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The map label for this gene is fdhA [H]

Identifier: 119870046

GI number: 119870046

Start: 4236393

End: 4238558

Strand: Direct

Name: fdhA [H]

Synonym: Mkms_4016

Alternate gene names: 119870046

Gene position: 4236393-4238558 (Clockwise)

Preceding gene: 119870045

Following gene: 119870049

Centisome position: 73.84

GC content: 70.27

Gene sequence:

>2166_bases
ATGCCCAGCACCACCGTGCACACCTTCTGCCATTACTGTCTGGCGTCGTGCGGGGTCGAGGTGACCGTCGAGGACAACCG
GGTCCGCAAGATCTCCGCCGACCGGCTCAACCCGCACAGCTGGCACGACTTCTGCGCGAAGGGGCGCACCGCGGCGGAAC
TCGTCGACCACCCCCGCCGGATCCGCGCGCCGATGCGGCGGGTCGGTGACCGCTACGTCGAGGCGACCTGGGACGAGGCG
ATCACCGACATCGCCGCGCGGATGAACGCGGCGATCGAGGCCGACGGCCCCGACGCGGTCGGCGCCTACTACGGCAACCC
GACCGGGTTCTCGGGGTCCAACGTCATCTTCATGAACGCCTGGCTCGACGCCGTCGGCACCCACAACCGCTACTTCGTCG
GCTCGGTCGACCAGAACGCGATGCACGTCGTCGCCGAGGCGATGTACGGCTCGATGCTGATGGCGCCGGTGTCCGACATC
GACAACTGTGACTACTTCCTGCTCGTCGGCACGAATCCCGCTGTGAGTGCGTGGAATTGGCTGGAGACGGTGCCCGGCGG
GTGGCGGCGGGCGCTGGAGCGCCAGAAGCGGGGCGCGACGCTGGTGGTGGTCGACCCGGTCCGCACCGAGAGTGCCGACC
ATGCCGATGTGCACCTCGCGATCCGGCCGGGTCAGGACTGGGCGCTGCTGCTGGCGATGGTGAAAGTCGTTCTGGACGAA
GGGCTCGAGCACCGCGGCGACTGCACCGACCTCGCGGTCGGGGTGCCCGAGCTGCGCAGCCTGGTCGCCGAGGCCGACCT
GGACGACCTCGCACAACGCTGCGGTGTCGACCGCGCGACGATCGAACGGGTGGCGCGCGACTTCGCGGCGGCCCGGGGCG
CGATGGTGGTGACCCGCACCGGGGTGTCGCTGCACGCGGCGGGCACGGTCGCCGAATGGCTCGGCCACGTGCTCAACGTC
ATCACCGGCCGGATGGACCGGCCCGGCGGACGGCGATTCGAACCTGGCTATGTCGACGCGCTGCGACTCGCCGCGCTGGC
GAAGGGCAAACCGCATGTGAGCCGGGTGGCCGGGCGTGAGATGGTCTCGGGCGCACACGCTTTGGCGGAGCTCCCGGACG
AGATCACCACACCCGGGCCGGGGCAGATCAAGGCCATACTGATCAACTGCGGCAACCCGGTGGTGTCCGGTCCGGACGGC
GCCAAGCTCGACCGGGCACTGGCCACGCTCGACCTGCTGGTCGTGATCGACCTGGTGCAGCGCGAAAGCCACCGCCACGC
GCACTGGCTGCTGCCCGCCGCGCACTGGCTCGAACGCGACGATCTGCTGGCGTTCACCAGCAGCATGCACGACGAGCCGT
TCGTGCAGTACGGGCGCCGTGCCGTCGAACCCCCGCCGGGCGCCCGCGAGGAATGGCAGATCTTCACGGACCTGGCGCTC
GCGATGGGCCTGCCCCTGTTCGGCGTGCGGGGAATGAACGGTTTCGTGCGGGCCACCCGGCGGGCCGCCGCGCTGACCCG
CCGTCCCGCACTGGCGTTCGGGCCGCAGTGGCTCAATCGCATCCTGGTGGCGACCTCACGAAAGGTCAACGGCCGCAAGT
TACGTTGGCGCGACGTGGCGAACAGTCCGCACGGGCTGGTGCTGGGGCCGCGCGAGTTCGGGCACTTCCGCGACGCGCTG
CGCACGCCCGACAAGAAGGTGCACGCCGCCCCGCCGGAGTTCGTGACGCGGACGCGCGAACTGCTCGCCGCACCGCATCC
GTCGGCGCCGGCCGGCTATCCGTTCCAACTCGGCAACCGCCGTCACCGCCACTCGATGAACTCCTGGCTCAACGACCTGC
CGGGGCTGCATCCGGGCGGTAAACGCAATGAGGTGGTCATCCATCCCGAGGACGCGGCAGCGTTGGGTGTGGCCGACGGC
GACCGGGTGCGGGTCTTCTCCCCCGTCGGCGCCGTCGAGGTGCATGCCACGGTCAGCGACCAGCCGCGCCGCGGCCTGGT
GGTCCTCGACCATGGCTGGGGCTCAAGGGTTTTCGACCCGCGCGGGGATGCGGAACCGCAGTCCTACGGCGTCAACCGCA
ACCTGCTCGTCGACGGCACAGGACTCGATCCACTGTCGCAGACCTCGACGCTGAGCGAGGCGTGGGTCGGGGTGCAGAAG
GTCTAG

Upstream 100 bases:

>100_bases
AGGCGGGCCGCATCGTCGAACGCGGAACGCACGAGGAACTCGTCGCCTCGCGTGGCGAATACTGGTCCATGACACAGGTC
TGAGCGGCAGGATGCGCGTT

Downstream 100 bases:

>100_bases
AGCTGCGGGCCTTCGGCGCGCAGATCGTCCACCTTCGCCATCGCGTCGCGCAGTTGAGCCAGCCACTCGTCGGCGTGCTG
ACCGACCAGCCGCACCGACC

Product: formate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 721; Mature: 720

Protein sequence:

>721_residues
MPSTTVHTFCHYCLASCGVEVTVEDNRVRKISADRLNPHSWHDFCAKGRTAAELVDHPRRIRAPMRRVGDRYVEATWDEA
ITDIAARMNAAIEADGPDAVGAYYGNPTGFSGSNVIFMNAWLDAVGTHNRYFVGSVDQNAMHVVAEAMYGSMLMAPVSDI
DNCDYFLLVGTNPAVSAWNWLETVPGGWRRALERQKRGATLVVVDPVRTESADHADVHLAIRPGQDWALLLAMVKVVLDE
GLEHRGDCTDLAVGVPELRSLVAEADLDDLAQRCGVDRATIERVARDFAAARGAMVVTRTGVSLHAAGTVAEWLGHVLNV
ITGRMDRPGGRRFEPGYVDALRLAALAKGKPHVSRVAGREMVSGAHALAELPDEITTPGPGQIKAILINCGNPVVSGPDG
AKLDRALATLDLLVVIDLVQRESHRHAHWLLPAAHWLERDDLLAFTSSMHDEPFVQYGRRAVEPPPGAREEWQIFTDLAL
AMGLPLFGVRGMNGFVRATRRAAALTRRPALAFGPQWLNRILVATSRKVNGRKLRWRDVANSPHGLVLGPREFGHFRDAL
RTPDKKVHAAPPEFVTRTRELLAAPHPSAPAGYPFQLGNRRHRHSMNSWLNDLPGLHPGGKRNEVVIHPEDAAALGVADG
DRVRVFSPVGAVEVHATVSDQPRRGLVVLDHGWGSRVFDPRGDAEPQSYGVNRNLLVDGTGLDPLSQTSTLSEAWVGVQK
V

Sequences:

>Translated_721_residues
MPSTTVHTFCHYCLASCGVEVTVEDNRVRKISADRLNPHSWHDFCAKGRTAAELVDHPRRIRAPMRRVGDRYVEATWDEA
ITDIAARMNAAIEADGPDAVGAYYGNPTGFSGSNVIFMNAWLDAVGTHNRYFVGSVDQNAMHVVAEAMYGSMLMAPVSDI
DNCDYFLLVGTNPAVSAWNWLETVPGGWRRALERQKRGATLVVVDPVRTESADHADVHLAIRPGQDWALLLAMVKVVLDE
GLEHRGDCTDLAVGVPELRSLVAEADLDDLAQRCGVDRATIERVARDFAAARGAMVVTRTGVSLHAAGTVAEWLGHVLNV
ITGRMDRPGGRRFEPGYVDALRLAALAKGKPHVSRVAGREMVSGAHALAELPDEITTPGPGQIKAILINCGNPVVSGPDG
AKLDRALATLDLLVVIDLVQRESHRHAHWLLPAAHWLERDDLLAFTSSMHDEPFVQYGRRAVEPPPGAREEWQIFTDLAL
AMGLPLFGVRGMNGFVRATRRAAALTRRPALAFGPQWLNRILVATSRKVNGRKLRWRDVANSPHGLVLGPREFGHFRDAL
RTPDKKVHAAPPEFVTRTRELLAAPHPSAPAGYPFQLGNRRHRHSMNSWLNDLPGLHPGGKRNEVVIHPEDAAALGVADG
DRVRVFSPVGAVEVHATVSDQPRRGLVVLDHGWGSRVFDPRGDAEPQSYGVNRNLLVDGTGLDPLSQTSTLSEAWVGVQK
V
>Mature_720_residues
PSTTVHTFCHYCLASCGVEVTVEDNRVRKISADRLNPHSWHDFCAKGRTAAELVDHPRRIRAPMRRVGDRYVEATWDEAI
TDIAARMNAAIEADGPDAVGAYYGNPTGFSGSNVIFMNAWLDAVGTHNRYFVGSVDQNAMHVVAEAMYGSMLMAPVSDID
NCDYFLLVGTNPAVSAWNWLETVPGGWRRALERQKRGATLVVVDPVRTESADHADVHLAIRPGQDWALLLAMVKVVLDEG
LEHRGDCTDLAVGVPELRSLVAEADLDDLAQRCGVDRATIERVARDFAAARGAMVVTRTGVSLHAAGTVAEWLGHVLNVI
TGRMDRPGGRRFEPGYVDALRLAALAKGKPHVSRVAGREMVSGAHALAELPDEITTPGPGQIKAILINCGNPVVSGPDGA
KLDRALATLDLLVVIDLVQRESHRHAHWLLPAAHWLERDDLLAFTSSMHDEPFVQYGRRAVEPPPGAREEWQIFTDLALA
MGLPLFGVRGMNGFVRATRRAAALTRRPALAFGPQWLNRILVATSRKVNGRKLRWRDVANSPHGLVLGPREFGHFRDALR
TPDKKVHAAPPEFVTRTRELLAAPHPSAPAGYPFQLGNRRHRHSMNSWLNDLPGLHPGGKRNEVVIHPEDAAALGVADGD
RVRVFSPVGAVEVHATVSDQPRRGLVVLDHGWGSRVFDPRGDAEPQSYGVNRNLLVDGTGLDPLSQTSTLSEAWVGVQKV

Specific function: Catalyzes the oxidation of formate [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868721, Length=696, Percent_Identity=24.5689655172414, Blast_Score=162, Evalue=9e-41,
Organism=Escherichia coli, GI1787870, Length=742, Percent_Identity=24.3935309973046, Blast_Score=134, Evalue=3e-32,
Organism=Escherichia coli, GI87081994, Length=699, Percent_Identity=24.0343347639485, Blast_Score=123, Evalue=5e-29,
Organism=Escherichia coli, GI87081797, Length=787, Percent_Identity=22.8716645489199, Blast_Score=109, Evalue=7e-25,
Organism=Escherichia coli, GI1788534, Length=544, Percent_Identity=21.875, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI171474008, Length=352, Percent_Identity=24.7159090909091, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006478
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 78742; Mature: 78611

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSTTVHTFCHYCLASCGVEVTVEDNRVRKISADRLNPHSWHDFCAKGRTAAELVDHPRR
CCCCHHHHHHHHHHHHCCEEEEECCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHCCHHH
IRAPMRRVGDRYVEATWDEAITDIAARMNAAIEADGPDAVGAYYGNPTGFSGSNVIFMNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEE
WLDAVGTHNRYFVGSVDQNAMHVVAEAMYGSMLMAPVSDIDNCDYFLLVGTNPAVSAWNW
HHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHH
LETVPGGWRRALERQKRGATLVVVDPVRTESADHADVHLAIRPGQDWALLLAMVKVVLDE
HHHCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHH
GLEHRGDCTDLAVGVPELRSLVAEADLDDLAQRCGVDRATIERVARDFAAARGAMVVTRT
CCCCCCCCHHHHCCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEC
GVSLHAAGTVAEWLGHVLNVITGRMDRPGGRRFEPGYVDALRLAALAKGKPHVSRVAGRE
CCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
MVSGAHALAELPDEITTPGPGQIKAILINCGNPVVSGPDGAKLDRALATLDLLVVIDLVQ
HHHHHHHHHHCCHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RESHRHAHWLLPAAHWLERDDLLAFTSSMHDEPFVQYGRRAVEPPPGAREEWQIFTDLAL
HHCCCCCEEECHHHHHHCCCHHHHHHHHCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHH
AMGLPLFGVRGMNGFVRATRRAAALTRRPALAFGPQWLNRILVATSRKVNGRKLRWRDVA
HHCCCHHCCCCCCHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCCCCCEEEEEECC
NSPHGLVLGPREFGHFRDALRTPDKKVHAAPPEFVTRTRELLAAPHPSAPAGYPFQLGNR
CCCCCEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHCCCC
RHRHSMNSWLNDLPGLHPGGKRNEVVIHPEDAAALGVADGDRVRVFSPVGAVEVHATVSD
HHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCEEECCCCCCEEEECCCCCEEEEEECCC
QPRRGLVVLDHGWGSRVFDPRGDAEPQSYGVNRNLLVDGTGLDPLSQTSTLSEAWVGVQK
CCCCCEEEEECCCCCCCCCCCCCCCHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCC
V
C
>Mature Secondary Structure 
PSTTVHTFCHYCLASCGVEVTVEDNRVRKISADRLNPHSWHDFCAKGRTAAELVDHPRR
CCCHHHHHHHHHHHHCCEEEEECCCCEEEEECCCCCCCCHHHHHHCCCHHHHHHCCHHH
IRAPMRRVGDRYVEATWDEAITDIAARMNAAIEADGPDAVGAYYGNPTGFSGSNVIFMNA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCCCCCEEEEEE
WLDAVGTHNRYFVGSVDQNAMHVVAEAMYGSMLMAPVSDIDNCDYFLLVGTNPAVSAWNW
HHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCHHHHH
LETVPGGWRRALERQKRGATLVVVDPVRTESADHADVHLAIRPGQDWALLLAMVKVVLDE
HHHCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHH
GLEHRGDCTDLAVGVPELRSLVAEADLDDLAQRCGVDRATIERVARDFAAARGAMVVTRT
CCCCCCCCHHHHCCHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEC
GVSLHAAGTVAEWLGHVLNVITGRMDRPGGRRFEPGYVDALRLAALAKGKPHVSRVAGRE
CCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
MVSGAHALAELPDEITTPGPGQIKAILINCGNPVVSGPDGAKLDRALATLDLLVVIDLVQ
HHHHHHHHHHCCHHHCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RESHRHAHWLLPAAHWLERDDLLAFTSSMHDEPFVQYGRRAVEPPPGAREEWQIFTDLAL
HHCCCCCEEECHHHHHHCCCHHHHHHHHCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHH
AMGLPLFGVRGMNGFVRATRRAAALTRRPALAFGPQWLNRILVATSRKVNGRKLRWRDVA
HHCCCHHCCCCCCHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCCCCCEEEEEECC
NSPHGLVLGPREFGHFRDALRTPDKKVHAAPPEFVTRTRELLAAPHPSAPAGYPFQLGNR
CCCCCEEECCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHCCCC
RHRHSMNSWLNDLPGLHPGGKRNEVVIHPEDAAALGVADGDRVRVFSPVGAVEVHATVSD
HHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCEEECCCCCCEEEECCCCCEEEEEECCC
QPRRGLVVLDHGWGSRVFDPRGDAEPQSYGVNRNLLVDGTGLDPLSQTSTLSEAWVGVQK
CCCCCEEEEECCCCCCCCCCCCCCCHHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHCC
V
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]