Click here to switch to the map view.

The map label for this gene is serC

Identifier: 119870580

GI number: 119870580

Start: 4785546

End: 4786658

Strand: Direct

Name: serC

Synonym: Mkms_4551

Alternate gene names: 119870580

Gene position: 4785546-4786658 (Clockwise)

Preceding gene: 119870577

Following gene: 119870581

Centisome position: 83.41

GC content: 69.45

Gene sequence:

>1113_bases
ATGGCCGAACTCACCATCCCCGCCGATCTCAAGCCCCGCGACGGACGCTTCGGGTCCGGACCGTCGAAGGTGCGTCCCGA
ACAACTGCAGGCGCTCGCCGCCGCGGGCGACCTGTTCGGCACCTCGCACCGACAGGCCCCGGTCAAGAACCTCGTGGGCC
GCGTGCGGGACGGCATCAAACAGCTGTTCTCGGTACCCGAGGGATACGACGTCATCCTCGGCAACGGCGGCAGCACGGCG
TTCTGGGATGCCGCGGCGTTCGGGCTGATCGACAAGCGCTCACTGCACCTCACCTACGGCGAGTTCAGCGCGAAATTCGC
CTCCGCGGTCGCCAAGAACCCGTTCGTCGGCGACCCGATCGTCGTCAAGGCCGATCCGGGCAGCGCCCCGGAACCGCAGT
CCGACCCGTCGGTCGACGTCATCGCCTGGGCGCACAACGAGACATCGACCGGTGTCGCCGTCCCGGTGCAGCGCCCCGCC
GACTCCGGCGACGCGCTGATCGTGATCGACGCGACGTCCGGCGCGGGCGGGCTGCCCGTCGACATCGCGCAGGCCGACGC
CTACTACTTCGCCCCGCAGAAGAACTTCGCCGGCGACGGCGGCCTCTGGCTCGCGGTGGTCAGCCCCGCCGCCCTGGCGC
GCATCGAGGCGATCGGCCAGTCGGGCCGCTGGGTGCCCGACTTCCTCTCCCTGCCGATCGCGGTGGAGAACAGCCTCAAG
AACCAGACGTACAACACCCCGGCGATCGGCACGCTCGTGCTGCTCGCCGACCAGCTGGACTGGCTCAACGGCAACGGCGG
ACTGGACTGGGCCGTCAAGCGCACCGCCGATTCGTCGCAGCGGCTGTACTCGTGGGCCGAGGCGTCGTCCTACGCGACAC
CGTTCGTCACCGATCCGGCGCTGCGCTCGCAGGTGGTCGGCACCATCGACTTCGCCGATGACGTCGACGCCGCCGCGGTG
GCAAAGGTGTTGCGCGCCAACGGAATCGTCGATACCGAGCCGTACCGCAAACTCGGTCGCAACCAGCTGCGGGTCGCGAT
GTTCGCCGCCGTCGACCCCGAGGACGTCAGTGCCCTGACCCGGTGCGTCGACTGGGTCGTCGAACGGTTGTAG

Upstream 100 bases:

>100_bases
TGTCCATGGCCACTCTGAGGGTTTGCTGTGGTTTCGGCGTCGTGGGTCGCGGTGAGCGCAACTGGCTGCACCGAAATCGC
AGGAACTACGCTGGTGCCCC

Downstream 100 bases:

>100_bases
ATCACGCCGCGTGTCACCGTGGTCACGGGCAGGTAACGCAGTAGGCTGACCAGCTAATCGGGCTGGCGCCTCGCGCCGCG
AAAAGAGCCCGGAGGAGGTC

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MAELTIPADLKPRDGRFGSGPSKVRPEQLQALAAAGDLFGTSHRQAPVKNLVGRVRDGIKQLFSVPEGYDVILGNGGSTA
FWDAAAFGLIDKRSLHLTYGEFSAKFASAVAKNPFVGDPIVVKADPGSAPEPQSDPSVDVIAWAHNETSTGVAVPVQRPA
DSGDALIVIDATSGAGGLPVDIAQADAYYFAPQKNFAGDGGLWLAVVSPAALARIEAIGQSGRWVPDFLSLPIAVENSLK
NQTYNTPAIGTLVLLADQLDWLNGNGGLDWAVKRTADSSQRLYSWAEASSYATPFVTDPALRSQVVGTIDFADDVDAAAV
AKVLRANGIVDTEPYRKLGRNQLRVAMFAAVDPEDVSALTRCVDWVVERL

Sequences:

>Translated_370_residues
MAELTIPADLKPRDGRFGSGPSKVRPEQLQALAAAGDLFGTSHRQAPVKNLVGRVRDGIKQLFSVPEGYDVILGNGGSTA
FWDAAAFGLIDKRSLHLTYGEFSAKFASAVAKNPFVGDPIVVKADPGSAPEPQSDPSVDVIAWAHNETSTGVAVPVQRPA
DSGDALIVIDATSGAGGLPVDIAQADAYYFAPQKNFAGDGGLWLAVVSPAALARIEAIGQSGRWVPDFLSLPIAVENSLK
NQTYNTPAIGTLVLLADQLDWLNGNGGLDWAVKRTADSSQRLYSWAEASSYATPFVTDPALRSQVVGTIDFADDVDAAAV
AKVLRANGIVDTEPYRKLGRNQLRVAMFAAVDPEDVSALTRCVDWVVERL
>Mature_369_residues
AELTIPADLKPRDGRFGSGPSKVRPEQLQALAAAGDLFGTSHRQAPVKNLVGRVRDGIKQLFSVPEGYDVILGNGGSTAF
WDAAAFGLIDKRSLHLTYGEFSAKFASAVAKNPFVGDPIVVKADPGSAPEPQSDPSVDVIAWAHNETSTGVAVPVQRPAD
SGDALIVIDATSGAGGLPVDIAQADAYYFAPQKNFAGDGGLWLAVVSPAALARIEAIGQSGRWVPDFLSLPIAVENSLKN
QTYNTPAIGTLVLLADQLDWLNGNGGLDWAVKRTADSSQRLYSWAEASSYATPFVTDPALRSQVVGTIDFADDVDAAAVA
KVLRANGIVDTEPYRKLGRNQLRVAMFAAVDPEDVSALTRCVDWVVERL

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily

Homologues:

Organism=Homo sapiens, GI17402893, Length=372, Percent_Identity=25.2688172043011, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI10863955, Length=328, Percent_Identity=24.6951219512195, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1787136, Length=369, Percent_Identity=25.4742547425474, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17506897, Length=365, Percent_Identity=21.6438356164384, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356589, Length=368, Percent_Identity=23.6413043478261, Blast_Score=76, Evalue=3e-14,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERC_MYCSJ (A3Q635)

Other databases:

- EMBL:   CP000580
- RefSeq:   YP_001073103.1
- ProteinModelPortal:   A3Q635
- SMR:   A3Q635
- STRING:   A3Q635
- EnsemblBacteria:   EBMYCT00000050045
- GeneID:   4880546
- GenomeReviews:   CP000580_GR
- KEGG:   mjl:Mjls_4847
- eggNOG:   COG1932
- GeneTree:   EBGT00050000017386
- HOGENOM:   HBG292317
- OMA:   SHRAKVG
- PhylomeDB:   A3Q635
- ProtClustDB:   PRK03080
- BioCyc:   MSP164757:MJLS_4847-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00160
- InterPro:   IPR000192
- InterPro:   IPR022278
- InterPro:   IPR006272
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PIRSF:   PIRSF000525
- TIGRFAMs:   TIGR01366

Pfam domain/function: PF00266 Aminotran_5; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.52

Molecular weight: Translated: 39170; Mature: 39039

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: BINDING 44-44 BINDING 102-102 BINDING 148-148 BINDING 170-170 BINDING 193-193

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELTIPADLKPRDGRFGSGPSKVRPEQLQALAAAGDLFGTSHRQAPVKNLVGRVRDGIK
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
QLFSVPEGYDVILGNGGSTAFWDAAAFGLIDKRSLHLTYGEFSAKFASAVAKNPFVGDPI
HHHCCCCCCEEEEECCCCCCHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHCCCCCCCCE
VVKADPGSAPEPQSDPSVDVIAWAHNETSTGVAVPVQRPADSGDALIVIDATSGAGGLPV
EEEECCCCCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCE
DIAQADAYYFAPQKNFAGDGGLWLAVVSPAALARIEAIGQSGRWVPDFLSLPIAVENSLK
EEECCCEEEECCCCCCCCCCCEEEEEECHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHC
NQTYNTPAIGTLVLLADQLDWLNGNGGLDWAVKRTADSSQRLYSWAEASSYATPFVTDPA
CCCCCCCCHHHEEEHHHHHCEECCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCHH
LRSQVVGTIDFADDVDAAAVAKVLRANGIVDTEPYRKLGRNQLRVAMFAAVDPEDVSALT
HHHHHEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEEEECCHHHHHHHH
RCVDWVVERL
HHHHHHHHHC
>Mature Secondary Structure 
AELTIPADLKPRDGRFGSGPSKVRPEQLQALAAAGDLFGTSHRQAPVKNLVGRVRDGIK
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
QLFSVPEGYDVILGNGGSTAFWDAAAFGLIDKRSLHLTYGEFSAKFASAVAKNPFVGDPI
HHHCCCCCCEEEEECCCCCCHHHHHHHCCCCCCEEEEEECHHHHHHHHHHHCCCCCCCCE
VVKADPGSAPEPQSDPSVDVIAWAHNETSTGVAVPVQRPADSGDALIVIDATSGAGGLPV
EEEECCCCCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCCCEEEEEECCCCCCCCCE
DIAQADAYYFAPQKNFAGDGGLWLAVVSPAALARIEAIGQSGRWVPDFLSLPIAVENSLK
EEECCCEEEECCCCCCCCCCCEEEEEECHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHC
NQTYNTPAIGTLVLLADQLDWLNGNGGLDWAVKRTADSSQRLYSWAEASSYATPFVTDPA
CCCCCCCCHHHEEEHHHHHCEECCCCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCHH
LRSQVVGTIDFADDVDAAAVAKVLRANGIVDTEPYRKLGRNQLRVAMFAAVDPEDVSALT
HHHHHEEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHCCCCEEEEEEEECCHHHHHHHH
RCVDWVVERL
HHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA