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The map label for this gene is adhC [C]

Identifier: 119869474

GI number: 119869474

Start: 3611251

End: 3612339

Strand: Direct

Name: adhC [C]

Synonym: Mkms_3442

Alternate gene names: 119869474

Gene position: 3611251-3612339 (Clockwise)

Preceding gene: 119869469

Following gene: 119869475

Centisome position: 62.94

GC content: 67.49

Gene sequence:

>1089_bases
ATGAGTCAGACAGTGCGCGGGGTGATCTCCCGGTCCAAGCAGCAGCCGGTGGAAGTGGTCGACATCGTGGTCCCGGATCC
GGGTCCGGGTGAGGTGGTCGTCGACATCATCGCGTGCGGGGTGTGCCACACCGATCTGACCTACCGCGAGGGCGGGATCA
ACGACGAGTACCCGTTCCTGTTGGGCCACGAGGCGGCCGGGACCGTGGAGTCGGTCGGCGAGGGTGTCACCAATGTGGTG
CCGGGCGATTTCGTGATCCTGAACTGGCGTGCGGTGTGCGGACAGTGCCGGGCGTGTAAGCGGGGCCGCCCCCATCTGTG
TTTCGACACCCACAACGCCGCGCAGAAGATGACGCTGACCGATGGCACGGAGCTGACCCCGGCGCTGGGCATCGGCGCGT
TCGCCGACAAGACCCTGGTGCACGAGGGGCAGTGCACGAAGGTCGATCCGGCGGCCGATCCGGCGGTGGCCGGGCTGCTC
GGCTGCGGCGTGATGGCCGGTATCGGGGCCGCGATCAACACCGGCGCGGTGGGCCGCGACGACACCGTCGCGGTGATCGG
CTGCGGCGGCGTCGGTGACGCGGCGATCGCGGGTGCGGCGCTGGTCGGGGCAAAGAAGATCATCGCCGTCGACACCGACG
ACAAGAAGCTGCAGTGGGCGCGCGAGTTCGGCGCCACCGACACGATCAACGCCCGCAGCGTCGACGACGTGGTCGAGGCC
ATCCAGGAGCTCACCGACGGATTCGGCACCGACGTGGTGATCGACGCGGTCGGAAGGCCCGAGACCTGGAAGCAGGCGTT
CTACGCCCGCGATCTGGCGGGAACCGTTGTGCTGGTGGGTGTTCCGACCCCGGACATGCGGTTGGAGATGCCACTGGTGG
ACTTCTTCTCCCGTGGCGGATCGCTGAAGTCGTCGTGGTACGGCGACTGCCTGCCCGAACGGGACTTCCCCACGCTGATC
AGTCTCTATCTGCAGGGCCGGTTGCCGTTGGACAAGTTCGTCTCCGAACGCATCGGCCTCGACGGCATCGAGGACGCCTT
CCACAAGATGCACGCCGGTGAGGTGCTGCGCTCAGTGGTGGTCCTGTGA

Upstream 100 bases:

>100_bases
CTCGCTCGGTTCAACGGTAGTGCGGACCCGACGGTTCAACCATGGGTTTGGCCGAGACCGACACGATTCGTTCCCACCGC
CGAGGCATTAGGTTGTAGGG

Downstream 100 bases:

>100_bases
TGATGAGCGGCGGACCGATCCAGCGGGTGGTCACCCACGGCACGTTCGAACTCGACGGCGGGTCCTGGGAGGTCGACAAC
AACATCTGGGTCGTCGGCGA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NAD/mycothiol-dependent formaldehyde dehydrogenase; MD-FALDH [H]

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MSQTVRGVISRSKQQPVEVVDIVVPDPGPGEVVVDIIACGVCHTDLTYREGGINDEYPFLLGHEAAGTVESVGEGVTNVV
PGDFVILNWRAVCGQCRACKRGRPHLCFDTHNAAQKMTLTDGTELTPALGIGAFADKTLVHEGQCTKVDPAADPAVAGLL
GCGVMAGIGAAINTGAVGRDDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDTDDKKLQWAREFGATDTINARSVDDVVEA
IQELTDGFGTDVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMRLEMPLVDFFSRGGSLKSSWYGDCLPERDFPTLI
SLYLQGRLPLDKFVSERIGLDGIEDAFHKMHAGEVLRSVVVL

Sequences:

>Translated_362_residues
MSQTVRGVISRSKQQPVEVVDIVVPDPGPGEVVVDIIACGVCHTDLTYREGGINDEYPFLLGHEAAGTVESVGEGVTNVV
PGDFVILNWRAVCGQCRACKRGRPHLCFDTHNAAQKMTLTDGTELTPALGIGAFADKTLVHEGQCTKVDPAADPAVAGLL
GCGVMAGIGAAINTGAVGRDDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDTDDKKLQWAREFGATDTINARSVDDVVEA
IQELTDGFGTDVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMRLEMPLVDFFSRGGSLKSSWYGDCLPERDFPTLI
SLYLQGRLPLDKFVSERIGLDGIEDAFHKMHAGEVLRSVVVL
>Mature_361_residues
SQTVRGVISRSKQQPVEVVDIVVPDPGPGEVVVDIIACGVCHTDLTYREGGINDEYPFLLGHEAAGTVESVGEGVTNVVP
GDFVILNWRAVCGQCRACKRGRPHLCFDTHNAAQKMTLTDGTELTPALGIGAFADKTLVHEGQCTKVDPAADPAVAGLLG
CGVMAGIGAAINTGAVGRDDTVAVIGCGGVGDAAIAGAALVGAKKIIAVDTDDKKLQWAREFGATDTINARSVDDVVEAI
QELTDGFGTDVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMRLEMPLVDFFSRGGSLKSSWYGDCLPERDFPTLIS
LYLQGRLPLDKFVSERIGLDGIEDAFHKMHAGEVLRSVVVL

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=360, Percent_Identity=34.4444444444444, Blast_Score=204, Evalue=9e-53,
Organism=Homo sapiens, GI4501929, Length=360, Percent_Identity=34.1666666666667, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI4501933, Length=359, Percent_Identity=32.033426183844, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI71565154, Length=358, Percent_Identity=35.4748603351955, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI156523966, Length=358, Percent_Identity=32.122905027933, Blast_Score=181, Evalue=7e-46,
Organism=Homo sapiens, GI71743840, Length=361, Percent_Identity=32.409972299169, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI262073058, Length=361, Percent_Identity=32.409972299169, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI4501939, Length=350, Percent_Identity=32.2857142857143, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI71565152, Length=372, Percent_Identity=31.989247311828, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI156627571, Length=357, Percent_Identity=26.0504201680672, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1786552, Length=366, Percent_Identity=34.9726775956284, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1790045, Length=351, Percent_Identity=25.6410256410256, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI87081918, Length=283, Percent_Identity=30.7420494699647, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788073, Length=344, Percent_Identity=25.5813953488372, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1786518, Length=362, Percent_Identity=27.3480662983425, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI87082125, Length=354, Percent_Identity=26.5536723163842, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1787863, Length=341, Percent_Identity=26.099706744868, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1786825, Length=251, Percent_Identity=30.2788844621514, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788075, Length=340, Percent_Identity=27.3529411764706, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI226510992, Length=361, Percent_Identity=25.207756232687, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790718, Length=319, Percent_Identity=24.1379310344828, Blast_Score=65, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=33.7801608579088, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=33.6, Blast_Score=181, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI17565904, Length=339, Percent_Identity=33.9233038348083, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17562876, Length=352, Percent_Identity=26.1363636363636, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17562878, Length=352, Percent_Identity=25.8522727272727, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71988145, Length=368, Percent_Identity=27.1739130434783, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=368, Percent_Identity=25, Blast_Score=85, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17562584, Length=356, Percent_Identity=28.0898876404494, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320033, Length=368, Percent_Identity=35.5978260869565, Blast_Score=199, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6323729, Length=366, Percent_Identity=26.2295081967213, Blast_Score=96, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6319621, Length=368, Percent_Identity=27.7173913043478, Blast_Score=96, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6322619, Length=355, Percent_Identity=28.4507042253521, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=355, Percent_Identity=28.169014084507, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324486, Length=366, Percent_Identity=25.4098360655738, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323961, Length=366, Percent_Identity=24.3169398907104, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6319257, Length=356, Percent_Identity=25, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319258, Length=284, Percent_Identity=25, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17737895, Length=378, Percent_Identity=34.9206349206349, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI17737897, Length=353, Percent_Identity=25.2124645892351, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR017816
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.306 [H]

Molecular weight: Translated: 38173; Mature: 38042

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTVRGVISRSKQQPVEVVDIVVPDPGPGEVVVDIIACGVCHTDLTYREGGINDEYPFL
CCHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCCCEE
LGHEAAGTVESVGEGVTNVVPGDFVILNWRAVCGQCRACKRGRPHLCFDTHNAAQKMTLT
ECCCCCCCHHHHHCCHHHCCCCCEEEEEHHHHHHHHHHHHCCCCCEEEECCCCHHEEEEC
DGTELTPALGIGAFADKTLVHEGQCTKVDPAADPAVAGLLGCGVMAGIGAAINTGAVGRD
CCCCCCHHHCCCHHHCCHHEECCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHCCCCCCCC
DTVAVIGCGGVGDAAIAGAALVGAKKIIAVDTDDKKLQWAREFGATDTINARSVDDVVEA
CCEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHH
IQELTDGFGTDVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMRLEMPLVDFFSRGG
HHHHHCCCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEECHHHHHHHCCC
SLKSSWYGDCLPERDFPTLISLYLQGRLPLDKFVSERIGLDGIEDAFHKMHAGEVLRSVV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VL
CC
>Mature Secondary Structure 
SQTVRGVISRSKQQPVEVVDIVVPDPGPGEVVVDIIACGVCHTDLTYREGGINDEYPFL
CHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCCCEE
LGHEAAGTVESVGEGVTNVVPGDFVILNWRAVCGQCRACKRGRPHLCFDTHNAAQKMTLT
ECCCCCCCHHHHHCCHHHCCCCCEEEEEHHHHHHHHHHHHCCCCCEEEECCCCHHEEEEC
DGTELTPALGIGAFADKTLVHEGQCTKVDPAADPAVAGLLGCGVMAGIGAAINTGAVGRD
CCCCCCHHHCCCHHHCCHHEECCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHCCCCCCCC
DTVAVIGCGGVGDAAIAGAALVGAKKIIAVDTDDKKLQWAREFGATDTINARSVDDVVEA
CCEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHH
IQELTDGFGTDVVIDAVGRPETWKQAFYARDLAGTVVLVGVPTPDMRLEMPLVDFFSRGG
HHHHHCCCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCEEECHHHHHHHCCC
SLKSSWYGDCLPERDFPTLISLYLQGRLPLDKFVSERIGLDGIEDAFHKMHAGEVLRSVV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VL
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9346279; 1597190; 9202149 [H]