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The map label for this gene is ubiE1 [H]

Identifier: 119896454

GI number: 119896454

Start: 179327

End: 180064

Strand: Reverse

Name: ubiE1 [H]

Synonym: azo0162

Alternate gene names: 119896454

Gene position: 180064-179327 (Counterclockwise)

Preceding gene: 119896455

Following gene: 119896453

Centisome position: 4.11

GC content: 65.18

Gene sequence:

>738_bases
ATGAACGACAAGACCACCCATTTCGGCTTCGAGACCGTCGCCGAAAATCAGAAGCAGCGCCGCGTCGCCGAAGTCTTTTC
CTCGGTCGCGTCGCGCTACGACGTGATGAACGATCTGATGTCCTTCGGTCTGCACAGACTGTGGAAGGCGTTCACGATCC
AGGTCTCGGGCGTGCGCAGCGGTGACCGGGTGCTCGACGTGGCCGGGGGCACCGCAGACCTGTCGCTGGCGTTTGCGCGC
AAGGTCGGTCCGACCGGCCAGGTCTGGCTTACCGACATCAACCACGCCATGTTGAGCCGCGGGCGCGACCGCGTGCTGGA
CCACGGTTTCGCGCTGCCGGTGGCGCAATGCAACGCCGAACGGCTTCCGTTCCCGGACGACTGGTTCGACTGTGTCACCG
TCGCTTTCGGGCTGCGCAACATGACGCACAAGGACGTCGCGCTGGCCGAGATGCGCCGCGTGCTGCGGCCCGGCGGGCGG
CTGCTGGTGCTGGAGTTCTCCAAGGTATGGAAGCCGCTCGCGCCGCTCTACGACCTTTACTCGTTCAAGCTCCTGCCGTG
GATGGGCGACAAGGTGGCCAAGGACGCAGACAGCTACCGCTACCTCGCGGAATCGATCCGCATGCATCCGGGCCAGGATG
AGTTGCGGGACATGATGGAGCAGGCCGGCCTCGCCCGGGTCGATTACTTCAACCTGAGCGCGGGCGTGGTCGCACTGCAC
CGCGGCTACAAGACCTGA

Upstream 100 bases:

>100_bases
TATCTCGACCGCCTCGCCGCAGCGGGCGGCAGCCGCGAAGCCGGCGCCGTCCCGCCCGCCGCACCCAAGTCCGGCTGCGG
ACATCACCACTGAATCGCCG

Downstream 100 bases:

>100_bases
GCGGCTCGCCCTTGCGCCACGCCCGTTGCTGCGCCTTCCGCCGATGATCGAACAAGCCGTCCTGGCCACCATCAATCACC
TGCTGGCTCAGTCCGGCTGG

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MNDKTTHFGFETVAENQKQRRVAEVFSSVASRYDVMNDLMSFGLHRLWKAFTIQVSGVRSGDRVLDVAGGTADLSLAFAR
KVGPTGQVWLTDINHAMLSRGRDRVLDHGFALPVAQCNAERLPFPDDWFDCVTVAFGLRNMTHKDVALAEMRRVLRPGGR
LLVLEFSKVWKPLAPLYDLYSFKLLPWMGDKVAKDADSYRYLAESIRMHPGQDELRDMMEQAGLARVDYFNLSAGVVALH
RGYKT

Sequences:

>Translated_245_residues
MNDKTTHFGFETVAENQKQRRVAEVFSSVASRYDVMNDLMSFGLHRLWKAFTIQVSGVRSGDRVLDVAGGTADLSLAFAR
KVGPTGQVWLTDINHAMLSRGRDRVLDHGFALPVAQCNAERLPFPDDWFDCVTVAFGLRNMTHKDVALAEMRRVLRPGGR
LLVLEFSKVWKPLAPLYDLYSFKLLPWMGDKVAKDADSYRYLAESIRMHPGQDELRDMMEQAGLARVDYFNLSAGVVALH
RGYKT
>Mature_245_residues
MNDKTTHFGFETVAENQKQRRVAEVFSSVASRYDVMNDLMSFGLHRLWKAFTIQVSGVRSGDRVLDVAGGTADLSLAFAR
KVGPTGQVWLTDINHAMLSRGRDRVLDHGFALPVAQCNAERLPFPDDWFDCVTVAFGLRNMTHKDVALAEMRRVLRPGGR
LLVLEFSKVWKPLAPLYDLYSFKLLPWMGDKVAKDADSYRYLAESIRMHPGQDELRDMMEQAGLARVDYFNLSAGVVALH
RGYKT

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=275, Percent_Identity=44.7272727272727, Blast_Score=228, Evalue=5e-60,
Organism=Escherichia coli, GI48994983, Length=246, Percent_Identity=64.2276422764228, Blast_Score=321, Evalue=2e-89,
Organism=Caenorhabditis elegans, GI17557039, Length=245, Percent_Identity=43.265306122449, Blast_Score=214, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6323526, Length=258, Percent_Identity=41.4728682170543, Blast_Score=173, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24641702, Length=258, Percent_Identity=46.5116279069767, Blast_Score=225, Evalue=2e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 27686; Mature: 27686

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDKTTHFGFETVAENQKQRRVAEVFSSVASRYDVMNDLMSFGLHRLWKAFTIQVSGVRS
CCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCC
GDRVLDVAGGTADLSLAFARKVGPTGQVWLTDINHAMLSRGRDRVLDHGFALPVAQCNAE
CCEEEEECCCCHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCHHHHHHCCCCCCHHHCCCC
RLPFPDDWFDCVTVAFGLRNMTHKDVALAEMRRVLRPGGRLLVLEFSKVWKPLAPLYDLY
CCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHH
SFKLLPWMGDKVAKDADSYRYLAESIRMHPGQDELRDMMEQAGLARVDYFNLSAGVVALH
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHH
RGYKT
CCCCC
>Mature Secondary Structure
MNDKTTHFGFETVAENQKQRRVAEVFSSVASRYDVMNDLMSFGLHRLWKAFTIQVSGVRS
CCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCC
GDRVLDVAGGTADLSLAFARKVGPTGQVWLTDINHAMLSRGRDRVLDHGFALPVAQCNAE
CCEEEEECCCCHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCHHHHHHCCCCCCHHHCCCC
RLPFPDDWFDCVTVAFGLRNMTHKDVALAEMRRVLRPGGRLLVLEFSKVWKPLAPLYDLY
CCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHH
SFKLLPWMGDKVAKDADSYRYLAESIRMHPGQDELRDMMEQAGLARVDYFNLSAGVVALH
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCHHHHHHH
RGYKT
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA