Click here to switch to the map view.

The map label for this gene is bcd [H]

Identifier: 119871235

GI number: 119871235

Start: 5450581

End: 5451687

Strand: Direct

Name: bcd [H]

Synonym: Mkms_5208

Alternate gene names: 119871235

Gene position: 5450581-5451687 (Clockwise)

Preceding gene: 119871234

Following gene: 119871238

Centisome position: 95.0

GC content: 69.92

Gene sequence:

>1107_bases
ATGGATTTCGACTTCACCGACGAGCAGGAACTGCTCCGCGACACCAGCCGCGAGGTGCTCTCCCGCACCTATGACATCGA
GACCCGGCTCAAGGTCGTCGACTCCGAGCTCGGCTGGAGCCGCGAGGTGTGGAATCAGCTGGCCGAGATCGGCATCCTGG
GCCTCGGTTTCGAGGAGGACGCCGGCGGACAGCTCGAGATCATGGTGGTGGCCACCGAGATCGGTCGACGGCTGGCGCCC
GAGCCGGTGCTTTCCGCCGCGCTCGGCCCCGGCGCCCTGATCGCCGAGGTCGGCAGCGACGAGCAGAAGCAGGTGCTCGA
CGAGGTGGCCGCCGGACAGCGTCTGCTCGCGTTCGCCCACACCGAACCCGGTATGCGCGGTGCCGGTGCGAAGCTCTCGA
CAACCGCTGCCCAGCAAGGGGATTCGTGGACGCTCACCGGCCGCAAGAACCCGGTGATCGCCGGTGACAGCGCCGACACG
CTGATCGTCAGCGCCGCACTGCCCGACGGCGGCGCGGGTCTGTTCCTGGCGGACGCCGCTGCGGTGTCGCGCAAGCCCTA
CCGCACCTTCGACGGTCACCGCGGTGCCGAGATCGACCTCGACGGGGTGGCCGCCACACCGCTGGGCGCCGGCGGGGACG
CCGGCGAAGCCATCTCGCGCGCGGTGGTCCGCCTGCAGTCGGCGCTGTGCGCCGAGGCGCTCGGCGCGATGGAGGAGGCG
CTGCGGCTGACCACCGATTACCTCAAGAACCGCAAGCAGTTCGGGGTCACGCTGAGCAAGTTCCAGACGCTGACGCAGCG
CGCGGCGGACATGTACGTGTCACTGGAGCTGGCCCGCAGCATGACCTTCTACGCGGCGATGTCGATCGCCGACGGCAACT
TCGACCCGGCGATCGCCGCACGCGCCAAGCTGCAGATCGGCCGCTCCGGCCGGCACATCGCCCAGGAGGCCATCCAGCTG
CACGGCGGTATCGGCGTCACCGCGGAGTATCCGGTCGGCCACTACGCCGCGCGGCTCACCGCGATCGAGAACACGCTGGG
GTCGGCGCAGGATCAGCTGCACGTGCTGATGGGCGGGCTGGGCGACTACGAGGTCGTCACCGTCTAG

Upstream 100 bases:

>100_bases
CCGACGTACCTCAACTACCGCAAGACGTCGATCTACGGCGGCAGCAACGAGGTCCAGCGCACCATCATCGCGTCGACCAT
TCTCGGATTGTGAGGTAGTC

Downstream 100 bases:

>100_bases
TCACACGCCGAGGATCCGCAGGATCGACTTCATCGGGATCGGCAGCCAGCTCGGCCGGTACCGCGCCTCGTAGCCGACCT
CGTAGACCGCCTTGTCGAGT

Product: acyl-CoA dehydrogenase domain-containing protein

Products: NA

Alternate protein names: Butyryl-CoA dehydrogenase; SCAD [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MDFDFTDEQELLRDTSREVLSRTYDIETRLKVVDSELGWSREVWNQLAEIGILGLGFEEDAGGQLEIMVVATEIGRRLAP
EPVLSAALGPGALIAEVGSDEQKQVLDEVAAGQRLLAFAHTEPGMRGAGAKLSTTAAQQGDSWTLTGRKNPVIAGDSADT
LIVSAALPDGGAGLFLADAAAVSRKPYRTFDGHRGAEIDLDGVAATPLGAGGDAGEAISRAVVRLQSALCAEALGAMEEA
LRLTTDYLKNRKQFGVTLSKFQTLTQRAADMYVSLELARSMTFYAAMSIADGNFDPAIAARAKLQIGRSGRHIAQEAIQL
HGGIGVTAEYPVGHYAARLTAIENTLGSAQDQLHVLMGGLGDYEVVTV

Sequences:

>Translated_368_residues
MDFDFTDEQELLRDTSREVLSRTYDIETRLKVVDSELGWSREVWNQLAEIGILGLGFEEDAGGQLEIMVVATEIGRRLAP
EPVLSAALGPGALIAEVGSDEQKQVLDEVAAGQRLLAFAHTEPGMRGAGAKLSTTAAQQGDSWTLTGRKNPVIAGDSADT
LIVSAALPDGGAGLFLADAAAVSRKPYRTFDGHRGAEIDLDGVAATPLGAGGDAGEAISRAVVRLQSALCAEALGAMEEA
LRLTTDYLKNRKQFGVTLSKFQTLTQRAADMYVSLELARSMTFYAAMSIADGNFDPAIAARAKLQIGRSGRHIAQEAIQL
HGGIGVTAEYPVGHYAARLTAIENTLGSAQDQLHVLMGGLGDYEVVTV
>Mature_368_residues
MDFDFTDEQELLRDTSREVLSRTYDIETRLKVVDSELGWSREVWNQLAEIGILGLGFEEDAGGQLEIMVVATEIGRRLAP
EPVLSAALGPGALIAEVGSDEQKQVLDEVAAGQRLLAFAHTEPGMRGAGAKLSTTAAQQGDSWTLTGRKNPVIAGDSADT
LIVSAALPDGGAGLFLADAAAVSRKPYRTFDGHRGAEIDLDGVAATPLGAGGDAGEAISRAVVRLQSALCAEALGAMEEA
LRLTTDYLKNRKQFGVTLSKFQTLTQRAADMYVSLELARSMTFYAAMSIADGNFDPAIAARAKLQIGRSGRHIAQEAIQL
HGGIGVTAEYPVGHYAARLTAIENTLGSAQDQLHVLMGGLGDYEVVTV

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=384, Percent_Identity=30.2083333333333, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4501857, Length=361, Percent_Identity=25.7617728531856, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI226958412, Length=352, Percent_Identity=25, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI226958414, Length=316, Percent_Identity=25.3164556962025, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI4501859, Length=350, Percent_Identity=24.5714285714286, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI187960098, Length=361, Percent_Identity=24.6537396121884, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI4557231, Length=361, Percent_Identity=24.6537396121884, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4503943, Length=391, Percent_Identity=25.8312020460358, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI7669494, Length=375, Percent_Identity=25.3333333333333, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI21361497, Length=327, Percent_Identity=24.7706422018349, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI87081958, Length=387, Percent_Identity=24.5478036175711, Blast_Score=78, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17538396, Length=352, Percent_Identity=26.7045454545455, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17569725, Length=356, Percent_Identity=26.123595505618, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17570075, Length=352, Percent_Identity=24.7159090909091, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17506239, Length=372, Percent_Identity=23.9247311827957, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17533517, Length=261, Percent_Identity=26.8199233716475, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71985184, Length=320, Percent_Identity=26.25, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17534899, Length=352, Percent_Identity=25.2840909090909, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17508101, Length=328, Percent_Identity=24.390243902439, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21355753, Length=315, Percent_Identity=29.2063492063492, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24646207, Length=358, Percent_Identity=27.0949720670391, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21356377, Length=380, Percent_Identity=25.5263157894737, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24666513, Length=352, Percent_Identity=25.2840909090909, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24660351, Length=263, Percent_Identity=24.7148288973384, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: =1.3.99.2 [H]

Molecular weight: Translated: 38957; Mature: 38957

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFDFTDEQELLRDTSREVLSRTYDIETRLKVVDSELGWSREVWNQLAEIGILGLGFEED
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHCEEECCCCCC
AGGQLEIMVVATEIGRRLAPEPVLSAALGPGALIAEVGSDEQKQVLDEVAAGQRLLAFAH
CCCEEEEEEEEEHHCCCCCCCHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCEEEEEEC
TEPGMRGAGAKLSTTAAQQGDSWTLTGRKNPVIAGDSADTLIVSAALPDGGAGLFLADAA
CCCCCCCCCCCEEHHHHCCCCCEEECCCCCCEEECCCCCEEEEEEECCCCCCCEEEEHHH
AVSRKPYRTFDGHRGAEIDLDGVAATPLGAGGDAGEAISRAVVRLQSALCAEALGAMEEA
HHCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRLTTDYLKNRKQFGVTLSKFQTLTQRAADMYVSLELARSMTFYAAMSIADGNFDPAIAA
HHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHH
RAKLQIGRSGRHIAQEAIQLHGGIGVTAEYPVGHYAARLTAIENTLGSAQDQLHVLMGGL
HHHEEECCCCHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCC
GDYEVVTV
CCEEEEEC
>Mature Secondary Structure
MDFDFTDEQELLRDTSREVLSRTYDIETRLKVVDSELGWSREVWNQLAEIGILGLGFEED
CCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHCEEECCCCCC
AGGQLEIMVVATEIGRRLAPEPVLSAALGPGALIAEVGSDEQKQVLDEVAAGQRLLAFAH
CCCEEEEEEEEEHHCCCCCCCHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCEEEEEEC
TEPGMRGAGAKLSTTAAQQGDSWTLTGRKNPVIAGDSADTLIVSAALPDGGAGLFLADAA
CCCCCCCCCCCEEHHHHCCCCCEEECCCCCCEEECCCCCEEEEEEECCCCCCCEEEEHHH
AVSRKPYRTFDGHRGAEIDLDGVAATPLGAGGDAGEAISRAVVRLQSALCAEALGAMEEA
HHCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRLTTDYLKNRKQFGVTLSKFQTLTQRAADMYVSLELARSMTFYAAMSIADGNFDPAIAA
HHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHH
RAKLQIGRSGRHIAQEAIQLHGGIGVTAEYPVGHYAARLTAIENTLGSAQDQLHVLMGGL
HHHEEECCCCHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHCCC
GDYEVVTV
CCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]