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The map label for this gene is yfhM [H]

Identifier: 119870926

GI number: 119870926

Start: 5134485

End: 5135438

Strand: Direct

Name: yfhM [H]

Synonym: Mkms_4898

Alternate gene names: 119870926

Gene position: 5134485-5135438 (Clockwise)

Preceding gene: 119870925

Following gene: 119870931

Centisome position: 89.49

GC content: 69.6

Gene sequence:

>954_bases
ATGCCCCCGCCTGACCCGTCGGTCGTCCGGATCGATGGTCCCTGGCGCCATCTCGAGGTCCACGCCAACGGCATCCGCTT
CCACGTCGTCGAGGCGGAAACCCCGGATGCGGCCACCGTTCCGGTGACCGAGCGGCCCCTGGTGATCCTGCTGCACGGGT
TCGCCTCGTTCTGGTGGTCGTGGCGTCATCAGCTCAGGGGGCTCGGCGGCGCCCGTGTCGTGGCGGTCGACCTCCGCGGA
TACGGCGGCAGCGACAAACCACCCCGCGGCTACGACGGCTGGACGTTGGCCGGTGACACGGCGGGTCTGGTGCGCGCCCT
GGGCCACCAGACCGCGACGCTGGTCGGTCACGCCGACGGTGGGCTGGTGTGCTGGGCGACATCGGTGCTGCACCCTCGCG
TGGTCCGCGCGATCGCGGTGGTCAGTTCACCGCATCCCGCGGCACTGCGGACGTCGGCGACGAGGCGGCGCGATCAGGGT
CGGGCGCTGCTGCCCTCGCTGCTGCGGTATCAGACGCCGATGTGGCCGGAACGGGCGCTCACCCGCCACGACGGCGCTGC
GGTCGAGAATCTCGTGCGCGCCCGCTCCGGCGTGAATTGGCAAGCGACGGAGGATTTCTCGGAGACGATCGGACATCTGC
GGAAGGCGATCCAGATTCCGTCGGCCGCACACTCCGCGCTGGAGTACCAACGCTGGGCGGTGCGCAGCCAGCTTCGCGGC
GAGGGTCGTCGCTTCATGCGTTTGATGAAGCGGCCACTGGTGGTCCCGATGCTGCATCTGCGTGGCGACTCCGATCCGTA
CGTCCTCGCCGACCCGGTGTACCGCACCCAGCACTTCACGCCGCACGGAAGTTACGTATCGCTCAGCGACGCAGGCCATT
ACGGTCACGAGGAAGCCCCCGAGGAGGCCAACGAGCACCTCGGCCGGTTCCTCGGCCACGTGTACGGCGGCTAG

Upstream 100 bases:

>100_bases
TGAAGGAGACGCGTGAAGCGCTGACCCCGGGCCATGACAAGGCGCCGAAGGCGGTCGCGATCACAGACGGTCAGAAGACC
GGCGACCCGTCCGGTTGGTA

Downstream 100 bases:

>100_bases
ATCAGCTCACGCAGACGCCGGTGGGCACCCGTGCGGTGTTACCCACCTTGGCCAGCTGAGCCCCCACCTCGTCGGAGGTC
AGCACGAACCCGGTGTCGGC

Product: alpha/beta hydrolase fold protein

Products: glycol

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MPPPDPSVVRIDGPWRHLEVHANGIRFHVVEAETPDAATVPVTERPLVILLHGFASFWWSWRHQLRGLGGARVVAVDLRG
YGGSDKPPRGYDGWTLAGDTAGLVRALGHQTATLVGHADGGLVCWATSVLHPRVVRAIAVVSSPHPAALRTSATRRRDQG
RALLPSLLRYQTPMWPERALTRHDGAAVENLVRARSGVNWQATEDFSETIGHLRKAIQIPSAAHSALEYQRWAVRSQLRG
EGRRFMRLMKRPLVVPMLHLRGDSDPYVLADPVYRTQHFTPHGSYVSLSDAGHYGHEEAPEEANEHLGRFLGHVYGG

Sequences:

>Translated_317_residues
MPPPDPSVVRIDGPWRHLEVHANGIRFHVVEAETPDAATVPVTERPLVILLHGFASFWWSWRHQLRGLGGARVVAVDLRG
YGGSDKPPRGYDGWTLAGDTAGLVRALGHQTATLVGHADGGLVCWATSVLHPRVVRAIAVVSSPHPAALRTSATRRRDQG
RALLPSLLRYQTPMWPERALTRHDGAAVENLVRARSGVNWQATEDFSETIGHLRKAIQIPSAAHSALEYQRWAVRSQLRG
EGRRFMRLMKRPLVVPMLHLRGDSDPYVLADPVYRTQHFTPHGSYVSLSDAGHYGHEEAPEEANEHLGRFLGHVYGG
>Mature_316_residues
PPPDPSVVRIDGPWRHLEVHANGIRFHVVEAETPDAATVPVTERPLVILLHGFASFWWSWRHQLRGLGGARVVAVDLRGY
GGSDKPPRGYDGWTLAGDTAGLVRALGHQTATLVGHADGGLVCWATSVLHPRVVRAIAVVSSPHPAALRTSATRRRDQGR
ALLPSLLRYQTPMWPERALTRHDGAAVENLVRARSGVNWQATEDFSETIGHLRKAIQIPSAAHSALEYQRWAVRSQLRGE
GRRFMRLMKRPLVVPMLHLRGDSDPYVLADPVYRTQHFTPHGSYVSLSDAGHYGHEEAPEEANEHLGRFLGHVYGG

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AB hydrolase superfamily. Epoxide hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI218777837, Length=314, Percent_Identity=27.7070063694268, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI27597073, Length=285, Percent_Identity=24.9122807017544, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI218777840, Length=315, Percent_Identity=27.9365079365079, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI13376164, Length=315, Percent_Identity=27.9365079365079, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17554012, Length=303, Percent_Identity=25.4125412541254, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17562298, Length=314, Percent_Identity=23.5668789808917, Blast_Score=101, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: 3.3.2.3

Molecular weight: Translated: 35077; Mature: 34946

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPPDPSVVRIDGPWRHLEVHANGIRFHVVEAETPDAATVPVTERPLVILLHGFASFWWS
CCCCCCCEEEECCCCEEEEEEECCEEEEEEECCCCCCCCCCCCCCCCEEEHHHHHHHHHH
WRHQLRGLGGARVVAVDLRGYGGSDKPPRGYDGWTLAGDTAGLVRALGHQTATLVGHADG
HHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCEEECCCHHHHHHHHCCCCEEEEECCCC
GLVCWATSVLHPRVVRAIAVVSSPHPAALRTSATRRRDQGRALLPSLLRYQTPMWPERAL
CEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHH
TRHDGAAVENLVRARSGVNWQATEDFSETIGHLRKAIQIPSAAHSALEYQRWAVRSQLRG
HHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
EGRRFMRLMKRPLVVPMLHLRGDSDPYVLADPVYRTQHFTPHGSYVSLSDAGHYGHEEAP
CHHHHHHHHHCCHHEEEHEECCCCCCEEEECCCHHCCCCCCCCCEEEECCCCCCCCCCCH
EEANEHLGRFLGHVYGG
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PPPDPSVVRIDGPWRHLEVHANGIRFHVVEAETPDAATVPVTERPLVILLHGFASFWWS
CCCCCCEEEECCCCEEEEEEECCEEEEEEECCCCCCCCCCCCCCCCEEEHHHHHHHHHH
WRHQLRGLGGARVVAVDLRGYGGSDKPPRGYDGWTLAGDTAGLVRALGHQTATLVGHADG
HHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCEEECCCHHHHHHHHCCCCEEEEECCCC
GLVCWATSVLHPRVVRAIAVVSSPHPAALRTSATRRRDQGRALLPSLLRYQTPMWPERAL
CEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHH
TRHDGAAVENLVRARSGVNWQATEDFSETIGHLRKAIQIPSAAHSALEYQRWAVRSQLRG
HHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
EGRRFMRLMKRPLVVPMLHLRGDSDPYVLADPVYRTQHFTPHGSYVSLSDAGHYGHEEAP
CHHHHHHHHHCCHHEEEHEECCCCCCEEEECCCHHCCCCCCCCCEEEECCCCCCCCCCCH
EEANEHLGRFLGHVYGG
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; epoxide

Specific reaction: H2O + an epoxide = a glycol

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8946165; 9384377 [H]