Click here to switch to the map view.

The map label for this gene is pyrE [H]

Identifier: 119871239

GI number: 119871239

Start: 5455726

End: 5456304

Strand: Direct

Name: pyrE [H]

Synonym: Mkms_5212

Alternate gene names: 119871239

Gene position: 5455726-5456304 (Clockwise)

Preceding gene: 119871238

Following gene: 119871244

Centisome position: 95.09

GC content: 68.91

Gene sequence:

>579_bases
ATGTCTGCGCAGAGCGACCGTCCGGAATCCTGGCAAGCGGCGTTCGAGTTGATCCGCACGCGCGGATACGAACACCGTGA
GGAGCCGTTCCGCCTCGCCAGCGGACAACTCAGCCACGACTACATCGACGGGAAGTACGCCGTCGACAACGGTGAGCGGC
TGACGATCGTGAGCCGCGCCGTCGCGGATCTCGCCGCACGCACCGGCATCGAGTTCGACGCCGTCGGCGGTCTGACGATG
GGCGCCGACCCGCTCGCCCACGGCGTCGCGATGGTCACCGGTGCGGCCTGGTTCTCGGTGCGCAAGGAGCAGAAGCAGCG
CGGCCGCGAACAGTGGATCGAGGGCACGCGTATCGAGCCCGGGATGCGGGTGCTGCTCGTCGACGACGTGATCAGCACCG
GTGGGTCGACGGCGCTGGCGTTCGACCGAGTGGTCGCGGCCGGCGCGGTGGTGACCGGGGTGATCCCGATGGTCGACCGC
GGTGACGTCGCGGCGACGCTGTTCGCCGAACGGGGCGTGCCGTTCGCCGCGCTGGTGACCTACCGCGATCTGGGAATCGA
ACCGATCAAAGCGGTCTGA

Upstream 100 bases:

>100_bases
GCCGCGCCGCTGAATTCGCCCGCCGAACTGCGGTCTGCCGCCGTGGAGTTGACGCGGCGGGCCCGTCAGGGCTGACGGGG
CGTCTAATACGATCTGCGGT

Downstream 100 bases:

>100_bases
CTGCCGTTGACTCTGCGTCCAGGGTCTCGCCCACTCGAGCTTTCGCGCCCTCAGCGCAAAGTCAACGCGATACGACGAGC
ACCGCGGTGGGTTCGACGCC

Product: orotate phosphoribosyltransferase

Products: NA

Alternate protein names: OPRT; OPRTase [H]

Number of amino acids: Translated: 192; Mature: 191

Protein sequence:

>192_residues
MSAQSDRPESWQAAFELIRTRGYEHREEPFRLASGQLSHDYIDGKYAVDNGERLTIVSRAVADLAARTGIEFDAVGGLTM
GADPLAHGVAMVTGAAWFSVRKEQKQRGREQWIEGTRIEPGMRVLLVDDVISTGGSTALAFDRVVAAGAVVTGVIPMVDR
GDVAATLFAERGVPFAALVTYRDLGIEPIKAV

Sequences:

>Translated_192_residues
MSAQSDRPESWQAAFELIRTRGYEHREEPFRLASGQLSHDYIDGKYAVDNGERLTIVSRAVADLAARTGIEFDAVGGLTM
GADPLAHGVAMVTGAAWFSVRKEQKQRGREQWIEGTRIEPGMRVLLVDDVISTGGSTALAFDRVVAAGAVVTGVIPMVDR
GDVAATLFAERGVPFAALVTYRDLGIEPIKAV
>Mature_191_residues
SAQSDRPESWQAAFELIRTRGYEHREEPFRLASGQLSHDYIDGKYAVDNGERLTIVSRAVADLAARTGIEFDAVGGLTMG
ADPLAHGVAMVTGAAWFSVRKEQKQRGREQWIEGTRIEPGMRVLLVDDVISTGGSTALAFDRVVAAGAVVTGVIPMVDRG
DVAATLFAERGVPFAALVTYRDLGIEPIKAV

Specific function: Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) [H]

COG id: COG0461

COG function: function code F; Orotate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily [H]

Homologues:

Organism=Caenorhabditis elegans, GI17508631, Length=155, Percent_Identity=30.9677419354839, Blast_Score=74, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004467
- InterPro:   IPR023031
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.10 [H]

Molecular weight: Translated: 20703; Mature: 20572

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAQSDRPESWQAAFELIRTRGYEHREEPFRLASGQLSHDYIDGKYAVDNGERLTIVSRA
CCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCEEEECCCCEEEHHHHH
VADLAARTGIEFDAVGGLTMGADPLAHGVAMVTGAAWFSVRKEQKQRGREQWIEGTRIEP
HHHHHHHCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GMRVLLVDDVISTGGSTALAFDRVVAAGAVVTGVIPMVDRGDVAATLFAERGVPFAALVT
CCEEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHEE
YRDLGIEPIKAV
HHHCCCCCCCCC
>Mature Secondary Structure 
SAQSDRPESWQAAFELIRTRGYEHREEPFRLASGQLSHDYIDGKYAVDNGERLTIVSRA
CCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCEEEECCCCEEEHHHHH
VADLAARTGIEFDAVGGLTMGADPLAHGVAMVTGAAWFSVRKEQKQRGREQWIEGTRIEP
HHHHHHHCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GMRVLLVDDVISTGGSTALAFDRVVAAGAVVTGVIPMVDRGDVAATLFAERGVPFAALVT
CCEEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHHEE
YRDLGIEPIKAV
HHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA