Click here to switch to the map view.

The map label for this gene is yjcE [H]

Identifier: 119896637

GI number: 119896637

Start: 369965

End: 371605

Strand: Direct

Name: yjcE [H]

Synonym: azo0346

Alternate gene names: 119896637

Gene position: 369965-371605 (Clockwise)

Preceding gene: 119896635

Following gene: 119896638

Centisome position: 8.45

GC content: 70.57

Gene sequence:

>1641_bases
ATGCAATCGATCGAAGTGGTGCTGGCAATGCTGCTGGCCGTGGTGGCCAGCGGCTATCTGGTGCGGGTGGTGCCGGTGTC
GCTGCCGCTGCCGCTGGTGCAGATCGCCCTCGGCGCCGGCATCGCCGCCATCTCCGGCCACGGCGTGCGGCTCGACCCGG
AAATCTTCTTCCTGCTGTTCCTGCCGCCGCTGCTATTCCTGGACGGCTGGCGCATTCCCAAGGTCGGCCTGTTCCGCGAC
AAGGGCACCATCCTCGAACTCGCCTTCGGGCTGGTGGTGTTCACCGTGCTCGGCGCCGGGCTGCTGATCCACTGGATGAT
TCCGGCGATGCCGCTGGCGGTGGCCTTCGCGCTTGCCGCCATCGTCTCGCCCACCGACCCGGTGGCGGTGTCGTCGATTG
CCGCGCGGGTGCCGATTCCGAAGCGGCTGATGCACATCCTGGAAGGCGAATCCCTGCTCAACGACGCCTCCGGCCTGGTG
TGCTTCCGCTTTGCGGTGGCCGCGGTGATGACCGGCGGCTTCTCGCTCGCGGCGGCCTCGCTCACCTTCCTGTGGGTGGC
GTTTGCGGGGCTGGCGGTGGGCGTCATCGTCACCTGGGTCATCAGCCTCGCGCAGCGCTGGCTCTCGCGCCACCTGGGCG
AGGAGGCCGGCTCGCCGATCCTGGTCAATCTGCTGATTCCCTTCGGCGCCTACCTGGTGGCGGAACACCTGGACGCCTCC
GGCATCCTCGCCGCGGTGGCCGCCGGGGTGACGATGAGCTACGTCGAACTCAGCGGCCGCGCGCTTGCCACCACCCGTGT
GCAGCGCGCCGCGGTGTGGGACACGGTGCAGTTCTCGCTCAACGGCATCATGTTCGTGCTGCTGGGCGAACAACTGCCGG
GCATCGTGCAGCGCGCGGCCGCGGCGGTGGAAGACAGCGGCCATGTTTCGCGCTGGTGGCTGCTGGTGTATGCGCTGGCG
ATCAGCGCCATCCTCGCCGCGCTGCGTTTCGCCTGGGTGTGGGTGTCGCTGCGGGTCACCTTGTTCAAGGCGCGCGAAGC
GGGCGAGCCGCTGCAGCGGCCGGACTGGCGCATCGTCGCCGCGGTGTCGCTCGCCGGGGTGCGTGGCGCGATCACGCTGG
CCGGCGTGCTGACCTTGCCGCTGCTGCTGCCGGACGGGCGCGATTTCCCCGCGCGCGATCTGGTGATCTTCCTCGCCGCG
GCGGTCATCCTGGTGTCGCTGCTGCTCGCCAGCTTGGGCCTGCCGCGCCTGCTGCGCGGGCTGGCGCTGCCGGACGAACC
CGCCGAACGGCGCGAGGAAGACCGCGCCCGGCGCGAGGCCGCGGCGGCGGCGATCGCCGCGATCGAGAAGGCGCGGCACG
CATTGTCGGAACCCGGCGCCGCCGACGCCGATCTCTATACCAATGCCGCCGTGCGCGTGATGGCCAACTACCAGCGCCGA
CTGGCGGACAGCGCCATGCCCGGCAGCGTCGCCGCAGACCGCCTGCGGGCGGCGGACCGCGCCGAAATGGCGCTGTGGCT
GGCGGCGCTGCAGGCCGAGCGCGAAGCCATCTTCCGCCTCGCGCGCGACTACGAACTGTCGGACGAAACCTCGCGCAAGC
TGGTGCGCCAGATCGATCTGATGGAAGCGCGCTACCGCTGA

Upstream 100 bases:

>100_bases
TGCCTGTAATTCTATCCAGTCCACCCCCGCCTACGGTAGCCGCGCGGCAGGCGGCGGGCGGCGGCGCTAAACTGGCGCCC
GTCCGGGGAGAGCGGGGTCT

Downstream 100 bases:

>100_bases
CCCGCCGGGAACCCGGCGCGTCGCCCCTTGCTGTCCGGAGGCCCGTCATGTCCCCCTCGCGTTCCGCCGTCCTGCTGATC
CTGCTGCTTGCCGCGCCGGC

Product: putative Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MQSIEVVLAMLLAVVASGYLVRVVPVSLPLPLVQIALGAGIAAISGHGVRLDPEIFFLLFLPPLLFLDGWRIPKVGLFRD
KGTILELAFGLVVFTVLGAGLLIHWMIPAMPLAVAFALAAIVSPTDPVAVSSIAARVPIPKRLMHILEGESLLNDASGLV
CFRFAVAAVMTGGFSLAAASLTFLWVAFAGLAVGVIVTWVISLAQRWLSRHLGEEAGSPILVNLLIPFGAYLVAEHLDAS
GILAAVAAGVTMSYVELSGRALATTRVQRAAVWDTVQFSLNGIMFVLLGEQLPGIVQRAAAAVEDSGHVSRWWLLVYALA
ISAILAALRFAWVWVSLRVTLFKAREAGEPLQRPDWRIVAAVSLAGVRGAITLAGVLTLPLLLPDGRDFPARDLVIFLAA
AVILVSLLLASLGLPRLLRGLALPDEPAERREEDRARREAAAAAIAAIEKARHALSEPGAADADLYTNAAVRVMANYQRR
LADSAMPGSVAADRLRAADRAEMALWLAALQAEREAIFRLARDYELSDETSRKLVRQIDLMEARYR

Sequences:

>Translated_546_residues
MQSIEVVLAMLLAVVASGYLVRVVPVSLPLPLVQIALGAGIAAISGHGVRLDPEIFFLLFLPPLLFLDGWRIPKVGLFRD
KGTILELAFGLVVFTVLGAGLLIHWMIPAMPLAVAFALAAIVSPTDPVAVSSIAARVPIPKRLMHILEGESLLNDASGLV
CFRFAVAAVMTGGFSLAAASLTFLWVAFAGLAVGVIVTWVISLAQRWLSRHLGEEAGSPILVNLLIPFGAYLVAEHLDAS
GILAAVAAGVTMSYVELSGRALATTRVQRAAVWDTVQFSLNGIMFVLLGEQLPGIVQRAAAAVEDSGHVSRWWLLVYALA
ISAILAALRFAWVWVSLRVTLFKAREAGEPLQRPDWRIVAAVSLAGVRGAITLAGVLTLPLLLPDGRDFPARDLVIFLAA
AVILVSLLLASLGLPRLLRGLALPDEPAERREEDRARREAAAAAIAAIEKARHALSEPGAADADLYTNAAVRVMANYQRR
LADSAMPGSVAADRLRAADRAEMALWLAALQAEREAIFRLARDYELSDETSRKLVRQIDLMEARYR
>Mature_546_residues
MQSIEVVLAMLLAVVASGYLVRVVPVSLPLPLVQIALGAGIAAISGHGVRLDPEIFFLLFLPPLLFLDGWRIPKVGLFRD
KGTILELAFGLVVFTVLGAGLLIHWMIPAMPLAVAFALAAIVSPTDPVAVSSIAARVPIPKRLMHILEGESLLNDASGLV
CFRFAVAAVMTGGFSLAAASLTFLWVAFAGLAVGVIVTWVISLAQRWLSRHLGEEAGSPILVNLLIPFGAYLVAEHLDAS
GILAAVAAGVTMSYVELSGRALATTRVQRAAVWDTVQFSLNGIMFVLLGEQLPGIVQRAAAAVEDSGHVSRWWLLVYALA
ISAILAALRFAWVWVSLRVTLFKAREAGEPLQRPDWRIVAAVSLAGVRGAITLAGVLTLPLLLPDGRDFPARDLVIFLAA
AVILVSLLLASLGLPRLLRGLALPDEPAERREEDRARREAAAAAIAAIEKARHALSEPGAADADLYTNAAVRVMANYQRR
LADSAMPGSVAADRLRAADRAEMALWLAALQAEREAIFRLARDYELSDETSRKLVRQIDLMEARYR

Specific function: Unknown

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family [H]

Homologues:

Organism=Homo sapiens, GI148727259, Length=444, Percent_Identity=25, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI15529998, Length=439, Percent_Identity=25.5125284738041, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI4759144, Length=370, Percent_Identity=27.2972972972973, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI194239733, Length=420, Percent_Identity=26.1904761904762, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI27777632, Length=459, Percent_Identity=27.6688453159041, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI27734935, Length=258, Percent_Identity=24.031007751938, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI14211919, Length=260, Percent_Identity=25.7692307692308, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI110227626, Length=259, Percent_Identity=25.8687258687259, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI41872703, Length=420, Percent_Identity=24.2857142857143, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI5454070, Length=259, Percent_Identity=25.8687258687259, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI294997330, Length=261, Percent_Identity=25.6704980842912, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1790501, Length=552, Percent_Identity=43.1159420289855, Blast_Score=376, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI71999821, Length=438, Percent_Identity=24.4292237442922, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71987537, Length=436, Percent_Identity=26.1467889908257, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71999817, Length=431, Percent_Identity=24.1299303944316, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71999819, Length=431, Percent_Identity=24.1299303944316, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71987535, Length=436, Percent_Identity=26.1467889908257, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71987559, Length=450, Percent_Identity=23.7777777777778, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71987545, Length=450, Percent_Identity=23.7777777777778, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71980847, Length=517, Percent_Identity=22.6305609284333, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71992101, Length=342, Percent_Identity=24.5614035087719, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71992107, Length=342, Percent_Identity=24.5614035087719, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25150332, Length=391, Percent_Identity=26.3427109974425, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71993590, Length=271, Percent_Identity=30.6273062730627, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71993582, Length=271, Percent_Identity=30.6273062730627, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI25147678, Length=414, Percent_Identity=23.6714975845411, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71990932, Length=520, Percent_Identity=23.2692307692308, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71990924, Length=482, Percent_Identity=23.2365145228216, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320663, Length=360, Percent_Identity=24.1666666666667, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI221510734, Length=402, Percent_Identity=26.3681592039801, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221510738, Length=402, Percent_Identity=26.3681592039801, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221510732, Length=383, Percent_Identity=26.6318537859008, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221510736, Length=383, Percent_Identity=26.6318537859008, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24585580, Length=383, Percent_Identity=26.6318537859008, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24585578, Length=383, Percent_Identity=26.6318537859008, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221510740, Length=383, Percent_Identity=26.6318537859008, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI281360447, Length=458, Percent_Identity=24.8908296943231, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281364513, Length=257, Percent_Identity=25.2918287937743, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI221473222, Length=257, Percent_Identity=25.2918287937743, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI221473212, Length=257, Percent_Identity=25.2918287937743, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI221473215, Length=257, Percent_Identity=25.2918287937743, Blast_Score=73, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 58581; Mature: 58581

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSIEVVLAMLLAVVASGYLVRVVPVSLPLPLVQIALGAGIAAISGHGVRLDPEIFFLLF
CCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCEECCCCEEECHHHHHHHH
LPPLLFLDGWRIPKVGLFRDKGTILELAFGLVVFTVLGAGLLIHWMIPAMPLAVAFALAA
HHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVSPTDPVAVSSIAARVPIPKRLMHILEGESLLNDASGLVCFRFAVAAVMTGGFSLAAAS
HCCCCCCHHHHHHHHCCCCHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHH
LTFLWVAFAGLAVGVIVTWVISLAQRWLSRHLGEEAGSPILVNLLIPFGAYLVAEHLDAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCH
GILAAVAAGVTMSYVELSGRALATTRVQRAAVWDTVQFSLNGIMFVLLGEQLPGIVQRAA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECHHCHHHHHHHH
AAVEDSGHVSRWWLLVYALAISAILAALRFAWVWVSLRVTLFKAREAGEPLQRPDWRIVA
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
AVSLAGVRGAITLAGVLTLPLLLPDGRDFPARDLVIFLAAAVILVSLLLASLGLPRLLRG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LALPDEPAERREEDRARREAAAAAIAAIEKARHALSEPGAADADLYTNAAVRVMANYQRR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
LADSAMPGSVAADRLRAADRAEMALWLAALQAEREAIFRLARDYELSDETSRKLVRQIDL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
MEARYR
HHHCCC
>Mature Secondary Structure
MQSIEVVLAMLLAVVASGYLVRVVPVSLPLPLVQIALGAGIAAISGHGVRLDPEIFFLLF
CCHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCEECCCCEEECHHHHHHHH
LPPLLFLDGWRIPKVGLFRDKGTILELAFGLVVFTVLGAGLLIHWMIPAMPLAVAFALAA
HHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVSPTDPVAVSSIAARVPIPKRLMHILEGESLLNDASGLVCFRFAVAAVMTGGFSLAAAS
HCCCCCCHHHHHHHHCCCCHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHH
LTFLWVAFAGLAVGVIVTWVISLAQRWLSRHLGEEAGSPILVNLLIPFGAYLVAEHLDAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHCCCH
GILAAVAAGVTMSYVELSGRALATTRVQRAAVWDTVQFSLNGIMFVLLGEQLPGIVQRAA
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEECHHCHHHHHHHH
AAVEDSGHVSRWWLLVYALAISAILAALRFAWVWVSLRVTLFKAREAGEPLQRPDWRIVA
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
AVSLAGVRGAITLAGVLTLPLLLPDGRDFPARDLVIFLAAAVILVSLLLASLGLPRLLRG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LALPDEPAERREEDRARREAAAAAIAAIEKARHALSEPGAADADLYTNAAVRVMANYQRR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
LADSAMPGSVAADRLRAADRAEMALWLAALQAEREAIFRLARDYELSDETSRKLVRQIDL
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
MEARYR
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]