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The map label for this gene is mmgC [H]

Identifier: 119870809

GI number: 119870809

Start: 5012323

End: 5013492

Strand: Direct

Name: mmgC [H]

Synonym: Mkms_4781

Alternate gene names: 119870809

Gene position: 5012323-5013492 (Clockwise)

Preceding gene: 119870808

Following gene: 119870810

Centisome position: 87.36

GC content: 69.15

Gene sequence:

>1170_bases
ATGGACCTGACGTTCGACGACGCGACCGAGGACTTCCGCGCCGAGGTGCGCGAGTTCCTGGCCGCTCACCGCGACGACTT
CCCGACGAAGTCCTACGACTGCGCCGAAGGGTTCGAGCAGCACCGGCGCTGGGACAAGGTGCTCTTCGACGCCGGCCTGT
CGGTGATCAGCTGGCCGGAGCGCTACGGCGGCCGCGATGCGACGCTGCTGCAGTGGATCGCATTCGAGGAGGAGTACTTC
CGCGCCGGCGCCCCCGGACGCGCGAGCGCCAACGGGACCTCGATGCTGGCGCCGACACTGTTCGCCCACGGCACCGAGGA
GCAGCTGGACCGGGTGCTGCCGAAGATGGCCAGCGGCGAGGAGATCTGGGCGCAGGCGTGGTCGGAGCCGGAGTCGGGTA
GCGATCTGGCCTCACTGCGGTCGACGGCGACGCGGACGGACGGGGGCTGGCTGCTCAACGGGCAGAAGATCTGGAGCTCC
CGGGCCGTGTTCGGCGACCGCGCGTTCGGGCTGTTCCGCTCCGATCCGGAGGCGCAGCGGCACAAGGGTTTGACGTACGT
CATGTTCGACCTGAAGGCCGAGGGGGTGACCGTCCGCCCGATCGCCCAGCTCGGCGGCGACACCGGGTTCGGCGAGATCT
TCCTCGACGACGTGTTCGTTCCCGACGCCGACGTCATCGGTGAGGTCAACGACGGCTGGCGTGCCGCGATGAGCACGTCG
AGCAACGAGCGCGGTATGTCGCTGCGCAGCCCGGCGCGATTCCTCGCCCCCGCCGAACGGCTGGTGGCCGAATGGAAGAA
GGACCGCGACCCGGCGTACGCCGAGCGGGTCGCCGATGCGTGGATCAAGGCGCAGGCCTACCGGCTGCACACCTTCGGGA
CCGTCACACGCGTTGCCGCGGGCGGTGAGCTCGGCGCGGAATCGTCGGTGACCAAGGTGTTCTGGTCCGATCTCGACGTC
GCGCTGCACCAGACGGCGCTCGATCTCCGAGGCGCGGACGGTGAACTCGCCGACCTTCCCGCACGCGAGGAGGACCCATA
CAACTGGACCGACGGGCTGCTGTTCGCGCTCGGCGGGCCGATCTACGCCGGCACCAACGAGATTCAGCGCAACATCATCG
CCGAGCGGTTGCTGGGTCTGCCCCGTGAGCCGAAAGGGCAAGCCAAGTGA

Upstream 100 bases:

>100_bases
CGCGAATTTCAAGACGCCGCGGTCGGTGGAATTCCTCGACGTGCTGCCCCGCAACCCGGGCGGCAAGGTCGTCAAACCGC
TCCTGAGGAAGAGAGCCTGA

Downstream 100 bases:

>100_bases
ACTTCGAACTCGACGATCAGCAACGCGATTTCGCCGCGAGCATCGATGCCGCGCTGGGCGCCGCCGACGTCCCCGCCGCG
GTCCGGGCGTGGTCCGAAGG

Product: acyl-CoA dehydrogenase domain-containing protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MDLTFDDATEDFRAEVREFLAAHRDDFPTKSYDCAEGFEQHRRWDKVLFDAGLSVISWPERYGGRDATLLQWIAFEEEYF
RAGAPGRASANGTSMLAPTLFAHGTEEQLDRVLPKMASGEEIWAQAWSEPESGSDLASLRSTATRTDGGWLLNGQKIWSS
RAVFGDRAFGLFRSDPEAQRHKGLTYVMFDLKAEGVTVRPIAQLGGDTGFGEIFLDDVFVPDADVIGEVNDGWRAAMSTS
SNERGMSLRSPARFLAPAERLVAEWKKDRDPAYAERVADAWIKAQAYRLHTFGTVTRVAAGGELGAESSVTKVFWSDLDV
ALHQTALDLRGADGELADLPAREEDPYNWTDGLLFALGGPIYAGTNEIQRNIIAERLLGLPREPKGQAK

Sequences:

