Click here to switch to the map view.

The map label for this gene is vsrA [H]

Identifier: 119896859

GI number: 119896859

Start: 598310

End: 599704

Strand: Direct

Name: vsrA [H]

Synonym: azo0568

Alternate gene names: 119896859

Gene position: 598310-599704 (Clockwise)

Preceding gene: 119896857

Following gene: 119896866

Centisome position: 13.67

GC content: 73.55

Gene sequence:

>1395_bases
ATGGGTTCAACCAAGCCAATGGCGGGCGAGCGCCAGTTGCGCGTGACCCACCGCGCACGCGCGGCGCTGCTGGCAGTAGG
GTGTGCGCTGGTGGTGGCGCTGGTCGGGGCGAGCTTCTGGCAGGCCGCCGCGGGCCTGCAGGCGCTCGAGACGATGCAAT
TGCAGGCGGCGCGCACTGCGCGCCTGGACAGCATGCTGATCCAGCTGGTCGATGCCGAAAGCGGCGCGCGCGGCTACCTG
CTGAGCCGCAACCACGACTATCTGGCGCCGTATCTGAACAGCCTGGCGACGGTGGAATACACGCTCGACGAGATCCGCCA
GGACGTCGGCCCCGATCCGCGCGACCAGGATGCACTGGCGCGGCTCACCGGCCTGATCACGCTGAAGCTGCGCGTACTGG
CCGACGCGGTGGGCGGCGCCGGCGCGGGCGAGGAGGCGCCCCGGCGCGCCGGGGTGTCGGACGGCGTGCGCTACATGGAC
ACCATCCGCACGACGCTGGCGGGCCTGAAGAGCCGCATGGCCGCCGAGGGCCAGGCTCTGCTGGAGGAGTCCACCCGCCA
TATCGGCCACACGCGCGCGGTGGCCGCCGTGCTTGCACTGAGCGCGCTGTTGCTGCTGGGCCTGCTGCACGCCGCGCTGC
GGCGCGAACTGCGCCTGCGTGCCCAGCTGGCGGGTTTGCTGCGCGACGAGAACGCGCGCCTGGAAGCGCTGGTGCAGGCG
CGCACGGCGGATCTGAGTGCGCTGGCGAGCTACCTGACGCGCAGCCAAGAGCGCGAACGCGAGCGGATCGCGCGCGAACT
GCACGACGAACTCGGCGCACTGCTGACGGCCGCGCGCATGGATGCGGCAGCGCTGGGCGGCGACATGGCACCCGCCCATC
AGGCGCGCCACGCCCGGCTCTTGCGCACGCTGGATGGCGGCATCACGCTCAAGCGCCGCATCATCGGCGACCTGCGTCCG
CCGCTGTTGCAGGAGCTGGGGCTGGTCGCGGCGCTGCGCGTGCTCGCCGAGGAACTGGCCGACAGCGACGGCACCGCGGT
GAGCGCCGAGCTGCCCGATGACGAACCCGCACTGGCGCCCGAATGCGCGCTGGCGCTGTTCCGGATCGCGCAGGAGGCGC
TGACGAATGCCCGCCGCCATGCCGGTGCGCGCCGCGTGCGACTGGGGCTGCGGGTGGAGCGGGGCGCGGTGCGGCTGGAG
GTGGAGGACGACGGCGCCGGCTTCGACCCTGCCGCGTGCGGCCCAGGCCGCCACGGCCTCGCGGGCATGCGCCACCGGGT
GCAGATGTTCGCCGGCCGCTTCAGTGTGGATAGCCGGGCCGGCGCCGGCACCCGCATCGCCGCGGCGTTGCCGCTGGATG
CGGCGCGCGGCGCGGAATTGGCGCTGGCGGCGTGA

Upstream 100 bases:

>100_bases
CTGCCCGGCGTTTCCGTTCCATCTTAGGCGGCGCGCGCGCAGGGGTTTGTCGGAGGGTGCGGAATCCGCTGTAGGACGAT
TCCCGCACGGGAGGGGACAG

Downstream 100 bases:

>100_bases
GCGGATCAGGCCACGATCAGGCCGTGGCGGATGGCGTAGGTGGCGAGTTCGGCGTTGCTGGTGACGTCCAGCTTTTCCAG
CACCCGGCTGCGGTAGGTGC

Product: putative sensory box histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MGSTKPMAGERQLRVTHRARAALLAVGCALVVALVGASFWQAAAGLQALETMQLQAARTARLDSMLIQLVDAESGARGYL
LSRNHDYLAPYLNSLATVEYTLDEIRQDVGPDPRDQDALARLTGLITLKLRVLADAVGGAGAGEEAPRRAGVSDGVRYMD
TIRTTLAGLKSRMAAEGQALLEESTRHIGHTRAVAAVLALSALLLLGLLHAALRRELRLRAQLAGLLRDENARLEALVQA
RTADLSALASYLTRSQERERERIARELHDELGALLTAARMDAAALGGDMAPAHQARHARLLRTLDGGITLKRRIIGDLRP
PLLQELGLVAALRVLAEELADSDGTAVSAELPDDEPALAPECALALFRIAQEALTNARRHAGARRVRLGLRVERGAVRLE
VEDDGAGFDPAACGPGRHGLAGMRHRVQMFAGRFSVDSRAGAGTRIAAALPLDAARGAELALAA

Sequences:

>Translated_464_residues
MGSTKPMAGERQLRVTHRARAALLAVGCALVVALVGASFWQAAAGLQALETMQLQAARTARLDSMLIQLVDAESGARGYL
LSRNHDYLAPYLNSLATVEYTLDEIRQDVGPDPRDQDALARLTGLITLKLRVLADAVGGAGAGEEAPRRAGVSDGVRYMD
TIRTTLAGLKSRMAAEGQALLEESTRHIGHTRAVAAVLALSALLLLGLLHAALRRELRLRAQLAGLLRDENARLEALVQA
RTADLSALASYLTRSQERERERIARELHDELGALLTAARMDAAALGGDMAPAHQARHARLLRTLDGGITLKRRIIGDLRP
PLLQELGLVAALRVLAEELADSDGTAVSAELPDDEPALAPECALALFRIAQEALTNARRHAGARRVRLGLRVERGAVRLE
VEDDGAGFDPAACGPGRHGLAGMRHRVQMFAGRFSVDSRAGAGTRIAAALPLDAARGAELALAA
>Mature_463_residues
GSTKPMAGERQLRVTHRARAALLAVGCALVVALVGASFWQAAAGLQALETMQLQAARTARLDSMLIQLVDAESGARGYLL
SRNHDYLAPYLNSLATVEYTLDEIRQDVGPDPRDQDALARLTGLITLKLRVLADAVGGAGAGEEAPRRAGVSDGVRYMDT
IRTTLAGLKSRMAAEGQALLEESTRHIGHTRAVAAVLALSALLLLGLLHAALRRELRLRAQLAGLLRDENARLEALVQAR
TADLSALASYLTRSQERERERIARELHDELGALLTAARMDAAALGGDMAPAHQARHARLLRTLDGGITLKRRIIGDLRPP
LLQELGLVAALRVLAEELADSDGTAVSAELPDDEPALAPECALALFRIAQEALTNARRHAGARRVRLGLRVERGAVRLEV
EDDGAGFDPAACGPGRHGLAGMRHRVQMFAGRFSVDSRAGAGTRIAAALPLDAARGAELALAA

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=230, Percent_Identity=35.2173913043478, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787474, Length=239, Percent_Identity=31.3807531380753, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49363; Mature: 49232

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSTKPMAGERQLRVTHRARAALLAVGCALVVALVGASFWQAAAGLQALETMQLQAARTA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLDSMLIQLVDAESGARGYLLSRNHDYLAPYLNSLATVEYTLDEIRQDVGPDPRDQDALA
HHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
RLTGLITLKLRVLADAVGGAGAGEEAPRRAGVSDGVRYMDTIRTTLAGLKSRMAAEGQAL
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEESTRHIGHTRAVAAVLALSALLLLGLLHAALRRELRLRAQLAGLLRDENARLEALVQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
RTADLSALASYLTRSQERERERIARELHDELGALLTAARMDAAALGGDMAPAHQARHARL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LRTLDGGITLKRRIIGDLRPPLLQELGLVAALRVLAEELADSDGTAVSAELPDDEPALAP
HHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCH
ECALALFRIAQEALTNARRHAGARRVRLGLRVERGAVRLEVEDDGAGFDPAACGPGRHGL
HHHHHHHHHHHHHHHHHHHHCCHHHHHCCEEEECCEEEEEECCCCCCCCCCCCCCCCCCH
AGMRHRVQMFAGRFSVDSRAGAGTRIAAALPLDAARGAELALAA
HHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCEEECC
>Mature Secondary Structure 
GSTKPMAGERQLRVTHRARAALLAVGCALVVALVGASFWQAAAGLQALETMQLQAARTA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLDSMLIQLVDAESGARGYLLSRNHDYLAPYLNSLATVEYTLDEIRQDVGPDPRDQDALA
HHHHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
RLTGLITLKLRVLADAVGGAGAGEEAPRRAGVSDGVRYMDTIRTTLAGLKSRMAAEGQAL
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEESTRHIGHTRAVAAVLALSALLLLGLLHAALRRELRLRAQLAGLLRDENARLEALVQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
RTADLSALASYLTRSQERERERIARELHDELGALLTAARMDAAALGGDMAPAHQARHARL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
LRTLDGGITLKRRIIGDLRPPLLQELGLVAALRVLAEELADSDGTAVSAELPDDEPALAP
HHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCH
ECALALFRIAQEALTNARRHAGARRVRLGLRVERGAVRLEVEDDGAGFDPAACGPGRHGL
HHHHHHHHHHHHHHHHHHHHCCHHHHHCCEEEECCEEEEEECCCCCCCCCCCCCCCCCCH
AGMRHRVQMFAGRFSVDSRAGAGTRIAAALPLDAARGAELALAA
HHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]