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The map label for this gene is paaG [H]

Identifier: 119870175

GI number: 119870175

Start: 4374317

End: 4375135

Strand: Direct

Name: paaG [H]

Synonym: Mkms_4145

Alternate gene names: 119870175

Gene position: 4374317-4375135 (Clockwise)

Preceding gene: 119870171

Following gene: 119870176

Centisome position: 76.24

GC content: 69.6

Gene sequence:

>819_bases
ATGACGACCACCGACTCCGGTACCGGCACCTACGTCAGCATCGACGATCTCATCGTGCGGCTCGACGACGGGGTGCTGTC
GGTGACGCTGAACCGGCCCGACAGCCTCAACTCGCTGACCGCCGACATGCTCAACGGCGTGGCCGATGCGCTGGACCAGG
CCGCCGGCGATCCCGCCGTGAAGGTGGTGCGACTCGGTGGCGCCGGGCGCGGGTTCAGTTCCGGCGCGGGCATCAGCGAA
GACGATCAGACGAAGAAGGCCGAGATCGGGATCAACGCCGTACTCGACGCGGCCAACCGCGCGGTGCGCGCCATCGTCGC
GGCGCCCAAACCGGTGGTCGCCGTGGTGCAGGGGCCGGCGGCCGGGGTCGGGGCCTCGCTCGCGTTGGCCAGTGATGTCG
TGATCGCCTCGGAGAAGGCGTTTTTCATGCTGGCGTTCACCAAGATCGGGTTGATGCCCGACGGTGGTGCGTCGGCGCTG
TTCGCCGCGGCGGTGGGCCGGATCCGTGCGATGCGGATGGCGCTGCTGGCCGAGCGGATCTCGGCTGCGGAGGCCTATGA
CTGGGGCCTGGTGACCGCGGTGCATTCCGCCGAGGCGTTCGACGCCGAGGTCGACAAGGTGCTGGCTGCGCTGAAGGCGG
GTCCGGCGGTGGCGCTGCGGAAGACCAAGCAGGCGATCAACGCGGCGACGCTGACCGAGCTCGAAGGCGCGCTGGGACGG
GAGAGCGAGGGTCAGCTGGAGCTGCTGGCGTCGCACGACTTCCGCGAGGGCACAAGGGCTTTCCAGGAGCGCCGCAGCGC
CTCGTTCACCGATCACTGA

Upstream 100 bases:

>100_bases
TTTCTACCGCCCCTTCGGAGTAGTTGACCGCGACATAGCTTACTTGTATAACCTTCTCGACCGGCCACGGGCTATCGGCC
CCTCATGCGAAGGTGTAGCC

Downstream 100 bases:

>100_bases
GTCGCTTCCTAACGACCACCTACCCTCTCCGAGATCCAATATCACCCGCGATAGCTGATAGCGCCCGCGACATCAGATCT
GACGAGCACCACACACCCGG

Product: enoyl-CoA hydratase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MTTTDSGTGTYVSIDDLIVRLDDGVLSVTLNRPDSLNSLTADMLNGVADALDQAAGDPAVKVVRLGGAGRGFSSGAGISE
DDQTKKAEIGINAVLDAANRAVRAIVAAPKPVVAVVQGPAAGVGASLALASDVVIASEKAFFMLAFTKIGLMPDGGASAL
FAAAVGRIRAMRMALLAERISAAEAYDWGLVTAVHSAEAFDAEVDKVLAALKAGPAVALRKTKQAINAATLTELEGALGR
ESEGQLELLASHDFREGTRAFQERRSASFTDH

Sequences:

>Translated_272_residues
MTTTDSGTGTYVSIDDLIVRLDDGVLSVTLNRPDSLNSLTADMLNGVADALDQAAGDPAVKVVRLGGAGRGFSSGAGISE
DDQTKKAEIGINAVLDAANRAVRAIVAAPKPVVAVVQGPAAGVGASLALASDVVIASEKAFFMLAFTKIGLMPDGGASAL
FAAAVGRIRAMRMALLAERISAAEAYDWGLVTAVHSAEAFDAEVDKVLAALKAGPAVALRKTKQAINAATLTELEGALGR
ESEGQLELLASHDFREGTRAFQERRSASFTDH
>Mature_271_residues
TTTDSGTGTYVSIDDLIVRLDDGVLSVTLNRPDSLNSLTADMLNGVADALDQAAGDPAVKVVRLGGAGRGFSSGAGISED
DQTKKAEIGINAVLDAANRAVRAIVAAPKPVVAVVQGPAAGVGASLALASDVVIASEKAFFMLAFTKIGLMPDGGASALF
AAAVGRIRAMRMALLAERISAAEAYDWGLVTAVHSAEAFDAEVDKVLAALKAGPAVALRKTKQAINAATLTELEGALGRE
SEGQLELLASHDFREGTRAFQERRSASFTDH

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=250, Percent_Identity=32.4, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI45643119, Length=220, Percent_Identity=33.6363636363636, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI260275230, Length=220, Percent_Identity=33.6363636363636, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI260274832, Length=220, Percent_Identity=33.6363636363636, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI4757968, Length=244, Percent_Identity=30.327868852459, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI49355787, Length=244, Percent_Identity=30.327868852459, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI25453481, Length=236, Percent_Identity=30.0847457627119, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI51538573, Length=236, Percent_Identity=30.0847457627119, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI4757966, Length=236, Percent_Identity=30.0847457627119, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI51538581, Length=236, Percent_Identity=30.0847457627119, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI221307494, Length=235, Percent_Identity=31.9148936170213, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI221136756, Length=235, Percent_Identity=31.9148936170213, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI221136753, Length=235, Percent_Identity=31.9148936170213, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI116235487, Length=234, Percent_Identity=30.7692307692308, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI37594469, Length=188, Percent_Identity=29.7872340425532, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI37594471, Length=188, Percent_Identity=29.7872340425532, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI31542718, Length=258, Percent_Identity=28.2945736434109, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI4502327, Length=271, Percent_Identity=28.7822878228782, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI70995211, Length=252, Percent_Identity=22.6190476190476, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1787660, Length=257, Percent_Identity=37.7431906614786, Blast_Score=147, Evalue=7e-37,
Organism=Escherichia coli, GI1787659, Length=257, Percent_Identity=32.295719844358, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788597, Length=258, Percent_Identity=29.8449612403101, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI221142681, Length=249, Percent_Identity=28.1124497991968, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17535521, Length=260, Percent_Identity=28.4615384615385, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI25145438, Length=248, Percent_Identity=29.4354838709677, Blast_Score=103, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17554946, Length=242, Percent_Identity=30.5785123966942, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17549921, Length=235, Percent_Identity=27.2340425531915, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17540714, Length=245, Percent_Identity=29.7959183673469, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17536985, Length=262, Percent_Identity=25.1908396946565, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17534483, Length=251, Percent_Identity=28.2868525896414, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24654903, Length=261, Percent_Identity=27.9693486590038, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI20129971, Length=245, Percent_Identity=29.7959183673469, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24653477, Length=245, Percent_Identity=29.7959183673469, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI19922422, Length=255, Percent_Identity=25.8823529411765, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI19920382, Length=180, Percent_Identity=25.5555555555556, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24653139, Length=272, Percent_Identity=29.0441176470588, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR011968 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 27963; Mature: 27832

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTDSGTGTYVSIDDLIVRLDDGVLSVTLNRPDSLNSLTADMLNGVADALDQAAGDPAV
CCCCCCCCCCEEEHHHEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCE
KVVRLGGAGRGFSSGAGISEDDQTKKAEIGINAVLDAANRAVRAIVAAPKPVVAVVQGPA
EEEEECCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
AGVGASLALASDVVIASEKAFFMLAFTKIGLMPDGGASALFAAAVGRIRAMRMALLAERI
CCCCHHHHHHHHEEEECCCCEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SAAEAYDWGLVTAVHSAEAFDAEVDKVLAALKAGPAVALRKTKQAINAATLTELEGALGR
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
ESEGQLELLASHDFREGTRAFQERRSASFTDH
CCCCCEEEEECCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TTTDSGTGTYVSIDDLIVRLDDGVLSVTLNRPDSLNSLTADMLNGVADALDQAAGDPAV
CCCCCCCCCEEEHHHEEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCE
KVVRLGGAGRGFSSGAGISEDDQTKKAEIGINAVLDAANRAVRAIVAAPKPVVAVVQGPA
EEEEECCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
AGVGASLALASDVVIASEKAFFMLAFTKIGLMPDGGASALFAAAVGRIRAMRMALLAERI
CCCCHHHHHHHHEEEECCCCEEEEEEHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
SAAEAYDWGLVTAVHSAEAFDAEVDKVLAALKAGPAVALRKTKQAINAATLTELEGALGR
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
ESEGQLELLASHDFREGTRAFQERRSASFTDH
CCCCCEEEEECCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]