Click here to switch to the map view.

The map label for this gene is adhB [H]

Identifier: 119870803

GI number: 119870803

Start: 5005808

End: 5006920

Strand: Direct

Name: adhB [H]

Synonym: Mkms_4775

Alternate gene names: 119870803

Gene position: 5005808-5006920 (Clockwise)

Preceding gene: 119870802

Following gene: 119870808

Centisome position: 87.25

GC content: 68.28

Gene sequence:

>1113_bases
ATGAAGACCAACGCGGCGATTCTGTGGGAGTACGGGGGCGACTGGACGGTCGAGGAGATCGATCTCGATCCGCCGGGCGA
CGGTGAGGTGCTGGTGTCCTGGGAGGCCACCGGACTGTGCCACTCCGACGAGCACATCCGCACCGGCGACCTCCCCGCCC
CGCTGCCGCTGATCGGTGGCCACGAGGGTGCCGGCATCGTGCGCGAGGTCGGGCCCGGTGTCGTCGGGCTGGCCCCCGGC
GATCACGTCGTCGCGTCGTTCCTGCCCGCGTGTGGCCGGTGCCGGTTCTGCTCGACCGGCCACCAGAATCTGTGCGATCT
CGGCGCGATGATCATGGCAGGCACCCAACTCGACGGCACCTACCGCAGGCACGTCCGCGGGCAGGACGTCGGCGTGATGG
CGCTGGTCGGTACGTTCTCGCAGTACGGCACCGTTCCCGAAGCGTCGATCGTCAAGATCGACGACGACCTGCCGTTGGCG
CGGGCCTGTCTCCTCGGTTGCGGCGTCACCACCGGCTGGGGTTCGGCGGTCAACACCGCCGACGTGTCGCCCGGCGACAC
CGTCGTCATCATCGGCCTCGGCGGGATCGGCAGCGGTGCCGTCCAGGGTGCGCGGCTGGCCGGCGCCGAGAAGATCGTCG
TCATCGAACCGGTGGAATCGAAACGGGAACTGGCCTTCCGGTTCGGCGCCACGCACTTCGTCACCACGATGGAGGAGGCC
AACGCACTGGTCGCCGACCTGACCCGCGGGGTGATGGCCGACTCGGCGATCCTGACCGTCGGCCTGCTGGAGGGCTCGAT
GCTCGAGGACGCCGCCAACATCATCCGCAAGGGCGGTGCCGTCGTGATGACGGCGCTGTCGACGATGGCCGACAACCAGC
CGACCCTGGGCATGATGATGTTCACGCTGTTCCAGAAGCGACTGCTGGGCAGCCTCTACGGCGAGGCCAACCCCCGCGCC
GACATCCCGCGGCTGCTGTCGCTGTACCGCGAGGGCAAGCTACTACTCGACGAGACCGTCACCCACGAGTACAAACTCGC
CGAGGTCAACGAGGGGTACGAGGACATGCGCGCGGGACGAAACATCCGCGGCGTGATCCTGCACGACCACTGA

Upstream 100 bases:

>100_bases
GGCAGTTTCGCCAGCTGGATCGTCGCGCTCGGCGGGTTGGCGCTCGCGCAATAACCGCATTCCCCGGTGATCTGCGCCGG
TCCGTTCATACACTCCCGGC

Downstream 100 bases:

>100_bases
GTTTCCCCACGAGCAGACGCAAATGTCCCTAAAATAGCGGTGTTTCGGGTACTTTTGCGTCTGCTCGGCAGGGGTCTGTG
CTCAGAGACGTTCGATGATC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MKTNAAILWEYGGDWTVEEIDLDPPGDGEVLVSWEATGLCHSDEHIRTGDLPAPLPLIGGHEGAGIVREVGPGVVGLAPG
DHVVASFLPACGRCRFCSTGHQNLCDLGAMIMAGTQLDGTYRRHVRGQDVGVMALVGTFSQYGTVPEASIVKIDDDLPLA
RACLLGCGVTTGWGSAVNTADVSPGDTVVIIGLGGIGSGAVQGARLAGAEKIVVIEPVESKRELAFRFGATHFVTTMEEA
NALVADLTRGVMADSAILTVGLLEGSMLEDAANIIRKGGAVVMTALSTMADNQPTLGMMMFTLFQKRLLGSLYGEANPRA
DIPRLLSLYREGKLLLDETVTHEYKLAEVNEGYEDMRAGRNIRGVILHDH

Sequences:

>Translated_370_residues
MKTNAAILWEYGGDWTVEEIDLDPPGDGEVLVSWEATGLCHSDEHIRTGDLPAPLPLIGGHEGAGIVREVGPGVVGLAPG
DHVVASFLPACGRCRFCSTGHQNLCDLGAMIMAGTQLDGTYRRHVRGQDVGVMALVGTFSQYGTVPEASIVKIDDDLPLA
RACLLGCGVTTGWGSAVNTADVSPGDTVVIIGLGGIGSGAVQGARLAGAEKIVVIEPVESKRELAFRFGATHFVTTMEEA
NALVADLTRGVMADSAILTVGLLEGSMLEDAANIIRKGGAVVMTALSTMADNQPTLGMMMFTLFQKRLLGSLYGEANPRA
DIPRLLSLYREGKLLLDETVTHEYKLAEVNEGYEDMRAGRNIRGVILHDH
>Mature_370_residues
MKTNAAILWEYGGDWTVEEIDLDPPGDGEVLVSWEATGLCHSDEHIRTGDLPAPLPLIGGHEGAGIVREVGPGVVGLAPG
DHVVASFLPACGRCRFCSTGHQNLCDLGAMIMAGTQLDGTYRRHVRGQDVGVMALVGTFSQYGTVPEASIVKIDDDLPLA
RACLLGCGVTTGWGSAVNTADVSPGDTVVIIGLGGIGSGAVQGARLAGAEKIVVIEPVESKRELAFRFGATHFVTTMEEA
NALVADLTRGVMADSAILTVGLLEGSMLEDAANIIRKGGAVVMTALSTMADNQPTLGMMMFTLFQKRLLGSLYGEANPRA
DIPRLLSLYREGKLLLDETVTHEYKLAEVNEGYEDMRAGRNIRGVILHDH

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=372, Percent_Identity=35.752688172043, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI4501933, Length=372, Percent_Identity=35.2150537634409, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI71743840, Length=368, Percent_Identity=34.2391304347826, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI262073058, Length=368, Percent_Identity=34.2391304347826, Blast_Score=228, Evalue=7e-60,
Organism=Homo sapiens, GI4501929, Length=373, Percent_Identity=33.2439678284182, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI71565154, Length=372, Percent_Identity=34.1397849462366, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI156523966, Length=373, Percent_Identity=34.0482573726542, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI71565152, Length=379, Percent_Identity=34.0369393139842, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI4501939, Length=366, Percent_Identity=33.879781420765, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI156627571, Length=371, Percent_Identity=22.1024258760108, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1786552, Length=381, Percent_Identity=36.4829396325459, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI87081918, Length=347, Percent_Identity=31.4121037463977, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI226510992, Length=361, Percent_Identity=29.3628808864266, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788073, Length=375, Percent_Identity=26.9333333333333, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1786825, Length=397, Percent_Identity=28.463476070529, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082125, Length=377, Percent_Identity=24.1379310344828, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790045, Length=362, Percent_Identity=25.9668508287293, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1787863, Length=352, Percent_Identity=23.5795454545455, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788075, Length=365, Percent_Identity=24.6575342465753, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786518, Length=357, Percent_Identity=27.1708683473389, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788407, Length=232, Percent_Identity=28.448275862069, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=378, Percent_Identity=32.8042328042328, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI71997431, Length=380, Percent_Identity=32.6315789473684, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17565904, Length=336, Percent_Identity=33.6309523809524, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI71988145, Length=371, Percent_Identity=28.8409703504043, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17562584, Length=372, Percent_Identity=29.5698924731183, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17562582, Length=371, Percent_Identity=28.3018867924528, Blast_Score=104, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17562876, Length=362, Percent_Identity=25.6906077348066, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562878, Length=233, Percent_Identity=27.0386266094421, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320033, Length=379, Percent_Identity=36.1477572559367, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6319621, Length=364, Percent_Identity=28.8461538461538, Blast_Score=115, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6323729, Length=361, Percent_Identity=28.2548476454294, Blast_Score=106, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6324486, Length=358, Percent_Identity=27.0949720670391, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6323961, Length=361, Percent_Identity=26.8698060941828, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319257, Length=342, Percent_Identity=27.4853801169591, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323099, Length=390, Percent_Identity=24.8717948717949, Blast_Score=73, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6319258, Length=234, Percent_Identity=27.7777777777778, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319949, Length=359, Percent_Identity=27.5766016713092, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322619, Length=369, Percent_Identity=25.2032520325203, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319955, Length=369, Percent_Identity=25.2032520325203, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=234, Percent_Identity=30.7692307692308, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737895, Length=374, Percent_Identity=36.3636363636364, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI17137530, Length=361, Percent_Identity=26.5927977839335, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17737897, Length=359, Percent_Identity=25.9052924791086, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 39135; Mature: 39135

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTNAAILWEYGGDWTVEEIDLDPPGDGEVLVSWEATGLCHSDEHIRTGDLPAPLPLIGG
CCCCEEEEEEECCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
HEGAGIVREVGPGVVGLAPGDHVVASFLPACGRCRFCSTGHQNLCDLGAMIMAGTQLDGT
CCCCCHHHHCCCCEEEECCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCCCCCCH
YRRHVRGQDVGVMALVGTFSQYGTVPEASIVKIDDDLPLARACLLGCGVTTGWGSAVNTA
HHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCC
DVSPGDTVVIIGLGGIGSGAVQGARLAGAEKIVVIEPVESKRELAFRFGATHFVTTMEEA
CCCCCCEEEEEEECCCCCCCCCCCEECCCCEEEEECCCCCCHHHHHHHCCHHHEEEHHHH
NALVADLTRGVMADSAILTVGLLEGSMLEDAANIIRKGGAVVMTALSTMADNQPTLGMMM
HHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCHHEEHHHHHHCCCCCHHHHHH
FTLFQKRLLGSLYGEANPRADIPRLLSLYREGKLLLDETVTHEYKLAEVNEGYEDMRAGR
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEHHCCCCEEEECCCCCHHHHHCCC
NIRGVILHDH
CEEEEEEECC
>Mature Secondary Structure
MKTNAAILWEYGGDWTVEEIDLDPPGDGEVLVSWEATGLCHSDEHIRTGDLPAPLPLIGG
CCCCEEEEEEECCCEEEEEEECCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
HEGAGIVREVGPGVVGLAPGDHVVASFLPACGRCRFCSTGHQNLCDLGAMIMAGTQLDGT
CCCCCHHHHCCCCEEEECCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCCCCCCH
YRRHVRGQDVGVMALVGTFSQYGTVPEASIVKIDDDLPLARACLLGCGVTTGWGSAVNTA
HHHHCCCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCC
DVSPGDTVVIIGLGGIGSGAVQGARLAGAEKIVVIEPVESKRELAFRFGATHFVTTMEEA
CCCCCCEEEEEEECCCCCCCCCCCEECCCCEEEEECCCCCCHHHHHHHCCHHHEEEHHHH
NALVADLTRGVMADSAILTVGLLEGSMLEDAANIIRKGGAVVMTALSTMADNQPTLGMMM
HHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHCCCHHEEHHHHHHCCCCCHHHHHH
FTLFQKRLLGSLYGEANPRADIPRLLSLYREGKLLLDETVTHEYKLAEVNEGYEDMRAGR
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEHHCCCCEEEECCCCCHHHHHCCC
NIRGVILHDH
CEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]