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The map label for this gene is rskA

Identifier: 119870488

GI number: 119870488

Start: 4691686

End: 4692417

Strand: Direct

Name: rskA

Synonym: Mkms_4459

Alternate gene names: 119870488

Gene position: 4691686-4692417 (Clockwise)

Preceding gene: 119870487

Following gene: 119870490

Centisome position: 81.78

GC content: 71.86

Gene sequence:

>732_bases
ATGACCGAGCCGAACAACACCGATCTCCTCGACCTCGCGACGCCGTATGCGCTGCATGCGGTGTCCATCGACGAGCGCTT
CGAGATCGACCGGTGGCTGGCCACCGCACCGCCCGAGGTGGCGGACGCCTTCACCGACGAGGTGCGCTCGGTCCAGGAGA
CGATGGCGGTGCTGTCGGCGGCCACGGCCACCGAACCGCCCGCTCACCTGCGCGACAACGTGCTCGCGATGGTCGCCGAC
GATCCGGTGCGTGACCTCGGCAGCGCGCGTCGACGGCGGGGCGGTGAGTCGCGCTGGCGCACGGCTGTGCTGGCGGCCGC
GGCGGTGGCGGTGGTCGGCCTCGGTGCGCTCGGCGTGGGGCTGGCGCTGCGGCCTGCCGTCTCCCCGACGACGGCGGATC
AGGTGTTCGCCGCACCGGATGTCCAGACCGTGTCGGGGCCGATCCCCGGCGGCGGCACCGCGACCGTGGTGTTCTCCAAG
GAACGGGACGCCGGGGTGCTGGTGATGAACGACGTCGCTCCGCCGAAGCCGGGCACCGTCTACCAGATGTGGCTGGTCGG
CTCCGACGGTCCGCATTCGGCGGGCACGATGGACGACAAGGCGATCTCGCCGTCGACCACCGCCGTGCTGTCCGACATCG
GGACGTCACAGGCGCTGGCGTTCACCGTCGAACCACCCGGCGGCTCGCAGCGGCCCACGTCGCCGGCGTTCGCGGAACTG
CCCCTGACTTAA

Upstream 100 bases:

>100_bases
CGTATGTCCAGGTCTCCGAGCGTCTGTCGGCGAATCTGGCCACAATCAAATCGCGGATGCGCGGCGGCATCCGCGGTCTC
AAGAACTGTCTGGGCATGTC

Downstream 100 bases:

>100_bases
GCCAGCGTCGCCTCGGCGACCGCGTCGATCACGTCGGCGATCTCGCCGCGACGCCGCCACGCCGCGCGCTGACGCATCGC
GCCGTTGCCCTCGTCGTCGA

Product: hypothetical protein

Products: NA

Alternate protein names: Regulator of sigK

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MTEPNNTDLLDLATPYALHAVSIDERFEIDRWLATAPPEVADAFTDEVRSVQETMAVLSAATATEPPAHLRDNVLAMVAD
DPVRDLGSARRRRGGESRWRTAVLAAAAVAVVGLGALGVGLALRPAVSPTTADQVFAAPDVQTVSGPIPGGGTATVVFSK
ERDAGVLVMNDVAPPKPGTVYQMWLVGSDGPHSAGTMDDKAISPSTTAVLSDIGTSQALAFTVEPPGGSQRPTSPAFAEL
PLT

Sequences:

>Translated_243_residues
MTEPNNTDLLDLATPYALHAVSIDERFEIDRWLATAPPEVADAFTDEVRSVQETMAVLSAATATEPPAHLRDNVLAMVAD
DPVRDLGSARRRRGGESRWRTAVLAAAAVAVVGLGALGVGLALRPAVSPTTADQVFAAPDVQTVSGPIPGGGTATVVFSK
ERDAGVLVMNDVAPPKPGTVYQMWLVGSDGPHSAGTMDDKAISPSTTAVLSDIGTSQALAFTVEPPGGSQRPTSPAFAEL
PLT
>Mature_242_residues
TEPNNTDLLDLATPYALHAVSIDERFEIDRWLATAPPEVADAFTDEVRSVQETMAVLSAATATEPPAHLRDNVLAMVADD
PVRDLGSARRRRGGESRWRTAVLAAAAVAVVGLGALGVGLALRPAVSPTTADQVFAAPDVQTVSGPIPGGGTATVVFSKE
RDAGVLVMNDVAPPKPGTVYQMWLVGSDGPHSAGTMDDKAISPSTTAVLSDIGTSQALAFTVEPPGGSQRPTSPAFAELP
LT

Specific function: Represses sigK, the extracytoplasmic function (ECF) sigma factor K, by binding to it and inhibiting its activity. This leads to a decreased expression of sigK-regulated genes

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anti-sigma-K factor family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RSKA_MYCSJ (A3Q5U1)

Other databases:

- EMBL:   CP000580
- RefSeq:   YP_001073009.1
- STRING:   A3Q5U1
- EnsemblBacteria:   EBMYCT00000051576
- GeneID:   4880452
- GenomeReviews:   CP000580_GR
- KEGG:   mjl:Mjls_4753
- GeneTree:   EBGT00050000018535
- HOGENOM:   HBG700106
- OMA:   VYQMWLI
- ProtClustDB:   CLSK790524
- BioCyc:   MSP164757:MJLS_4753-MONOMER
- InterPro:   IPR018764

Pfam domain/function: PF10099 DUF2337

EC number: NA

Molecular weight: Translated: 25147; Mature: 25016

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x17c6c25c)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPNNTDLLDLATPYALHAVSIDERFEIDRWLATAPPEVADAFTDEVRSVQETMAVLSA
CCCCCCCCEEECCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
ATATEPPAHLRDNVLAMVADDPVRDLGSARRRRGGESRWRTAVLAAAAVAVVGLGALGVG
HCCCCCCHHHHCCEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
LALRPAVSPTTADQVFAAPDVQTVSGPIPGGGTATVVFSKERDAGVLVMNDVAPPKPGTV
EEECCCCCCCCCCCEEECCCCCCCCCCCCCCCEEEEEEECCCCCCEEEECCCCCCCCCCE
YQMWLVGSDGPHSAGTMDDKAISPSTTAVLSDIGTSQALAFTVEPPGGSQRPTSPAFAEL
EEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCC
PLT
CCH
>Mature Secondary Structure 
TEPNNTDLLDLATPYALHAVSIDERFEIDRWLATAPPEVADAFTDEVRSVQETMAVLSA
CCCCCCCEEECCCCEEEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
ATATEPPAHLRDNVLAMVADDPVRDLGSARRRRGGESRWRTAVLAAAAVAVVGLGALGVG
HCCCCCCHHHHCCEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHC
LALRPAVSPTTADQVFAAPDVQTVSGPIPGGGTATVVFSKERDAGVLVMNDVAPPKPGTV
EEECCCCCCCCCCCEEECCCCCCCCCCCCCCCEEEEEEECCCCCCEEEECCCCCCCCCCE
YQMWLVGSDGPHSAGTMDDKAISPSTTAVLSDIGTSQALAFTVEPPGGSQRPTSPAFAEL
EEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCC
PLT
CCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA