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The map label for this gene is hprA [H]

Identifier: 119897117

GI number: 119897117

Start: 883724

End: 884674

Strand: Direct

Name: hprA [H]

Synonym: azo0826

Alternate gene names: 119897117

Gene position: 883724-884674 (Clockwise)

Preceding gene: 119897116

Following gene: 119897118

Centisome position: 20.19

GC content: 70.98

Gene sequence:

>951_bases
ATGACGCTGTCGATCGTCTGTCTGGAGCGCGACGCGGTCGGTGCCGCGTTCGGCCGTCCGCGCGCACCCCATCGCTGGAC
CGAGTTTCCCTCCAGCGCCCAGGAGCAGGTCGTCGAGCGGCTGCGCGACGCCGAGGTCGCCATCATCAACAAACTGCGGC
TGGGCGCGTCCGAAATCGCCGCGCTGCCCCGCTTGCAGATGGTGGCGGTGGCTGCAACCGGTTCCGACAATGTCGATCTG
GAGGCCTGCCGTGCGCGCGGCATCGTGGTGTCCAACGTGCGCGGCTACGCGGTCCACACCGTGCCGGAGCATGCGCTGAT
GCTGATGCTGGCCTTGCGCCGCCGGCTGTTCGACTATGTCGCCGACGTGCGGGCCGGCCGTTGGGCGCGTAGCGACAACT
TCTGCTTCTTCGACCATCCCATCGGCGACCTGCACGGCGCCACGCTCGCCATCATCGGACGGGGCGGTCTGGGGGACGGC
GTGGCGCGGCTCGGCGCCGCCTTCGGCATGCGCGTGATCTACGCCGAGCACAAAGGTGTGGCCGGCGTGCGCGAGGGCTA
CACCGCGTTCGAGCGCGTGCTGGCGGAGGCCGACGTGCTGTCGCTGCACTGCCCGCTGACGCCCGCGACGCGCGGCCTGA
TCGGTGCGTCCGAGCTGGCGTCGATGAAACGGGAGGCGGTGCTGGTCAACACGGCGCGCGGCGGCGTGGTCGACGAGCCG
GCGCTGGCTGCCGCGCTGCGCGCGGGGGTGATTGCCGGTGCCGCGACCGACGTGCTGTCCTCGGAGCCGCCGCGGGAAGG
CAATCCGCTGCTCGCGGCGGACATCCCCAACCTGATCGTCACGCCTCACGTCGCATGGGCCTCGCGCCAGGCGATGCAGA
CGCTGGCCGACCAGGTCATCGATAATATCGACGCGTTTGCGGCGGGCGCCCCGCGTAACCGCCTGGCGTGA

Upstream 100 bases:

>100_bases
GCGCCTGGAGTGGCGCGGCGATGCCGATGGTGATCGAAGCGCGTGCCAAGGTGGCGGTGCCGGCCCTGGCGGGGCGGCGT
TGGCCTGAGCGGGAGGCCGC

Downstream 100 bases:

>100_bases
GCCGCATGAGTCGCGGCAACCGTCGTTGAGGCCGCGATCACGCCCCCGGGGCGACTGGGCAGCGTCACGGTTGCTCACGC
TGCAGTGCAAAAAAATGACG

Product: glycerate dehydrogenase

Products: NA

Alternate protein names: GDH; Glyoxylate reductase; Hydroxypyruvate dehydrogenase; NADH-dependent hydroxypyruvate reductase; HPR; HPR-A [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MTLSIVCLERDAVGAAFGRPRAPHRWTEFPSSAQEQVVERLRDAEVAIINKLRLGASEIAALPRLQMVAVAATGSDNVDL
EACRARGIVVSNVRGYAVHTVPEHALMLMLALRRRLFDYVADVRAGRWARSDNFCFFDHPIGDLHGATLAIIGRGGLGDG
VARLGAAFGMRVIYAEHKGVAGVREGYTAFERVLAEADVLSLHCPLTPATRGLIGASELASMKREAVLVNTARGGVVDEP
ALAAALRAGVIAGAATDVLSSEPPREGNPLLAADIPNLIVTPHVAWASRQAMQTLADQVIDNIDAFAAGAPRNRLA

Sequences:

>Translated_316_residues
MTLSIVCLERDAVGAAFGRPRAPHRWTEFPSSAQEQVVERLRDAEVAIINKLRLGASEIAALPRLQMVAVAATGSDNVDL
EACRARGIVVSNVRGYAVHTVPEHALMLMLALRRRLFDYVADVRAGRWARSDNFCFFDHPIGDLHGATLAIIGRGGLGDG
VARLGAAFGMRVIYAEHKGVAGVREGYTAFERVLAEADVLSLHCPLTPATRGLIGASELASMKREAVLVNTARGGVVDEP
ALAAALRAGVIAGAATDVLSSEPPREGNPLLAADIPNLIVTPHVAWASRQAMQTLADQVIDNIDAFAAGAPRNRLA
>Mature_315_residues
TLSIVCLERDAVGAAFGRPRAPHRWTEFPSSAQEQVVERLRDAEVAIINKLRLGASEIAALPRLQMVAVAATGSDNVDLE
ACRARGIVVSNVRGYAVHTVPEHALMLMLALRRRLFDYVADVRAGRWARSDNFCFFDHPIGDLHGATLAIIGRGGLGDGV
ARLGAAFGMRVIYAEHKGVAGVREGYTAFERVLAEADVLSLHCPLTPATRGLIGASELASMKREAVLVNTARGGVVDEPA
LAAALRAGVIAGAATDVLSSEPPREGNPLLAADIPNLIVTPHVAWASRQAMQTLADQVIDNIDAFAAGAPRNRLA

Specific function: Plays a central role in assimilation of carbon. It converts hydroxypyruvate to glycerate as a key step in the serine cycle, and may also play an important role in C2 reactions, by interconverting glyoxylate and glycolate [H]

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=274, Percent_Identity=33.2116788321168, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI145580578, Length=270, Percent_Identity=35.9259259259259, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI4557499, Length=270, Percent_Identity=35.9259259259259, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI61743967, Length=269, Percent_Identity=34.5724907063197, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI4557497, Length=269, Percent_Identity=34.5724907063197, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI145580575, Length=269, Percent_Identity=36.0594795539033, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI6912396, Length=252, Percent_Identity=30.1587301587302, Blast_Score=110, Evalue=1e-24,
Organism=Escherichia coli, GI87082289, Length=296, Percent_Identity=30.4054054054054, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1789279, Length=279, Percent_Identity=31.1827956989247, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1787645, Length=259, Percent_Identity=28.5714285714286, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI87081824, Length=198, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=257, Percent_Identity=34.6303501945525, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI25147481, Length=278, Percent_Identity=31.294964028777, Blast_Score=114, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6320925, Length=287, Percent_Identity=29.9651567944251, Blast_Score=136, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6322116, Length=287, Percent_Identity=29.2682926829268, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6324055, Length=299, Percent_Identity=30.4347826086957, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324964, Length=292, Percent_Identity=26.7123287671233, Blast_Score=102, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6324980, Length=186, Percent_Identity=24.7311827956989, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921140, Length=287, Percent_Identity=31.7073170731707, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24646446, Length=242, Percent_Identity=35.1239669421488, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24646448, Length=242, Percent_Identity=35.1239669421488, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24646452, Length=242, Percent_Identity=35.1239669421488, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24646450, Length=242, Percent_Identity=35.1239669421488, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI62472511, Length=242, Percent_Identity=35.1239669421488, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI28574286, Length=291, Percent_Identity=30.9278350515464, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI28571528, Length=255, Percent_Identity=32.9411764705882, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI45551003, Length=258, Percent_Identity=29.0697674418605, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI45552429, Length=258, Percent_Identity=29.0697674418605, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28574284, Length=258, Percent_Identity=29.0697674418605, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24585514, Length=258, Percent_Identity=29.0697674418605, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28574282, Length=258, Percent_Identity=29.0697674418605, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24585516, Length=239, Percent_Identity=29.7071129707113, Blast_Score=99, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.29 [H]

Molecular weight: Translated: 33544; Mature: 33413

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSIVCLERDAVGAAFGRPRAPHRWTEFPSSAQEQVVERLRDAEVAIINKLRLGASEIA
CEEEEEEEECCCCHHHCCCCCCCCHHHCCCCHHHHHHHHHHHCCHHHHHHHHHCCHHHHH
ALPRLQMVAVAATGSDNVDLEACRARGIVVSNVRGYAVHTVPEHALMLMLALRRRLFDYV
HCCCEEEEEEEECCCCCCCHHHHHHCCEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHH
ADVRAGRWARSDNFCFFDHPIGDLHGATLAIIGRGGLGDGVARLGAAFGMRVIYAEHKGV
HHHHHCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCEEEEEECCCCC
AGVREGYTAFERVLAEADVLSLHCPLTPATRGLIGASELASMKREAVLVNTARGGVVDEP
CHHHHHHHHHHHHHHHCCEEEEECCCCHHHHCCCCHHHHHHHHHCEEEEECCCCCCCCCH
ALAAALRAGVIAGAATDVLSSEPPREGNPLLAADIPNLIVTPHVAWASRQAMQTLADQVI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEECCCHHHHHHHHHHHHHHHHH
DNIDAFAAGAPRNRLA
HHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TLSIVCLERDAVGAAFGRPRAPHRWTEFPSSAQEQVVERLRDAEVAIINKLRLGASEIA
EEEEEEEECCCCHHHCCCCCCCCHHHCCCCHHHHHHHHHHHCCHHHHHHHHHCCHHHHH
ALPRLQMVAVAATGSDNVDLEACRARGIVVSNVRGYAVHTVPEHALMLMLALRRRLFDYV
HCCCEEEEEEEECCCCCCCHHHHHHCCEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHH
ADVRAGRWARSDNFCFFDHPIGDLHGATLAIIGRGGLGDGVARLGAAFGMRVIYAEHKGV
HHHHHCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCEEEEEECCCCC
AGVREGYTAFERVLAEADVLSLHCPLTPATRGLIGASELASMKREAVLVNTARGGVVDEP
CHHHHHHHHHHHHHHHCCEEEEECCCCHHHHCCCCHHHHHHHHHCEEEEECCCCCCCCCH
ALAAALRAGVIAGAATDVLSSEPPREGNPLLAADIPNLIVTPHVAWASRQAMQTLADQVI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCEEECCCHHHHHHHHHHHHHHHHH
DNIDAFAAGAPRNRLA
HHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8144463; 1729225; 1657886 [H]