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The map label for this gene is ragA [H]

Identifier: 119896748

GI number: 119896748

Start: 488198

End: 488884

Strand: Direct

Name: ragA [H]

Synonym: azo0457

Alternate gene names: 119896748

Gene position: 488198-488884 (Clockwise)

Preceding gene: 119896747

Following gene: 119896749

Centisome position: 11.16

GC content: 69.72

Gene sequence:

>687_bases
ATGAAGATCCTGCTCGTCGAAGACGACGCCCAACAGGCGGGCTACATCCGCAAGGGCCTGCAGGAAGCCGGCCACACGGT
CGATGTCGCCGCCGACGGCCGCGACGGGCTCTTTCTCGCCACCACCGCCAGCTTCGATGCGATCGTGCTTGACCGCATGC
TGCCGCGCGTGGACGGCCTCACCGTGCTGCGCACGCTGCGGGCCTCTCGGATAGCGACCCCGGTGGTGGTGCTGTCCGCG
CTCGGCGAGGTGGACGACCGCGTCGCCGGGCTGCGCGCCGGCAGCGACGACTATCTGGTCAAGCCCTTCGCGTTGTCCGA
ACTGCTCGCGCGGCTGGACGCGCTGCAGCGGCGCGGCAACGGCCGCGCGGAAGCGGAGCAGACCCGGCTGCAGACCGCCG
ACCTCGAGATGGACCTGCTGCGGCGCAGTGTCAGCCGCGGCGCCACCCGCATCGAACTCAAGCCGAAGGAGTTCCGTCTG
CTCGAATTCCTGCTGCGCCATTCCGGCCAGGTGGTCACCCGCAGCATGCTGCTGGAGGCGGTGTGGGACTACCACTTCGA
CCCCCAGACCAACGTCATCGACGTGCACATCTCCAACCTGCGCGCCAAGATCGACCTGCCCGGGCTGCCGCCGCTGATCC
ACACCGTGCGTGGTGCCGGCTACCGGCTGGGCGGCGATGCCGCGTGA

Upstream 100 bases:

>100_bases
CAGGCGGCGCGATGGCCGCGCCGCGACTTGCCCATCGACCCCCGTCCCGCGGCTTCGCCGCGGGCACGCACGACGCCCGG
AGCCGGCGCGGGAGGACCGC

Downstream 100 bases:

>100_bases
GCGCGCCGGCGGGCTGCGAGCCTGGTTCGCCAGCCCCTTCCACCGCTTCGCGGTCGCGCTGCCGGCGGCCATCGCGCTGA
TCGTCGGTGCGCTGTTCTAC

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MKILLVEDDAQQAGYIRKGLQEAGHTVDVAADGRDGLFLATTASFDAIVLDRMLPRVDGLTVLRTLRASRIATPVVVLSA
LGEVDDRVAGLRAGSDDYLVKPFALSELLARLDALQRRGNGRAEAEQTRLQTADLEMDLLRRSVSRGATRIELKPKEFRL
LEFLLRHSGQVVTRSMLLEAVWDYHFDPQTNVIDVHISNLRAKIDLPGLPPLIHTVRGAGYRLGGDAA

Sequences:

>Translated_228_residues
MKILLVEDDAQQAGYIRKGLQEAGHTVDVAADGRDGLFLATTASFDAIVLDRMLPRVDGLTVLRTLRASRIATPVVVLSA
LGEVDDRVAGLRAGSDDYLVKPFALSELLARLDALQRRGNGRAEAEQTRLQTADLEMDLLRRSVSRGATRIELKPKEFRL
LEFLLRHSGQVVTRSMLLEAVWDYHFDPQTNVIDVHISNLRAKIDLPGLPPLIHTVRGAGYRLGGDAA
>Mature_228_residues
MKILLVEDDAQQAGYIRKGLQEAGHTVDVAADGRDGLFLATTASFDAIVLDRMLPRVDGLTVLRTLRASRIATPVVVLSA
LGEVDDRVAGLRAGSDDYLVKPFALSELLARLDALQRRGNGRAEAEQTRLQTADLEMDLLRRSVSRGATRIELKPKEFRL
LEFLLRHSGQVVTRSMLLEAVWDYHFDPQTNVIDVHISNLRAKIDLPGLPPLIHTVRGAGYRLGGDAA

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=51.1210762331839, Blast_Score=221, Evalue=3e-59,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=45.7013574660633, Blast_Score=190, Evalue=6e-50,
Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=40.625, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1790552, Length=223, Percent_Identity=39.0134529147982, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=34.3891402714932, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=35.5555555555556, Blast_Score=127, Evalue=4e-31,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=37.6681614349776, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=38.0530973451327, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=34.4827586206897, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=34.4978165938865, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=35.5555555555556, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=28.1385281385281, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=32.7510917030568, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1787229, Length=231, Percent_Identity=27.7056277056277, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=32.7102803738318, Blast_Score=71, Evalue=5e-14,
Organism=Escherichia coli, GI1790437, Length=113, Percent_Identity=30.9734513274336, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=30.5785123966942, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25085; Mature: 25085

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILLVEDDAQQAGYIRKGLQEAGHTVDVAADGRDGLFLATTASFDAIVLDRMLPRVDGL
CEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCHHHHHHHHHHCCCCHH
TVLRTLRASRIATPVVVLSALGEVDDRVAGLRAGSDDYLVKPFALSELLARLDALQRRGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHCCC
GRAEAEQTRLQTADLEMDLLRRSVSRGATRIELKPKEFRLLEFLLRHSGQVVTRSMLLEA
CCCHHHHHHHHHHCCHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHCCCHHHHHHHHHHH
VWDYHFDPQTNVIDVHISNLRAKIDLPGLPPLIHTVRGAGYRLGGDAA
HHHCCCCCCCCEEEEEEECEEEEECCCCCCHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKILLVEDDAQQAGYIRKGLQEAGHTVDVAADGRDGLFLATTASFDAIVLDRMLPRVDGL
CEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCEEEEECCCHHHHHHHHHHCCCCHH
TVLRTLRASRIATPVVVLSALGEVDDRVAGLRAGSDDYLVKPFALSELLARLDALQRRGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECHHHHHHHHHHHHHHHHCCC
GRAEAEQTRLQTADLEMDLLRRSVSRGATRIELKPKEFRLLEFLLRHSGQVVTRSMLLEA
CCCHHHHHHHHHHCCHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHCCCHHHHHHHHHHH
VWDYHFDPQTNVIDVHISNLRAKIDLPGLPPLIHTVRGAGYRLGGDAA
HHHCCCCCCCCEEEEEEECEEEEECCCCCCHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]