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The map label for this gene is tetR [H]

Identifier: 119869166

GI number: 119869166

Start: 3277243

End: 3277821

Strand: Direct

Name: tetR [H]

Synonym: Mkms_3134

Alternate gene names: 119869166

Gene position: 3277243-3277821 (Clockwise)

Preceding gene: 119869162

Following gene: 119869171

Centisome position: 57.12

GC content: 69.95

Gene sequence:

>579_bases
GTGCAACTGCACAAACGCGATGTGGTCGATGCCGCGACGGTGATCCTGGACTCCCACGGGATCGCCGATCTGACGATGCG
CCGGCTCGCCCGCGAGCTCAACGTCTCCCCCGGCGCCCTGTACTGGCACTTCGCCAACAAACAACAACTCCTCGGCGCGA
TCGCGGACCGCATCCTGACCCCGGCGCGCGGGCTGCCCGCCGAGGCGGACTGGCGCGACCGCATCGTCGCGGTGTGTTCG
GCGCTGCGCGATGCGCTGCTGTCGCACACCGACGGGGCCGAACTCGTCTCCGCCAGCTTCGCCGCCGGACAGTCGGAGGC
CGCGGGCGAGATCCTCGCGGTGCTCTCCGCTGCGGCCGCGGACGCGGGTGTCGCCGCCGGTGAGGCCGAACTCGCCGCGC
GCACCGTCATCTACTACGTCCTAGGATTCACCGTCGACGAGCAGTCGAAGCTGCAATGGGACTCCGCCGGCGTGCTCGAC
CCCGACGAGTCGGTCGCCACCATCGACCACGACCGCCGCTTCGGCTTCGGTCTGCGGCTGCTGATCGACGGTCTCGGGGT
CATCTCACCGGTCAGGTGA

Upstream 100 bases:

>100_bases
CGCGCGCCACCGCCAGAATGTCGCTCACCCGTTGCCTCCTCGACTCTTGAACACGTCGGCCGAGCCGACAATTGAACACC
GTTCAGGTTAGGGTAGCGGC

Downstream 100 bases:

>100_bases
TCGGGTACTCGACGCGGTTGTTTCCGTCCCAGTGACGTAGGCCCACAATTCGGCACCGCAGGTCGCGGCCGAGCCCCGGC
ACCGCCACCGCCGCGGGGAG

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MQLHKRDVVDAATVILDSHGIADLTMRRLARELNVSPGALYWHFANKQQLLGAIADRILTPARGLPAEADWRDRIVAVCS
ALRDALLSHTDGAELVSASFAAGQSEAAGEILAVLSAAAADAGVAAGEAELAARTVIYYVLGFTVDEQSKLQWDSAGVLD
PDESVATIDHDRRFGFGLRLLIDGLGVISPVR

Sequences:

>Translated_192_residues
MQLHKRDVVDAATVILDSHGIADLTMRRLARELNVSPGALYWHFANKQQLLGAIADRILTPARGLPAEADWRDRIVAVCS
ALRDALLSHTDGAELVSASFAAGQSEAAGEILAVLSAAAADAGVAAGEAELAARTVIYYVLGFTVDEQSKLQWDSAGVLD
PDESVATIDHDRRFGFGLRLLIDGLGVISPVR
>Mature_192_residues
MQLHKRDVVDAATVILDSHGIADLTMRRLARELNVSPGALYWHFANKQQLLGAIADRILTPARGLPAEADWRDRIVAVCS
ALRDALLSHTDGAELVSASFAAGQSEAAGEILAVLSAAAADAGVAAGEAELAARTVIYYVLGFTVDEQSKLQWDSAGVLD
PDESVATIDHDRRFGFGLRLLIDGLGVISPVR

Specific function: TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to tetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter opera

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR003012
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR004111
- InterPro:   IPR001647 [H]

Pfam domain/function: PF02909 TetR_C; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 20413; Mature: 20413

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLHKRDVVDAATVILDSHGIADLTMRRLARELNVSPGALYWHFANKQQLLGAIADRILT
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHC
PARGLPAEADWRDRIVAVCSALRDALLSHTDGAELVSASFAAGQSEAAGEILAVLSAAAA
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHH
DAGVAAGEAELAARTVIYYVLGFTVDEQSKLQWDSAGVLDPDESVATIDHDRRFGFGLRL
HCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHH
LIDGLGVISPVR
HHHHHCCCCCCC
>Mature Secondary Structure
MQLHKRDVVDAATVILDSHGIADLTMRRLARELNVSPGALYWHFANKQQLLGAIADRILT
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHC
PARGLPAEADWRDRIVAVCSALRDALLSHTDGAELVSASFAAGQSEAAGEILAVLSAAAA
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHH
DAGVAAGEAELAARTVIYYVLGFTVDEQSKLQWDSAGVLDPDESVATIDHDRRFGFGLRL
HCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCHHHHH
LIDGLGVISPVR
HHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3241623 [H]