>Translated_389_residues
MDLTFDDATEDFRAEVREFLAAHRDDFPTKSYDCAEGFEQHRRWDKVLFDAGLSVISWPERYGGRDATLLQWIAFEEEYF
RAGAPGRASANGTSMLAPTLFAHGTEEQLDRVLPKMASGEEIWAQAWSEPESGSDLASLRSTATRTDGGWLLNGQKIWSS
RAVFGDRAFGLFRSDPEAQRHKGLTYVMFDLKAEGVTVRPIAQLGGDTGFGEIFLDDVFVPDADVIGEVNDGWRAAMSTS
SNERGMSLRSPARFLAPAERLVAEWKKDRDPAYAERVADAWIKAQAYRLHTFGTVTRVAAGGELGAESSVTKVFWSDLDV
ALHQTALDLRGADGELADLPAREEDPYNWTDGLLFALGGPIYAGTNEIQRNIIAERLLGLPREPKGQAK
>Mature_389_residues
MDLTFDDATEDFRAEVREFLAAHRDDFPTKSYDCAEGFEQHRRWDKVLFDAGLSVISWPERYGGRDATLLQWIAFEEEYF
RAGAPGRASANGTSMLAPTLFAHGTEEQLDRVLPKMASGEEIWAQAWSEPESGSDLASLRSTATRTDGGWLLNGQKIWSS
RAVFGDRAFGLFRSDPEAQRHKGLTYVMFDLKAEGVTVRPIAQLGGDTGFGEIFLDDVFVPDADVIGEVNDGWRAAMSTS
SNERGMSLRSPARFLAPAERLVAEWKKDRDPAYAERVADAWIKAQAYRLHTFGTVTRVAAGGELGAESSVTKVFWSDLDV
ALHQTALDLRGADGELADLPAREEDPYNWTDGLLFALGGPIYAGTNEIQRNIIAERLLGLPREPKGQAK

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=395, Percent_Identity=25.8227848101266, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI226958414, Length=352, Percent_Identity=26.1363636363636, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI4501857, Length=395, Percent_Identity=25.8227848101266, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI21361497, Length=393, Percent_Identity=26.7175572519084, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI4501859, Length=389, Percent_Identity=24.9357326478149, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4557235, Length=299, Percent_Identity=28.7625418060201, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI76496475, Length=299, Percent_Identity=28.7625418060201, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI4557233, Length=342, Percent_Identity=26.9005847953216, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI187960098, Length=389, Percent_Identity=23.3933161953728, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI4557231, Length=389, Percent_Identity=23.3933161953728, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1786223, Length=251, Percent_Identity=28.2868525896414, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI87081958, Length=247, Percent_Identity=27.5303643724696, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17538396, Length=394, Percent_Identity=24.8730964467005, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17570075, Length=394, Percent_Identity=26.6497461928934, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17508101, Length=353, Percent_Identity=24.6458923512748, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17506239, Length=393, Percent_Identity=23.1552162849873, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17505929, Length=346, Percent_Identity=25.4335260115607, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17569725, Length=346, Percent_Identity=25.7225433526012, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17551932, Length=346, Percent_Identity=25.4335260115607, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17534899, Length=336, Percent_Identity=25.297619047619, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71990804, Length=193, Percent_Identity=27.979274611399, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17533517, Length=345, Percent_Identity=26.0869565217391, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71985192, Length=153, Percent_Identity=31.3725490196078, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71985184, Length=153, Percent_Identity=31.3725490196078, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71982178, Length=207, Percent_Identity=26.5700483091787, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21355753, Length=362, Percent_Identity=25.1381215469613, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24646207, Length=352, Percent_Identity=26.1363636363636, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24666513, Length=346, Percent_Identity=25.4335260115607, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI21356377, Length=342, Percent_Identity=23.9766081871345, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281363737, Length=302, Percent_Identity=25.8278145695364, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24660351, Length=359, Percent_Identity=24.5125348189415, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 43030; Mature: 43030

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLTFDDATEDFRAEVREFLAAHRDDFPTKSYDCAEGFEQHRRWDKVLFDAGLSVISWPE
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHEECHH
RYGGRDATLLQWIAFEEEYFRAGAPGRASANGTSMLAPTLFAHGTEEQLDRVLPKMASGE
HHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCH
EIWAQAWSEPESGSDLASLRSTATRTDGGWLLNGQKIWSSRAVFGDRAFGLFRSDPEAQR
HHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEECCHHHHCCCCHHCCHHHHCCCCCCHHHH
HKGLTYVMFDLKAEGVTVRPIAQLGGDTGFGEIFLDDVFVPDADVIGEVNDGWRAAMSTS
HCCCEEEEEEEECCCEEEEEHHHHCCCCCCCCEEECCCCCCCHHHHCCCCCCHHHHHCCC
SNERGMSLRSPARFLAPAERLVAEWKKDRDPAYAERVADAWIKAQAYRLHTFGTVTRVAA
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEHHHHHHHHHC
GGELGAESSVTKVFWSDLDVALHQTALDLRGADGELADLPAREEDPYNWTDGLLFALGGP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCCHHHHHHCCC
IYAGTNEIQRNIIAERLLGLPREPKGQAK
CCCCHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MDLTFDDATEDFRAEVREFLAAHRDDFPTKSYDCAEGFEQHRRWDKVLFDAGLSVISWPE
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHEECHH
RYGGRDATLLQWIAFEEEYFRAGAPGRASANGTSMLAPTLFAHGTEEQLDRVLPKMASGE
HHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCH
EIWAQAWSEPESGSDLASLRSTATRTDGGWLLNGQKIWSSRAVFGDRAFGLFRSDPEAQR
HHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEECCHHHHCCCCHHCCHHHHCCCCCCHHHH
HKGLTYVMFDLKAEGVTVRPIAQLGGDTGFGEIFLDDVFVPDADVIGEVNDGWRAAMSTS
HCCCEEEEEEEECCCEEEEEHHHHCCCCCCCCEEECCCCCCCHHHHCCCCCCHHHHHCCC
SNERGMSLRSPARFLAPAERLVAEWKKDRDPAYAERVADAWIKAQAYRLHTFGTVTRVAA
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEHHHHHHHHHC
GGELGAESSVTKVFWSDLDVALHQTALDLRGADGELADLPAREEDPYNWTDGLLFALGGP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCCHHHHHHCCC
IYAGTNEIQRNIIAERLLGLPREPKGQAK
CCCCHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]