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The map label for this gene is pat [H]

Identifier: 119871097

GI number: 119871097

Start: 5307848

End: 5308924

Strand: Direct

Name: pat [H]

Synonym: Mkms_5070

Alternate gene names: 119871097

Gene position: 5307848-5308924 (Clockwise)

Preceding gene: 119871095

Following gene: 119871098

Centisome position: 92.52

GC content: 68.43

Gene sequence:

>1077_bases
GTGACCGCCCGCCTCCGCCCCGAATTGGCCGACATCCCGGCCTACACACCGGGTAAGACGGTTCCGGGAGCCATCAAGAT
CGCCAGCAACGAGACCGTGCACGGCCCGCTGCCGAGTGTGCGTGCCGCGATCGAGAAGGCAACCGACCAGCTCAACCGCT
ATCCCGACAACGGCTACCTCGAGCTACGCGAGCACCTGGCCAGCCACCTCGACAAGAACCTCGGGGCCGGCGCCTTCACC
CCCGAGCAGATCGCCGTCGGCTGCGGTTCGGTGAGCCTGTGCCAGCAGCTGATCCAGATCACCTCATCGGTCGGCGACGA
GGTGATCTTCGCCTGGCGCAGCTTCGAGATCTACCCGCTGCAGGTGCGCACCGCCGGGGCCACGCCGGTGCAGGTGCCGC
TGCGTGACCACACCCACGACCTCGATGCGATGCTGGCCGCGATCACCGACCGCACCCGGCTGATCTTCGTCTGCAACCCG
AACAACCCGACCAGCACGGTCGTCGACCCGGCGGCGCTCAAACGGTTCGTCGAGGCCGTCCCGCCGCACATCCTCGTCGT
CATCGACGAGGCCTACGTCGAGTACATCCGCGGCGATCAGGTGCCCGACAGTTTCGGGTTGGTCCGCGCCCATCCGAATG
TCGTGGTGCTGCGGACGTTTTCGAAGGCCTACGGGCTGGCCGGGCTGCGCATCGGATACGCCGTCGCCGACGCCGACATC
GTCACCGCGCTCGGGAAGGTCTACGTCCCGTTCTCGGCGACCAGCATCTCGCAGGCCGCCGCGATCGCCTCGATCGACGC
CGCCGATGAACTGCTCGCCCGCACCGACCAGGTGGTCGCTGAGCGCGACCGCGTGACCGCGGCGCTGCGCGAAGCCGGGT
TCACCCTGCCCCCGTCGCAGTCGAACTTCGTGTGGCTGCCGTTGGCCGAGCGCACCCTCGACTTCGTCCGTCGCGCCGCC
GAGAACCGCCTGGTGGTCCGCCCGTACGGCGAGGACGGTGTGCGTGTCACGATCGCCGCACCCCACGAGAACGACGCCTT
CCTCGAATTCGCCCGCAACTGGATCGGACAGCCATGA

Upstream 100 bases:

>100_bases
CCGCTCTGGCACGCCTCCTGACGTTACCGCCGGTCGCACAGCCTACACATCGGTCGGCCGCGGAAGCAAAGCGGTCGATC
CACCGCCCTATGCTGGTCAG

Downstream 100 bases:

>100_bases
CCTCGACGCGCACGGCCCGCGAGACCTTCGACGAACTCACCTCGCGCACCGACACCATCGGCGACGCCGAACTCGACCGG
TTCTGGGCCACCCTCGAACC

Product: putative aminotransferase

Products: 3-(imidazol-4-yl)-2-oxopropyl phosphate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MTARLRPELADIPAYTPGKTVPGAIKIASNETVHGPLPSVRAAIEKATDQLNRYPDNGYLELREHLASHLDKNLGAGAFT
PEQIAVGCGSVSLCQQLIQITSSVGDEVIFAWRSFEIYPLQVRTAGATPVQVPLRDHTHDLDAMLAAITDRTRLIFVCNP
NNPTSTVVDPAALKRFVEAVPPHILVVIDEAYVEYIRGDQVPDSFGLVRAHPNVVVLRTFSKAYGLAGLRIGYAVADADI
VTALGKVYVPFSATSISQAAAIASIDAADELLARTDQVVAERDRVTAALREAGFTLPPSQSNFVWLPLAERTLDFVRRAA
ENRLVVRPYGEDGVRVTIAAPHENDAFLEFARNWIGQP

Sequences:

>Translated_358_residues
MTARLRPELADIPAYTPGKTVPGAIKIASNETVHGPLPSVRAAIEKATDQLNRYPDNGYLELREHLASHLDKNLGAGAFT
PEQIAVGCGSVSLCQQLIQITSSVGDEVIFAWRSFEIYPLQVRTAGATPVQVPLRDHTHDLDAMLAAITDRTRLIFVCNP
NNPTSTVVDPAALKRFVEAVPPHILVVIDEAYVEYIRGDQVPDSFGLVRAHPNVVVLRTFSKAYGLAGLRIGYAVADADI
VTALGKVYVPFSATSISQAAAIASIDAADELLARTDQVVAERDRVTAALREAGFTLPPSQSNFVWLPLAERTLDFVRRAA
ENRLVVRPYGEDGVRVTIAAPHENDAFLEFARNWIGQP
>Mature_357_residues
TARLRPELADIPAYTPGKTVPGAIKIASNETVHGPLPSVRAAIEKATDQLNRYPDNGYLELREHLASHLDKNLGAGAFTP
EQIAVGCGSVSLCQQLIQITSSVGDEVIFAWRSFEIYPLQVRTAGATPVQVPLRDHTHDLDAMLAAITDRTRLIFVCNPN
NPTSTVVDPAALKRFVEAVPPHILVVIDEAYVEYIRGDQVPDSFGLVRAHPNVVVLRTFSKAYGLAGLRIGYAVADADIV
TALGKVYVPFSATSISQAAAIASIDAADELLARTDQVVAERDRVTAALREAGFTLPPSQSNFVWLPLAERTLDFVRRAAE
NRLVVRPYGEDGVRVTIAAPHENDAFLEFARNWIGQP

Specific function: May catalyze the transamination reaction in phenylalanine biosynthesis [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=247, Percent_Identity=30.7692307692308, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1786816, Length=265, Percent_Identity=28.3018867924528, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788722, Length=281, Percent_Identity=28.1138790035587, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788627, Length=195, Percent_Identity=27.6923076923077, Blast_Score=65, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=380, Percent_Identity=23.6842105263158, Blast_Score=105, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.9

Molecular weight: Translated: 38893; Mature: 38761

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARLRPELADIPAYTPGKTVPGAIKIASNETVHGPLPSVRAAIEKATDQLNRYPDNGYL
CCCCCCCCHHCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHH
ELREHLASHLDKNLGAGAFTPEQIAVGCGSVSLCQQLIQITSSVGDEVIFAWRSFEIYPL
HHHHHHHHHHHHCCCCCCCCHHHHEECCCCHHHHHHHHHHHHHCCCCEEEEEECEEEEEE
QVRTAGATPVQVPLRDHTHDLDAMLAAITDRTRLIFVCNPNNPTSTVVDPAALKRFVEAV
EEEECCCCEEEECCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCEECHHHHHHHHHHC
PPHILVVIDEAYVEYIRGDQVPDSFGLVRAHPNVVVLRTFSKAYGLAGLRIGYAVADADI
CCEEEEEECHHHHHHHCCCCCCCCCCEEEECCCEEEEEECHHHHCCCHHEEEHEEHHHHH
VTALGKVYVPFSATSISQAAAIASIDAADELLARTDQVVAERDRVTAALREAGFTLPPSQ
HHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SNFVWLPLAERTLDFVRRAAENRLVVRPYGEDGVRVTIAAPHENDAFLEFARNWIGQP
CCEEEEEHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
TARLRPELADIPAYTPGKTVPGAIKIASNETVHGPLPSVRAAIEKATDQLNRYPDNGYL
CCCCCCCHHCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHH
ELREHLASHLDKNLGAGAFTPEQIAVGCGSVSLCQQLIQITSSVGDEVIFAWRSFEIYPL
HHHHHHHHHHHHCCCCCCCCHHHHEECCCCHHHHHHHHHHHHHCCCCEEEEEECEEEEEE
QVRTAGATPVQVPLRDHTHDLDAMLAAITDRTRLIFVCNPNNPTSTVVDPAALKRFVEAV
EEEECCCCEEEECCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCEECHHHHHHHHHHC
PPHILVVIDEAYVEYIRGDQVPDSFGLVRAHPNVVVLRTFSKAYGLAGLRIGYAVADADI
CCEEEEEECHHHHHHHCCCCCCCCCCEEEECCCEEEEEECHHHHCCCHHEEEHEEHHHHH
VTALGKVYVPFSATSISQAAAIASIDAADELLARTDQVVAERDRVTAALREAGFTLPPSQ
HHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SNFVWLPLAERTLDFVRRAAENRLVVRPYGEDGVRVTIAAPHENDAFLEFARNWIGQP
CCEEEEEHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-histidinol phosphate; 2-oxoglutarate

Specific reaction: L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA