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The map label for this gene is kgd

Identifier: 119870077

GI number: 119870077

Start: 4271732

End: 4275541

Strand: Direct

Name: kgd

Synonym: Mkms_4047

Alternate gene names: 119870077

Gene position: 4271732-4275541 (Clockwise)

Preceding gene: 119870076

Following gene: 119870079

Centisome position: 74.46

GC content: 66.3

Gene sequence:

>3810_bases
GTGAGCAGTTCACCTTCACCATTCGGCCAGAACGAATGGTTGGTCGAGGAGATGTATCGCAAGTTCCGCGAGGATCCCTC
GTCGGTAGACCCCAGTTGGCACGAGTTCCTCGTCGACTACAACCCGGAACCGACCACCGACTCCAGCGCGAGCGAGAACG
GTCAGCAGACGCGCACCGCGGCGCCCAAGGCCCCGCCGGAGCCGGCGCCCGCCCCGGCGCCGAAGACGCCGGACTCGAAG
ACGCCGGACTCGAAGTCGCAGGCCCCCAAGCAGGATTCGAAGCCTCAGGAGTCCAAGCCGCAGGCGAAAGCCAAGCCCGC
CGAATCGAAGTCGTCGACCAAGCCGGCCGACGCCAAATCCGAGAAATCCGGCAAGTCGGGCACCAACGGCGCCGCCAAAC
CCGCCGCCCAGCCTGCCGACGACAGCGATCAGAACCAGGTGCTGCGCGGCGCGGCCGCGGCCGTCGCCAAGAACATGTCG
GCGTCTCTGGACGTGCCCACCGCGACCAGCGTGCGCGCCATCCCGGCGAAGCTGATGATCGACAACCGCGTCGTCATCAA
CAACCACCTCAAGCGCACCCGCGGCGGCAAGATCAGCTTCACCCACCTGATCGGCTATGCGATCGTGGCGGCGGTCAAGA
AGTTCCCGAACATGAACCGTCACTTCGCCGAGGTCGACGGCAAGCCCAACGCGGTCACCCCGGCGCACACGAACCTGGGC
CTGGCGATCGACCTGCAGGGCAAGGACGGTAACCGGCAACTGGTGGTCGCGGCCATCAAGAAGGCCGACACCATGCGGTT
CGGCCAGTTCATCGCCGCGTACGAGGACATCGTGCGGCGCGCGCGCGACGGCAAGCTCACCGCCGAGGACTTCTCCGGTG
TGACGATCTCGCTGACCAACCCGGGGACCATCGGCACCGTGCACTCGGTGCCGCGGCTGATGCGCGGTCAGGGCGCGATC
ATCGGCGTCGGCGCGATGGAGTACCCGGCGGAGTTCCAGGGGGCCAGCGAGGAACGCATCGCCGACCTCGGCATCGGCAA
ACTCATCACGCTGACGTCGACCTATGACCACCGCATCATCCAGGGCGCGGAATCCGGTGACTTCCTGCGGACCGTGCACC
AGCTGCTGCTGTCCGACGACTTCTTCGACGAGATCTTCCGCGAACTCGGCATCCCGTACGAGCCGGTGCGCTGGCGCACC
GACAACCCCGATTCGATCGAAGACAAGAACGCCCGCGTCATCGAACTGATCGCGGCCTACCGCAACCGCGGCCACCTGAT
GGCCGACATCGACCCGCTCCGGTTGGACAGCAACCGCTTCCGCAGCCACCCCGACCTCGACGTGCTCACCCACGGGCTGA
CGCTGTGGGATCTGGACCGCGAGTTCAAGGTCAACGGATTCGCCGGTGCTGAGCGCAAGAAGCTGCGCGACGTGCTCGCC
GTGCTGCGCGACGCCTACTGCCGCCACATCGGCGTCGAGTACACCCACATCCTCGAACCCGAACAGCAGCAGTGGCTGCA
GGAGCGCATCGAGGGCAAACACGAGAAGCCCACCGTCGCGCAGCAGAAGTACATCCTGAGCCGGCTCAACGCCGCCGAGG
CCTTCGAAACCTTCCTGCAGACCAAATACGTTGGGCAGAAACGGTTCTCGCTCGAGGGCGCGGAGACCGTCATCCCGGCG
ATGGACGCGGTGATCGACCAGTGCGCCGAGCATGCGCTCGACGAGGTCGTCATCGGTATGCCGCACCGCGGCCGGCTCAA
CGTGCTGGCCAACATCGTCGGCAAGCCCTACAGCCAGATCTTCAGCGAGTTCGAGGGCAACCTCAACCCGTCGCAGGCGC
ACGGCTCCGGCGACGTGAAGTACCACCTCGGCTCCAGCGGCACCTACCTGCAGATGTTCGGCGACAACGACATCACGGTG
TCGCTGACGGCCAACCCCAGCCACCTCGAGGCCGTCGACCCGGTGATGGAGGGCCTGGTCCGCGCCAAACAGGATCTGCT
CGACAAGGGCGACACCGAGGACGGATACACCGTCGTCCCGCTGATGCTGCACGGCGACGCCGCATTCGCCGGACAGGGTG
TGGTGGCCGAGACGCTGAACCTGGCGCTGCTGCGGGGCTACCGCACCGGCGGCACCATCCACCTGATCGTCAACAACCAG
ATCGGCTTCACCACGTCGCCGGCGGCCGCGAAGTCGTCGGAGTACTGCACCGACGTGGCGAAGATGATCGGTGCGCCGAT
CTTCCACGTCAACGGCGACGATCCCGAGGCCGCGGTGTGGGTGTCCAGGCTGGCCGTCGACTTCCGGCAGAAGTTCAAGA
AGGACGTCGTCATCGACCTGCTGTGCTACCGCCGCCGCGGGCACAACGAGGGTGACGACCCGTCGATGACCCAGCCGTCG
ATGTACGACGTGATCGACACCAAACGCGGGGTCCGCAAGAGCTACACCGAAGCACTGATCGGCCGCGGCGACATCTCCAT
GAAAGAGGCCGAGGACGCCCTGCGCGACTACCAGGGTCAGCTGGAGCAGGTCTTCAACGAGGTCCGCGAGCTGGAGAAGC
ACGAGATCGAGCCCAGCGAATCAGTGGAAGCCGACCAGCAGATCCCGGCCAAACTCGCCACCGCGGTGGACAAATCGCTG
CTGGCCCGCATCGGCGACGCCCACCTGGCGGTGCCGGAGGGTTTCACCGTGCACCCCCGCGTCAAGCCGGTGCTCGAGAA
GCGTCGCGAGATGGCCTACGAGGGCAAGGTCGACTGGGCGTTCGCCGAACTGCTGGCCCTGGGCACCATGATCTCCGAGG
GCAAACTGGTCCGGCTCAGCGGTCAGGACACCCGCCGCGGCACGTTCACCCAGCGGCACTCGGTGGTGATCGACCGCAAG
ACCGGCAAGGAGTTCACGCCGCTGCAGCTGCTGGCGACCGACTCCGACGGCAACCCGACCGGCGGCAAGTTCCTGGTGTA
CGACTCGCCGCTGTCGGAGTTCGCCGCGGTGGGCTTCGAGTACGGGTACTCCGTCGGCAACCCGGACGCAATGGTGTTGT
GGGAGGCGCAGTTCGGCGACTTCATCAACGGCGCCCAGTCGATCATCGACGAGTTCATCAGTTCGGGTGAGGCCAAGTGG
GGTCAGCTCTCCGACGTCGTGCTGCTGCTGCCGCACGGCCACGAGGGTCAGGGCCCCGACCACACCTCGGGCCGCATCGA
ACGGTTCCTGCAGCTGTGGGCCGAAGGGTCGATGACGATCGCGCTGCCGTCGACCCCGGCGAACTATTTCCACCTGCTGC
GCAGGCACAGCCTCGACGGGATCCAGCGGCCGCTGATCGTCTTCACGCCGAAGTCGATGCTGCGCAACAAGGCCGCGGTG
TCCGACATCCGCGACTTCACCGAGCAGAAGTTCCGCTCGGTGCTCGAGGAGCCGACCTACACCGACGGCGACGGCGACCG
CAACAAGGTCACGCGGATCCTGCTCACCAGCGGCAAGATCTACTACGAGCTGGTGGCGCGCAAGAACAAGGAGAGCCGCG
ACGACGTGGCGATCGTGCGCATCGAACAGCTCGCACCGCTGCCCAAACGGCGGCTGGCCGAGACGCTGGACAAGTACCCG
AACGTCGAGGAGAAGTTCTGGGTGCAGGAGGAGCCGGCCAACCAGGGTGCATGGCCCACGTTCGGGCTGACGTTGCCCGA
GATGCTGCCGGACCACTTCACCGGCATCAAGCGGATCTCGCGACGCGCGATGTCGGCGCCGTCGTCGGGTTCGTCGAAGG
TGCACGCCGTCGAACAGCAGGAGATCCTCGACGAGGCCTTCGCCCCGTAG

Upstream 100 bases:

>100_bases
TTAGGCGGCGCCAAAGCGGGTAACCCGCAGAACAGAACATGAGCGGCGAGCATCCTTGCCATGCTCGCCTGAGACGACGG
AATCGAGGCGAGTAGCTGCC

Downstream 100 bases:

>100_bases
GACAGCGCAGCGGGTGCCGGCGGACTACAGGCCGGGGAGCGGAAGCGGCGACTTGCCGTAGGCGAGCGCCGCGACCGCGC
CCGGGCAGAACACCTGGATC

Product: alpha-ketoglutarate decarboxylase

Products: NA

Alternate protein names: 2-oxoglutarate carboxy-lyase; Alpha-ketoglutarate decarboxylase

Number of amino acids: Translated: 1269; Mature: 1268

Protein sequence:

>1269_residues
MSSSPSPFGQNEWLVEEMYRKFREDPSSVDPSWHEFLVDYNPEPTTDSSASENGQQTRTAAPKAPPEPAPAPAPKTPDSK
TPDSKSQAPKQDSKPQESKPQAKAKPAESKSSTKPADAKSEKSGKSGTNGAAKPAAQPADDSDQNQVLRGAAAAVAKNMS
ASLDVPTATSVRAIPAKLMIDNRVVINNHLKRTRGGKISFTHLIGYAIVAAVKKFPNMNRHFAEVDGKPNAVTPAHTNLG
LAIDLQGKDGNRQLVVAAIKKADTMRFGQFIAAYEDIVRRARDGKLTAEDFSGVTISLTNPGTIGTVHSVPRLMRGQGAI
IGVGAMEYPAEFQGASEERIADLGIGKLITLTSTYDHRIIQGAESGDFLRTVHQLLLSDDFFDEIFRELGIPYEPVRWRT
DNPDSIEDKNARVIELIAAYRNRGHLMADIDPLRLDSNRFRSHPDLDVLTHGLTLWDLDREFKVNGFAGAERKKLRDVLA
VLRDAYCRHIGVEYTHILEPEQQQWLQERIEGKHEKPTVAQQKYILSRLNAAEAFETFLQTKYVGQKRFSLEGAETVIPA
MDAVIDQCAEHALDEVVIGMPHRGRLNVLANIVGKPYSQIFSEFEGNLNPSQAHGSGDVKYHLGSSGTYLQMFGDNDITV
SLTANPSHLEAVDPVMEGLVRAKQDLLDKGDTEDGYTVVPLMLHGDAAFAGQGVVAETLNLALLRGYRTGGTIHLIVNNQ
IGFTTSPAAAKSSEYCTDVAKMIGAPIFHVNGDDPEAAVWVSRLAVDFRQKFKKDVVIDLLCYRRRGHNEGDDPSMTQPS
MYDVIDTKRGVRKSYTEALIGRGDISMKEAEDALRDYQGQLEQVFNEVRELEKHEIEPSESVEADQQIPAKLATAVDKSL
LARIGDAHLAVPEGFTVHPRVKPVLEKRREMAYEGKVDWAFAELLALGTMISEGKLVRLSGQDTRRGTFTQRHSVVIDRK
TGKEFTPLQLLATDSDGNPTGGKFLVYDSPLSEFAAVGFEYGYSVGNPDAMVLWEAQFGDFINGAQSIIDEFISSGEAKW
GQLSDVVLLLPHGHEGQGPDHTSGRIERFLQLWAEGSMTIALPSTPANYFHLLRRHSLDGIQRPLIVFTPKSMLRNKAAV
SDIRDFTEQKFRSVLEEPTYTDGDGDRNKVTRILLTSGKIYYELVARKNKESRDDVAIVRIEQLAPLPKRRLAETLDKYP
NVEEKFWVQEEPANQGAWPTFGLTLPEMLPDHFTGIKRISRRAMSAPSSGSSKVHAVEQQEILDEAFAP

Sequences:

>Translated_1269_residues
MSSSPSPFGQNEWLVEEMYRKFREDPSSVDPSWHEFLVDYNPEPTTDSSASENGQQTRTAAPKAPPEPAPAPAPKTPDSK
TPDSKSQAPKQDSKPQESKPQAKAKPAESKSSTKPADAKSEKSGKSGTNGAAKPAAQPADDSDQNQVLRGAAAAVAKNMS
ASLDVPTATSVRAIPAKLMIDNRVVINNHLKRTRGGKISFTHLIGYAIVAAVKKFPNMNRHFAEVDGKPNAVTPAHTNLG
LAIDLQGKDGNRQLVVAAIKKADTMRFGQFIAAYEDIVRRARDGKLTAEDFSGVTISLTNPGTIGTVHSVPRLMRGQGAI
IGVGAMEYPAEFQGASEERIADLGIGKLITLTSTYDHRIIQGAESGDFLRTVHQLLLSDDFFDEIFRELGIPYEPVRWRT
DNPDSIEDKNARVIELIAAYRNRGHLMADIDPLRLDSNRFRSHPDLDVLTHGLTLWDLDREFKVNGFAGAERKKLRDVLA
VLRDAYCRHIGVEYTHILEPEQQQWLQERIEGKHEKPTVAQQKYILSRLNAAEAFETFLQTKYVGQKRFSLEGAETVIPA
MDAVIDQCAEHALDEVVIGMPHRGRLNVLANIVGKPYSQIFSEFEGNLNPSQAHGSGDVKYHLGSSGTYLQMFGDNDITV
SLTANPSHLEAVDPVMEGLVRAKQDLLDKGDTEDGYTVVPLMLHGDAAFAGQGVVAETLNLALLRGYRTGGTIHLIVNNQ
IGFTTSPAAAKSSEYCTDVAKMIGAPIFHVNGDDPEAAVWVSRLAVDFRQKFKKDVVIDLLCYRRRGHNEGDDPSMTQPS
MYDVIDTKRGVRKSYTEALIGRGDISMKEAEDALRDYQGQLEQVFNEVRELEKHEIEPSESVEADQQIPAKLATAVDKSL
LARIGDAHLAVPEGFTVHPRVKPVLEKRREMAYEGKVDWAFAELLALGTMISEGKLVRLSGQDTRRGTFTQRHSVVIDRK
TGKEFTPLQLLATDSDGNPTGGKFLVYDSPLSEFAAVGFEYGYSVGNPDAMVLWEAQFGDFINGAQSIIDEFISSGEAKW
GQLSDVVLLLPHGHEGQGPDHTSGRIERFLQLWAEGSMTIALPSTPANYFHLLRRHSLDGIQRPLIVFTPKSMLRNKAAV
SDIRDFTEQKFRSVLEEPTYTDGDGDRNKVTRILLTSGKIYYELVARKNKESRDDVAIVRIEQLAPLPKRRLAETLDKYP
NVEEKFWVQEEPANQGAWPTFGLTLPEMLPDHFTGIKRISRRAMSAPSSGSSKVHAVEQQEILDEAFAP
>Mature_1268_residues
SSSPSPFGQNEWLVEEMYRKFREDPSSVDPSWHEFLVDYNPEPTTDSSASENGQQTRTAAPKAPPEPAPAPAPKTPDSKT
PDSKSQAPKQDSKPQESKPQAKAKPAESKSSTKPADAKSEKSGKSGTNGAAKPAAQPADDSDQNQVLRGAAAAVAKNMSA
SLDVPTATSVRAIPAKLMIDNRVVINNHLKRTRGGKISFTHLIGYAIVAAVKKFPNMNRHFAEVDGKPNAVTPAHTNLGL
AIDLQGKDGNRQLVVAAIKKADTMRFGQFIAAYEDIVRRARDGKLTAEDFSGVTISLTNPGTIGTVHSVPRLMRGQGAII
GVGAMEYPAEFQGASEERIADLGIGKLITLTSTYDHRIIQGAESGDFLRTVHQLLLSDDFFDEIFRELGIPYEPVRWRTD
NPDSIEDKNARVIELIAAYRNRGHLMADIDPLRLDSNRFRSHPDLDVLTHGLTLWDLDREFKVNGFAGAERKKLRDVLAV
LRDAYCRHIGVEYTHILEPEQQQWLQERIEGKHEKPTVAQQKYILSRLNAAEAFETFLQTKYVGQKRFSLEGAETVIPAM
DAVIDQCAEHALDEVVIGMPHRGRLNVLANIVGKPYSQIFSEFEGNLNPSQAHGSGDVKYHLGSSGTYLQMFGDNDITVS
LTANPSHLEAVDPVMEGLVRAKQDLLDKGDTEDGYTVVPLMLHGDAAFAGQGVVAETLNLALLRGYRTGGTIHLIVNNQI
GFTTSPAAAKSSEYCTDVAKMIGAPIFHVNGDDPEAAVWVSRLAVDFRQKFKKDVVIDLLCYRRRGHNEGDDPSMTQPSM
YDVIDTKRGVRKSYTEALIGRGDISMKEAEDALRDYQGQLEQVFNEVRELEKHEIEPSESVEADQQIPAKLATAVDKSLL
ARIGDAHLAVPEGFTVHPRVKPVLEKRREMAYEGKVDWAFAELLALGTMISEGKLVRLSGQDTRRGTFTQRHSVVIDRKT
GKEFTPLQLLATDSDGNPTGGKFLVYDSPLSEFAAVGFEYGYSVGNPDAMVLWEAQFGDFINGAQSIIDEFISSGEAKWG
QLSDVVLLLPHGHEGQGPDHTSGRIERFLQLWAEGSMTIALPSTPANYFHLLRRHSLDGIQRPLIVFTPKSMLRNKAAVS
DIRDFTEQKFRSVLEEPTYTDGDGDRNKVTRILLTSGKIYYELVARKNKESRDDVAIVRIEQLAPLPKRRLAETLDKYPN
VEEKFWVQEEPANQGAWPTFGLTLPEMLPDHFTGIKRISRRAMSAPSSGSSKVHAVEQQEILDEAFAP

Specific function: Catalyzes an oxidative decarboxylation from five-carbon 2-oxoglutarate (alpha-ketoglutarate) to four-carbon succinate semialdehyde

COG id: COG0567

COG function: function code C; 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 2-oxoacid dehydrogenase family. Kgd subfamily

Homologues:

Organism=Homo sapiens, GI259013553, Length=916, Percent_Identity=41.8122270742358, Blast_Score=675, Evalue=0.0,
Organism=Homo sapiens, GI51873036, Length=920, Percent_Identity=41.5217391304348, Blast_Score=671, Evalue=0.0,
Organism=Homo sapiens, GI221316661, Length=925, Percent_Identity=41.2972972972973, Blast_Score=664, Evalue=0.0,
Organism=Homo sapiens, GI221316665, Length=906, Percent_Identity=41.0596026490066, Blast_Score=654, Evalue=0.0,
Organism=Homo sapiens, GI221316669, Length=812, Percent_Identity=42.3645320197044, Blast_Score=617, Evalue=1e-176,
Organism=Homo sapiens, GI38788380, Length=912, Percent_Identity=37.390350877193, Blast_Score=579, Evalue=1e-165,
Organism=Homo sapiens, GI51873038, Length=295, Percent_Identity=41.6949152542373, Blast_Score=208, Evalue=2e-53,
Organism=Escherichia coli, GI1786945, Length=892, Percent_Identity=43.609865470852, Blast_Score=715, Evalue=0.0,
Organism=Escherichia coli, GI1786946, Length=222, Percent_Identity=29.2792792792793, Blast_Score=87, Evalue=5e-18,
Organism=Escherichia coli, GI1786305, Length=186, Percent_Identity=27.4193548387097, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17542494, Length=903, Percent_Identity=41.4174972314507, Blast_Score=662, Evalue=0.0,
Organism=Caenorhabditis elegans, GI72001668, Length=900, Percent_Identity=36.4444444444444, Blast_Score=548, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6322066, Length=904, Percent_Identity=40.8185840707965, Blast_Score=662, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320352, Length=326, Percent_Identity=23.9263803680982, Blast_Score=82, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6324258, Length=182, Percent_Identity=25.8241758241758, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24665669, Length=918, Percent_Identity=40.1960784313725, Blast_Score=639, Evalue=0.0,
Organism=Drosophila melanogaster, GI24665673, Length=918, Percent_Identity=40.1960784313725, Blast_Score=639, Evalue=0.0,
Organism=Drosophila melanogaster, GI24665677, Length=918, Percent_Identity=40.1960784313725, Blast_Score=639, Evalue=0.0,
Organism=Drosophila melanogaster, GI28574592, Length=918, Percent_Identity=40.1960784313725, Blast_Score=639, Evalue=0.0,
Organism=Drosophila melanogaster, GI28574590, Length=927, Percent_Identity=40.3451995685005, Blast_Score=638, Evalue=0.0,
Organism=Drosophila melanogaster, GI161084450, Length=927, Percent_Identity=40.3451995685005, Blast_Score=638, Evalue=0.0,
Organism=Drosophila melanogaster, GI161084461, Length=864, Percent_Identity=41.4351851851852, Blast_Score=630, Evalue=1e-180,
Organism=Drosophila melanogaster, GI281365454, Length=916, Percent_Identity=39.1921397379913, Blast_Score=616, Evalue=1e-176,
Organism=Drosophila melanogaster, GI281365452, Length=916, Percent_Identity=39.1921397379913, Blast_Score=616, Evalue=1e-176,
Organism=Drosophila melanogaster, GI78706592, Length=916, Percent_Identity=39.1921397379913, Blast_Score=615, Evalue=1e-176,
Organism=Drosophila melanogaster, GI78706596, Length=916, Percent_Identity=39.1921397379913, Blast_Score=615, Evalue=1e-176,
Organism=Drosophila melanogaster, GI78706594, Length=938, Percent_Identity=38.3795309168444, Blast_Score=602, Evalue=1e-172,
Organism=Drosophila melanogaster, GI78706598, Length=938, Percent_Identity=38.3795309168444, Blast_Score=602, Evalue=1e-172,
Organism=Drosophila melanogaster, GI24651589, Length=918, Percent_Identity=35.5119825708061, Blast_Score=522, Evalue=1e-148,
Organism=Drosophila melanogaster, GI161079314, Length=758, Percent_Identity=38.7862796833773, Blast_Score=489, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24651591, Length=758, Percent_Identity=38.7862796833773, Blast_Score=489, Evalue=1e-138,

Paralogues:

None

Copy number: 1200 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): KGD_MYCSK (A1UK81)

Other databases:

- EMBL:   CP000518
- RefSeq:   YP_940029.1
- ProteinModelPortal:   A1UK81
- STRING:   A1UK81
- EnsemblBacteria:   EBMYCT00000058396
- GeneID:   4611987
- GenomeReviews:   CP000518_GR
- KEGG:   mkm:Mkms_4047
- eggNOG:   COG0567
- GeneTree:   EBGT00050000014858
- HOGENOM:   HBG289950
- OMA:   EGDEPAF
- ProtClustDB:   PRK12270
- BioCyc:   MSP189918:MKMS_4047-MONOMER
- GO:   GO:0006096
- InterPro:   IPR001078
- InterPro:   IPR011603
- InterPro:   IPR023213
- InterPro:   IPR001017
- InterPro:   IPR005475
- Gene3D:   G3DSA:3.30.559.10
- PANTHER:   PTHR23152
- PIRSF:   PIRSF000157
- SMART:   SM00861
- TIGRFAMs:   TIGR00239

Pfam domain/function: PF00198 2-oxoacid_dh; PF00676 E1_dh; PF02779 Transket_pyr

EC number: =4.1.1.71

Molecular weight: Translated: 140120; Mature: 139989

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSPSPFGQNEWLVEEMYRKFREDPSSVDPSWHEFLVDYNPEPTTDSSASENGQQTRTA
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHEEECCCCCCCCCCCCCCCCHHHCC
APKAPPEPAPAPAPKTPDSKTPDSKSQAPKQDSKPQESKPQAKAKPAESKSSTKPADAKS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
EKSGKSGTNGAAKPAAQPADDSDQNQVLRGAAAAVAKNMSASLDVPTATSVRAIPAKLMI
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCEEEE
DNRVVINNHLKRTRGGKISFTHLIGYAIVAAVKKFPNMNRHFAEVDGKPNAVTPAHTNLG
CCEEEECCHHHHCCCCCEEHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCE
LAIDLQGKDGNRQLVVAAIKKADTMRFGQFIAAYEDIVRRARDGKLTAEDFSGVTISLTN
EEEEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCEEEEECC
PGTIGTVHSVPRLMRGQGAIIGVGAMEYPAEFQGASEERIADLGIGKLITLTSTYDHRII
CCCCCHHHHHHHHHCCCCCEEECCCCCCCHHHCCCCHHHHHHCCCCCEEEEECCCCHHHH
QGAESGDFLRTVHQLLLSDDFFDEIFRELGIPYEPVRWRTDNPDSIEDKNARVIELIAAY
CCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
RNRGHLMADIDPLRLDSNRFRSHPDLDVLTHGLTLWDLDREFKVNGFAGAERKKLRDVLA
HCCCCEEECCCCEEECHHHHCCCCCHHHHHCCCEEEECCCCEEECCCCCHHHHHHHHHHH
VLRDAYCRHIGVEYTHILEPEQQQWLQERIEGKHEKPTVAQQKYILSRLNAAEAFETFLQ
HHHHHHHHHCCCCHHEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TKYVGQKRFSLEGAETVIPAMDAVIDQCAEHALDEVVIGMPHRGRLNVLANIVGKPYSQI
HHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHH
FSEFEGNLNPSQAHGSGDVKYHLGSSGTYLQMFGDNDITVSLTANPSHLEAVDPVMEGLV
HHHHCCCCCCCCCCCCCCEEEEECCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHH
RAKQDLLDKGDTEDGYTVVPLMLHGDAAFAGQGVVAETLNLALLRGYRTGGTIHLIVNNQ
HHHHHHHHCCCCCCCEEEEEEEEECCCHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEECC
IGFTTSPAAAKSSEYCTDVAKMIGAPIFHVNGDDPEAAVWVSRLAVDFRQKFKKDVVIDL
CCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LCYRRRGHNEGDDPSMTQPSMYDVIDTKRGVRKSYTEALIGRGDISMKEAEDALRDYQGQ
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LEQVFNEVRELEKHEIEPSESVEADQQIPAKLATAVDKSLLARIGDAHLAVPEGFTVHPR
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEECCC
VKPVLEKRREMAYEGKVDWAFAELLALGTMISEGKLVRLSGQDTRRGTFTQRHSVVIDRK
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEEEECC
TGKEFTPLQLLATDSDGNPTGGKFLVYDSPLSEFAAVGFEYGYSVGNPDAMVLWEAQFGD
CCCCCCCEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCEEEEEECHHCH
FINGAQSIIDEFISSGEAKWGQLSDVVLLLPHGHEGQGPDHTSGRIERFLQLWAEGSMTI
HHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEE
ALPSTPANYFHLLRRHSLDGIQRPLIVFTPKSMLRNKAAVSDIRDFTEQKFRSVLEEPTY
EECCCCHHHHHHHHHHCCCHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TDGDGDRNKVTRILLTSGKIYYELVARKNKESRDDVAIVRIEQLAPLPKRRLAETLDKYP
CCCCCCHHHEEEEEEECCCEEEHHHHHCCCCCCCCEEEEEEHHHCCCCHHHHHHHHHHCC
NVEEKFWVQEEPANQGAWPTFGLTLPEMLPDHFTGIKRISRRAMSAPSSGSSKVHAVEQQ
CCCHHEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHH
EILDEAFAP
HHHHHHCCC
>Mature Secondary Structure 
SSSPSPFGQNEWLVEEMYRKFREDPSSVDPSWHEFLVDYNPEPTTDSSASENGQQTRTA
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHEEECCCCCCCCCCCCCCCCHHHCC
APKAPPEPAPAPAPKTPDSKTPDSKSQAPKQDSKPQESKPQAKAKPAESKSSTKPADAKS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
EKSGKSGTNGAAKPAAQPADDSDQNQVLRGAAAAVAKNMSASLDVPTATSVRAIPAKLMI
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCEEEE
DNRVVINNHLKRTRGGKISFTHLIGYAIVAAVKKFPNMNRHFAEVDGKPNAVTPAHTNLG
CCEEEECCHHHHCCCCCEEHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCE
LAIDLQGKDGNRQLVVAAIKKADTMRFGQFIAAYEDIVRRARDGKLTAEDFSGVTISLTN
EEEEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCEEEEECC
PGTIGTVHSVPRLMRGQGAIIGVGAMEYPAEFQGASEERIADLGIGKLITLTSTYDHRII
CCCCCHHHHHHHHHCCCCCEEECCCCCCCHHHCCCCHHHHHHCCCCCEEEEECCCCHHHH
QGAESGDFLRTVHQLLLSDDFFDEIFRELGIPYEPVRWRTDNPDSIEDKNARVIELIAAY
CCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHH
RNRGHLMADIDPLRLDSNRFRSHPDLDVLTHGLTLWDLDREFKVNGFAGAERKKLRDVLA
HCCCCEEECCCCEEECHHHHCCCCCHHHHHCCCEEEECCCCEEECCCCCHHHHHHHHHHH
VLRDAYCRHIGVEYTHILEPEQQQWLQERIEGKHEKPTVAQQKYILSRLNAAEAFETFLQ
HHHHHHHHHCCCCHHEECCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
TKYVGQKRFSLEGAETVIPAMDAVIDQCAEHALDEVVIGMPHRGRLNVLANIVGKPYSQI
HHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHH
FSEFEGNLNPSQAHGSGDVKYHLGSSGTYLQMFGDNDITVSLTANPSHLEAVDPVMEGLV
HHHHCCCCCCCCCCCCCCEEEEECCCCCEEEEECCCCEEEEEECCCHHHHHHHHHHHHHH
RAKQDLLDKGDTEDGYTVVPLMLHGDAAFAGQGVVAETLNLALLRGYRTGGTIHLIVNNQ
HHHHHHHHCCCCCCCEEEEEEEEECCCHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEECC
IGFTTSPAAAKSSEYCTDVAKMIGAPIFHVNGDDPEAAVWVSRLAVDFRQKFKKDVVIDL
CCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LCYRRRGHNEGDDPSMTQPSMYDVIDTKRGVRKSYTEALIGRGDISMKEAEDALRDYQGQ
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LEQVFNEVRELEKHEIEPSESVEADQQIPAKLATAVDKSLLARIGDAHLAVPEGFTVHPR
HHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEECCC
VKPVLEKRREMAYEGKVDWAFAELLALGTMISEGKLVRLSGQDTRRGTFTQRHSVVIDRK
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEEEECC
TGKEFTPLQLLATDSDGNPTGGKFLVYDSPLSEFAAVGFEYGYSVGNPDAMVLWEAQFGD
CCCCCCCEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCEEEEEECHHCH
FINGAQSIIDEFISSGEAKWGQLSDVVLLLPHGHEGQGPDHTSGRIERFLQLWAEGSMTI
HHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCEEE
ALPSTPANYFHLLRRHSLDGIQRPLIVFTPKSMLRNKAAVSDIRDFTEQKFRSVLEEPTY
EECCCCHHHHHHHHHHCCCHHCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TDGDGDRNKVTRILLTSGKIYYELVARKNKESRDDVAIVRIEQLAPLPKRRLAETLDKYP
CCCCCCHHHEEEEEEECCCEEEHHHHHCCCCCCCCEEEEEEHHHCCCCHHHHHHHHHHCC
NVEEKFWVQEEPANQGAWPTFGLTLPEMLPDHFTGIKRISRRAMSAPSSGSSKVHAVEQQ
CCCHHEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEHHHHH
EILDEAFAP
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA