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The map label for this gene is pepA [H]

Identifier: 119869404

GI number: 119869404

Start: 3534555

End: 3536096

Strand: Direct

Name: pepA [H]

Synonym: Mkms_3372

Alternate gene names: 119869404

Gene position: 3534555-3536096 (Clockwise)

Preceding gene: 119869401

Following gene: 119869407

Centisome position: 61.61

GC content: 70.95

Gene sequence:

>1542_bases
GTGAGTTCCGATCCCGGCTATCAGGCCCCCGTCGTCACCGTCAGTTCCTCCATCCCGCGCCGCGGAGTGGGTGACTCCGT
GCTCATCGTGCCCGTGGTCACGCGGGACGACGCGGCGGCGGTTCTCGCCGCCGCCCCGTTCCTGGACAAAGACGCCGTCA
GGGAGATCGAGGCCGCGCTCAAGTCGCTCGGCGCGACCGGCGGTGAAGGGCAGACGCACCGCCTGGTGGTGTCCGCGCTG
CCGGTGGCCAGTGTGCTGACGATCGGGCTGGGCAAGGAGCGCGACGAGTGGCCCGCCGACACCGTGCGGCGGGTGGCCGG
CAACGCGGCCCGGTCGCTCGACAAGGTGGCGGCGGTGCTGACCACGCTGTCCGCGCTGGACCTGGAGGCGGCGATCGAGG
GCCTGATCCTGGGCTCGTACCGCTTCACCGAGTTCCGCAGCGCCAAGACCGCGCCCAAGGACGGCGGTCTGCGCGCGATC
ACCGCGCTGTCCCAGGAGTCGAAGAGCCGTGCCCGCGACGCCGCGCAGCGCGCCACCGACATCGCCACCGCCGTCGCGAC
GGCCCGCGACTTCGTCAACACCCCGCCCAGCCACCTCTACCCCGACGAGTTCGCCAAGCGTGCGAAGGCGCTGGGAGAGG
CGGCCGGTCTGGAGGTCGAGATCCTCGACGACAAGGCGTTGGTCAAGGCGGGTTACGGCGGCATCGTCGGCGTCGGCAAG
GGTTCGTCGCGGCCGCCGCGGCTGGTGCGGCTGTCGCACAAGGGTGCTGTGCGCACGCGCACGCGAGGAGCACGACCAGG
CGGAAGTAAGCGGGTCGCGCTCGTCGGCAAGGGCATCACCTTCGACACCGGCGGCATCTCGATCAAGCCGGCCGCCAACA
TGCACCACATGACCTCCGACATGGGCGGGGCGGCCGCGGTGATCGCCACCGTCGTGCTGGCCGCCAAACAGAAGCTGCCG
ATCGACGTGATCGCGACCGTGCCGATGGCCGAGAACATGCCGTCGGCGACCGCGCAGCGCCCCGGCGACGTGCTGACCCA
GTACGGCGGCACCACCGTGGAGGTGCTCAACACCGATGCCGAGGGCCGGCTGATCCTGGCCGACGCGATCGTGCGGGCGT
GTGAGGACAACCCCGACTATCTGATCGAGACCTCGACGCTGACCGGCGCCCAGACCGTGGCGCTCGGTTCGCGCACGCCC
GGCGTGATGGGCAGCGACGCGTTCCGCGACCGGGTGGCGACACTGTCGCAGCAGGTGGGCGAGAACGCGTGGGCGATGCC
GCTGCCCGAGGAACTCAAGGACGACCTCAAGTCGACGGTCGCCGACCTCGCCAACGTCAGCGGTTCACGCTTCGCGGGCA
TGCTCGTCGCGGGCACCTACCTGCGCGAATTCGTCGCCGACGGTGTCGAATGGGCGCACATCGACGTCGCGGCGCCGGCG
TACAACTCCGGCGGTCCGTGGGGTTACACCCCCAAGGGCGGCACCGGGGTGCCGACGCGGACGATGTTCGCGGTCCTGGA
AGAGATCGCCCGGGAAGGCTAG

Upstream 100 bases:

>100_bases
GCCGCCGAACTCGGCGAACGTCGCTCCCAGCTCGCGGTGGCGGTCTTCCAGAGGGCCGTGCAGGGGTTCACTCACGTCTG
ACACCTTATGGTGGATTCTC

Downstream 100 bases:

>100_bases
AGCACGCGGCCGCGGGCGGTGCTGCGCAGCGCCTGCGGCAACACCCGGGACACCCCGTAGACGAAGTAGGCCTCCGGCAT
CACCGGCCGGATCGCCTTGT

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MSSDPGYQAPVVTVSSSIPRRGVGDSVLIVPVVTRDDAAAVLAAAPFLDKDAVREIEAALKSLGATGGEGQTHRLVVSAL
PVASVLTIGLGKERDEWPADTVRRVAGNAARSLDKVAAVLTTLSALDLEAAIEGLILGSYRFTEFRSAKTAPKDGGLRAI
TALSQESKSRARDAAQRATDIATAVATARDFVNTPPSHLYPDEFAKRAKALGEAAGLEVEILDDKALVKAGYGGIVGVGK
GSSRPPRLVRLSHKGAVRTRTRGARPGGSKRVALVGKGITFDTGGISIKPAANMHHMTSDMGGAAAVIATVVLAAKQKLP
IDVIATVPMAENMPSATAQRPGDVLTQYGGTTVEVLNTDAEGRLILADAIVRACEDNPDYLIETSTLTGAQTVALGSRTP
GVMGSDAFRDRVATLSQQVGENAWAMPLPEELKDDLKSTVADLANVSGSRFAGMLVAGTYLREFVADGVEWAHIDVAAPA
YNSGGPWGYTPKGGTGVPTRTMFAVLEEIAREG

Sequences:

>Translated_513_residues
MSSDPGYQAPVVTVSSSIPRRGVGDSVLIVPVVTRDDAAAVLAAAPFLDKDAVREIEAALKSLGATGGEGQTHRLVVSAL
PVASVLTIGLGKERDEWPADTVRRVAGNAARSLDKVAAVLTTLSALDLEAAIEGLILGSYRFTEFRSAKTAPKDGGLRAI
TALSQESKSRARDAAQRATDIATAVATARDFVNTPPSHLYPDEFAKRAKALGEAAGLEVEILDDKALVKAGYGGIVGVGK
GSSRPPRLVRLSHKGAVRTRTRGARPGGSKRVALVGKGITFDTGGISIKPAANMHHMTSDMGGAAAVIATVVLAAKQKLP
IDVIATVPMAENMPSATAQRPGDVLTQYGGTTVEVLNTDAEGRLILADAIVRACEDNPDYLIETSTLTGAQTVALGSRTP
GVMGSDAFRDRVATLSQQVGENAWAMPLPEELKDDLKSTVADLANVSGSRFAGMLVAGTYLREFVADGVEWAHIDVAAPA
YNSGGPWGYTPKGGTGVPTRTMFAVLEEIAREG
>Mature_512_residues
SSDPGYQAPVVTVSSSIPRRGVGDSVLIVPVVTRDDAAAVLAAAPFLDKDAVREIEAALKSLGATGGEGQTHRLVVSALP
VASVLTIGLGKERDEWPADTVRRVAGNAARSLDKVAAVLTTLSALDLEAAIEGLILGSYRFTEFRSAKTAPKDGGLRAIT
ALSQESKSRARDAAQRATDIATAVATARDFVNTPPSHLYPDEFAKRAKALGEAAGLEVEILDDKALVKAGYGGIVGVGKG
SSRPPRLVRLSHKGAVRTRTRGARPGGSKRVALVGKGITFDTGGISIKPAANMHHMTSDMGGAAAVIATVVLAAKQKLPI
DVIATVPMAENMPSATAQRPGDVLTQYGGTTVEVLNTDAEGRLILADAIVRACEDNPDYLIETSTLTGAQTVALGSRTPG
VMGSDAFRDRVATLSQQVGENAWAMPLPEELKDDLKSTVADLANVSGSRFAGMLVAGTYLREFVADGVEWAHIDVAAPAY
NSGGPWGYTPKGGTGVPTRTMFAVLEEIAREG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=493, Percent_Identity=33.6713995943205, Blast_Score=234, Evalue=2e-61,
Organism=Homo sapiens, GI47155554, Length=307, Percent_Identity=36.8078175895765, Blast_Score=163, Evalue=4e-40,
Organism=Escherichia coli, GI1790710, Length=468, Percent_Identity=34.4017094017094, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI87082123, Length=328, Percent_Identity=37.1951219512195, Blast_Score=170, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17556903, Length=352, Percent_Identity=32.3863636363636, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI17565172, Length=226, Percent_Identity=26.9911504424779, Blast_Score=75, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24661038, Length=464, Percent_Identity=28.0172413793103, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI21355725, Length=443, Percent_Identity=28.8939051918736, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI21357381, Length=335, Percent_Identity=32.8358208955224, Blast_Score=156, Evalue=3e-38,
Organism=Drosophila melanogaster, GI221379063, Length=335, Percent_Identity=32.8358208955224, Blast_Score=156, Evalue=4e-38,
Organism=Drosophila melanogaster, GI221379062, Length=335, Percent_Identity=32.8358208955224, Blast_Score=156, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24662227, Length=419, Percent_Identity=26.9689737470167, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI20129969, Length=422, Percent_Identity=27.7251184834123, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21355645, Length=427, Percent_Identity=27.6346604215457, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24662223, Length=427, Percent_Identity=27.6346604215457, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI161077148, Length=445, Percent_Identity=28.5393258426966, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI20130057, Length=445, Percent_Identity=28.5393258426966, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI19922386, Length=440, Percent_Identity=25.6818181818182, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI20129963, Length=471, Percent_Identity=25.9023354564756, Blast_Score=113, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24646701, Length=278, Percent_Identity=30.2158273381295, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24646703, Length=278, Percent_Identity=30.2158273381295, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21358201, Length=278, Percent_Identity=30.2158273381295, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53339; Mature: 53208

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSDPGYQAPVVTVSSSIPRRGVGDSVLIVPVVTRDDAAAVLAAAPFLDKDAVREIEAAL
CCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHH
KSLGATGGEGQTHRLVVSALPVASVLTIGLGKERDEWPADTVRRVAGNAARSLDKVAAVL
HHCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TTLSALDLEAAIEGLILGSYRFTEFRSAKTAPKDGGLRAITALSQESKSRARDAAQRATD
HHHHHHHHHHHHHHEEECCEEHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IATAVATARDFVNTPPSHLYPDEFAKRAKALGEAAGLEVEILDDKALVKAGYGGIVGVGK
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHCCCCCEEEECC
GSSRPPRLVRLSHKGAVRTRTRGARPGGSKRVALVGKGITFDTGGISIKPAANMHHMTSD
CCCCCCCEEEECCCCCCHHCCCCCCCCCCCEEEEEECCEEECCCCEEECCCCCHHHHHHC
MGGAAAVIATVVLAAKQKLPIDVIATVPMAENMPSATAQRPGDVLTQYGGTTVEVLNTDA
CCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHCCCHHHHHHCCCCEEEEEECCC
EGRLILADAIVRACEDNPDYLIETSTLTGAQTVALGSRTPGVMGSDAFRDRVATLSQQVG
CCCEEHHHHHHHHHCCCCCEEEEECCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHC
ENAWAMPLPEELKDDLKSTVADLANVSGSRFAGMLVAGTYLREFVADGVEWAHIDVAAPA
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
YNSGGPWGYTPKGGTGVPTRTMFAVLEEIAREG
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SSDPGYQAPVVTVSSSIPRRGVGDSVLIVPVVTRDDAAAVLAAAPFLDKDAVREIEAAL
CCCCCCCCCEEEECCCCCCCCCCCCEEEEEEEECCCHHHHHHHCCCCCHHHHHHHHHHH
KSLGATGGEGQTHRLVVSALPVASVLTIGLGKERDEWPADTVRRVAGNAARSLDKVAAVL
HHCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
TTLSALDLEAAIEGLILGSYRFTEFRSAKTAPKDGGLRAITALSQESKSRARDAAQRATD
HHHHHHHHHHHHHHEEECCEEHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IATAVATARDFVNTPPSHLYPDEFAKRAKALGEAAGLEVEILDDKALVKAGYGGIVGVGK
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHCCCCCEEEECC
GSSRPPRLVRLSHKGAVRTRTRGARPGGSKRVALVGKGITFDTGGISIKPAANMHHMTSD
CCCCCCCEEEECCCCCCHHCCCCCCCCCCCEEEEEECCEEECCCCEEECCCCCHHHHHHC
MGGAAAVIATVVLAAKQKLPIDVIATVPMAENMPSATAQRPGDVLTQYGGTTVEVLNTDA
CCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHCCCHHHHHHCCCCEEEEEECCC
EGRLILADAIVRACEDNPDYLIETSTLTGAQTVALGSRTPGVMGSDAFRDRVATLSQQVG
CCCEEHHHHHHHHHCCCCCEEEEECCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHC
ENAWAMPLPEELKDDLKSTVADLANVSGSRFAGMLVAGTYLREFVADGVEWAHIDVAAPA
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCC
YNSGGPWGYTPKGGTGVPTRTMFAVLEEIAREG
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA