGGTGC
ACGACGTCGTGTCGGGCGCGCGCGACCAGATCATGGAAGACATGCGCGCCAAGGCCGACCAGGATGCACGCAAGATCGGT
GTCCAGATTCTTGATGTGCGCCTGAAGCGGGTCGATCTGCCGAACGAGGTCTCGGAGTCGGTGTATCGGCGCATGGAGGC
GGAGCGCAAACGGGTGGCTAACGAACTGCGCTCCCAGGGTGCGGCCGAGGCAGAGAAGATCCGTGCCGATGCCGACCGCC
AGCGCGAGGTGCTGATCGCCGGAGCCTACCGCGAAGCGCAGCAGGTCAAGGGTGCGGGCGACGCGAAGGCTACCCAGATC
TATGCCGAGGCCTTTGGCCAGAGTCCCGACTTCTATTCCTTCTATCGCAGCCTCGAGGCCTATCGAGCCAGCTTCGATGG
CAAGGACGACGTCATGGTGGTGGATCCGAGTTCGGACTTCTTCAAGTTCATGAAGAACTCCGGAGGCGCGCGAAGGAACT
GA

Upstream 100 bases:

>100_bases
GTGAGCCGACGGCCTCCGTGCCGCCGCCGTCCCCGTCTTCCGGGTTGCCCGATACCCGGACCCGTGAATTGACCCGCAAC
CGCGACCGGGGAGAACGCTG

Downstream 100 bases:

>100_bases
TCGCCGGATGGGTTCCAGTGTGATGATGGCCTTCGCGCTGATGTTGATCATCGAAGGCATCCTGCCTTTTGTCGCGCCAA
CCGCCTGGCGCGAAACTTTT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MRDKLSVIAGVVLFAIVLASMSLFTVDQRQYAIVFQLGQVKEVIDAPGLNFKLPLIQNVRYFEKRILTMDTPEPERFITS
EKKNVLVDHFVKWRIIDPRLYYESVAGDETRARTRLNQTVNSGLREEFGKRTVHDVVSGARDQIMEDMRAKADQDARKIG
VQILDVRLKRVDLPNEVSESVYRRMEAERKRVANELRSQGAAEAEKIRADADRQREVLIAGAYREAQQVKGAGDAKATQI
YAEAFGQSPDFYSFYRSLEAYRASFDGKDDVMVVDPSSDFFKFMKNSGGARRN

Sequences:

>Translated_293_residues
MRDKLSVIAGVVLFAIVLASMSLFTVDQRQYAIVFQLGQVKEVIDAPGLNFKLPLIQNVRYFEKRILTMDTPEPERFITS
EKKNVLVDHFVKWRIIDPRLYYESVAGDETRARTRLNQTVNSGLREEFGKRTVHDVVSGARDQIMEDMRAKADQDARKIG
VQILDVRLKRVDLPNEVSESVYRRMEAERKRVANELRSQGAAEAEKIRADADRQREVLIAGAYREAQQVKGAGDAKATQI
YAEAFGQSPDFYSFYRSLEAYRASFDGKDDVMVVDPSSDFFKFMKNSGGARRN
>Mature_293_residues
MRDKLSVIAGVVLFAIVLASMSLFTVDQRQYAIVFQLGQVKEVIDAPGLNFKLPLIQNVRYFEKRILTMDTPEPERFITS
EKKNVLVDHFVKWRIIDPRLYYESVAGDETRARTRLNQTVNSGLREEFGKRTVHDVVSGARDQIMEDMRAKADQDARKIG
VQILDVRLKRVDLPNEVSESVYRRMEAERKRVANELRSQGAAEAEKIRADADRQREVLIAGAYREAQQVKGAGDAKATQI
YAEAFGQSPDFYSFYRSLEAYRASFDGKDDVMVVDPSSDFFKFMKNSGGARRN

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Homo sapiens, GI7305503, Length=212, Percent_Identity=27.8301886792453, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1790617, Length=318, Percent_Identity=36.7924528301887, Blast_Score=209, Evalue=2e-55,
Organism=Escherichia coli, GI1786697, Length=290, Percent_Identity=24.1379310344828, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI32564147, Length=222, Percent_Identity=27.4774774774775, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17569493, Length=180, Percent_Identity=27.2222222222222, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193209764, Length=180, Percent_Identity=27.2222222222222, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17569499, Length=203, Percent_Identity=29.5566502463054, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45550506, Length=218, Percent_Identity=28.4403669724771, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI18860517, Length=167, Percent_Identity=28.7425149700599, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 33432; Mature: 33432

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDKLSVIAGVVLFAIVLASMSLFTVDQRQYAIVFQLGQVKEVIDAPGLNFKLPLIQNVR
CCCHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEEHHHHHHHHCCCCCCEECHHHHHHH
YFEKRILTMDTPEPERFITSEKKNVLVDHFVKWRIIDPRLYYESVAGDETRARTRLNQTV
HHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHEEECHHHHHHHHCCCHHHHHHHHHHHH
NSGLREEFGKRTVHDVVSGARDQIMEDMRAKADQDARKIGVQILDVRLKRVDLPNEVSES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
VYRRMEAERKRVANELRSQGAAEAEKIRADADRQREVLIAGAYREAQQVKGAGDAKATQI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEHHHHHHHHHCCCCCHHHHHH
YAEAFGQSPDFYSFYRSLEAYRASFDGKDDVMVVDPSSDFFKFMKNSGGARRN
HHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRDKLSVIAGVVLFAIVLASMSLFTVDQRQYAIVFQLGQVKEVIDAPGLNFKLPLIQNVR
CCCHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEEHHHHHHHHCCCCCCEECHHHHHHH
YFEKRILTMDTPEPERFITSEKKNVLVDHFVKWRIIDPRLYYESVAGDETRARTRLNQTV
HHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHEEECHHHHHHHHCCCHHHHHHHHHHHH
NSGLREEFGKRTVHDVVSGARDQIMEDMRAKADQDARKIGVQILDVRLKRVDLPNEVSES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
VYRRMEAERKRVANELRSQGAAEAEKIRADADRQREVLIAGAYREAQQVKGAGDAKATQI
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEHHHHHHHHHCCCCCHHHHHH
YAEAFGQSPDFYSFYRSLEAYRASFDGKDDVMVVDPSSDFFKFMKNSGGARRN
HHHHHCCCCCHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]