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The map label for this gene is upp [H]

Identifier: 119871308

GI number: 119871308

Start: 5516866

End: 5517495

Strand: Direct

Name: upp [H]

Synonym: Mkms_5281

Alternate gene names: 119871308

Gene position: 5516866-5517495 (Clockwise)

Preceding gene: 119871307

Following gene: 119871309

Centisome position: 96.16

GC content: 65.87

Gene sequence:

>630_bases
ATGAGCGAAGTCCACCTGGTCGACCACCCGCTGGTGGCGCACAAGCTGACCTTGTTGCGCCGCAAGGATGCCTCCACACA
CAGCTTCCGCCAGCTGTTGCACGAGATCTCCGCGCTGATGGCCTACGAGGTGCTGCGTGACATCCCGACCCAGGACTTCG
AGGTGGAGACACCGCTGGAGACGACGGTCGGTCAGGTCATCGACGGTAAGAAGCTGGTGTTCGTGTCGATTCTGCGGGCG
GGCACTGGCATCCTCGACGGCATGCTGGCCGTGGTGCCCGGGGCGCGGGTCGGGCACATCGGGCTGTATCGCGATCCCAA
GACGCTCGTCGCCGTCGAGTACTACTTCAAGATGCCGGCGGACCTGGAGGAGCGCGACGTCGTCGTGGTCGACCCGATGC
TCGCCACCGGCCACTCGGCGGTGGCGGCGGTGGACCGGATCAAGGAGTGCGGGCCGAAGTCGATCAAGTTCGTCTGCCTG
TTGACGTGTCCCGAGGGCATCGCCGCGATGCAGGATGCTCATCCCGACGTCCCGATCTTCACCGCGGCCGTCGACCGTCA
GCTCGACGAGCACGGCTACATCGTGCCGGGGCTCGGCGATGCGGGTGACCGGATCTTCGGCACCAAGTAG

Upstream 100 bases:

>100_bases
GGGACCTGGGCGGCCGGACGCCTTCTGGCGCAACAACTCCGCGGCGGGTTGCCGCCGTTGACCATCGACAGCGACGGCAC
CGTCTTCTGAAGGAGAGCGC

Downstream 100 bases:

>100_bases
CGCCGCCCCGGCTCCCCTGAAGGGGTGTCGTCGCGGATGCTGTGCTCGTTTTCGACACCACGGTCGTGGTTCCGGTGGCC
GGACTCGCCGTCAACGACCC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MSEVHLVDHPLVAHKLTLLRRKDASTHSFRQLLHEISALMAYEVLRDIPTQDFEVETPLETTVGQVIDGKKLVFVSILRA
GTGILDGMLAVVPGARVGHIGLYRDPKTLVAVEYYFKMPADLEERDVVVVDPMLATGHSAVAAVDRIKECGPKSIKFVCL
LTCPEGIAAMQDAHPDVPIFTAAVDRQLDEHGYIVPGLGDAGDRIFGTK

Sequences:

>Translated_209_residues
MSEVHLVDHPLVAHKLTLLRRKDASTHSFRQLLHEISALMAYEVLRDIPTQDFEVETPLETTVGQVIDGKKLVFVSILRA
GTGILDGMLAVVPGARVGHIGLYRDPKTLVAVEYYFKMPADLEERDVVVVDPMLATGHSAVAAVDRIKECGPKSIKFVCL
LTCPEGIAAMQDAHPDVPIFTAAVDRQLDEHGYIVPGLGDAGDRIFGTK
>Mature_208_residues
SEVHLVDHPLVAHKLTLLRRKDASTHSFRQLLHEISALMAYEVLRDIPTQDFEVETPLETTVGQVIDGKKLVFVSILRAG
TGILDGMLAVVPGARVGHIGLYRDPKTLVAVEYYFKMPADLEERDVVVVDPMLATGHSAVAAVDRIKECGPKSIKFVCLL
TCPEGIAAMQDAHPDVPIFTAAVDRQLDEHGYIVPGLGDAGDRIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI57863312, Length=206, Percent_Identity=31.0679611650485, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI301129207, Length=206, Percent_Identity=31.0679611650485, Blast_Score=90, Evalue=2e-18,
Organism=Homo sapiens, GI21450816, Length=170, Percent_Identity=30, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI87082118, Length=206, Percent_Identity=50, Blast_Score=213, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17539892, Length=206, Percent_Identity=25.2427184466019, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17539894, Length=206, Percent_Identity=25.2427184466019, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=38.5416666666667, Blast_Score=121, Evalue=1e-28,
Organism=Drosophila melanogaster, GI45550449, Length=196, Percent_Identity=29.5918367346939, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28573516, Length=196, Percent_Identity=29.5918367346939, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28573514, Length=196, Percent_Identity=29.5918367346939, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28573512, Length=196, Percent_Identity=29.5918367346939, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21358379, Length=203, Percent_Identity=28.0788177339901, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 22820; Mature: 22689

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVHLVDHPLVAHKLTLLRRKDASTHSFRQLLHEISALMAYEVLRDIPTQDFEVETPLE
CCCCEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHH
TTVGQVIDGKKLVFVSILRAGTGILDGMLAVVPGARVGHIGLYRDPKTLVAVEYYFKMPA
HHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEEECCCEEEEEEEEECCCC
DLEERDVVVVDPMLATGHSAVAAVDRIKECGPKSIKFVCLLTCPEGIAAMQDAHPDVPIF
CCCCCCEEEECCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHCCCCCCEE
TAAVDRQLDEHGYIVPGLGDAGDRIFGTK
HHHHHHHHHHCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SEVHLVDHPLVAHKLTLLRRKDASTHSFRQLLHEISALMAYEVLRDIPTQDFEVETPLE
CCCEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHH
TTVGQVIDGKKLVFVSILRAGTGILDGMLAVVPGARVGHIGLYRDPKTLVAVEYYFKMPA
HHHHHHCCCCHHHHHHHHHHCCHHHHHHHHHCCCCCCCEEEEEECCCEEEEEEEEECCCC
DLEERDVVVVDPMLATGHSAVAAVDRIKECGPKSIKFVCLLTCPEGIAAMQDAHPDVPIF
CCCCCCEEEECCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHCCCCCCEE
TAAVDRQLDEHGYIVPGLGDAGDRIFGTK
HHHHHHHHHHCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA