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The map label for this gene is fgd1 [H]

Identifier: 119870714

GI number: 119870714

Start: 4909198

End: 4910187

Strand: Direct

Name: fgd1 [H]

Synonym: Mkms_4685

Alternate gene names: 119870714

Gene position: 4909198-4910187 (Clockwise)

Preceding gene: 119870713

Following gene: 119870715

Centisome position: 85.57

GC content: 69.19

Gene sequence:

>990_bases
ATGACCGTCATCGGCTTCCACTGCTCACACGAGCAGATCGACCCCGCCCAACTCCTCAAGGACGTCCAGCACGCCGAGCA
GGCCGGTTTCACCGCAGGCATGTCATCAGACCACTTCAGCCCGTGGAGCGAGCGGCAGGGCGAATCCGGCTTCGCCTGGG
CCTTCCTCGGCGCCGCGCTGGCCACCACCGACCTGCCGTTCGGTGTCGTCAACGCGCCGGGTCAGCGCTACCACCCCGCG
ATCATCGCCCAGGCCATCGCCACGCTGGCGCAGATGTTCCCCGGCCGGTTCTGGGCGGCGCTGGGCTCGGGTGAGGCGTC
CAACGAACGGATCACCGGTCAGGCGTGGCCCCGCAAGGAGGTGCGCGACGCACGGCTCGTCGAGTGTGTCGACGTCATCC
GCCGTCTGCTGCGCGGTGAAGAGGTCAGCCACGAGGGTTTGGTGGAGGTCAACCGGGCCCGACTGTGGACGCTGCCCGAA
GTCACCCCCGACCTGGTCGGCCCGGCCGTCACGCCGCAGACCGCGGCCCGCCACGCCGCCTGGGCGGACGGCCTCATCAC
GGTCAACCAACCACCGGAGAAGCTGCGCGCGGTCCTCGACGCGTACCGCCAAGCCGGTGGTCGCGGACCGGCGCGGCTCC
AGATCCATCTGAGCTGGGCGGCCTCCGACGACGAGGCCATGGCGATCGCGCACGACCAGTGGCGCAACAACGTCTTCGAC
CCGCCGGTGTCGTGGGATATCGAGACCGTCGACGCGTTCGACGTGATCGGCAGCGCCGTCTCGACGGAGAAGGTCAGCGG
TGCGGTACGTGTCTCGGCCGACCTCGGACGCCACGCCGAGTGGCTGGCCGAGTACGTCGAACAGGGTTGGGATGAGCTCT
ACCTGCACTTCGTCGGCCAGCAGCAGGCCGGCTTCATCGACGCCTTCGGTGAGCACGTCCTTCCACAGCTGTCACCGACC
GCTCCCACGTCGAGCGCGGCGATCGCATGA

Upstream 100 bases:

>100_bases
ACCACCGGACCCGAGGATCCCGCGCCCGGTATGGGTGACGACGAGGGCTGCGGTGACCAGCTGACGTTGGCGTCAGGGCT
TTCCGGGGTATGCCAGGGCG

Downstream 100 bases:

>100_bases
GGAAGATCGAGACCGGCGACCTGTGGTGGAAGAACGCCGTCTTCTACTGCGCCGACATCGAGACGTTCTACGACTGGAAC
GGCGACGGCACCGTCGACAT

Product: putative dehydrogenase protein

Products: NA

Alternate protein names: F420_G6P_DH [H]

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MTVIGFHCSHEQIDPAQLLKDVQHAEQAGFTAGMSSDHFSPWSERQGESGFAWAFLGAALATTDLPFGVVNAPGQRYHPA
IIAQAIATLAQMFPGRFWAALGSGEASNERITGQAWPRKEVRDARLVECVDVIRRLLRGEEVSHEGLVEVNRARLWTLPE
VTPDLVGPAVTPQTAARHAAWADGLITVNQPPEKLRAVLDAYRQAGGRGPARLQIHLSWAASDDEAMAIAHDQWRNNVFD
PPVSWDIETVDAFDVIGSAVSTEKVSGAVRVSADLGRHAEWLAEYVEQGWDELYLHFVGQQQAGFIDAFGEHVLPQLSPT
APTSSAAIA

Sequences:

>Translated_329_residues
MTVIGFHCSHEQIDPAQLLKDVQHAEQAGFTAGMSSDHFSPWSERQGESGFAWAFLGAALATTDLPFGVVNAPGQRYHPA
IIAQAIATLAQMFPGRFWAALGSGEASNERITGQAWPRKEVRDARLVECVDVIRRLLRGEEVSHEGLVEVNRARLWTLPE
VTPDLVGPAVTPQTAARHAAWADGLITVNQPPEKLRAVLDAYRQAGGRGPARLQIHLSWAASDDEAMAIAHDQWRNNVFD
PPVSWDIETVDAFDVIGSAVSTEKVSGAVRVSADLGRHAEWLAEYVEQGWDELYLHFVGQQQAGFIDAFGEHVLPQLSPT
APTSSAAIA
>Mature_328_residues
TVIGFHCSHEQIDPAQLLKDVQHAEQAGFTAGMSSDHFSPWSERQGESGFAWAFLGAALATTDLPFGVVNAPGQRYHPAI
IAQAIATLAQMFPGRFWAALGSGEASNERITGQAWPRKEVRDARLVECVDVIRRLLRGEEVSHEGLVEVNRARLWTLPEV
TPDLVGPAVTPQTAARHAAWADGLITVNQPPEKLRAVLDAYRQAGGRGPARLQIHLSWAASDDEAMAIAHDQWRNNVFDP
PVSWDIETVDAFDVIGSAVSTEKVSGAVRVSADLGRHAEWLAEYVEQGWDELYLHFVGQQQAGFIDAFGEHVLPQLSPTA
PTSSAAIA

Specific function: Involved in the bioreductive activation of the prodrug PA-824 (nitroimidazo-oxazine) developed for anti-tuberculosis therapy against both replicating and persistent bacteria. It does not interact directly with PA-824 but, rather, provides reduced F420 to

COG id: COG2141

COG function: function code C; Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the F420-dependent glucose-6-phosphate dehydrogenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019945
- InterPro:   IPR019944
- InterPro:   IPR011251
- InterPro:   IPR016048 [H]

Pfam domain/function: PF00296 Bac_luciferase [H]

EC number: =1.1.99.34 [H]

Molecular weight: Translated: 35793; Mature: 35662

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVIGFHCSHEQIDPAQLLKDVQHAEQAGFTAGMSSDHFSPWSERQGESGFAWAFLGAAL
CEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHH
ATTDLPFGVVNAPGQRYHPAIIAQAIATLAQMFPGRFWAALGSGEASNERITGQAWPRKE
HHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCHHH
VRDARLVECVDVIRRLLRGEEVSHEGLVEVNRARLWTLPEVTPDLVGPAVTPQTAARHAA
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCHHEEECCCCCHHHCCCCCCHHHHHHHHH
WADGLITVNQPPEKLRAVLDAYRQAGGRGPARLQIHLSWAASDDEAMAIAHDQWRNNVFD
HCCCEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCEEEEEHHHHHCCCCC
PPVSWDIETVDAFDVIGSAVSTEKVSGAVRVSADLGRHAEWLAEYVEQGWDELYLHFVGQ
CCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEHHHCHHHHHHHHHHHHCHHHHHHHHHCC
QQAGFIDAFGEHVLPQLSPTAPTSSAAIA
CCCCHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TVIGFHCSHEQIDPAQLLKDVQHAEQAGFTAGMSSDHFSPWSERQGESGFAWAFLGAAL
EEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHH
ATTDLPFGVVNAPGQRYHPAIIAQAIATLAQMFPGRFWAALGSGEASNERITGQAWPRKE
HHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCHHH
VRDARLVECVDVIRRLLRGEEVSHEGLVEVNRARLWTLPEVTPDLVGPAVTPQTAARHAA
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCHHEEECCCCCHHHCCCCCCHHHHHHHHH
WADGLITVNQPPEKLRAVLDAYRQAGGRGPARLQIHLSWAASDDEAMAIAHDQWRNNVFD
HCCCEEECCCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCEEEEEHHHHHCCCCC
PPVSWDIETVDAFDVIGSAVSTEKVSGAVRVSADLGRHAEWLAEYVEQGWDELYLHFVGQ
CCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEHHHCHHHHHHHHHHHHCHHHHHHHHHCC
QQAGFIDAFGEHVLPQLSPTAPTSSAAIA
CCCCHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]