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The map label for this gene is macA [H]

Identifier: 119896903

GI number: 119896903

Start: 641535

End: 642686

Strand: Reverse

Name: macA [H]

Synonym: azo0612

Alternate gene names: 119896903

Gene position: 642686-641535 (Counterclockwise)

Preceding gene: 119896904

Following gene: 119896902

Centisome position: 14.69

GC content: 68.66

Gene sequence:

>1152_bases
TTGTTCGGCAACGGCGATCCCACGGCGCTCTACCAGTTCGCCACCGTCAGCCGCGGAGACATCGAGGACGTGGTGACCGC
CACCGGAACGCTGCAGCCGCGCGAGTATGTCGACGTCGGCGCGCAGGTTTCCGGACAGCTGAAGAAGATCCACGTCGAGG
TCGGCTCGCTGGTCAAGAACGGCGACCTGCTCGGCGAGATCGACTCCACCGTCTACCTTTCCAAGGTGGATGCCTCGCGC
GCCCAGCTGCGTAACCTGCGTGCCCAGCTGAAGGAGCGCGAGGCCCAGGTCGCCCTCGCGCAGGTGCAGTTCAAGCGCCA
GACCGCGCTGATGGCCGAGGACGCCACCACCACCGAAACGCTGCAGACCGCCGAGGCCACGCTGAAGTCGGCCGAGGCGC
AGCTCGAAGCGCTGCGCGCGCAGATCGAGCAGTACGAATCGACGCTGCGCGGCGACGAGGCCAACCTGCAGTACGCCCGC
ATCATGTCGCCGATGACCGGCACCGTGGTCTCGATCACCGCCCGCCAGGGCCAGACGCTGAACACCAACCAGTCGGCGCC
GACCATCCTGCGGGTCGCCGACCTGACGACGATGACCGTGCAGACCCAGGTGTCCGAAGCCGATGTGAGCCGTCTCAAGC
TCGGCATGGCGGCCTACTTCACCACGCTTGGCGGCCACGGCAAGCGCTGGTACGGCAAGCTGGACAAGATCGAACCGACG
CCCACGGTGACCAACAACGTGGTGCTGTACAACGCGCTGTTCGACGTTCCCAACGACGACAACCTGTTGATGACGCAGAT
GACCGCCCAGGTGTTCTTCATCGTCGCCCAGGCCAAGGACGTGCTGCAGATTCCGCTCGCGGCGGTCTCGCAGGGCGCGC
GCGGTCCGCGCGCCGGAGCGCAACCCGCCGCGGGCGGCGCACCCGCCGGCGCCGCCCGCGGGAACGGCCCGCGCCGGGCC
ACGGTCAAGGTGCTGCGCGCCGACAACACGCTGGAGGAACGCGAGGTGCAGATCGGCGTGTCCAACCGCGTCCAGGCCCA
GGTGCTGGACGGGCTGCAGGAAGGCGAGCGCGTGGTCACCGGCCTGCTGAGCGCACCCGCACCCGCTGCATCGACCACCA
GCAACCGTCAGGGACCGCCACCCCGCCTATGA

Upstream 100 bases:

>100_bases
GCCCACCCCGCCACTCCGTCCGCGCCTTCGCCGCCGCATCCTCATCGCAGCCCTCGGCCTGGGCGCCCTCGCCGTCGGCG
CCGCCTTCACCTGGCCCCGA

Downstream 100 bases:

>100_bases
AGCGCGAAGCCTTCTCCCCCTCGGCCAGCAGTACCGGAGCGGGAACGCCGCTGATCGAACTCGCCGGCATCACGCGCAGC
TTCCGCAACGGCGAGATCGA

Product: periplasmic component of efflux system

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MFGNGDPTALYQFATVSRGDIEDVVTATGTLQPREYVDVGAQVSGQLKKIHVEVGSLVKNGDLLGEIDSTVYLSKVDASR
AQLRNLRAQLKEREAQVALAQVQFKRQTALMAEDATTTETLQTAEATLKSAEAQLEALRAQIEQYESTLRGDEANLQYAR
IMSPMTGTVVSITARQGQTLNTNQSAPTILRVADLTTMTVQTQVSEADVSRLKLGMAAYFTTLGGHGKRWYGKLDKIEPT
PTVTNNVVLYNALFDVPNDDNLLMTQMTAQVFFIVAQAKDVLQIPLAAVSQGARGPRAGAQPAAGGAPAGAARGNGPRRA
TVKVLRADNTLEEREVQIGVSNRVQAQVLDGLQEGERVVTGLLSAPAPAASTTSNRQGPPPRL

Sequences:

>Translated_383_residues
MFGNGDPTALYQFATVSRGDIEDVVTATGTLQPREYVDVGAQVSGQLKKIHVEVGSLVKNGDLLGEIDSTVYLSKVDASR
AQLRNLRAQLKEREAQVALAQVQFKRQTALMAEDATTTETLQTAEATLKSAEAQLEALRAQIEQYESTLRGDEANLQYAR
IMSPMTGTVVSITARQGQTLNTNQSAPTILRVADLTTMTVQTQVSEADVSRLKLGMAAYFTTLGGHGKRWYGKLDKIEPT
PTVTNNVVLYNALFDVPNDDNLLMTQMTAQVFFIVAQAKDVLQIPLAAVSQGARGPRAGAQPAAGGAPAGAARGNGPRRA
TVKVLRADNTLEEREVQIGVSNRVQAQVLDGLQEGERVVTGLLSAPAPAASTTSNRQGPPPRL
>Mature_383_residues
MFGNGDPTALYQFATVSRGDIEDVVTATGTLQPREYVDVGAQVSGQLKKIHVEVGSLVKNGDLLGEIDSTVYLSKVDASR
AQLRNLRAQLKEREAQVALAQVQFKRQTALMAEDATTTETLQTAEATLKSAEAQLEALRAQIEQYESTLRGDEANLQYAR
IMSPMTGTVVSITARQGQTLNTNQSAPTILRVADLTTMTVQTQVSEADVSRLKLGMAAYFTTLGGHGKRWYGKLDKIEPT
PTVTNNVVLYNALFDVPNDDNLLMTQMTAQVFFIVAQAKDVLQIPLAAVSQGARGPRAGAQPAAGGAPAGAARGNGPRRA
TVKVLRADNTLEEREVQIGVSNRVQAQVLDGLQEGERVVTGLLSAPAPAASTTSNRQGPPPRL

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=355, Percent_Identity=40.2816901408451, Blast_Score=227, Evalue=9e-61,
Organism=Escherichia coli, GI1789929, Length=361, Percent_Identity=26.5927977839335, Blast_Score=79, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 40969; Mature: 40969

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGNGDPTALYQFATVSRGDIEDVVTATGTLQPREYVDVGAQVSGQLKKIHVEVGSLVKN
CCCCCCCHHEEEEEECCCCCHHHHHHHCCCCCCHHHHHCCCCCCCCCEEEEEEHHHHHHC
GDLLGEIDSTVYLSKVDASRAQLRNLRAQLKEREAQVALAQVQFKRQTALMAEDATTTET
CCCEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LQTAEATLKSAEAQLEALRAQIEQYESTLRGDEANLQYARIMSPMTGTVVSITARQGQTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEEEECCCCCC
NTNQSAPTILRVADLTTMTVQTQVSEADVSRLKLGMAAYFTTLGGHGKRWYGKLDKIEPT
CCCCCCCEEEEEECCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCC
PTVTNNVVLYNALFDVPNDDNLLMTQMTAQVFFIVAQAKDVLQIPLAAVSQGARGPRAGA
CCCCCCEEEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
QPAAGGAPAGAARGNGPRRATVKVLRADNTLEEREVQIGVSNRVQAQVLDGLQEGERVVT
CCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCHHEEEECCCCCHHHHHHHHHHHHHHHHH
GLLSAPAPAASTTSNRQGPPPRL
HHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFGNGDPTALYQFATVSRGDIEDVVTATGTLQPREYVDVGAQVSGQLKKIHVEVGSLVKN
CCCCCCCHHEEEEEECCCCCHHHHHHHCCCCCCHHHHHCCCCCCCCCEEEEEEHHHHHHC
GDLLGEIDSTVYLSKVDASRAQLRNLRAQLKEREAQVALAQVQFKRQTALMAEDATTTET
CCCEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
LQTAEATLKSAEAQLEALRAQIEQYESTLRGDEANLQYARIMSPMTGTVVSITARQGQTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEEEECCCCCC
NTNQSAPTILRVADLTTMTVQTQVSEADVSRLKLGMAAYFTTLGGHGKRWYGKLDKIEPT
CCCCCCCEEEEEECCEEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCCC
PTVTNNVVLYNALFDVPNDDNLLMTQMTAQVFFIVAQAKDVLQIPLAAVSQGARGPRAGA
CCCCCCEEEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
QPAAGGAPAGAARGNGPRRATVKVLRADNTLEEREVQIGVSNRVQAQVLDGLQEGERVVT
CCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCHHEEEECCCCCHHHHHHHHHHHHHHHHH
GLLSAPAPAASTTSNRQGPPPRL
HHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]