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The map label for this gene is atoC [H]

Identifier: 119896363

GI number: 119896363

Start: 80784

End: 82139

Strand: Direct

Name: atoC [H]

Synonym: azo0071

Alternate gene names: 119896363

Gene position: 80784-82139 (Clockwise)

Preceding gene: 119896361

Following gene: 119896364

Centisome position: 1.85

GC content: 69.62

Gene sequence:

>1356_bases
ATGAACCCGGAATCCGCTCCCGCCAGCGCGCCCCAGCAGTCCGTCCTGGTGGTCGATGACGAACAGGGCATGCGCAACTT
CCTCAGCCGTGCGCTGGCCTTGCGCGGCTTCGTGGTGGACACCGCCGAATCCGCCGAAGAAGGCGCCGAAAAACTCGCTG
CCACGCGCTTCGACCTGGTGATCCTGGACATCGCGCTGCCCGGCAAGGCCGGCATCGAATGGCTGCAGGATCTCACCGCG
GCGGGCTTTGCCGGCGAAGTGATCCTGATCACCGCGTTCGCCGACATGCAGACCGCGATCGACGCGCTGCGCGCCGGCGC
CGCGGACTTCATCCTGAAGCCCTTCCGCATCGACCAGATCCTCAACTCGATCCACCGCTCCACCGAACGCGCCCGCCTCG
CGCGCGAGAACTTCCTGCTGCGCCGCCAGGTAGCCGGCAGCGGCAGCGCGAGCGACGGCATGATCGGCGCCTCGCCGGCG
ATCGGCCAGTTGCGCCAGATCCTGCACCGCATCGCGCCGACGCCCTCCACCGTGCTGATCCAGGGCGAATCCGGGGTCGG
CAAGGAAGTGGTGGCGCGCGCGCTGCATCAGCTCTCGCCGCGCGCCGAACAACCTTTCGTCGCGGTCAATTGCGCGGCGA
TCTCGGCCGAGCTGATCGAGTCCGAACTCTTCGGCCACGTGAAGGGTGCCTTCACCGGCGCGCGCGAGGCGCGCAACGGC
CTGTTCCACTACGCCCACGGCGGCACCCTGTTCCTGGACGAGATCGGCGAGTTGCCGCTGGCCCTGCAATCCCGCCTGCT
GCGCGTGCTGGAAGAACGCAAGGTGCGCCCGGTGGGCACCGAACAGGAAGTGCCGGTGGATGTGCGCGTGCTCGCCGCCA
CCAACCGCGACCTGCGTGCCGAGGTGGCGGCGTGCCGCTTCCGTGAGGACCTGTTCTACCGCCTCGAAGTGATCACGCTG
ACGGTGCCGCCACTGCGCGAGCGCGCGGAGGACGTACCGGCGCTGGCGGCGGCCTTCATGCAGCAGCTGGCGATGCAGCT
CGGCCTGCCGCCGCTGCTGATCTCGCCCGAGGTGTCGGCGCGGCTGATGGCGCACCCCTGGCCGGGCAACGTGCGCGAAC
TGCGCAATTTCGTCGAACGTTCGCTGCTGTTCGGCGATTTTCCGCTCGCCAGCCTGGCCGGCGCGGTGGCACCGCCGCCG
CCCGCCTCCGCCGCGCCGCTGCTGCTCGAAGAGGTGGAGAAGCGCCACATCCTCGCGGTGCTCGACCAGTGCGGCGGCAA
CAAGACGCGCGCCGCGGAACTGCTCGGCGTGTCGCGCAAGACCCTGGAACGCAAGTGCGCGGAGTGGTCGGTATGA

Upstream 100 bases:

>100_bases
ACAGGGGCTGCAGTCTAGCGAATCGCCCCGGCGCACGGGCGCTGGTCTCGTTCATGTTGCGGTGCGACAATGCCGCTCCC
GCCGCCAACCCGCCCTTCGC

Downstream 100 bases:

>100_bases
CCCCGGCGGCACGCCGCGATGGCTGAGCGCGCCTTGCGCCGCTGGCGCAAACGCTGGCCGGTGCCGCGCTCGGTGCGGGC
GCGGCTGCTGCTGCTGGTGC

Product: sigma-54 dependent response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MNPESAPASAPQQSVLVVDDEQGMRNFLSRALALRGFVVDTAESAEEGAEKLAATRFDLVILDIALPGKAGIEWLQDLTA
AGFAGEVILITAFADMQTAIDALRAGAADFILKPFRIDQILNSIHRSTERARLARENFLLRRQVAGSGSASDGMIGASPA
IGQLRQILHRIAPTPSTVLIQGESGVGKEVVARALHQLSPRAEQPFVAVNCAAISAELIESELFGHVKGAFTGAREARNG
LFHYAHGGTLFLDEIGELPLALQSRLLRVLEERKVRPVGTEQEVPVDVRVLAATNRDLRAEVAACRFREDLFYRLEVITL
TVPPLRERAEDVPALAAAFMQQLAMQLGLPPLLISPEVSARLMAHPWPGNVRELRNFVERSLLFGDFPLASLAGAVAPPP
PASAAPLLLEEVEKRHILAVLDQCGGNKTRAAELLGVSRKTLERKCAEWSV

Sequences:

>Translated_451_residues
MNPESAPASAPQQSVLVVDDEQGMRNFLSRALALRGFVVDTAESAEEGAEKLAATRFDLVILDIALPGKAGIEWLQDLTA
AGFAGEVILITAFADMQTAIDALRAGAADFILKPFRIDQILNSIHRSTERARLARENFLLRRQVAGSGSASDGMIGASPA
IGQLRQILHRIAPTPSTVLIQGESGVGKEVVARALHQLSPRAEQPFVAVNCAAISAELIESELFGHVKGAFTGAREARNG
LFHYAHGGTLFLDEIGELPLALQSRLLRVLEERKVRPVGTEQEVPVDVRVLAATNRDLRAEVAACRFREDLFYRLEVITL
TVPPLRERAEDVPALAAAFMQQLAMQLGLPPLLISPEVSARLMAHPWPGNVRELRNFVERSLLFGDFPLASLAGAVAPPP
PASAAPLLLEEVEKRHILAVLDQCGGNKTRAAELLGVSRKTLERKCAEWSV
>Mature_451_residues
MNPESAPASAPQQSVLVVDDEQGMRNFLSRALALRGFVVDTAESAEEGAEKLAATRFDLVILDIALPGKAGIEWLQDLTA
AGFAGEVILITAFADMQTAIDALRAGAADFILKPFRIDQILNSIHRSTERARLARENFLLRRQVAGSGSASDGMIGASPA
IGQLRQILHRIAPTPSTVLIQGESGVGKEVVARALHQLSPRAEQPFVAVNCAAISAELIESELFGHVKGAFTGAREARNG
LFHYAHGGTLFLDEIGELPLALQSRLLRVLEERKVRPVGTEQEVPVDVRVLAATNRDLRAEVAACRFREDLFYRLEVITL
TVPPLRERAEDVPALAAAFMQQLAMQLGLPPLLISPEVSARLMAHPWPGNVRELRNFVERSLLFGDFPLASLAGAVAPPP
PASAAPLLLEEVEKRHILAVLDQCGGNKTRAAELLGVSRKTLERKCAEWSV

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=451, Percent_Identity=42.350332594235, Blast_Score=347, Evalue=1e-96,
Organism=Escherichia coli, GI1790437, Length=437, Percent_Identity=43.4782608695652, Blast_Score=330, Evalue=9e-92,
Organism=Escherichia coli, GI1790299, Length=465, Percent_Identity=41.2903225806452, Blast_Score=312, Evalue=4e-86,
Organism=Escherichia coli, GI1788905, Length=429, Percent_Identity=37.995337995338, Blast_Score=271, Evalue=8e-74,
Organism=Escherichia coli, GI87082117, Length=336, Percent_Identity=45.5357142857143, Blast_Score=254, Evalue=8e-69,
Organism=Escherichia coli, GI1789233, Length=321, Percent_Identity=42.9906542056075, Blast_Score=252, Evalue=3e-68,
Organism=Escherichia coli, GI1789087, Length=327, Percent_Identity=44.954128440367, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI87082152, Length=314, Percent_Identity=45.2229299363057, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1786524, Length=337, Percent_Identity=43.620178041543, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI87081872, Length=311, Percent_Identity=39.871382636656, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1787583, Length=342, Percent_Identity=36.2573099415205, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1789828, Length=317, Percent_Identity=33.4384858044164, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI87081858, Length=296, Percent_Identity=33.445945945946, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1786911, Length=107, Percent_Identity=41.1214953271028, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1789809, Length=195, Percent_Identity=30.7692307692308, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1786784, Length=108, Percent_Identity=32.4074074074074, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 48783; Mature: 48783

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPESAPASAPQQSVLVVDDEQGMRNFLSRALALRGFVVDTAESAEEGAEKLAATRFDLV
CCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHEEE
ILDIALPGKAGIEWLQDLTAAGFAGEVILITAFADMQTAIDALRAGAADFILKPFRIDQI
EEEEECCCHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHCCCHHHHHCHHHHHHH
LNSIHRSTERARLARENFLLRRQVAGSGSASDGMIGASPAIGQLRQILHRIAPTPSTVLI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEE
QGESGVGKEVVARALHQLSPRAEQPFVAVNCAAISAELIESELFGHVKGAFTGAREARNG
ECCCCCCHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LFHYAHGGTLFLDEIGELPLALQSRLLRVLEERKVRPVGTEQEVPVDVRVLAATNRDLRA
CEEEECCCEEEHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCHHHH
EVAACRFREDLFYRLEVITLTVPPLRERAEDVPALAAAFMQQLAMQLGLPPLLISPEVSA
HHHHHHHHHHHHEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCC
RLMAHPWPGNVRELRNFVERSLLFGDFPLASLAGAVAPPPPASAAPLLLEEVEKRHILAV
CEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LDQCGGNKTRAAELLGVSRKTLERKCAEWSV
HHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNPESAPASAPQQSVLVVDDEQGMRNFLSRALALRGFVVDTAESAEEGAEKLAATRFDLV
CCCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHEEE
ILDIALPGKAGIEWLQDLTAAGFAGEVILITAFADMQTAIDALRAGAADFILKPFRIDQI
EEEEECCCHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHCCCHHHHHCHHHHHHH
LNSIHRSTERARLARENFLLRRQVAGSGSASDGMIGASPAIGQLRQILHRIAPTPSTVLI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEE
QGESGVGKEVVARALHQLSPRAEQPFVAVNCAAISAELIESELFGHVKGAFTGAREARNG
ECCCCCCHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LFHYAHGGTLFLDEIGELPLALQSRLLRVLEERKVRPVGTEQEVPVDVRVLAATNRDLRA
CEEEECCCEEEHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCHHHH
EVAACRFREDLFYRLEVITLTVPPLRERAEDVPALAAAFMQQLAMQLGLPPLLISPEVSA
HHHHHHHHHHHHEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCC
RLMAHPWPGNVRELRNFVERSLLFGDFPLASLAGAVAPPPPASAAPLLLEEVEKRHILAV
CEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LDQCGGNKTRAAELLGVSRKTLERKCAEWSV
HHHCCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]