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The map label for this gene is linC [H]

Identifier: 119869901

GI number: 119869901

Start: 4085194

End: 4085958

Strand: Direct

Name: linC [H]

Synonym: Mkms_3870

Alternate gene names: 119869901

Gene position: 4085194-4085958 (Clockwise)

Preceding gene: 119869898

Following gene: 119869902

Centisome position: 71.21

GC content: 68.37

Gene sequence:

>765_bases
ATGCAGATTGCCGGTAGCTCAGCGATCGTCGTCGGGGGCGCAGGTGGACTGGGCGAGGCGACGGTGCGCCGACTGCAGGG
CGCCGGCGCGAAAGTGGTCGTCGCCGACCTGGCCGACGAGAAGGGTGCGGCGCTCGAGAAGGAACTCGGTGTGCGGTACG
TGCGCACCGACGCAACCTCCGAGGAGTCGGTGAACGCCGCGATCGCAGAGGCCGAATCGATGGGCCCGCTGCGGATCTCG
GTGGACACCCACGGCGGCCCCGCCAGCGGCGGCCGGCTGATCGGCAAGGACGGTTCACCCCTTGACCTCGACGGATTCAA
GAAGACGATCGAGTTCTACCTGACGGCGGTGTTCAACGTGATGCGGCTGACGGCCGCGGCGATCGCGAAGTCCGAGCCAC
TGGAAGAGGGCGGCCGCGGCGTCATCGTCAACACCGCGTCGATCGCCGGGTACGAGGGACAGATCGGCCAGCTCCCGTAC
TCGGCGGCCAAGGGCGGGGTGCTCGGGATGACGCTGGTGGCGGCGCGTGACCTGTCACCGTTGGGCATCCGGGTCTGCAC
GATCGCGCCGGGGACGATCAACACGCCCGCCTACGGCAAGGCGGCCGACCAGCTGGAGCAGTACTGGGGTCCGCAGGTGC
CGTTCCCCAAGCGGATGGGCCGCTCGACGGAGTACGCGCAACTGGCGCAGAGCATCATCGAGAACGACTACCTCAACGGT
GAGATCATCCGCCTCGACGGAGCGCTTCGGTTCCCGCCCAAGTGA

Upstream 100 bases:

>100_bases
AGACGATGACGGCTTCTGGCATGAGTTGACTCCGTTTCGGCGTCGGATGAGAATAGTATTCTCTCAGGACGAGAGTCATC
GTTGCAAGAAGGAGAAGCGC

Downstream 100 bases:

>100_bases
GTCTCGCCGGGAAGGTCGCCTTCGTCGCCGGCGCCAGCCGTGGCATCGGCGCGACGGTGGCGAAAGCCCTCGCCGCAGAA
GGCGCTGCCGTGGCAGTCGC

Product: short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: 2,5-DDOL dehydrogenase [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MQIAGSSAIVVGGAGGLGEATVRRLQGAGAKVVVADLADEKGAALEKELGVRYVRTDATSEESVNAAIAEAESMGPLRIS
VDTHGGPASGGRLIGKDGSPLDLDGFKKTIEFYLTAVFNVMRLTAAAIAKSEPLEEGGRGVIVNTASIAGYEGQIGQLPY
SAAKGGVLGMTLVAARDLSPLGIRVCTIAPGTINTPAYGKAADQLEQYWGPQVPFPKRMGRSTEYAQLAQSIIENDYLNG
EIIRLDGALRFPPK

Sequences:

>Translated_254_residues
MQIAGSSAIVVGGAGGLGEATVRRLQGAGAKVVVADLADEKGAALEKELGVRYVRTDATSEESVNAAIAEAESMGPLRIS
VDTHGGPASGGRLIGKDGSPLDLDGFKKTIEFYLTAVFNVMRLTAAAIAKSEPLEEGGRGVIVNTASIAGYEGQIGQLPY
SAAKGGVLGMTLVAARDLSPLGIRVCTIAPGTINTPAYGKAADQLEQYWGPQVPFPKRMGRSTEYAQLAQSIIENDYLNG
EIIRLDGALRFPPK
>Mature_254_residues
MQIAGSSAIVVGGAGGLGEATVRRLQGAGAKVVVADLADEKGAALEKELGVRYVRTDATSEESVNAAIAEAESMGPLRIS
VDTHGGPASGGRLIGKDGSPLDLDGFKKTIEFYLTAVFNVMRLTAAAIAKSEPLEEGGRGVIVNTASIAGYEGQIGQLPY
SAAKGGVLGMTLVAARDLSPLGIRVCTIAPGTINTPAYGKAADQLEQYWGPQVPFPKRMGRSTEYAQLAQSIIENDYLNG
EIIRLDGALRFPPK

Specific function: Catalyzes the degradation of 2,5-dichloro-2,5- cyclohexadiene-1,4-diol (2,5-DDOL) into 2,5-dichlorohydroquinone (2,5-DCHQ) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=254, Percent_Identity=45.6692913385827, Blast_Score=215, Evalue=3e-56,
Organism=Homo sapiens, GI83715985, Length=254, Percent_Identity=42.5196850393701, Blast_Score=194, Evalue=9e-50,
Organism=Homo sapiens, GI59889578, Length=183, Percent_Identity=32.2404371584699, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI15277342, Length=257, Percent_Identity=29.9610894941634, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI40254992, Length=245, Percent_Identity=27.3469387755102, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1787335, Length=259, Percent_Identity=28.957528957529, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI2367365, Length=255, Percent_Identity=29.4117647058824, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789057, Length=264, Percent_Identity=25.3787878787879, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=249, Percent_Identity=41.3654618473896, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI25147288, Length=262, Percent_Identity=29.7709923664122, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17555706, Length=253, Percent_Identity=29.6442687747036, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17560332, Length=199, Percent_Identity=31.6582914572864, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=45.6692913385827, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24639444, Length=266, Percent_Identity=30.8270676691729, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21355319, Length=256, Percent_Identity=30.46875, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 26387; Mature: 26387

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIAGSSAIVVGGAGGLGEATVRRLQGAGAKVVVADLADEKGAALEKELGVRYVRTDATS
CCCCCCCEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHCEEEEECCCCC
EESVNAAIAEAESMGPLRISVDTHGGPASGGRLIGKDGSPLDLDGFKKTIEFYLTAVFNV
CHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHH
MRLTAAAIAKSEPLEEGGRGVIVNTASIAGYEGQIGQLPYSAAKGGVLGMTLVAARDLSP
HHHHHHHHHHCCCHHHCCCEEEEEEEEECCCCCCCCCCCCHHHCCCCHHHHHHHHCCCCC
LGIRVCTIAPGTINTPAYGKAADQLEQYWGPQVPFPKRMGRSTEYAQLAQSIIENDYLNG
CCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCC
EIIRLDGALRFPPK
EEEEECCEECCCCC
>Mature Secondary Structure
MQIAGSSAIVVGGAGGLGEATVRRLQGAGAKVVVADLADEKGAALEKELGVRYVRTDATS
CCCCCCCEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHCEEEEECCCCC
EESVNAAIAEAESMGPLRISVDTHGGPASGGRLIGKDGSPLDLDGFKKTIEFYLTAVFNV
CHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHH
MRLTAAAIAKSEPLEEGGRGVIVNTASIAGYEGQIGQLPYSAAKGGVLGMTLVAARDLSP
HHHHHHHHHHCCCHHHCCCEEEEEEEEECCCCCCCCCCCCHHHCCCCHHHHHHHHCCCCC
LGIRVCTIAPGTINTPAYGKAADQLEQYWGPQVPFPKRMGRSTEYAQLAQSIIENDYLNG
CCEEEEEECCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCC
EIIRLDGALRFPPK
EEEEECCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7515041; 12450824 [H]