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The map label for this gene is livH [H]

Identifier: 119896603

GI number: 119896603

Start: 336157

End: 337194

Strand: Direct

Name: livH [H]

Synonym: azo0312

Alternate gene names: 119896603

Gene position: 336157-337194 (Clockwise)

Preceding gene: 119896602

Following gene: 119896604

Centisome position: 7.68

GC content: 68.11

Gene sequence:

>1038_bases
ATGGATTTTCAGATAGCGCTGTTGCTTGGCCAGGACGGCATCACCAACGGAGCGATCTACGCGCTGCTGGCACTGGCGCT
GGTGCTGGTGTTTGCGGTGACGCGGGTGATCTTCATCCCGCAAGGGGAGTTCGTTGCCTACGGGGCGTTGACGCTGGCGA
TGCTGCAGGCGGGCGCGGTGCCGGCGACGGTGTGGCTGCTGGCCGGGCTGGGTGCGGTGGCGGCGGTGCTGGACGGGCGC
GGCGCGCTGCAGTCGGGTAACGCGAAGAAGCTGCCCGGCATCGTCGGCTGGAACCTTGCCTATCCGCTGGCGCTCGCGGG
CGTGCTGATGGCGCTGCCGGTCAAGGAGCTGCCGCTGGCGGTGCAGGTGCTGCTCGCGCTCGCGGTGGTGGTGCCGATGG
GCCCCTACCTGTACCGCGTGGTGTATCAGCCGATCGCCGCCGCCCCGGTGCTGATCCTGCTGATCGTCTCGGTCGCGGTG
CACGTCGGCATGGTCGGCCTCGGCCTGCTCTTCTTCGGCGCCGAAGGCCAGCGCACCCCGGCGTTCTCGGATGCGCGCTT
CGAAGTCGGCCCGCTGCTGGTGTCCGGCCAGACGATCTGGGTGATCGTCGCCTCGATCGCGCTGATCGCCGCGCTGTACC
AGTTCTTCGAGCGCACGCTGTACGGCAAGGCGCTGCGCGCGACCGCGATCAACCGCGTCGGCGCCCAGCTGATGGGTATC
TCGCCCGCGCTCGCCGGCAAGCTCACCTTCGTGCTCGCCGCCTTCATCGGCGCGCTGTCGGGCGTGCTGATCGCCCCGAT
CACCACCATCTACTACGACACCGGCTTCCTGATCGGCCTGAAGGGGTTCGTCGCCGCCATCATCGGCGGGCTCGGCAGCT
ACCCGATCGCCGCCATCGGCGCCGTGCTGGTGGGGCTGCTCGAAGCCTTCTCCTCGTTCTGGGCCAGCGCCTACAAGGAA
GTGATCGTCTTCACGCTGATCATCCCGGTGCTGCTGTGGCGCTCGCTCACCAGCCATCACCTGGAGGAAGAAGAATGA

Upstream 100 bases:

>100_bases
CTGGAGCGGGGGCCCGCGGCCCCCGCGCTGCATTTCCCGACAGAGATAGAAATACAGGACACGTCATCCCGCGCGGGAGG
CAGTGTCGCAGGGGTACGCC

Downstream 100 bases:

>100_bases
CCGCCCGTCTTCCGATCGAGCCGTCGTCCGCGACCCCCTCCGCCTCCACCCCGGGAGCCTCCACCATGCTTTCGCCCCGC
CTCGTGCTCGGCGTCTTTCT

Product: ABC transporter permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MDFQIALLLGQDGITNGAIYALLALALVLVFAVTRVIFIPQGEFVAYGALTLAMLQAGAVPATVWLLAGLGAVAAVLDGR
GALQSGNAKKLPGIVGWNLAYPLALAGVLMALPVKELPLAVQVLLALAVVVPMGPYLYRVVYQPIAAAPVLILLIVSVAV
HVGMVGLGLLFFGAEGQRTPAFSDARFEVGPLLVSGQTIWVIVASIALIAALYQFFERTLYGKALRATAINRVGAQLMGI
SPALAGKLTFVLAAFIGALSGVLIAPITTIYYDTGFLIGLKGFVAAIIGGLGSYPIAAIGAVLVGLLEAFSSFWASAYKE
VIVFTLIIPVLLWRSLTSHHLEEEE

Sequences:

>Translated_345_residues
MDFQIALLLGQDGITNGAIYALLALALVLVFAVTRVIFIPQGEFVAYGALTLAMLQAGAVPATVWLLAGLGAVAAVLDGR
GALQSGNAKKLPGIVGWNLAYPLALAGVLMALPVKELPLAVQVLLALAVVVPMGPYLYRVVYQPIAAAPVLILLIVSVAV
HVGMVGLGLLFFGAEGQRTPAFSDARFEVGPLLVSGQTIWVIVASIALIAALYQFFERTLYGKALRATAINRVGAQLMGI
SPALAGKLTFVLAAFIGALSGVLIAPITTIYYDTGFLIGLKGFVAAIIGGLGSYPIAAIGAVLVGLLEAFSSFWASAYKE
VIVFTLIIPVLLWRSLTSHHLEEEE
>Mature_345_residues
MDFQIALLLGQDGITNGAIYALLALALVLVFAVTRVIFIPQGEFVAYGALTLAMLQAGAVPATVWLLAGLGAVAAVLDGR
GALQSGNAKKLPGIVGWNLAYPLALAGVLMALPVKELPLAVQVLLALAVVVPMGPYLYRVVYQPIAAAPVLILLIVSVAV
HVGMVGLGLLFFGAEGQRTPAFSDARFEVGPLLVSGQTIWVIVASIALIAALYQFFERTLYGKALRATAINRVGAQLMGI
SPALAGKLTFVLAAFIGALSGVLIAPITTIYYDTGFLIGLKGFVAAIIGGLGSYPIAAIGAVLVGLLEAFSSFWASAYKE
VIVFTLIIPVLLWRSLTSHHLEEEE

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=352, Percent_Identity=26.7045454545455, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 36039; Mature: 36039

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFQIALLLGQDGITNGAIYALLALALVLVFAVTRVIFIPQGEFVAYGALTLAMLQAGAV
CCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCH
PATVWLLAGLGAVAAVLDGRGALQSGNAKKLPGIVGWNLAYPLALAGVLMALPVKELPLA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHH
VQVLLALAVVVPMGPYLYRVVYQPIAAAPVLILLIVSVAVHVGMVGLGLLFFGAEGQRTP
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
AFSDARFEVGPLLVSGQTIWVIVASIALIAALYQFFERTLYGKALRATAINRVGAQLMGI
CCCCCCEEECCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SPALAGKLTFVLAAFIGALSGVLIAPITTIYYDTGFLIGLKGFVAAIIGGLGSYPIAAIG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHH
AVLVGLLEAFSSFWASAYKEVIVFTLIIPVLLWRSLTSHHLEEEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDFQIALLLGQDGITNGAIYALLALALVLVFAVTRVIFIPQGEFVAYGALTLAMLQAGAV
CCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCH
PATVWLLAGLGAVAAVLDGRGALQSGNAKKLPGIVGWNLAYPLALAGVLMALPVKELPLA
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHH
VQVLLALAVVVPMGPYLYRVVYQPIAAAPVLILLIVSVAVHVGMVGLGLLFFGAEGQRTP
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
AFSDARFEVGPLLVSGQTIWVIVASIALIAALYQFFERTLYGKALRATAINRVGAQLMGI
CCCCCCEEECCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SPALAGKLTFVLAAFIGALSGVLIAPITTIYYDTGFLIGLKGFVAAIIGGLGSYPIAAIG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHH
AVLVGLLEAFSSFWASAYKEVIVFTLIIPVLLWRSLTSHHLEEEE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]