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The map label for this gene is liaR [H]

Identifier: 119869444

GI number: 119869444

Start: 3577708

End: 3578391

Strand: Direct

Name: liaR [H]

Synonym: Mkms_3412

Alternate gene names: 119869444

Gene position: 3577708-3578391 (Clockwise)

Preceding gene: 119869442

Following gene: 119869445

Centisome position: 62.36

GC content: 66.23

Gene sequence:

>684_bases
ATGTCGGTCTCATCGGGGGGAACCGGCGAGTCGGCGACGTCGATCGTCGTCATCGACCGCCAGGCCGTGGTGCACGCCGG
CATCGAGCACTGGCTCATCGGCAGCGTGCCACCGATCAAGATCGTCGGGCACTTCTCGGATCCGGCCGAGTTCCTCGCGG
CGTACCCGACGGCGGATCCGACGGTCGATGTCGTCCTCTCGGCGCTGAAATACGACGACCACGGGCCGGATTTCGATTCA
CTTCGCCGGATCTGCGCCGGCGGGCACCGGGTCATCGTCTATTCGTACCTCGTCACCGACGAAGTCATCCTGACCTGCCT
CGACGAAGGGGCACTCACGTTCGTGGCGAAGTCCGAGAGCGGAAACCACTTGCGCGACGCGATCTACGCGGCGCGGACGA
GTACGCCGTACGTCGCCCCGCGAATGGCCAGAGCGCTGCTCAACGACAAGACGGGCGGGCGGCCCCACCTCACCAAACGG
GAACGCGAGGTACTCGTCGCCTGGTTCCAGACCGAGAACAAGGATGTCGTGGGACGGCGATTGTTCATCGAGCCGTCCAC
AGTCCGCACACACCTGCAGCGGGCACGGGCGAAGTACGCCGCAGTGGGCCGACCCGCGCCCACCAAAGCGGCCCTTGTCG
CGCGGGCGATCCAGGACGGGATCCTCAGCGTCGACGATCTGTGA

Upstream 100 bases:

>100_bases
ATTGCCAAGCACAGAATCTTGCGGATCCCGCTAAATCTTCCTCTGACCGCCCGACAGTGCTTTGATACATGAACAGGGGG
TTTTGGCAAAGGAGGTCGAG

Downstream 100 bases:

>100_bases
GACGGACGGGACCGGTTGCGCGCCCGAGTGCGTCTCCCCGCAAATCAGCGCGCGGATGGATTTTTGGCAAACTCGACTTA
TGCTGTGGCGTCTACCGTTC

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 226

Protein sequence:

>227_residues
MSVSSGGTGESATSIVVIDRQAVVHAGIEHWLIGSVPPIKIVGHFSDPAEFLAAYPTADPTVDVVLSALKYDDHGPDFDS
LRRICAGGHRVIVYSYLVTDEVILTCLDEGALTFVAKSESGNHLRDAIYAARTSTPYVAPRMARALLNDKTGGRPHLTKR
EREVLVAWFQTENKDVVGRRLFIEPSTVRTHLQRARAKYAAVGRPAPTKAALVARAIQDGILSVDDL

Sequences:

>Translated_227_residues
MSVSSGGTGESATSIVVIDRQAVVHAGIEHWLIGSVPPIKIVGHFSDPAEFLAAYPTADPTVDVVLSALKYDDHGPDFDS
LRRICAGGHRVIVYSYLVTDEVILTCLDEGALTFVAKSESGNHLRDAIYAARTSTPYVAPRMARALLNDKTGGRPHLTKR
EREVLVAWFQTENKDVVGRRLFIEPSTVRTHLQRARAKYAAVGRPAPTKAALVARAIQDGILSVDDL
>Mature_226_residues
SVSSGGTGESATSIVVIDRQAVVHAGIEHWLIGSVPPIKIVGHFSDPAEFLAAYPTADPTVDVVLSALKYDDHGPDFDSL
RRICAGGHRVIVYSYLVTDEVILTCLDEGALTFVAKSESGNHLRDAIYAARTSTPYVAPRMARALLNDKTGGRPHLTKRE
REVLVAWFQTENKDVVGRRLFIEPSTVRTHLQRARAKYAAVGRPAPTKAALVARAIQDGILSVDDL

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 24626; Mature: 24495

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSSGGTGESATSIVVIDRQAVVHAGIEHWLIGSVPPIKIVGHFSDPAEFLAAYPTADP
CCCCCCCCCCCCCEEEEEECHHHHHHCHHHHCCCCCCCEEEEECCCCHHHHHEECCCCCC
TVDVVLSALKYDDHGPDFDSLRRICAGGHRVIVYSYLVTDEVILTCLDEGALTFVAKSES
HHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHCCCCEEEEEECCC
GNHLRDAIYAARTSTPYVAPRMARALLNDKTGGRPHLTKREREVLVAWFQTENKDVVGRR
CCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEE
LFIEPSTVRTHLQRARAKYAAVGRPAPTKAALVARAIQDGILSVDDL
EEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEECCCC
>Mature Secondary Structure 
SVSSGGTGESATSIVVIDRQAVVHAGIEHWLIGSVPPIKIVGHFSDPAEFLAAYPTADP
CCCCCCCCCCCCEEEEEECHHHHHHCHHHHCCCCCCCEEEEECCCCHHHHHEECCCCCC
TVDVVLSALKYDDHGPDFDSLRRICAGGHRVIVYSYLVTDEVILTCLDEGALTFVAKSES
HHHHHHHHHHCCCCCCCHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHCCCCEEEEEECCC
GNHLRDAIYAARTSTPYVAPRMARALLNDKTGGRPHLTKREREVLVAWFQTENKDVVGRR
CCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEE
LFIEPSTVRTHLQRARAKYAAVGRPAPTKAALVARAIQDGILSVDDL
EEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]