Click here to switch to the map view.

The map label for this gene is lpxC

Identifier: 119897181

GI number: 119897181

Start: 952910

End: 953833

Strand: Direct

Name: lpxC

Synonym: azo0890

Alternate gene names: 119897181

Gene position: 952910-953833 (Clockwise)

Preceding gene: 119897180

Following gene: 119897182

Centisome position: 21.78

GC content: 66.02

Gene sequence:

>924_bases
ATGATCCGGCAACGTACGCTCAAGTCCACGGTCAAGGCGACCGGGGTCGGCCTCCATGGCGGGCGCAAGGTCAACCTTGT
GCTGCGGCCTGCCGCGCCGGATACCGGCATCGTCTTCCATCGCGTCGACCTCGATCCGCCGCTCGACCTGCCGGCCGATC
CGTACGCCGTCTGCGACACCCGCATGTGCTCCGGGCTGGAGAAGGGCGGGCAGAAGGTCGGCACCGTCGAGCACCTGATG
TCCGCGCTGGCCGGGCTGGGTATCGACAATCTGCATATCGACGTCGATGCGCCGGAGATTCCCATCCTCGACGGCAGTTC
CGGCCCCTTCGTGTTCCTGCTGCAGTCCGCCGGCATCGAGGAGCAGAAGGCGCCCAAGCGCTTCCTGCGGGTCAAGAAGC
CGGTGGAGTACCGCGAGGGCGACAAATGGGTGCGGCTGGAACCCTACGACGGTTTCCGGCTCGACTTCTCGATCGTCTTC
AATCATCCGGCCATCGACAGCACCTCGACCGCGGTCAGCATCGACTTCGCCACCCACTCCTATGTGCGCGATGTCGCGCG
GGCGCGCACCTTCGGCTTCATGCAGGATGTCGAGTTCATGCGCGCCAACGGGCTGGCGCTGGGTGGCAGCCTGGAAAACG
CGATCGTGATGGACGAGTACCGGGTGCTCAACGCCGACGGGCTTCGCTACGCGGACGAGTTCGTCAAGCACAAGGTGCTC
GATGCGATCGGCGACCTCTATCTGTGCGGCCATCCGCTGCTGGCGCGTTATTCGGCTCACAAGTCCGGCCATGCCTTGAA
CAACCAGATCCTGCGTGTGCTGCTCGAAGACCGCAGCGCCTGGGAGATCGTCAGCTTCGAACGCGAGGCCGCGACGCCGC
CGGCGGTGGCCCACCAGTTCGCGCCGGTGCTGGCGGCCGCGTGA

Upstream 100 bases:

>100_bases
GATGCCCGTCGCTTTTTCCTATCGCCGCGATAGCGCCCCCGCTGCCGGAAGCCCTCCATGGCACGTGCTAAACTATTGGC
GTGATGAAGGAAAACAACAA

Downstream 100 bases:

>100_bases
GCGCTCCGCACCCATCAAAAACCGGAGCGGCGCAATGCTGATCATGCGGCTCGCCATCCTGCTCGTGGTGCTGGGCACCG
GCGGCTCGCTGCTGCTGTGG

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: NA

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MIRQRTLKSTVKATGVGLHGGRKVNLVLRPAAPDTGIVFHRVDLDPPLDLPADPYAVCDTRMCSGLEKGGQKVGTVEHLM
SALAGLGIDNLHIDVDAPEIPILDGSSGPFVFLLQSAGIEEQKAPKRFLRVKKPVEYREGDKWVRLEPYDGFRLDFSIVF
NHPAIDSTSTAVSIDFATHSYVRDVARARTFGFMQDVEFMRANGLALGGSLENAIVMDEYRVLNADGLRYADEFVKHKVL
DAIGDLYLCGHPLLARYSAHKSGHALNNQILRVLLEDRSAWEIVSFEREAATPPAVAHQFAPVLAAA

Sequences:

>Translated_307_residues
MIRQRTLKSTVKATGVGLHGGRKVNLVLRPAAPDTGIVFHRVDLDPPLDLPADPYAVCDTRMCSGLEKGGQKVGTVEHLM
SALAGLGIDNLHIDVDAPEIPILDGSSGPFVFLLQSAGIEEQKAPKRFLRVKKPVEYREGDKWVRLEPYDGFRLDFSIVF
NHPAIDSTSTAVSIDFATHSYVRDVARARTFGFMQDVEFMRANGLALGGSLENAIVMDEYRVLNADGLRYADEFVKHKVL
DAIGDLYLCGHPLLARYSAHKSGHALNNQILRVLLEDRSAWEIVSFEREAATPPAVAHQFAPVLAAA
>Mature_307_residues
MIRQRTLKSTVKATGVGLHGGRKVNLVLRPAAPDTGIVFHRVDLDPPLDLPADPYAVCDTRMCSGLEKGGQKVGTVEHLM
SALAGLGIDNLHIDVDAPEIPILDGSSGPFVFLLQSAGIEEQKAPKRFLRVKKPVEYREGDKWVRLEPYDGFRLDFSIVF
NHPAIDSTSTAVSIDFATHSYVRDVARARTFGFMQDVEFMRANGLALGGSLENAIVMDEYRVLNADGLRYADEFVKHKVL
DAIGDLYLCGHPLLARYSAHKSGHALNNQILRVLLEDRSAWEIVSFEREAATPPAVAHQFAPVLAAA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family

Homologues:

Organism=Escherichia coli, GI1786285, Length=296, Percent_Identity=55.4054054054054, Blast_Score=367, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXC_AZOSB (A1K3V2)

Other databases:

- EMBL:   AM406670
- RefSeq:   YP_932394.1
- ProteinModelPortal:   A1K3V2
- SMR:   A1K3V2
- STRING:   A1K3V2
- GeneID:   4608843
- GenomeReviews:   AM406670_GR
- KEGG:   azo:azo0890
- eggNOG:   COG0774
- HOGENOM:   HBG482342
- OMA:   ATDPAKE
- PhylomeDB:   A1K3V2
- ProtClustDB:   PRK13186
- BioCyc:   ASP62928:AZO0890-MONOMER
- HAMAP:   MF_00388
- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870
- Gene3D:   G3DSA:3.30.1700.10
- Gene3D:   G3DSA:3.30.230.20
- TIGRFAMs:   TIGR00325

Pfam domain/function: PF03331 LpxC; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: 3.5.1.-

Molecular weight: Translated: 33697; Mature: 33697

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRQRTLKSTVKATGVGLHGGRKVNLVLRPAAPDTGIVFHRVDLDPPLDLPADPYAVCDT
CCCHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCHHHHHH
RMCSGLEKGGQKVGTVEHLMSALAGLGIDNLHIDVDAPEIPILDGSSGPFVFLLQSAGIE
HHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCEEEECCCCCEEEEEECCCCC
EQKAPKRFLRVKKPVEYREGDKWVRLEPYDGFRLDFSIVFNHPAIDSTSTAVSIDFATHS
HHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEEEEEEECCCCCCCCCCEEEEEHHHHH
YVRDVARARTFGFMQDVEFMRANGLALGGSLENAIVMDEYRVLNADGLRYADEFVKHKVL
HHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECEEEECCCCCHHHHHHHHHHHH
DAIGDLYLCGHPLLARYSAHKSGHALNNQILRVLLEDRSAWEIVSFEREAATPPAVAHQF
HHHCCCEECCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECHHCCCCHHHHHHH
APVLAAA
HHHHHCC
>Mature Secondary Structure
MIRQRTLKSTVKATGVGLHGGRKVNLVLRPAAPDTGIVFHRVDLDPPLDLPADPYAVCDT
CCCHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCCEEEEEECCCCCCCCCCCCHHHHHH
RMCSGLEKGGQKVGTVEHLMSALAGLGIDNLHIDVDAPEIPILDGSSGPFVFLLQSAGIE
HHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCEEEECCCCCEEEEEECCCCC
EQKAPKRFLRVKKPVEYREGDKWVRLEPYDGFRLDFSIVFNHPAIDSTSTAVSIDFATHS
HHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEEEEEEECCCCCCCCCCEEEEEHHHHH
YVRDVARARTFGFMQDVEFMRANGLALGGSLENAIVMDEYRVLNADGLRYADEFVKHKVL
HHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCEEEEECEEEECCCCCHHHHHHHHHHHH
DAIGDLYLCGHPLLARYSAHKSGHALNNQILRVLLEDRSAWEIVSFEREAATPPAVAHQF
HHHCCCEECCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECHHCCCCHHHHHHH
APVLAAA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA