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The map label for this gene is pgi [H]

Identifier: 119870449

GI number: 119870449

Start: 4649800

End: 4651464

Strand: Direct

Name: pgi [H]

Synonym: Mkms_4420

Alternate gene names: 119870449

Gene position: 4649800-4651464 (Clockwise)

Preceding gene: 119870446

Following gene: 119870458

Centisome position: 81.05

GC content: 67.27

Gene sequence:

>1665_bases
ATGACGGCCGACGACCAGCTCACCGACATATCCGCCACTTCCGCCTGGCAGGCGTTGCAGCGCCATCACGGCGAGATCGC
CGGGAGACATCTGCGGGAGCTGTTCGCCGAGGATCCGTCGCGGGGCACCGAGTTGACGGTGTCGGTGGGCGATCTGTACA
TCGACTACAGCAAACATCGGGTCACCCGGGAGACGCTGCGGCTGCTGGTCGATCTCGCCCGCGCTGCGGGTCTGGAGAAG
CGTCGTGACGCGATGTTGTCCGGCGTGCACATCAACACCTCCGAGGACCGGGCGGTGCTGCACACCGCGCTGCGGCTGCC
GCGTGACGCGAGCCTGACCGTCGACGGTCAGGATGTGGTCGCCGACGTGCACGAGGTGCTGGACCGGATGGGCGATTTCA
CCGACCGGCTGCGCAGCGGCGAGTGGACGGGTGCGACCGGCGAGCGCATCAGGACCGTCGTCAACATCGGGATCGGCGGC
TCGGATCTGGGGCCGGCGATGGTCTACGAGTCGTTGCGGCACTACGCGGACGCCGGCATCTCGGCGCGCTTCGTGTCCAA
TGTCGACCCGGCCGATCTGGTCGCGAAGCTCGACGGACTCGATCCGGCGACAACGCTTTTCATCGTCGCCTCCAAGACCT
TCTCCACCCTGGAGACGCTGACCAACGCCACCGCCGCGCGGCGCTGGCTGACCAACACCCTGGGCGACGCCGCGGTCGCC
AGGCATTTCGTCGCGGTCTCCACCAACCAGAAGCTGGTCGACGAGTTCGGCATCGACACCGCCAACATGTTCGGGTTCTG
GGACTGGGTCGGCGGGCGTTACTCGGTGGACAGCGCGATCGGGCTCAGCGTGATGGCCGCGATCGGCAGGGAGCGTTTCG
CCGAATTCCTGGCCGGGTTCCATCTGGTCGACGAGCACTTCCGCACCGCGCCGCTGGAAGCCAACGCGCCTGCGCTGCTG
GGCCTGATCGGGCTGTGGTACTCCAACTTCTTCGGCGCCCAGTCCCGCGCGGTGCTGCCCTACTCCAACGATCTGTCCCG
GTTCGCGGCCTATCTGCAGCAGCTCACCATGGAGTCCAACGGCAAGTCGGTGCGCGCCGACGGCACGCCCGTGTCCACCG
ACACCGGGGAGATCTTCTGGGGTGAGCCGGGCACCAACGGCCAACACGCCTTCTACCAGTTGCTGCACCAGGGCACGCGG
CTCGTGCCTGCGGATTTCATCGGGTTCTCCCAGCCCACCGACGACCTGCCGACAGCCGACGGCACCGGCAGCATGCACGA
CCTGCTGATGAGCAACTTCTTCGCCCAGACGCAGGTGCTGGCGTTCGGTAAGACCGCCGAGGAGATCGCGGCCGAGGACA
CCCCCGCCGACGTCGTACCGCACAAGGTGATGCCCGGAAATCGGCCCACCACAAGCATTCTCGCGACCAAACTCACTCCG
TCGGTGGTCGGCCAGCTCATCGCGCTCTACGAGCATCAGGTGTTCACCGAAGGCGTCGTCTGGGGTGTCGACAGCTTCGA
CCAGTGGGGCGTGGAACTCGGCAAGACCCAGGCCAAGGCGCTGCTGCCGGTCATCACCGCCGACGACTCCCCTGCCGAAC
AGTCCGACACCTCGACCGACGCGCTGGTGCGCCGCTACCGAGCGGAGCGGGGTCGCTCGGCCTGA

Upstream 100 bases:

>100_bases
CGATCCACAGTCCGGTGGGAACTGACTTCAACAGTGCGGTGGTGTCCATACATCCATCATTTACACCTTCATAACGGCGT
CCGCACTAGGGTCGGAACAC

Downstream 100 bases:

>100_bases
GGGATTTCGGCGTGCTGGGTCGCGGTAGGCGCGACCCAGCACGCCGAAATCACGCGAAGAGTCGCGTGAGCCGCGGCGGC
AGGACCCGCATCAGCTGCAC

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI [H]

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MTADDQLTDISATSAWQALQRHHGEIAGRHLRELFAEDPSRGTELTVSVGDLYIDYSKHRVTRETLRLLVDLARAAGLEK
RRDAMLSGVHINTSEDRAVLHTALRLPRDASLTVDGQDVVADVHEVLDRMGDFTDRLRSGEWTGATGERIRTVVNIGIGG
SDLGPAMVYESLRHYADAGISARFVSNVDPADLVAKLDGLDPATTLFIVASKTFSTLETLTNATAARRWLTNTLGDAAVA
RHFVAVSTNQKLVDEFGIDTANMFGFWDWVGGRYSVDSAIGLSVMAAIGRERFAEFLAGFHLVDEHFRTAPLEANAPALL
GLIGLWYSNFFGAQSRAVLPYSNDLSRFAAYLQQLTMESNGKSVRADGTPVSTDTGEIFWGEPGTNGQHAFYQLLHQGTR
LVPADFIGFSQPTDDLPTADGTGSMHDLLMSNFFAQTQVLAFGKTAEEIAAEDTPADVVPHKVMPGNRPTTSILATKLTP
SVVGQLIALYEHQVFTEGVVWGVDSFDQWGVELGKTQAKALLPVITADDSPAEQSDTSTDALVRRYRAERGRSA

Sequences:

>Translated_554_residues
MTADDQLTDISATSAWQALQRHHGEIAGRHLRELFAEDPSRGTELTVSVGDLYIDYSKHRVTRETLRLLVDLARAAGLEK
RRDAMLSGVHINTSEDRAVLHTALRLPRDASLTVDGQDVVADVHEVLDRMGDFTDRLRSGEWTGATGERIRTVVNIGIGG
SDLGPAMVYESLRHYADAGISARFVSNVDPADLVAKLDGLDPATTLFIVASKTFSTLETLTNATAARRWLTNTLGDAAVA
RHFVAVSTNQKLVDEFGIDTANMFGFWDWVGGRYSVDSAIGLSVMAAIGRERFAEFLAGFHLVDEHFRTAPLEANAPALL
GLIGLWYSNFFGAQSRAVLPYSNDLSRFAAYLQQLTMESNGKSVRADGTPVSTDTGEIFWGEPGTNGQHAFYQLLHQGTR
LVPADFIGFSQPTDDLPTADGTGSMHDLLMSNFFAQTQVLAFGKTAEEIAAEDTPADVVPHKVMPGNRPTTSILATKLTP
SVVGQLIALYEHQVFTEGVVWGVDSFDQWGVELGKTQAKALLPVITADDSPAEQSDTSTDALVRRYRAERGRSA
>Mature_553_residues
TADDQLTDISATSAWQALQRHHGEIAGRHLRELFAEDPSRGTELTVSVGDLYIDYSKHRVTRETLRLLVDLARAAGLEKR
RDAMLSGVHINTSEDRAVLHTALRLPRDASLTVDGQDVVADVHEVLDRMGDFTDRLRSGEWTGATGERIRTVVNIGIGGS
DLGPAMVYESLRHYADAGISARFVSNVDPADLVAKLDGLDPATTLFIVASKTFSTLETLTNATAARRWLTNTLGDAAVAR
HFVAVSTNQKLVDEFGIDTANMFGFWDWVGGRYSVDSAIGLSVMAAIGRERFAEFLAGFHLVDEHFRTAPLEANAPALLG
LIGLWYSNFFGAQSRAVLPYSNDLSRFAAYLQQLTMESNGKSVRADGTPVSTDTGEIFWGEPGTNGQHAFYQLLHQGTRL
VPADFIGFSQPTDDLPTADGTGSMHDLLMSNFFAQTQVLAFGKTAEEIAAEDTPADVVPHKVMPGNRPTTSILATKLTPS
VVGQLIALYEHQVFTEGVVWGVDSFDQWGVELGKTQAKALLPVITADDSPAEQSDTSTDALVRRYRAERGRSA

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family [H]

Homologues:

Organism=Homo sapiens, GI18201905, Length=563, Percent_Identity=47.9573712255773, Blast_Score=536, Evalue=1e-152,
Organism=Homo sapiens, GI296080693, Length=563, Percent_Identity=44.582593250444, Blast_Score=481, Evalue=1e-136,
Organism=Escherichia coli, GI1790457, Length=551, Percent_Identity=52.6315789473684, Blast_Score=561, Evalue=1e-161,
Organism=Caenorhabditis elegans, GI71996703, Length=548, Percent_Identity=49.6350364963504, Blast_Score=516, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI71996708, Length=553, Percent_Identity=49.1862567811935, Blast_Score=516, Evalue=1e-146,
Organism=Saccharomyces cerevisiae, GI6319673, Length=543, Percent_Identity=48.8029465930018, Blast_Score=514, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24651916, Length=558, Percent_Identity=49.8207885304659, Blast_Score=539, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24651914, Length=558, Percent_Identity=49.8207885304659, Blast_Score=539, Evalue=1e-153,
Organism=Drosophila melanogaster, GI17737445, Length=558, Percent_Identity=49.8207885304659, Blast_Score=539, Evalue=1e-153,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189 [H]

Pfam domain/function: PF00342 PGI [H]

EC number: =5.3.1.9 [H]

Molecular weight: Translated: 60256; Mature: 60125

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1 ; PS00174 P_GLUCOSE_ISOMERASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTADDQLTDISATSAWQALQRHHGEIAGRHLRELFAEDPSRGTELTVSVGDLYIDYSKHR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCEEEECHHHH
VTRETLRLLVDLARAAGLEKRRDAMLSGVHINTSEDRAVLHTALRLPRDASLTVDGQDVV
HHHHHHHHHHHHHHHHCCHHHHHHHHCCEEECCCCCHHHHHHHHHCCCCCCEEECCHHHH
ADVHEVLDRMGDFTDRLRSGEWTGATGERIRTVVNIGIGGSDLGPAMVYESLRHYADAGI
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEHEEECCCCCCCCHHHHHHHHHHHHCCCC
SARFVSNVDPADLVAKLDGLDPATTLFIVASKTFSTLETLTNATAARRWLTNTLGDAAVA
CEEHHCCCCHHHHHHHHCCCCCHHEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHFVAVSTNQKLVDEFGIDTANMFGFWDWVGGRYSVDSAIGLSVMAAIGRERFAEFLAGF
HHHHEECCCHHHHHHHCCCHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHH
HLVDEHFRTAPLEANAPALLGLIGLWYSNFFGAQSRAVLPYSNDLSRFAAYLQQLTMESN
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHCCC
GKSVRADGTPVSTDTGEIFWGEPGTNGQHAFYQLLHQGTRLVPADFIGFSQPTDDLPTAD
CCEEECCCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCC
GTGSMHDLLMSNFFAQTQVLAFGKTAEEIAAEDTPADVVPHKVMPGNRPTTSILATKLTP
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCH
SVVGQLIALYEHQVFTEGVVWGVDSFDQWGVELGKTQAKALLPVITADDSPAEQSDTSTD
HHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHCCHHHHHHEEEEECCCCCCCCCCCHHH
ALVRRYRAERGRSA
HHHHHHHHHCCCCC
>Mature Secondary Structure 
TADDQLTDISATSAWQALQRHHGEIAGRHLRELFAEDPSRGTELTVSVGDLYIDYSKHR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCEEEECHHHH
VTRETLRLLVDLARAAGLEKRRDAMLSGVHINTSEDRAVLHTALRLPRDASLTVDGQDVV
HHHHHHHHHHHHHHHHCCHHHHHHHHCCEEECCCCCHHHHHHHHHCCCCCCEEECCHHHH
ADVHEVLDRMGDFTDRLRSGEWTGATGERIRTVVNIGIGGSDLGPAMVYESLRHYADAGI
HHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEEHEEECCCCCCCCHHHHHHHHHHHHCCCC
SARFVSNVDPADLVAKLDGLDPATTLFIVASKTFSTLETLTNATAARRWLTNTLGDAAVA
CEEHHCCCCHHHHHHHHCCCCCHHEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHFVAVSTNQKLVDEFGIDTANMFGFWDWVGGRYSVDSAIGLSVMAAIGRERFAEFLAGF
HHHHEECCCHHHHHHHCCCHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHH
HLVDEHFRTAPLEANAPALLGLIGLWYSNFFGAQSRAVLPYSNDLSRFAAYLQQLTMESN
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHHHCCC
GKSVRADGTPVSTDTGEIFWGEPGTNGQHAFYQLLHQGTRLVPADFIGFSQPTDDLPTAD
CCEEECCCCCCCCCCCCEEECCCCCCHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCC
GTGSMHDLLMSNFFAQTQVLAFGKTAEEIAAEDTPADVVPHKVMPGNRPTTSILATKLTP
CCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHCCH
SVVGQLIALYEHQVFTEGVVWGVDSFDQWGVELGKTQAKALLPVITADDSPAEQSDTSTD
HHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHCCHHHHHHEEEEECCCCCCCCCCCHHH
ALVRRYRAERGRSA
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA