Click here to switch to the map view.

The map label for this gene is rnz

Identifier: 119869610

GI number: 119869610

Start: 3767555

End: 3768412

Strand: Direct

Name: rnz

Synonym: Mkms_3578

Alternate gene names: 119869610

Gene position: 3767555-3768412 (Clockwise)

Preceding gene: 119869608

Following gene: 119869614

Centisome position: 65.67

GC content: 73.08

Gene sequence:

>858_bases
ATGATCGAAGTGACCCTGCTCGGAACCGGAAGTCCCGTCCCCGACGCGCGGCGGGCCGGCCCGTCGACGCTGGTGCGCGC
GGGCGGTCACGCCTTCCTCGTCGACTGCGGTCGCGGCGTCCAGCTCCGCATGGCCGCCGCCGGGATCGCCGCGAACGGGT
TGTCGGCGCTACTGCTGACCCATCTGCACAGTGACCACATCGCCGACCTCGGCGACCTGCTGATCACCCGCTGGGTGACC
ACCTTCACCGACCAGGTGCCGCTGCAGATCATCGGCCCGCCCGGTACCGCCGAGACCGTGACGGCGATGCTCGCGGCGTT
CGGCCGCGACATCGGCTACCGCATCGCCCACCACCCCGACCTGACCGCACCCCCACCGGTCGAGGTGCACGAGGTCACCG
AGGGTGTGGCGTGGGACCACGACGGCGTTACCGTCCGCGTCGCGCCCACCGACCACCGCCCGGTCGCCCCGACCATCGGG
TTCCGCGTCGAACACGCCGACGCCTCGGTGGTGCTCGCCGGCGACACCGTGCCGTGCGCGACGCTCGACGCGCTCGCGGC
GGGCGCAGGCGCCCTGGTGCACACCGCCATTCGCAAGGATCTGGTCGAACTGGCGCCCCAGCAGCGGGTGCGCGAGGTCT
GCGAGTACCACTCGTCGGTCGAAGAGGCCGCCGAGACCGCGGAGCGGGCCGGCGTCGGGATCCTGGTGCTCACGCACTAC
CTGCCGCCGATCGCCCCAGGGCAGGAGGCCGACTGGCGGGCGAGGGCGGCCACCGCGTTCCCCCGCCAGATCGAGCTGGG
CGACGACCTGCACCGCGTCGAGGTGCATCCGGGCGTGTGCGTCAAGCCAGCCGGGTGA

Upstream 100 bases:

>100_bases
GCCTTCTGTGATACGGCTCACACCAGGCTAGGCCGTCTTCCCCGGAAGCGGAATAGCCAATCGCCTGACGCCCGCCGCGG
CGCAAGGTACCTATGAGGCC

Downstream 100 bases:

>100_bases
TCTCCACGACGACGTCGAGGTCGGTGGACCCCTCCCCCGAGTAGATGCCCTTGAGCGGTGACACGTCCGCGTAGTCGCGT
CCGACGCCCACGCTGATGTA

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MIEVTLLGTGSPVPDARRAGPSTLVRAGGHAFLVDCGRGVQLRMAAAGIAANGLSALLLTHLHSDHIADLGDLLITRWVT
TFTDQVPLQIIGPPGTAETVTAMLAAFGRDIGYRIAHHPDLTAPPPVEVHEVTEGVAWDHDGVTVRVAPTDHRPVAPTIG
FRVEHADASVVLAGDTVPCATLDALAAGAGALVHTAIRKDLVELAPQQRVREVCEYHSSVEEAAETAERAGVGILVLTHY
LPPIAPGQEADWRARAATAFPRQIELGDDLHRVEVHPGVCVKPAG

Sequences:

>Translated_285_residues
MIEVTLLGTGSPVPDARRAGPSTLVRAGGHAFLVDCGRGVQLRMAAAGIAANGLSALLLTHLHSDHIADLGDLLITRWVT
TFTDQVPLQIIGPPGTAETVTAMLAAFGRDIGYRIAHHPDLTAPPPVEVHEVTEGVAWDHDGVTVRVAPTDHRPVAPTIG
FRVEHADASVVLAGDTVPCATLDALAAGAGALVHTAIRKDLVELAPQQRVREVCEYHSSVEEAAETAERAGVGILVLTHY
LPPIAPGQEADWRARAATAFPRQIELGDDLHRVEVHPGVCVKPAG
>Mature_285_residues
MIEVTLLGTGSPVPDARRAGPSTLVRAGGHAFLVDCGRGVQLRMAAAGIAANGLSALLLTHLHSDHIADLGDLLITRWVT
TFTDQVPLQIIGPPGTAETVTAMLAAFGRDIGYRIAHHPDLTAPPPVEVHEVTEGVAWDHDGVTVRVAPTDHRPVAPTIG
FRVEHADASVVLAGDTVPCATLDALAAGAGALVHTAIRKDLVELAPQQRVREVCEYHSSVEEAAETAERAGVGILVLTHY
LPPIAPGQEADWRARAATAFPRQIELGDDLHRVEVHPGVCVKPAG

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

Organism=Homo sapiens, GI8922122, Length=101, Percent_Identity=31.6831683168317, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_MYCSJ (A3Q2B8)

Other databases:

- EMBL:   CP000580
- RefSeq:   YP_001071786.1
- ProteinModelPortal:   A3Q2B8
- SMR:   A3Q2B8
- STRING:   A3Q2B8
- EnsemblBacteria:   EBMYCT00000051280
- GeneID:   4879229
- GenomeReviews:   CP000580_GR
- KEGG:   mjl:Mjls_3518
- eggNOG:   COG1234
- GeneTree:   EBGT00050000017432
- HOGENOM:   HBG648406
- OMA:   VWDRDGV
- ProtClustDB:   PRK00055
- BioCyc:   MSP164757:MJLS_3518-MONOMER
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- SMART:   SM00849

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 29979; Mature: 29979

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEVTLLGTGSPVPDARRAGPSTLVRAGGHAFLVDCGRGVQLRMAAAGIAANGLSALLLT
CEEEEEEECCCCCCCHHHCCCHHHHHCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHH
HLHSDHIADLGDLLITRWVTTFTDQVPLQIIGPPGTAETVTAMLAAFGRDIGYRIAHHPD
HHCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCEEECCCC
LTAPPPVEVHEVTEGVAWDHDGVTVRVAPTDHRPVAPTIGFRVEHADASVVLAGDTVPCA
CCCCCCCHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCEEEEECCCCCHH
TLDALAAGAGALVHTAIRKDLVELAPQQRVREVCEYHSSVEEAAETAERAGVGILVLTHY
HHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHC
LPPIAPGQEADWRARAATAFPRQIELGDDLHRVEVHPGVCVKPAG
CCCCCCCCCCCCHHHHHHCCCCEECCCCCEEEEEECCCEEEECCC
>Mature Secondary Structure
MIEVTLLGTGSPVPDARRAGPSTLVRAGGHAFLVDCGRGVQLRMAAAGIAANGLSALLLT
CEEEEEEECCCCCCCHHHCCCHHHHHCCCCEEEEECCCCCEEEEEHHHHHHHHHHHHHHH
HLHSDHIADLGDLLITRWVTTFTDQVPLQIIGPPGTAETVTAMLAAFGRDIGYRIAHHPD
HHCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHCCEEECCCC
LTAPPPVEVHEVTEGVAWDHDGVTVRVAPTDHRPVAPTIGFRVEHADASVVLAGDTVPCA
CCCCCCCHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCEEEEECCCCCHH
TLDALAAGAGALVHTAIRKDLVELAPQQRVREVCEYHSSVEEAAETAERAGVGILVLTHY
HHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHC
LPPIAPGQEADWRARAATAFPRQIELGDDLHRVEVHPGVCVKPAG
CCCCCCCCCCCCHHHHHHCCCCEECCCCCEEEEEECCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA