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The map label for this gene is pbpA [H]

Identifier: 119870939

GI number: 119870939

Start: 5144433

End: 5146883

Strand: Direct

Name: pbpA [H]

Synonym: Mkms_4911

Alternate gene names: 119870939

Gene position: 5144433-5146883 (Clockwise)

Preceding gene: 119870937

Following gene: 119870940

Centisome position: 89.67

GC content: 68.38

Gene sequence:

>2451_bases
ATGCCGGAGCGTCCGCCAACAGCCGTCACGGTCGTCAAGCTCGCCTGGTGCTGCTTGCTGGCCAGCGTGCTGGCCGCCGC
ACTCATGTTCCCCGTGGTCGGCGGCATCGGTCTGATGTCCAACCGCGCATCCGACGTCGTCGCCAACGGTTCGGCCGCCC
TCGTCGAGGGTGAGATCCCGCAGGTGTCGACGATGGTCGACGCCAAGGGCAACACGATCGCGTGGCTGTACTCCCAGCGA
CGTTTCGAGGTGCCCAGCGAGCAGATCGCCAACACGATGAAGTTGGCGATCGTGTCCATCGAGGACAAGCGGTTCGCCGA
ACACAACGGCGTGGACTGGCAGGGCACGCTCACCGGGTTGGCCGGCTACCTGCGCGGTGACACCGACACCCGCGGCGGGT
CGACGCTGGAGCAGCAGTACGTCAAGAACTATCAGTTGCTGGTGGTGGCGCAGACCGACTCGGAGAAGCGCGCGGCGATC
GAGACCACCCCGGCCCGCAAGCTGCGCGAGATCCGGATGGCGCTCACGCTGGACAAGACGTTCACCAAACCCGAGATCCT
GACCCGTTACCTCAACCTGGTGTCGTTCGGTAACGGCGCGTTCGGCATCCAGGACGCCGCGCAGACGTACTTCGGCGTCA
ACGCCTCGGAACTGAACTGGCAGCAGTCTGCGTTGCTGGCCGGGCTGGTGCAGTCGACGAGCACGCTGAACCCCTACACG
AACCCCGACGGTGCGCTGGCGCGCCGCAACCTGGTCCTCGACACGATGATCGAGAACCTGCCGAACGAGGCGGAGGCACT
GCGCGCGGCCAAGAACGAGCCGCTCGGCGTGCTCCCGGTCCCCAATGAGTTGCCGCGGGGCTGCATCGCCGCCGGTGACC
GGGCCTTCTTCTGCGACTACGCGCTGGAGTACCTGGCCCGCGCCGGCATCAGCAAGGAACAGGTCGCCAAGGGCGGCTAC
CTGATCAAGACGACGCTGGATCCCGATGTCCAGGGCCCGGTGAAGTCCGCGGTCGACAATTTCGCCGACCCGACGACGCC
GGGCGTCGCGAGCGTGATGAGCGTGATCCGGCCCGGTAAGGAATCCCATCCGGTGCTGGCGATGGCGTCGAACCGCACCT
ACGGCCTCAACCTCGACGCCTACGAGACCATGCAGCCGCAGCCGTTCACCCTTGCGGGCAACGGCGCCGGGTCGGTGTTC
AAGATCTTCACCACCGCGGCCGCCATGGAGATGGGCATGGGGATCAACACCCAGCTGCAGGTGCCGGGGTCGTTCCAGGC
CAAGGGGCTGGGCAGCAGCGATCGCCCGGGCTGCCCGGCGGCGACCTGGTGTGTGAGCAACGCCGGCGGCTACCGCGGGT
CGATGAACGTCACCGATGCGCTGGCCACCTCCCCCAACACCGCGTTCGCGAAGCTCATCTCACAGGTGGGTGTGCCGCGC
GCCGTGGACATGTCCGTCCGGCTGGGTCTGCGCTCCTACGCGCTGCCGGGCACCGCCCGCGACTACGACCCGGAGAGCAA
CGAGAGCCTGGCCGACTTCGTCAAACGGCAGAACATCGGCTCGTTCACACTCGGTCCGATCGAGGTCAACGGGCTCGAAC
TGTCGAACGTCGCGGCGACGCTGGCCTCCGGTGGCGTCTGGTGCCCGCCGAACCCGATCGCCCAGGTCCTCGACCGCAAG
GGTGAAGAGGTGTCGGTGACCACCGAGACGTGCGAACAGGCGGTCCCGGAGGGGTTGGCGAACACGCTGGCCAACGCGAT
GAGCAAGGACGACACCGGCGCGGGCACCGCCGCCGGGGCGGCCGGTTCGGTCGGCTGGGATCTGCCGATGTCCGGTAAGA
CCGGGACGACGGAGTCCAACCGGTCCTCTGCGTTCCTCGGCTTCACCAACCAGTTGGCCGCCGCGAACTACATCTACGAC
GATTCGCCCACGCCGGGTGAGCTGTGCTCGTTCCCGCTGCGCCAATGCGGTTCGGGCAACCTGTTCGGCGGTAACGAACC
GGCACGCACCTGGTTCACGGCGATGAAACCGATCGCCACCAACTTCGGTCCGGTGGCGCTGCCGCCGACCGATCCGCGCT
ATGTCGACGGCGGCCCCGGTTCGCAGGTGCCGAGTGTGTCGGGCCTGACCGTGGACGCGGCCCGCCAGCGCATCAAGGAC
GCCGGGTTCCAGGTGGCCGACGGGACCAGCTCGGTGAACAGCGGTTCGCGGGCCGGCACGGTCGTCGGTACCAACCCGAG
CGGACAGACCATTCCGGGATCGATCGTCACGATCCAGGTGAGCAACGGCATCGCCCCCGCGCCGCCGCCCCCGACGTACA
GCGTGCCCAGCCTGCCCGGCCTGCCCGGAGGACCGCCGCCGCCTATCGGTCAGACGGTCGTCGAGATCCCCGGTCTGCCG
CCGATCACCGTGCCGGTGCTCGGACCGCCGCCGCCACCGCCGCCACCGTGA

Upstream 100 bases:

>100_bases
TTAGATATTGAAGAATCCCGGCACGGCCCGCGGGCGATCGCAAAGCCCGCAATCCCGCTGCTCCGGCGATGCCGCTGGGC
GTCGTCGTTACTCTGTACAC

Downstream 100 bases:

>100_bases
TCGGGTGGGAGGCGGTGGGCGCGGCCATCTGGCAGTAGGCTGCTGCCATGGCTGCTGCTTCGCCACGACCGTCCGCTTCG
GCGGTCAAGCTCCTGAAGAA

Product: glycosyl transferase family protein

Products: NA

Alternate protein names: PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]

Number of amino acids: Translated: 816; Mature: 815

Protein sequence:

>816_residues
MPERPPTAVTVVKLAWCCLLASVLAAALMFPVVGGIGLMSNRASDVVANGSAALVEGEIPQVSTMVDAKGNTIAWLYSQR
RFEVPSEQIANTMKLAIVSIEDKRFAEHNGVDWQGTLTGLAGYLRGDTDTRGGSTLEQQYVKNYQLLVVAQTDSEKRAAI
ETTPARKLREIRMALTLDKTFTKPEILTRYLNLVSFGNGAFGIQDAAQTYFGVNASELNWQQSALLAGLVQSTSTLNPYT
NPDGALARRNLVLDTMIENLPNEAEALRAAKNEPLGVLPVPNELPRGCIAAGDRAFFCDYALEYLARAGISKEQVAKGGY
LIKTTLDPDVQGPVKSAVDNFADPTTPGVASVMSVIRPGKESHPVLAMASNRTYGLNLDAYETMQPQPFTLAGNGAGSVF
KIFTTAAAMEMGMGINTQLQVPGSFQAKGLGSSDRPGCPAATWCVSNAGGYRGSMNVTDALATSPNTAFAKLISQVGVPR
AVDMSVRLGLRSYALPGTARDYDPESNESLADFVKRQNIGSFTLGPIEVNGLELSNVAATLASGGVWCPPNPIAQVLDRK
GEEVSVTTETCEQAVPEGLANTLANAMSKDDTGAGTAAGAAGSVGWDLPMSGKTGTTESNRSSAFLGFTNQLAAANYIYD
DSPTPGELCSFPLRQCGSGNLFGGNEPARTWFTAMKPIATNFGPVALPPTDPRYVDGGPGSQVPSVSGLTVDAARQRIKD
AGFQVADGTSSVNSGSRAGTVVGTNPSGQTIPGSIVTIQVSNGIAPAPPPPTYSVPSLPGLPGGPPPPIGQTVVEIPGLP
PITVPVLGPPPPPPPP

Sequences:

>Translated_816_residues
MPERPPTAVTVVKLAWCCLLASVLAAALMFPVVGGIGLMSNRASDVVANGSAALVEGEIPQVSTMVDAKGNTIAWLYSQR
RFEVPSEQIANTMKLAIVSIEDKRFAEHNGVDWQGTLTGLAGYLRGDTDTRGGSTLEQQYVKNYQLLVVAQTDSEKRAAI
ETTPARKLREIRMALTLDKTFTKPEILTRYLNLVSFGNGAFGIQDAAQTYFGVNASELNWQQSALLAGLVQSTSTLNPYT
NPDGALARRNLVLDTMIENLPNEAEALRAAKNEPLGVLPVPNELPRGCIAAGDRAFFCDYALEYLARAGISKEQVAKGGY
LIKTTLDPDVQGPVKSAVDNFADPTTPGVASVMSVIRPGKESHPVLAMASNRTYGLNLDAYETMQPQPFTLAGNGAGSVF
KIFTTAAAMEMGMGINTQLQVPGSFQAKGLGSSDRPGCPAATWCVSNAGGYRGSMNVTDALATSPNTAFAKLISQVGVPR
AVDMSVRLGLRSYALPGTARDYDPESNESLADFVKRQNIGSFTLGPIEVNGLELSNVAATLASGGVWCPPNPIAQVLDRK
GEEVSVTTETCEQAVPEGLANTLANAMSKDDTGAGTAAGAAGSVGWDLPMSGKTGTTESNRSSAFLGFTNQLAAANYIYD
DSPTPGELCSFPLRQCGSGNLFGGNEPARTWFTAMKPIATNFGPVALPPTDPRYVDGGPGSQVPSVSGLTVDAARQRIKD
AGFQVADGTSSVNSGSRAGTVVGTNPSGQTIPGSIVTIQVSNGIAPAPPPPTYSVPSLPGLPGGPPPPIGQTVVEIPGLP
PITVPVLGPPPPPPPP
>Mature_815_residues
PERPPTAVTVVKLAWCCLLASVLAAALMFPVVGGIGLMSNRASDVVANGSAALVEGEIPQVSTMVDAKGNTIAWLYSQRR
FEVPSEQIANTMKLAIVSIEDKRFAEHNGVDWQGTLTGLAGYLRGDTDTRGGSTLEQQYVKNYQLLVVAQTDSEKRAAIE
TTPARKLREIRMALTLDKTFTKPEILTRYLNLVSFGNGAFGIQDAAQTYFGVNASELNWQQSALLAGLVQSTSTLNPYTN
PDGALARRNLVLDTMIENLPNEAEALRAAKNEPLGVLPVPNELPRGCIAAGDRAFFCDYALEYLARAGISKEQVAKGGYL
IKTTLDPDVQGPVKSAVDNFADPTTPGVASVMSVIRPGKESHPVLAMASNRTYGLNLDAYETMQPQPFTLAGNGAGSVFK
IFTTAAAMEMGMGINTQLQVPGSFQAKGLGSSDRPGCPAATWCVSNAGGYRGSMNVTDALATSPNTAFAKLISQVGVPRA
VDMSVRLGLRSYALPGTARDYDPESNESLADFVKRQNIGSFTLGPIEVNGLELSNVAATLASGGVWCPPNPIAQVLDRKG
EEVSVTTETCEQAVPEGLANTLANAMSKDDTGAGTAAGAAGSVGWDLPMSGKTGTTESNRSSAFLGFTNQLAAANYIYDD
SPTPGELCSFPLRQCGSGNLFGGNEPARTWFTAMKPIATNFGPVALPPTDPRYVDGGPGSQVPSVSGLTVDAARQRIKDA
GFQVADGTSSVNSGSRAGTVVGTNPSGQTIPGSIVTIQVSNGIAPAPPPPTYSVPSLPGLPGGPPPPIGQTVVEIPGLPP
ITVPVLGPPPPPPPP

Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal

COG id: COG0744

COG function: function code M; Membrane carboxypeptidase (penicillin-binding protein)

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI87082258, Length=304, Percent_Identity=30.5921052631579, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI1786343, Length=591, Percent_Identity=26.2267343485618, Blast_Score=110, Evalue=5e-25,
Organism=Escherichia coli, GI1789601, Length=186, Percent_Identity=33.8709677419355, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788867, Length=306, Percent_Identity=26.4705882352941, Blast_Score=80, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001264
- InterPro:   IPR011816
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]

EC number: 2.4.2.-; 3.4.-.- [C]

Molecular weight: Translated: 85179; Mature: 85048

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPERPPTAVTVVKLAWCCLLASVLAAALMFPVVGGIGLMSNRASDVVANGSAALVEGEIP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHEECCCEEEEECCCC
QVSTMVDAKGNTIAWLYSQRRFEVPSEQIANTMKLAIVSIEDKRFAEHNGVDWQGTLTGL
CCCEEECCCCCEEEEEECCCCCCCCHHHHHCCEEEEEEEECCHHHHHCCCCCCCHHHHHH
AGYLRGDTDTRGGSTLEQQYVKNYQLLVVAQTDSEKRAAIETTPARKLREIRMALTLDKT
HHHHCCCCCCCCCCHHHHHHHCCEEEEEEEECCCCCCCEECCCHHHHHHHHHHHHEECCC
FTKPEILTRYLNLVSFGNGAFGIQDAAQTYFGVNASELNWQQSALLAGLVQSTSTLNPYT
CCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHCCCCCCCC
NPDGALARRNLVLDTMIENLPNEAEALRAAKNEPLGVLPVPNELPRGCIAAGDRAFFCDY
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCCCCCHHHHCCCCEEHHHH
ALEYLARAGISKEQVAKGGYLIKTTLDPDVQGPVKSAVDNFADPTTPGVASVMSVIRPGK
HHHHHHHCCCCHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCC
ESHPVLAMASNRTYGLNLDAYETMQPQPFTLAGNGAGSVFKIFTTAAAMEMGMGINTQLQ
CCCCEEEEECCCEEECCCCHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEE
VPGSFQAKGLGSSDRPGCPAATWCVSNAGGYRGSMNVTDALATSPNTAFAKLISQVGVPR
CCCCCCCCCCCCCCCCCCCHHHHEECCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHCCCC
AVDMSVRLGLRSYALPGTARDYDPESNESLADFVKRQNIGSFTLGPIEVNGLELSNVAAT
EECHHHHHCHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEECCEEECCEEHHHHHHH
LASGGVWCPPNPIAQVLDRKGEEVSVTTETCEQAVPEGLANTLANAMSKDDTGAGTAAGA
HHCCCCCCCCCHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
AGSVGWDLPMSGKTGTTESNRSSAFLGFTNQLAAANYIYDDSPTPGELCSFPLRQCGSGN
CCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHEEECCCCCCHHHHHHHHHHCCCCC
LFGGNEPARTWFTAMKPIATNFGPVALPPTDPRYVDGGPGSQVPSVSGLTVDAARQRIKD
CCCCCCHHHHHHHHHHHHHCCCCCEECCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHH
AGFQVADGTSSVNSGSRAGTVVGTNPSGQTIPGSIVTIQVSNGIAPAPPPPTYSVPSLPG
CCCEEECCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCC
LPGGPPPPIGQTVVEIPGLPPITVPVLGPPPPPPPP
CCCCCCCCCCCHHEECCCCCCEEEECCCCCCCCCCC
>Mature Secondary Structure 
PERPPTAVTVVKLAWCCLLASVLAAALMFPVVGGIGLMSNRASDVVANGSAALVEGEIP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHEECCCEEEEECCCC
QVSTMVDAKGNTIAWLYSQRRFEVPSEQIANTMKLAIVSIEDKRFAEHNGVDWQGTLTGL
CCCEEECCCCCEEEEEECCCCCCCCHHHHHCCEEEEEEEECCHHHHHCCCCCCCHHHHHH
AGYLRGDTDTRGGSTLEQQYVKNYQLLVVAQTDSEKRAAIETTPARKLREIRMALTLDKT
HHHHCCCCCCCCCCHHHHHHHCCEEEEEEEECCCCCCCEECCCHHHHHHHHHHHHEECCC
FTKPEILTRYLNLVSFGNGAFGIQDAAQTYFGVNASELNWQQSALLAGLVQSTSTLNPYT
CCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHCCCCCCCC
NPDGALARRNLVLDTMIENLPNEAEALRAAKNEPLGVLPVPNELPRGCIAAGDRAFFCDY
CCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCCCCCCHHHHCCCCEEHHHH
ALEYLARAGISKEQVAKGGYLIKTTLDPDVQGPVKSAVDNFADPTTPGVASVMSVIRPGK
HHHHHHHCCCCHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCC
ESHPVLAMASNRTYGLNLDAYETMQPQPFTLAGNGAGSVFKIFTTAAAMEMGMGINTQLQ
CCCCEEEEECCCEEECCCCHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEE
VPGSFQAKGLGSSDRPGCPAATWCVSNAGGYRGSMNVTDALATSPNTAFAKLISQVGVPR
CCCCCCCCCCCCCCCCCCCHHHHEECCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHCCCC
AVDMSVRLGLRSYALPGTARDYDPESNESLADFVKRQNIGSFTLGPIEVNGLELSNVAAT
EECHHHHHCHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEECCEEECCEEHHHHHHH
LASGGVWCPPNPIAQVLDRKGEEVSVTTETCEQAVPEGLANTLANAMSKDDTGAGTAAGA
HHCCCCCCCCCHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
AGSVGWDLPMSGKTGTTESNRSSAFLGFTNQLAAANYIYDDSPTPGELCSFPLRQCGSGN
CCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHEEECCCCCCHHHHHHHHHHCCCCC
LFGGNEPARTWFTAMKPIATNFGPVALPPTDPRYVDGGPGSQVPSVSGLTVDAARQRIKD
CCCCCCHHHHHHHHHHHHHCCCCCEECCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHH
AGFQVADGTSSVNSGSRAGTVVGTNPSGQTIPGSIVTIQVSNGIAPAPPPPTYSVPSLPG
CCCEEECCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCC
LPGGPPPPIGQTVVEIPGLPPITVPVLGPPPPPPPP
CCCCCCCCCCCHHEECCCCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA