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The map label for this gene is pncB1 [H]

Identifier: 119869958

GI number: 119869958

Start: 4131255

End: 4132577

Strand: Direct

Name: pncB1 [H]

Synonym: Mkms_3928

Alternate gene names: 119869958

Gene position: 4131255-4132577 (Clockwise)

Preceding gene: 119869945

Following gene: 119869959

Centisome position: 72.01

GC content: 72.03

Gene sequence:

>1323_bases
GTGGCAGCTGTGACAGCCGCGCTGCTGACCGACAAATACGAGCTGACAATGCTGGCAGCCGCGCTGCGCGACGGGACCGC
ACACCGGCGCGCGACGTTCGAGATCTTCGCCCGGCGGCTGCCCGACGGCCGCCGGTACGGCGTAGTGGCCGGCACCGCCC
GGTTGGTCGAGGCGTTGCGCGAGTTCACCTTCGACGACACGGCGCTGGCCGCCGTCGCCGACTTCCTCGACGACGAGACC
CTGGGGTACCTCGCCGGGTACCGCTTCGGCGGCGACATCGACGGCTACCCGGAGGGCGAGCTGTTCTTCCCGGGCTCGCC
GGTGCTGTCGGTGCACGGCACGTTCGCCGAGTGCGTGGTGCTCGAGACGCTGGCGCTGTCGATCTTCAACCACGACAGCG
CGATCGCCGCGGCCGCCGCCCGGATGGCCACCGCGGCCGACGGCCGACCGCTCATCGAGATGGGGTCGCGACGCACCCAT
GAGCAGGCGGCCGTGGCCGCCGCCAGGGCGGCCTATCTGGCGGGATTCGCCGGCAGTTCGAATCTCGAGGCGCAGCGCCG
TTACGGGGTGCCCGCCATGGGGACCAGCGCCCACGCCTTCACGCTGCTGCACACCACCGCCGACGGGCCCGACGAGGTGG
CCGCGTTCCGGGCCCAGGTCGAGGCCCTGGGAGTGGACACCACGCTGTTGGTCGACACCTACGACATCACCGCGGGCGTC
GCCAACGCCGTCGAGGCGGCCGGTCCGCGGTTGGGTGCGGTGCGCATCGACTCCGGCGACCTCGGTGTGCTGGCCCGCCA
GGTGCGCGCCCAACTCGACGGACTCGGCGCGACCGGGACCCGCATCGTGGTGTCCGGCGACCTGGACGAGTTCTCGATCG
CCGCCCTGCGCGCCGAACCGGTCGACTTCTACGGAGTCGGCACCTCACTGGTCACCGGCTCCGGCGCACCGACGGCGGGC
ATGGTCTACAAACTCGTCGAGGTCGACGGCCTGCCCGTCGAGAAACGCAGCAGCCACAAGGAATCCCACGGCGGACGCAA
ACAGGCGGCCCGGCTGGCGAAACCGTCCGGCACCATCGTCGAGGAGGTGGTGCACCCGTTCGGTTCCCCACCTGAGGCCA
CCGCCGGTTACGACCTGCGCCCGCTGACGGTTCCGCTGGTCCGCGACGGTGAACCGGTCGGCGACGTCGACCTCGCCGCC
GCGCGTGAGCGGGTCGTCGCCGGACTGCACAGCCTGCCGTGGGACGGGCTGAAACTGTCCCGCGGCGAACCGGCGATCCC
GACCCGCATGATGGCCCCTGTCCGCGGCGCCGGACGACCCTAG

Upstream 100 bases:

>100_bases
GATCCGGCACCGTGGCCACGTCTCGCTGCTCGCGGGTTCCCGGGGCTTTCGCCGGTGTGACCATGCCCGTCAGGATACCG
GGGCGGCCATCCGGGTTACG

Downstream 100 bases:

>100_bases
GAGTGGCCACGGGTAACGACGACGCCGGCGAACGCGTCACCGATCTGTTGGCCGCGGCCGTCGCTGCGGTGGGCGGTGCC
GAGCGGCCCGGTCAGGTCGA

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase pncB1 [H]

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MAAVTAALLTDKYELTMLAAALRDGTAHRRATFEIFARRLPDGRRYGVVAGTARLVEALREFTFDDTALAAVADFLDDET
LGYLAGYRFGGDIDGYPEGELFFPGSPVLSVHGTFAECVVLETLALSIFNHDSAIAAAAARMATAADGRPLIEMGSRRTH
EQAAVAAARAAYLAGFAGSSNLEAQRRYGVPAMGTSAHAFTLLHTTADGPDEVAAFRAQVEALGVDTTLLVDTYDITAGV
ANAVEAAGPRLGAVRIDSGDLGVLARQVRAQLDGLGATGTRIVVSGDLDEFSIAALRAEPVDFYGVGTSLVTGSGAPTAG
MVYKLVEVDGLPVEKRSSHKESHGGRKQAARLAKPSGTIVEEVVHPFGSPPEATAGYDLRPLTVPLVRDGEPVGDVDLAA
ARERVVAGLHSLPWDGLKLSRGEPAIPTRMMAPVRGAGRP

Sequences:

>Translated_440_residues
MAAVTAALLTDKYELTMLAAALRDGTAHRRATFEIFARRLPDGRRYGVVAGTARLVEALREFTFDDTALAAVADFLDDET
LGYLAGYRFGGDIDGYPEGELFFPGSPVLSVHGTFAECVVLETLALSIFNHDSAIAAAAARMATAADGRPLIEMGSRRTH
EQAAVAAARAAYLAGFAGSSNLEAQRRYGVPAMGTSAHAFTLLHTTADGPDEVAAFRAQVEALGVDTTLLVDTYDITAGV
ANAVEAAGPRLGAVRIDSGDLGVLARQVRAQLDGLGATGTRIVVSGDLDEFSIAALRAEPVDFYGVGTSLVTGSGAPTAG
MVYKLVEVDGLPVEKRSSHKESHGGRKQAARLAKPSGTIVEEVVHPFGSPPEATAGYDLRPLTVPLVRDGEPVGDVDLAA
ARERVVAGLHSLPWDGLKLSRGEPAIPTRMMAPVRGAGRP
>Mature_439_residues
AAVTAALLTDKYELTMLAAALRDGTAHRRATFEIFARRLPDGRRYGVVAGTARLVEALREFTFDDTALAAVADFLDDETL
GYLAGYRFGGDIDGYPEGELFFPGSPVLSVHGTFAECVVLETLALSIFNHDSAIAAAAARMATAADGRPLIEMGSRRTHE
QAAVAAARAAYLAGFAGSSNLEAQRRYGVPAMGTSAHAFTLLHTTADGPDEVAAFRAQVEALGVDTTLLVDTYDITAGVA
NAVEAAGPRLGAVRIDSGDLGVLARQVRAQLDGLGATGTRIVVSGDLDEFSIAALRAEPVDFYGVGTSLVTGSGAPTAGM
VYKLVEVDGLPVEKRSSHKESHGGRKQAARLAKPSGTIVEEVVHPFGSPPEATAGYDLRPLTVPLVRDGEPVGDVDLAAA
RERVVAGLHSLPWDGLKLSRGEPAIPTRMMAPVRGAGRP

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=439, Percent_Identity=32.1184510250569, Blast_Score=144, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71997952, Length=428, Percent_Identity=29.6728971962617, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71997947, Length=428, Percent_Identity=29.6728971962617, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71997955, Length=236, Percent_Identity=29.6610169491525, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24581587, Length=436, Percent_Identity=28.2110091743119, Blast_Score=125, Evalue=6e-29,
Organism=Drosophila melanogaster, GI161076680, Length=205, Percent_Identity=29.7560975609756, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24581595, Length=205, Percent_Identity=29.7560975609756, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI28574709, Length=205, Percent_Identity=29.7560975609756, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24581593, Length=205, Percent_Identity=29.7560975609756, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24581591, Length=205, Percent_Identity=29.7560975609756, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 46016; Mature: 45885

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAVTAALLTDKYELTMLAAALRDGTAHRRATFEIFARRLPDGRRYGVVAGTARLVEALR
CCHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHH
EFTFDDTALAAVADFLDDETLGYLAGYRFGGDIDGYPEGELFFPGSPVLSVHGTFAECVV
HCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCEECCCCCEEEECCCHHHHHH
LETLALSIFNHDSAIAAAAARMATAADGRPLIEMGSRRTHEQAAVAAARAAYLAGFAGSS
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCC
NLEAQRRYGVPAMGTSAHAFTLLHTTADGPDEVAAFRAQVEALGVDTTLLVDTYDITAGV
CCCHHHHCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEECHHHHHH
ANAVEAAGPRLGAVRIDSGDLGVLARQVRAQLDGLGATGTRIVVSGDLDEFSIAALRAEP
HHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEEECCC
VDFYGVGTSLVTGSGAPTAGMVYKLVEVDGLPVEKRSSHKESHGGRKQAARLAKPSGTIV
CEEEECCCCEEECCCCCCHHHEEEEEECCCCCCHHHCCCCHHCCCHHHHHHHCCCCCHHH
EEVVHPFGSPPEATAGYDLRPLTVPLVRDGEPVGDVDLAAARERVVAGLHSLPWDGLKLS
HHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEC
RGEPAIPTRMMAPVRGAGRP
CCCCCCCHHHHCCCCCCCCC
>Mature Secondary Structure 
AAVTAALLTDKYELTMLAAALRDGTAHRRATFEIFARRLPDGRRYGVVAGTARLVEALR
CHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHH
EFTFDDTALAAVADFLDDETLGYLAGYRFGGDIDGYPEGELFFPGSPVLSVHGTFAECVV
HCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCEECCCCCEEEECCCHHHHHH
LETLALSIFNHDSAIAAAAARMATAADGRPLIEMGSRRTHEQAAVAAARAAYLAGFAGSS
HHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCC
NLEAQRRYGVPAMGTSAHAFTLLHTTADGPDEVAAFRAQVEALGVDTTLLVDTYDITAGV
CCCHHHHCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEECHHHHHH
ANAVEAAGPRLGAVRIDSGDLGVLARQVRAQLDGLGATGTRIVVSGDLDEFSIAALRAEP
HHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEEECCC
VDFYGVGTSLVTGSGAPTAGMVYKLVEVDGLPVEKRSSHKESHGGRKQAARLAKPSGTIV
CEEEECCCCEEECCCCCCHHHEEEEEECCCCCCHHHCCCCHHCCCHHHHHHHCCCCCHHH
EEVVHPFGSPPEATAGYDLRPLTVPLVRDGEPVGDVDLAAARERVVAGLHSLPWDGLKLS
HHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEC
RGEPAIPTRMMAPVRGAGRP
CCCCCCCHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]