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The map label for this gene is prp [H]

Identifier: 119896503

GI number: 119896503

Start: 232564

End: 233067

Strand: Reverse

Name: prp [H]

Synonym: azo0212

Alternate gene names: 119896503

Gene position: 233067-232564 (Counterclockwise)

Preceding gene: 119896504

Following gene: 119896502

Centisome position: 5.33

GC content: 61.51

Gene sequence:

>504_bases
ATGACCATCACGACCGCCATGCCCAAACTCGACCGGCTCGACCTGCGCATCCTGTGCCAGCTCCAGCGCAACGGCCGCAT
CACCAACGTGGACCTGGCCGATGCCGTCGGCCTGTCGCCCAGCCCCTGCCTGATCCGGGTCAAGCGCCTGGAGCAGGCCG
GCTACATCGCCGGCTACGGCGCGCAGGTGAAGCTCGACAAGCTCGGCGAGATGCTGACCGTGTTCACCGAGGTGACGCTC
GCCGACCACCGCCGCGAGGACTTCATGCGTTTCGAGTCGGCCATCCGCAACATCGACGAGATCCTCGAATGCCATCTGGT
CAGCGGCGGCTACGACTACTTGCTGAAGTTCATGACCCAGGGCGTGAACCACTACCAGAGCATCATCGAAGGCCTGCTCG
AACGCAGCATCGGCATCGAGAAGTACTTCAGCTACATCGTCATCAAATCGCCCTTCATCAAGAACTACTACCCGATCGAA
CGGGTGGTCGACACCAGCAAATAG

Upstream 100 bases:

>100_bases
CCGACGTGCGCCGCGCGCTGGCCTGAGGATCAGCGGCATGCATCTTGCTGGACACTGCCCGACTCCATCACCTCCGCTCC
AGTGCGGAAAGTAGTTCGCA

Downstream 100 bases:

>100_bases
CGCCTTCCGCCGTGCCCGCCTCCACGCCCCCGCGTTCCCCGCGCTTCGTCCGCCTCGCCGAAACCGGCCGCCGCCCCGTC
GGTCTGAGGGTGGACGGCCG

Product: proline dehydrogenase transcriptional activator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 167; Mature: 166

Protein sequence:

>167_residues
MTITTAMPKLDRLDLRILCQLQRNGRITNVDLADAVGLSPSPCLIRVKRLEQAGYIAGYGAQVKLDKLGEMLTVFTEVTL
ADHRREDFMRFESAIRNIDEILECHLVSGGYDYLLKFMTQGVNHYQSIIEGLLERSIGIEKYFSYIVIKSPFIKNYYPIE
RVVDTSK

Sequences:

>Translated_167_residues
MTITTAMPKLDRLDLRILCQLQRNGRITNVDLADAVGLSPSPCLIRVKRLEQAGYIAGYGAQVKLDKLGEMLTVFTEVTL
ADHRREDFMRFESAIRNIDEILECHLVSGGYDYLLKFMTQGVNHYQSIIEGLLERSIGIEKYFSYIVIKSPFIKNYYPIE
RVVDTSK
>Mature_166_residues
TITTAMPKLDRLDLRILCQLQRNGRITNVDLADAVGLSPSPCLIRVKRLEQAGYIAGYGAQVKLDKLGEMLTVFTEVTLA
DHRREDFMRFESAIRNIDEILECHLVSGGYDYLLKFMTQGVNHYQSIIEGLLERSIGIEKYFSYIVIKSPFIKNYYPIER
VVDTSK

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=140, Percent_Identity=44.2857142857143, Blast_Score=122, Evalue=1e-29,
Organism=Escherichia coli, GI87081742, Length=151, Percent_Identity=29.1390728476821, Blast_Score=76, Evalue=1e-15,
Organism=Escherichia coli, GI1790182, Length=149, Percent_Identity=26.1744966442953, Blast_Score=65, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 19112; Mature: 18980

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTITTAMPKLDRLDLRILCQLQRNGRITNVDLADAVGLSPSPCLIRVKRLEQAGYIAGYG
CCCCCCCCCCHHHHHHHHHHHHCCCCEEEECHHHHCCCCCCHHHHHHHHHHHCCCEECCC
AQVKLDKLGEMLTVFTEVTLADHRREDFMRFESAIRNIDEILECHLVSGGYDYLLKFMTQ
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
GVNHYQSIIEGLLERSIGIEKYFSYIVIKSPFIKNYYPIERVVDTSK
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHCCCCCHHHHHCCCC
>Mature Secondary Structure 
TITTAMPKLDRLDLRILCQLQRNGRITNVDLADAVGLSPSPCLIRVKRLEQAGYIAGYG
CCCCCCCCCHHHHHHHHHHHHCCCCEEEECHHHHCCCCCCHHHHHHHHHHHCCCEECCC
AQVKLDKLGEMLTVFTEVTLADHRREDFMRFESAIRNIDEILECHLVSGGYDYLLKFMTQ
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
GVNHYQSIIEGLLERSIGIEKYFSYIVIKSPFIKNYYPIERVVDTSK
HHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]