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The map label for this gene is uvrC [C]

Identifier: 119869383

GI number: 119869383

Start: 3513740

End: 3515632

Strand: Direct

Name: uvrC [C]

Synonym: Mkms_3351

Alternate gene names: 119869383

Gene position: 3513740-3515632 (Clockwise)

Preceding gene: 119869378

Following gene: 119869385

Centisome position: 61.24

GC content: 74.43

Gene sequence:

>1893_bases
ATGGGTCAGGGCAGCGTCGGTGCCGTCGGGGGCGCGGCCGAGCAGCTGTCGTTCGACATGGAGGCGCTGTCGCTGCGCGA
CACCACGTTCGTCGTCGTGGACCTGGAGACCACCGGCGGTCGCGCCACGGGTGAGCGTCCGGATGCGATCACCGAGATCG
GCGCGGTCAAGGTCCGCGGCGGTGAGGTGCTCGGTGAGCTCGCCACCCTGGTCGACCCCGGGCGGGCGATACCGCCGCAG
ATCGTCTCGCTGACCGGCATCACCACCGCGATGGTGTGCGCCGCCCCCCGCATCGAATCGGTGCTGCCCGCATTCCTCGA
GTTCGCGCGCGGCTCGGTGCTGGTGGCCCACAACGCCGGCTTCGACATCGGCTTCCTGCGGGCGGCGGCCGAACAGTGCG
CGCTGACCTGGCCCCGCCCGCCGGTGCTGTGCACGGTCAAGCTCGCGCGCCGCGTGCTCACCCGCGACGAGGCGCCCAGC
GTGCGGCTGTCAGCGCTGGCGCAGTTGTTCCGCGCGAAGACGACGCCGACGCACCGGGCCCTCGACGATGCCCGCGCCAC
GGTGGACGTACTGCACGGGCTGATCGAACGGATCGGCAACCAGGGCGTGCACACCTACACCGACCTGCGCGCCTACCTGC
CCGACGTCACCCCCGCGCAGCGCCGCAACCGCCGCCTCGCCGACGGTCTGCCCCACCGGCCGGGGGTGTACCTGTTCCGC
GGCCCGGGCGACGAGGTGCTCTACATCGGCACCGCGGTGGACCTGCGCCGCCGCGTCGGCCAGTACTTCACCGGAGCCGA
CCCGCGGGCGCGGATGAAGGAGATGGCGTCCCTGGCCACCCGCGTGGACCACGTGGAATGCGCCCACGAACTCGAGGCGG
GCGTGCGTGAGCTGCGCCTGCTGGCCGCCCATGCGCCGCCCTACAACCGGCGTTCGAAGTTCCCGCAGCGCTGGTGGTGG
GTGGTGCTGACCGACGAGCCCTTCCCGCGGTTCTCGGTCGTGCGCGCACCCCGTCACGGTTCGGCGGTCGGGCCGTTCCG
GGCCCGCACGGACGCCGTGCAGACCGCTGAACTGCTCGCCCGGTTCACCGGTGTGCGGACCTGCACCGCCCGGCTCGCCC
GCGCGGCCCGGCACGGCGCGGCCTGCGCCGAGCGTGAACTGTCACCGTGCCCGGCGCCGCGCGACATCGACGCGGCGGCC
TACGCCCCGGCCCACCGCCGCGCCGCCGACCTCATCGAGGGCCGCGACGATGCGGCGCTGGCCGCGGTGGTCGACGGGAT
CGCCGCGCTGGCGGCCGTCAACCGGTACGAATCGGCCGCGCGCCTGCGTGACCACGCCGCCACGGGCATCGACGTGCTGT
GGCGGGGGCAGCGACTGCGTGCGCTCGCCGACCAGACCGAGTTGGTCGCGGCCCGTCCGGACGGCAGCGGTGGATGGGAC
CTCGCCGTCGTGCGGTACGGACGCCTGGCCGCCGCCGGGTGCGCCCGTCGCGGGGTGCCGCCGATGCCGGTCGTCGACGC
GCTGACCGCCGCGGCGCAGACGGTGCTGCCCGATCCCGCCCCGCTTGGCGGTGCGCTGGTCGAGGAGACCGGGCTGATCA
CCCGCTGGCTCACCAGCCCCGGTGTGCGGATCGTGCGGTGCGAACCCGGGTACGCCACACCGATCGGCGCGGCGGGCCGC
TGGCTGGGCTGGGCGGATACGGCGCGTTCGGCACGGTTGGCCGCCGAGCAGACCGGTGCGGACGCGAGGACCAGAGAGTC
GGTCCCCTCAGAGCTTCTGGGTGAACCGCACCCAACGCGCGAGCAGCTTTTCGGCCGCCCCGGAGTCGATGGTCTCGGTC
GCCCGGGCCAGGCCCGCCTCCCAGGCCGGCACCCATTTGGCGTCGCTGGATAG

Upstream 100 bases:

>100_bases
GTGCCCGCACGCTAGCGACGCCCACCGACACGGCCCGTCCGGAACACCGCGGCCCGCGTGGCACCGCCGCGCTGTCGGTG
CCATTCCCTACGTTTCTCGC

Downstream 100 bases:

>100_bases
CCCGGCGTGTGCGACCAGCGCGCCCGCGGCGTTGAGCACCACCGCATCGCGCACCGCGCCCTTTGCACCCCCGAGCACCG
CCCGCACCTCGGCGGCGTTG

Product: hypothetical protein

Products: diphosphate; DNAn+1

Alternate protein names: NA

Number of amino acids: Translated: 630; Mature: 629

Protein sequence:

>630_residues
MGQGSVGAVGGAAEQLSFDMEALSLRDTTFVVVDLETTGGRATGERPDAITEIGAVKVRGGEVLGELATLVDPGRAIPPQ
IVSLTGITTAMVCAAPRIESVLPAFLEFARGSVLVAHNAGFDIGFLRAAAEQCALTWPRPPVLCTVKLARRVLTRDEAPS
VRLSALAQLFRAKTTPTHRALDDARATVDVLHGLIERIGNQGVHTYTDLRAYLPDVTPAQRRNRRLADGLPHRPGVYLFR
GPGDEVLYIGTAVDLRRRVGQYFTGADPRARMKEMASLATRVDHVECAHELEAGVRELRLLAAHAPPYNRRSKFPQRWWW
VVLTDEPFPRFSVVRAPRHGSAVGPFRARTDAVQTAELLARFTGVRTCTARLARAARHGAACAERELSPCPAPRDIDAAA
YAPAHRRAADLIEGRDDAALAAVVDGIAALAAVNRYESAARLRDHAATGIDVLWRGQRLRALADQTELVAARPDGSGGWD
LAVVRYGRLAAAGCARRGVPPMPVVDALTAAAQTVLPDPAPLGGALVEETGLITRWLTSPGVRIVRCEPGYATPIGAAGR
WLGWADTARSARLAAEQTGADARTRESVPSELLGEPHPTREQLFGRPGVDGLGRPGQARLPGRHPFGVAG

Sequences:

>Translated_630_residues
MGQGSVGAVGGAAEQLSFDMEALSLRDTTFVVVDLETTGGRATGERPDAITEIGAVKVRGGEVLGELATLVDPGRAIPPQ
IVSLTGITTAMVCAAPRIESVLPAFLEFARGSVLVAHNAGFDIGFLRAAAEQCALTWPRPPVLCTVKLARRVLTRDEAPS
VRLSALAQLFRAKTTPTHRALDDARATVDVLHGLIERIGNQGVHTYTDLRAYLPDVTPAQRRNRRLADGLPHRPGVYLFR
GPGDEVLYIGTAVDLRRRVGQYFTGADPRARMKEMASLATRVDHVECAHELEAGVRELRLLAAHAPPYNRRSKFPQRWWW
VVLTDEPFPRFSVVRAPRHGSAVGPFRARTDAVQTAELLARFTGVRTCTARLARAARHGAACAERELSPCPAPRDIDAAA
YAPAHRRAADLIEGRDDAALAAVVDGIAALAAVNRYESAARLRDHAATGIDVLWRGQRLRALADQTELVAARPDGSGGWD
LAVVRYGRLAAAGCARRGVPPMPVVDALTAAAQTVLPDPAPLGGALVEETGLITRWLTSPGVRIVRCEPGYATPIGAAGR
WLGWADTARSARLAAEQTGADARTRESVPSELLGEPHPTREQLFGRPGVDGLGRPGQARLPGRHPFGVAG
>Mature_629_residues
GQGSVGAVGGAAEQLSFDMEALSLRDTTFVVVDLETTGGRATGERPDAITEIGAVKVRGGEVLGELATLVDPGRAIPPQI
VSLTGITTAMVCAAPRIESVLPAFLEFARGSVLVAHNAGFDIGFLRAAAEQCALTWPRPPVLCTVKLARRVLTRDEAPSV
RLSALAQLFRAKTTPTHRALDDARATVDVLHGLIERIGNQGVHTYTDLRAYLPDVTPAQRRNRRLADGLPHRPGVYLFRG
PGDEVLYIGTAVDLRRRVGQYFTGADPRARMKEMASLATRVDHVECAHELEAGVRELRLLAAHAPPYNRRSKFPQRWWWV
VLTDEPFPRFSVVRAPRHGSAVGPFRARTDAVQTAELLARFTGVRTCTARLARAARHGAACAERELSPCPAPRDIDAAAY
APAHRRAADLIEGRDDAALAAVVDGIAALAAVNRYESAARLRDHAATGIDVLWRGQRLRALADQTELVAARPDGSGGWDL
AVVRYGRLAAAGCARRGVPPMPVVDALTAAAQTVLPDPAPLGGALVEETGLITRWLTSPGVRIVRCEPGYATPIGAAGRW
LGWADTARSARLAAEQTGADARTRESVPSELLGEPHPTREQLFGRPGVDGLGRPGQARLPGRHPFGVAG

Specific function: The Uvrabc Repair System Catalyzes The Recognition And Processing Of DNA Lesions. Uvrc Both Incises The 5' And 3' Sides Of The Lesion. The N-Terminal Half Is Responsible For The 3' Incision And The C-Terminal Half Is Responsible For The 5' Incision. [C]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87081999, Length=218, Percent_Identity=23.8532110091743, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1788149, Length=176, Percent_Identity=32.3863636363636, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1786409, Length=167, Percent_Identity=29.940119760479, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006054
- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR012337
- InterPro:   IPR000305 [H]

Pfam domain/function: PF00929 Exonuc_X-T; PF01541 GIY-YIG [H]

EC number: 2.7.7.7

Molecular weight: Translated: 67391; Mature: 67259

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS50164 UVRC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQGSVGAVGGAAEQLSFDMEALSLRDTTFVVVDLETTGGRATGERPDAITEIGAVKVRG
CCCCCCCCCCCHHHHHHHHHHHHEECCCEEEEEEEECCCCCCCCCCCCHHHHHCEEEEEC
GEVLGELATLVDPGRAIPPQIVSLTGITTAMVCAAPRIESVLPAFLEFARGSVLVAHNAG
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEEEECCC
FDIGFLRAAAEQCALTWPRPPVLCTVKLARRVLTRDEAPSVRLSALAQLFRAKTTPTHRA
CCHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHH
LDDARATVDVLHGLIERIGNQGVHTYTDLRAYLPDVTPAQRRNRRLADGLPHRPGVYLFR
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHCCHHHCCCCCCCCEEEEE
GPGDEVLYIGTAVDLRRRVGQYFTGADPRARMKEMASLATRVDHVECAHELEAGVRELRL
CCCCCEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAHAPPYNRRSKFPQRWWWVVLTDEPFPRFSVVRAPRHGSAVGPFRARTDAVQTAELLA
HHHCCCCCCHHCCCCCEEEEEEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHH
RFTGVRTCTARLARAARHGAACAERELSPCPAPRDIDAAAYAPAHRRAADLIEGRDDAAL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCHHHHHHHHHCCCCCHHH
AAVVDGIAALAAVNRYESAARLRDHAATGIDVLWRGQRLRALADQTELVAARPDGSGGWD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEECCHHHHHHHCCCCEEEECCCCCCCCE
LAVVRYGRLAAAGCARRGVPPMPVVDALTAAAQTVLPDPAPLGGALVEETGLITRWLTSP
EEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHCCC
GVRIVRCEPGYATPIGAAGRWLGWADTARSARLAAEQTGADARTRESVPSELLGEPHPTR
CCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCHHHCCCCCCCH
EQLFGRPGVDGLGRPGQARLPGRHPFGVAG
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GQGSVGAVGGAAEQLSFDMEALSLRDTTFVVVDLETTGGRATGERPDAITEIGAVKVRG
CCCCCCCCCCHHHHHHHHHHHHEECCCEEEEEEEECCCCCCCCCCCCHHHHHCEEEEEC
GEVLGELATLVDPGRAIPPQIVSLTGITTAMVCAAPRIESVLPAFLEFARGSVLVAHNAG
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCEEEEECCC
FDIGFLRAAAEQCALTWPRPPVLCTVKLARRVLTRDEAPSVRLSALAQLFRAKTTPTHRA
CCHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHH
LDDARATVDVLHGLIERIGNQGVHTYTDLRAYLPDVTPAQRRNRRLADGLPHRPGVYLFR
HHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHCCHHHCCCCCCCCEEEEE
GPGDEVLYIGTAVDLRRRVGQYFTGADPRARMKEMASLATRVDHVECAHELEAGVRELRL
CCCCCEEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAAHAPPYNRRSKFPQRWWWVVLTDEPFPRFSVVRAPRHGSAVGPFRARTDAVQTAELLA
HHHCCCCCCHHCCCCCEEEEEEEECCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHH
RFTGVRTCTARLARAARHGAACAERELSPCPAPRDIDAAAYAPAHRRAADLIEGRDDAAL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHCCCHHHHHHHHHCCCCCHHH
AAVVDGIAALAAVNRYESAARLRDHAATGIDVLWRGQRLRALADQTELVAARPDGSGGWD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEECCHHHHHHHCCCCEEEECCCCCCCCE
LAVVRYGRLAAAGCARRGVPPMPVVDALTAAAQTVLPDPAPLGGALVEETGLITRWLTSP
EEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHHHHHHCCC
GVRIVRCEPGYATPIGAAGRWLGWADTARSARLAAEQTGADARTRESVPSELLGEPHPTR
CCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHCCCHHHCCCCCCCH
EQLFGRPGVDGLGRPGQARLPGRHPFGVAG
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: deoxynucleoside triphosphate; DNAn

Specific reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]