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The map label for this gene is npd1 [H]

Identifier: 119896528

GI number: 119896528

Start: 262974

End: 263831

Strand: Reverse

Name: npd1 [H]

Synonym: azo0237

Alternate gene names: 119896528

Gene position: 263831-262974 (Counterclockwise)

Preceding gene: 119896529

Following gene: 119896527

Centisome position: 6.03

GC content: 73.89

Gene sequence:

>858_bases
GTGACCGCCCCGCCGCCCTCCACGTTGCACGCCGCCGCGCAGGACGCCGCCGCGGCGCTGGCGGGCGCCGATGCGCTGCT
CGTGACTGCGGGCGCCGGCATGGGCGTGGATTCCGGCCTGCCGGACTTTCGCGGCGCGGAAGGCTTCTGGCGCGCCTACC
CGGCGCTGCGCCAGACCGGCCTGCGCTTCGAGGAGATCGCCGATCCGGTCCATTTCGAGCGCGATCCCGCGCTGGCTTGG
GGCTTCTACGGCCACCGCCTGGCGCTCTACCGCCGCACCGTGCCGCATGCCGGCTTCGGCCTGCTGCGCGAACTCGGCCG
CGCACTGGCGCAGGGCGTCTTCGTATTCACCAGCAATGTCGATGGCCAGTTCCAGCGCGCCGGCTTCGACGCGGACCGCA
TCGTCGAGGTGCACGGCTCGATCCACCACTTGCAATGCATCCACGGCTGCCGCGACGCGATCTGGCCCGCCGACGCCTTT
GCGCCAGACGTGAACGAAGCCACCTGCCGGCTGAGCAACCCGCCCCCGCGCTGTCCGCATTGCGGCGCGGTGGCACGGCC
CAACATCCTGATGTTCGGCGACTGGGGCTGGCTGGAAGAGCGCAGCGCCGCGCAGCAGGCACGCCTTGCGGACTGGCTGG
ATCGGGTGCAGCGGCCGCTGGTCGTGGAGATCGGCGCCGGGACCGCCATCCCCACCGTGCGCCGCGTGGGCGAACGCGCC
GGCGCCACGCTGGTGCGGATCAACCCGCAGGCGGACCGCGACCCGCCCCCCGGCAGCATCGCGCTGCACTGCGGCGGCCT
GGCCGGCATCCGCGCGTTGCACGCCGCGGCCGCGGCAGCCGGCCTCGTCGGCGCATAA

Upstream 100 bases:

>100_bases
GCCTGCCCCCGCCGGCCGAAGGCAGCTGCCACCGCTGTGGCGCCGGACCTGAGCCGGGCGATCGCTTCTGCACCGCCTGC
GGCTGCCTGCTGACCCGCCC

Downstream 100 bases:

>100_bases
TGGCAGGCCGCGCGCGGGGCGCCAGCGCGCGGCCAAGACGATCTTCCCCCTGACCGGACACGGAGGTGGCAATGGATCCT
TCCCGTCTCACCGACCTGCA

Product: putative NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MTAPPPSTLHAAAQDAAAALAGADALLVTAGAGMGVDSGLPDFRGAEGFWRAYPALRQTGLRFEEIADPVHFERDPALAW
GFYGHRLALYRRTVPHAGFGLLRELGRALAQGVFVFTSNVDGQFQRAGFDADRIVEVHGSIHHLQCIHGCRDAIWPADAF
APDVNEATCRLSNPPPRCPHCGAVARPNILMFGDWGWLEERSAAQQARLADWLDRVQRPLVVEIGAGTAIPTVRRVGERA
GATLVRINPQADRDPPPGSIALHCGGLAGIRALHAAAAAAGLVGA

Sequences:

>Translated_285_residues
MTAPPPSTLHAAAQDAAAALAGADALLVTAGAGMGVDSGLPDFRGAEGFWRAYPALRQTGLRFEEIADPVHFERDPALAW
GFYGHRLALYRRTVPHAGFGLLRELGRALAQGVFVFTSNVDGQFQRAGFDADRIVEVHGSIHHLQCIHGCRDAIWPADAF
APDVNEATCRLSNPPPRCPHCGAVARPNILMFGDWGWLEERSAAQQARLADWLDRVQRPLVVEIGAGTAIPTVRRVGERA
GATLVRINPQADRDPPPGSIALHCGGLAGIRALHAAAAAAGLVGA
>Mature_284_residues
TAPPPSTLHAAAQDAAAALAGADALLVTAGAGMGVDSGLPDFRGAEGFWRAYPALRQTGLRFEEIADPVHFERDPALAWG
FYGHRLALYRRTVPHAGFGLLRELGRALAQGVFVFTSNVDGQFQRAGFDADRIVEVHGSIHHLQCIHGCRDAIWPADAFA
PDVNEATCRLSNPPPRCPHCGAVARPNILMFGDWGWLEERSAAQQARLADWLDRVQRPLVVEIGAGTAIPTVRRVGERAG
ATLVRINPQADRDPPPGSIALHCGGLAGIRALHAAAAAAGLVGA

Specific function: Modulates the activity of chromatin proteins, thereby having an effect on transcription per subunit [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI13787215, Length=199, Percent_Identity=28.643216080402, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI6912664, Length=199, Percent_Identity=28.643216080402, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI300795542, Length=187, Percent_Identity=27.2727272727273, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI308199517, Length=173, Percent_Identity=28.3236994219653, Blast_Score=70, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6325242, Length=240, Percent_Identity=27.0833333333333, Blast_Score=69, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6324504, Length=167, Percent_Identity=28.7425149700599, Blast_Score=68, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 30227; Mature: 30095

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPPPSTLHAAAQDAAAALAGADALLVTAGAGMGVDSGLPDFRGAEGFWRAYPALRQTG
CCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
LRFEEIADPVHFERDPALAWGFYGHRLALYRRTVPHAGFGLLRELGRALAQGVFVFTSNV
CCHHHHCCCCCCCCCCCEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCC
DGQFQRAGFDADRIVEVHGSIHHLQCIHGCRDAIWPADAFAPDVNEATCRLSNPPPRCPH
CCCHHHCCCCHHHEEECCCCHHHHHHHHHHHHHCCCCHHCCCCCCCCEEEECCCCCCCCC
CGAVARPNILMFGDWGWLEERSAAQQARLADWLDRVQRPLVVEIGAGTAIPTVRRVGERA
CCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHH
GATLVRINPQADRDPPPGSIALHCGGLAGIRALHAAAAAAGLVGA
CCEEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TAPPPSTLHAAAQDAAAALAGADALLVTAGAGMGVDSGLPDFRGAEGFWRAYPALRQTG
CCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
LRFEEIADPVHFERDPALAWGFYGHRLALYRRTVPHAGFGLLRELGRALAQGVFVFTSNV
CCHHHHCCCCCCCCCCCEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCEEEEECCC
DGQFQRAGFDADRIVEVHGSIHHLQCIHGCRDAIWPADAFAPDVNEATCRLSNPPPRCPH
CCCHHHCCCCHHHEEECCCCHHHHHHHHHHHHHCCCCHHCCCCCCCCEEEECCCCCCCCC
CGAVARPNILMFGDWGWLEERSAAQQARLADWLDRVQRPLVVEIGAGTAIPTVRRVGERA
CCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHH
GATLVRINPQADRDPPPGSIALHCGGLAGIRALHAAAAAAGLVGA
CCEEEEECCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA