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The map label for this gene is helD [H]

Identifier: 119871379

GI number: 119871379

Start: 5589310

End: 5591484

Strand: Direct

Name: helD [H]

Synonym: Mkms_5355

Alternate gene names: 119871379

Gene position: 5589310-5591484 (Clockwise)

Preceding gene: 119871378

Following gene: 119871380

Centisome position: 97.42

GC content: 69.93

Gene sequence:

>2175_bases
ATGCCGGGGTACGAGGACGAACTGCGCTCCGAACGCACCTATGTGTCGGGGCTCTACACCCGGCTCGACGGGGAACGCGC
GCGGGCCAAGGAGAAGTACGCCGCGGCGCTGCGCGGGGACGGCGCGCTCGTCGAACGCGACGCCGAGGTGAGGGCCCTGG
CCAAGGAGATGCAGCGGCTCGACGTGGCCGACGACGGCCTGTGTTTCGGCCGACTGGACGCCGACTCCGGTGAGCGTCTC
TACATCGGCCGGATCGGGATCTTCGACCGCGACAACGACTTCGAACCGCTGCTCCTCGACTGGCGGGCGCCGCTGTCTCG
CGCTTTCTACGTCGCCACCGCCGCGCACCCCGAGGGGATGCGGCGGCGCCGCCAGTTCCGCACCCGCGGGCGGCAGATCC
TCGACTTCACCGACGAGGTCTTCGGCAGGCCTCGCGGCGACGAACGGGGCGGCGATTCGGCGCTGCTCGCCGCGGTGAAC
GCGCCTCGCGGTGAGGGTATGCGCGACATCGTCGCGACGATCCAGGCCGAGCAGGATGCGATCATCCGGCTCGACCACCC
GGGGGTGCTGGTGATCGAGGGCGGGCCGGGGACCGGTAAGACCGTGGTGGCACTGCACCGGGTCGCCTATCTGCTGTACA
CGCAGCGCGCCCGCATCGAACGTCACGGCGTGCTGGTGATCGGTCCGAATCCGGCGTTCCTCGACCACATCAGCCGTGTG
CTGCCGTCGCTGGGTGAGACCAACGTCGTGCTCATGACGACCGGCGATCTGGTGCCGGGCATTTCGGCCACCGCCGAGGA
CGACGCCGCCGACGTGAAGGGTTCGCTGACGATGCTCGACGTGCTGGCGGCGGCGGTCGCTGACCGGCAACGGGTGCCCG
AACAGCCCCTGGTCATCGAGCTGCCGGACGTCACCGTGCAGATCGACCCCGACACCGCCCAGTGGGCGATCGAAGAGGCT
CGCGGCAGCGGACTGCCACACAACCACGCGCGCAAGGTCTTTCGCGAGACGGTCGAATGGGTGCTCACCGAACGGGCGGT
GTCCCGAATCGGTCGGGGCTGGTTGTCGCGCGCGGACAAGGGGGCTTGGGAGGAGCTGCGCGCCGATGTCCTCGAAGACC
TCGCCGACAGCGAGCAGTACCTCGCGGCGCTCGACGAGTTGTGGCCGGTGCTCACCCCGCAGACCCTGCTGGCCGATCTG
TACGAGTCCCGGGAACGTTTGCGTGCGGCGGGCGCCGACGAAAGGCTGTGGCGCTCCGACGGTGCCGCGTGGACGGTGTC
GGACGTGCCGTTGCTCGACGAACTCGTCGACCTGCTGGGCCGCGACATGGCGGCCGACATCGCCGCCGCGAAGGAACGCG
AGGCCGAGACCGATTACGCCGAGGGCGTCCTCGAATCGATGGTCGCCCACGAGGATCTGATGGACGACGAAGACCTGCTG
CTCGCGACCGACCTGTTGCACGGCGAGGAGCTGGCCGAACGCTTCACCGAACGCGACAACCGCGAGCTGGCCGAACGCGC
TGCCGCGGATCGTGATTGGACCTATCGGCACGTCGTGGTCGACGAGGCACAGGAACTGTCGGCGATGGACTGGCGGGTGC
TGATGCGGCGCTGCCCGAGCAAATCGTTCACCATCGTGGGCGATCTCGCGCAGCGCCGCTCGGCCGCAGGCGCCCGGTCC
TGGGGGGCGATGCTCGACACGTACGTACCCGGCCGCTGGGTCTACCGCCCCCTGTCGGTCAACTACCGCACCCCCGCGGA
GATCATGGCGGTCGCGGCCGCGGTACTCGCCGAGTTCGCACCCGACGTCACACCGCCCGAGTCGGTGCGGTCGACGGGGG
TGCAGCCGTGGCGCCGACAGGTGACTCCGGACGAATTGCCCTCGGCGATCGGCGAATTCGTGGACGACGAATCCGGACGC
GAAGGCACCAGTGTCGCGATCGGTCCACCGGATGTGCCGGGGACGGTGGCGCCGAGCGAGGTCAAGGGTCTGGAGTTCGA
CGCCGTCCTCGTGGTCGAGCCGGAGCGGATCTTCGACGGTCCCCGGGGCGCGGCCGAACTCTACGTCGCCCTCACCCGCG
CCACCCAGCGCCTCGGCATCGCGCACTGCGGGCCCCTTCCGCCTGCGCTGGCGGCACTGGTCGATATCCCCGTCGATCGG
GAAGCCGCGCGTTAG

Upstream 100 bases:

>100_bases
ACGCGGCCCCCATTCTATCGGCGGGGTGGGGGCTTGCGGCAAGGCCGGGGTCGTCCCCCACAATGGCTGGCTTCGGCCGG
AAGGAAGTGGTGAGGCGGTC

Downstream 100 bases:

>100_bases
GGTCGATCGATGCGCATCGTCCGCCGATCCGTCACGGCCCTCGTCCTGACCGCCGGCTCACTCGGCGCGGCGATCCCGGC
CACGGCCCAGCCCGCGACGC

Product: putative helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 724; Mature: 723

Protein sequence:

>724_residues
MPGYEDELRSERTYVSGLYTRLDGERARAKEKYAAALRGDGALVERDAEVRALAKEMQRLDVADDGLCFGRLDADSGERL
YIGRIGIFDRDNDFEPLLLDWRAPLSRAFYVATAAHPEGMRRRRQFRTRGRQILDFTDEVFGRPRGDERGGDSALLAAVN
APRGEGMRDIVATIQAEQDAIIRLDHPGVLVIEGGPGTGKTVVALHRVAYLLYTQRARIERHGVLVIGPNPAFLDHISRV
LPSLGETNVVLMTTGDLVPGISATAEDDAADVKGSLTMLDVLAAAVADRQRVPEQPLVIELPDVTVQIDPDTAQWAIEEA
RGSGLPHNHARKVFRETVEWVLTERAVSRIGRGWLSRADKGAWEELRADVLEDLADSEQYLAALDELWPVLTPQTLLADL
YESRERLRAAGADERLWRSDGAAWTVSDVPLLDELVDLLGRDMAADIAAAKEREAETDYAEGVLESMVAHEDLMDDEDLL
LATDLLHGEELAERFTERDNRELAERAAADRDWTYRHVVVDEAQELSAMDWRVLMRRCPSKSFTIVGDLAQRRSAAGARS
WGAMLDTYVPGRWVYRPLSVNYRTPAEIMAVAAAVLAEFAPDVTPPESVRSTGVQPWRRQVTPDELPSAIGEFVDDESGR
EGTSVAIGPPDVPGTVAPSEVKGLEFDAVLVVEPERIFDGPRGAAELYVALTRATQRLGIAHCGPLPPALAALVDIPVDR
EAAR

Sequences:

>Translated_724_residues
MPGYEDELRSERTYVSGLYTRLDGERARAKEKYAAALRGDGALVERDAEVRALAKEMQRLDVADDGLCFGRLDADSGERL
YIGRIGIFDRDNDFEPLLLDWRAPLSRAFYVATAAHPEGMRRRRQFRTRGRQILDFTDEVFGRPRGDERGGDSALLAAVN
APRGEGMRDIVATIQAEQDAIIRLDHPGVLVIEGGPGTGKTVVALHRVAYLLYTQRARIERHGVLVIGPNPAFLDHISRV
LPSLGETNVVLMTTGDLVPGISATAEDDAADVKGSLTMLDVLAAAVADRQRVPEQPLVIELPDVTVQIDPDTAQWAIEEA
RGSGLPHNHARKVFRETVEWVLTERAVSRIGRGWLSRADKGAWEELRADVLEDLADSEQYLAALDELWPVLTPQTLLADL
YESRERLRAAGADERLWRSDGAAWTVSDVPLLDELVDLLGRDMAADIAAAKEREAETDYAEGVLESMVAHEDLMDDEDLL
LATDLLHGEELAERFTERDNRELAERAAADRDWTYRHVVVDEAQELSAMDWRVLMRRCPSKSFTIVGDLAQRRSAAGARS
WGAMLDTYVPGRWVYRPLSVNYRTPAEIMAVAAAVLAEFAPDVTPPESVRSTGVQPWRRQVTPDELPSAIGEFVDDESGR
EGTSVAIGPPDVPGTVAPSEVKGLEFDAVLVVEPERIFDGPRGAAELYVALTRATQRLGIAHCGPLPPALAALVDIPVDR
EAAR
>Mature_723_residues
PGYEDELRSERTYVSGLYTRLDGERARAKEKYAAALRGDGALVERDAEVRALAKEMQRLDVADDGLCFGRLDADSGERLY
IGRIGIFDRDNDFEPLLLDWRAPLSRAFYVATAAHPEGMRRRRQFRTRGRQILDFTDEVFGRPRGDERGGDSALLAAVNA
PRGEGMRDIVATIQAEQDAIIRLDHPGVLVIEGGPGTGKTVVALHRVAYLLYTQRARIERHGVLVIGPNPAFLDHISRVL
PSLGETNVVLMTTGDLVPGISATAEDDAADVKGSLTMLDVLAAAVADRQRVPEQPLVIELPDVTVQIDPDTAQWAIEEAR
GSGLPHNHARKVFRETVEWVLTERAVSRIGRGWLSRADKGAWEELRADVLEDLADSEQYLAALDELWPVLTPQTLLADLY
ESRERLRAAGADERLWRSDGAAWTVSDVPLLDELVDLLGRDMAADIAAAKEREAETDYAEGVLESMVAHEDLMDDEDLLL
ATDLLHGEELAERFTERDNRELAERAAADRDWTYRHVVVDEAQELSAMDWRVLMRRCPSKSFTIVGDLAQRRSAAGARSW
GAMLDTYVPGRWVYRPLSVNYRTPAEIMAVAAAVLAEFAPDVTPPESVRSTGVQPWRRQVTPDELPSAIGEFVDDESGRE
GTSVAIGPPDVPGTVAPSEVKGLEFDAVLVVEPERIFDGPRGAAELYVALTRATQRLGIAHCGPLPPALAALVDIPVDRE
AAR

Specific function: Catalyzes the unwinding of duplex DNA in the 3' to 5' direction; this reaction is dependent on the hydrolysis of ATP [H]

COG id: COG3973

COG function: function code R; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase ATP-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 79769; Mature: 79637

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGYEDELRSERTYVSGLYTRLDGERARAKEKYAAALRGDGALVERDAEVRALAKEMQRL
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHC
DVADDGLCFGRLDADSGERLYIGRIGIFDRDNDFEPLLLDWRAPLSRAFYVATAAHPEGM
CCCCCCCEEEEECCCCCCEEEEEEEEEECCCCCCCCEEEECCCCCCCEEEEEECCCHHHH
RRRRQFRTRGRQILDFTDEVFGRPRGDERGGDSALLAAVNAPRGEGMRDIVATIQAEQDA
HHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCC
IIRLDHPGVLVIEGGPGTGKTVVALHRVAYLLYTQRARIERHGVLVIGPNPAFLDHISRV
EEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHH
LPSLGETNVVLMTTGDLVPGISATAEDDAADVKGSLTMLDVLAAAVADRQRVPEQPLVIE
HHCCCCCCEEEEECCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEE
LPDVTVQIDPDTAQWAIEEARGSGLPHNHARKVFRETVEWVLTERAVSRIGRGWLSRADK
CCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GAWEELRADVLEDLADSEQYLAALDELWPVLTPQTLLADLYESRERLRAAGADERLWRSD
CHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCC
GAAWTVSDVPLLDELVDLLGRDMAADIAAAKEREAETDYAEGVLESMVAHEDLMDDEDLL
CCEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHH
LATDLLHGEELAERFTERDNRELAERAAADRDWTYRHVVVDEAQELSAMDWRVLMRRCPS
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCC
KSFTIVGDLAQRRSAAGARSWGAMLDTYVPGRWVYRPLSVNYRTPAEIMAVAAAVLAEFA
CCEEEEHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHC
PDVTPPESVRSTGVQPWRRQVTPDELPSAIGEFVDDESGREGTSVAIGPPDVPGTVAPSE
CCCCCHHHHHHCCCCHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCHH
VKGLEFDAVLVVEPERIFDGPRGAAELYVALTRATQRLGIAHCGPLPPALAALVDIPVDR
CCCCEECEEEEECCHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCC
EAAR
CCCC
>Mature Secondary Structure 
PGYEDELRSERTYVSGLYTRLDGERARAKEKYAAALRGDGALVERDAEVRALAKEMQRL
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHC
DVADDGLCFGRLDADSGERLYIGRIGIFDRDNDFEPLLLDWRAPLSRAFYVATAAHPEGM
CCCCCCCEEEEECCCCCCEEEEEEEEEECCCCCCCCEEEECCCCCCCEEEEEECCCHHHH
RRRRQFRTRGRQILDFTDEVFGRPRGDERGGDSALLAAVNAPRGEGMRDIVATIQAEQDA
HHHHHHHHHCCHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCC
IIRLDHPGVLVIEGGPGTGKTVVALHRVAYLLYTQRARIERHGVLVIGPNPAFLDHISRV
EEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHH
LPSLGETNVVLMTTGDLVPGISATAEDDAADVKGSLTMLDVLAAAVADRQRVPEQPLVIE
HHCCCCCCEEEEECCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEEE
LPDVTVQIDPDTAQWAIEEARGSGLPHNHARKVFRETVEWVLTERAVSRIGRGWLSRADK
CCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GAWEELRADVLEDLADSEQYLAALDELWPVLTPQTLLADLYESRERLRAAGADERLWRSD
CHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHCC
GAAWTVSDVPLLDELVDLLGRDMAADIAAAKEREAETDYAEGVLESMVAHEDLMDDEDLL
CCEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHH
LATDLLHGEELAERFTERDNRELAERAAADRDWTYRHVVVDEAQELSAMDWRVLMRRCPS
HHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCC
KSFTIVGDLAQRRSAAGARSWGAMLDTYVPGRWVYRPLSVNYRTPAEIMAVAAAVLAEFA
CCEEEEHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHC
PDVTPPESVRSTGVQPWRRQVTPDELPSAIGEFVDDESGREGTSVAIGPPDVPGTVAPSE
CCCCCHHHHHHCCCCHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCHH
VKGLEFDAVLVVEPERIFDGPRGAAELYVALTRATQRLGIAHCGPLPPALAALVDIPVDR
CCCCEECEEEEECCHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCC
EAAR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]