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The map label for this gene is map [H]

Identifier: 119869157

GI number: 119869157

Start: 3268956

End: 3269726

Strand: Direct

Name: map [H]

Synonym: Mkms_3125

Alternate gene names: 119869157

Gene position: 3268956-3269726 (Clockwise)

Preceding gene: 119869155

Following gene: 119869161

Centisome position: 56.98

GC content: 70.56

Gene sequence:

>771_bases
GTGCTGGAACTGAAGACACCCCGCGAGATCGAGGCGATGCGCACCACCGGCGCCTTCATCGCCGGGCTGCTCGACGACCT
GCAGACGCGGGCCCGGGTCGGCGTGAACCTGCTCGATCTCGAACAGCGCGCCCGGCAGTTGATCGACGAGCGTGGTGCGG
TGTCCTGCTACTGGGACTACGCACCGTCGTTCGGTCGCGGCCCTTTCCGCAACGTCATCTGCCTCTCGGTCAACGATGCG
GTCCTGCACGGCCTCCCGCACGACTACACCCTGCGCGACGGCGACCTGCTGAGCATGGACATCGCGGTGTCGATCGACGG
GTGGGTGGCCGACTCGGCGCGCAGCATCATCGTCGGGACGCCGCAGGCCGAGGACCAGCGGCTGATCGAGGCCACCGAAC
AGGCACTGGTCGCAGGCATCGACGCGGCACGGCCCGGTAACCGCCTCGGCGACATCTCCGCGGCGATCGGGTCCGTCGCC
GCCGACTACGGGTATCCGGTGAACACCGATTTCGGCGGGCACGGGCTCGGGCGGACCATGCACGAGGATCCGCACGTGCC
GAACCGGGGACGGCCCGGGCGCGGTCTGGTGCTGCGTCCCGGTCTGACGCTCGCCCTCGAACCCTGGTTCGCCCGCGGTA
CCGACCGGATCGTCTACGACCCCGACGGCTGGACCATCCGGTCGGCCGACGGCTCGCGCACCGCCCACAGCGAACACACC
ATCGCCGTCACCGACGGCGACCCGCTGGTACTGACGCGCCGCGCGGCCTGA

Upstream 100 bases:

>100_bases
AGTCAGCGGAGATCGGACCATGCGTCCGAGGATACGTCAGCTCGGTATGAAAATACCGGCCCCACCGCTACTCTGGTATT
TCTATACCGAAGGAGAGCGC

Downstream 100 bases:

>100_bases
TGCGGTGGTGTCTCAGACGTCGAGGCCGATGTCGAGCACACGCACGGAATGGGTGAGCGCCCCGACGGCGAGGTAGTCGA
CGCCGGTACCCGCGTACTCG

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MLELKTPREIEAMRTTGAFIAGLLDDLQTRARVGVNLLDLEQRARQLIDERGAVSCYWDYAPSFGRGPFRNVICLSVNDA
VLHGLPHDYTLRDGDLLSMDIAVSIDGWVADSARSIIVGTPQAEDQRLIEATEQALVAGIDAARPGNRLGDISAAIGSVA
ADYGYPVNTDFGGHGLGRTMHEDPHVPNRGRPGRGLVLRPGLTLALEPWFARGTDRIVYDPDGWTIRSADGSRTAHSEHT
IAVTDGDPLVLTRRAA

Sequences:

>Translated_256_residues
MLELKTPREIEAMRTTGAFIAGLLDDLQTRARVGVNLLDLEQRARQLIDERGAVSCYWDYAPSFGRGPFRNVICLSVNDA
VLHGLPHDYTLRDGDLLSMDIAVSIDGWVADSARSIIVGTPQAEDQRLIEATEQALVAGIDAARPGNRLGDISAAIGSVA
ADYGYPVNTDFGGHGLGRTMHEDPHVPNRGRPGRGLVLRPGLTLALEPWFARGTDRIVYDPDGWTIRSADGSRTAHSEHT
IAVTDGDPLVLTRRAA
>Mature_256_residues
MLELKTPREIEAMRTTGAFIAGLLDDLQTRARVGVNLLDLEQRARQLIDERGAVSCYWDYAPSFGRGPFRNVICLSVNDA
VLHGLPHDYTLRDGDLLSMDIAVSIDGWVADSARSIIVGTPQAEDQRLIEATEQALVAGIDAARPGNRLGDISAAIGSVA
ADYGYPVNTDFGGHGLGRTMHEDPHVPNRGRPGRGLVLRPGLTLALEPWFARGTDRIVYDPDGWTIRSADGSRTAHSEHT
IAVTDGDPLVLTRRAA

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=253, Percent_Identity=28.4584980237154, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI40385867, Length=194, Percent_Identity=28.8659793814433, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI1786364, Length=255, Percent_Identity=34.1176470588235, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1788728, Length=214, Percent_Identity=24.7663551401869, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71996291, Length=255, Percent_Identity=27.843137254902, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6323273, Length=247, Percent_Identity=26.7206477732794, Blast_Score=112, Evalue=8e-26,
Organism=Drosophila melanogaster, GI21355531, Length=248, Percent_Identity=31.4516129032258, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24583427, Length=253, Percent_Identity=31.6205533596838, Blast_Score=125, Evalue=2e-29,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 27715; Mature: 27715

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELKTPREIEAMRTTGAFIAGLLDDLQTRARVGVNLLDLEQRARQLIDERGAVSCYWDY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHCCCCEEEEECC
APSFGRGPFRNVICLSVNDAVLHGLPHDYTLRDGDLLSMDIAVSIDGWVADSARSIIVGT
CCCCCCCCCCCEEEEEECHHHHHCCCCCCEECCCCEEEEEEEEEECCEECCCCCEEEEEC
PQAEDQRLIEATEQALVAGIDAARPGNRLGDISAAIGSVAADYGYPVNTDFGGHGLGRTM
CCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
HEDPHVPNRGRPGRGLVLRPGLTLALEPWFARGTDRIVYDPDGWTIRSADGSRTAHSEHT
CCCCCCCCCCCCCCCEEECCCCEEEECCHHHCCCCEEEECCCCCEEECCCCCCCCCCCCE
IAVTDGDPLVLTRRAA
EEEECCCCEEEEECCC
>Mature Secondary Structure
MLELKTPREIEAMRTTGAFIAGLLDDLQTRARVGVNLLDLEQRARQLIDERGAVSCYWDY
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHCCCCEEEEECC
APSFGRGPFRNVICLSVNDAVLHGLPHDYTLRDGDLLSMDIAVSIDGWVADSARSIIVGT
CCCCCCCCCCCEEEEEECHHHHHCCCCCCEECCCCEEEEEEEEEECCEECCCCCEEEEEC
PQAEDQRLIEATEQALVAGIDAARPGNRLGDISAAIGSVAADYGYPVNTDFGGHGLGRTM
CCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
HEDPHVPNRGRPGRGLVLRPGLTLALEPWFARGTDRIVYDPDGWTIRSADGSRTAHSEHT
CCCCCCCCCCCCCCCEEECCCCEEEECCHHHCCCCEEEECCCCCEEECCCCCCCCCCCCE
IAVTDGDPLVLTRRAA
EEEECCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]