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The map label for this gene is mlhB [H]

Identifier: 119868959

GI number: 119868959

Start: 3065161

End: 3066213

Strand: Direct

Name: mlhB [H]

Synonym: Mkms_2927

Alternate gene names: 119868959

Gene position: 3065161-3066213 (Clockwise)

Preceding gene: 119868954

Following gene: 119868960

Centisome position: 53.43

GC content: 70.37

Gene sequence:

>1053_bases
GTGATCCCCGCCGCACTGCGCTGCGTGCCCGCCGGTCAGGTCGACGTCACCGCGCCCGTGACCATCGACGGCCTGAGCTA
CATCGCACCCGACGACCCCGCGATGCCGATGTACCGGGTGATCGCGAACAACCGGCAGCCGGTGGCGTTGCGGGATCTGA
TGATCCAGCCGGTGCGCAGCGGCTACATCGGTGACGGACATCAGCCGGACCCGGCGCTGGTCCCGCCCACCGGGGCGCAG
GCGGTGCCGGACGTCGACGTCGACCAGGTGTACCTGCCGGTGCGCGACGGGGTGGCGCGGTGCCAGCTGTACCGGCCCAG
GGCGGCGCCCGCCGACGAGCAGCTACCGGTGATCGTCTACTACCACGGCGGCGGGTTCACCGTCGGTGTGTCCGAGGACT
GCGACTTCCTCGCGCGCAAACTGGCCTTCACCAACTCCGCGCTGGTGGTGTCGGCCAATTACCGCTCCGCACCGGAGTTC
ATGTTCCCCACGCCGCTCGACGACGCCTTCGACGTGTACCGCTGGGTGACCGTGAACGCCGAACTCGTGGGCGGGGACGC
GACCCGCGTCGCGGTGGCGGGCGACTCGGCCGGCTCGAACTTCGCTGCGGCGCTGGCGTTGCGGGCCCGCGACGAGCACG
CCCGGGTTCCCGATGCGGTGGTGATGCTCGGCGCGATGCCCGATTTCCACTTCGAACGCTGGGATTCGTTCCGCGCCCAG
GCGCCGCGCGGGATCGTCTACGACATGGCCTTCGCGGGGTTCATCCGCGGCGCGTACGTCGGCCCCACGCCGTGGGACCA
TCCGTGGGTCAGCCCCATCGAGGGCGACCTGACCGGATACCCGCTCACCGTGATCACCGCTGGCACCCACGATCCGATCG
TCGACTCCGCCAGAGCGTTCGGCGAGCGGATCCGGGCGGCCGGCGGTCAGACCGTCGAGTACTTCCCCGCGGGGATGCCG
CACGGCTACTACTTCTTCCCCGGCGTGCATGCCGAAGAGGACGTCGCCTACGAAATCGTCGCCGAGGTGCTGGCGAAACC
GTTCCGCCGCTAG

Upstream 100 bases:

>100_bases
TGTAGTTCCTTCGGCATGTGGAAGTCCTTTCTGCGACGGAATCAGGCGTACCCGCGTGAACGGGATCGAACACCTCGAAC
ACCTCCGTAGGCTTTCGGTC

Downstream 100 bases:

>100_bases
GCTTTTGGTCGTGTCCGGGTATACGCGCTACGTGGCGATCGGCGACAGCCAGACCGAGGGGCTGTGGGACCGCGACGGCG
ACGGCGGGTTGATCGGTTTC

Product: alpha/beta hydrolase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MIPAALRCVPAGQVDVTAPVTIDGLSYIAPDDPAMPMYRVIANNRQPVALRDLMIQPVRSGYIGDGHQPDPALVPPTGAQ
AVPDVDVDQVYLPVRDGVARCQLYRPRAAPADEQLPVIVYYHGGGFTVGVSEDCDFLARKLAFTNSALVVSANYRSAPEF
MFPTPLDDAFDVYRWVTVNAELVGGDATRVAVAGDSAGSNFAAALALRARDEHARVPDAVVMLGAMPDFHFERWDSFRAQ
APRGIVYDMAFAGFIRGAYVGPTPWDHPWVSPIEGDLTGYPLTVITAGTHDPIVDSARAFGERIRAAGGQTVEYFPAGMP
HGYYFFPGVHAEEDVAYEIVAEVLAKPFRR

Sequences:

>Translated_350_residues
MIPAALRCVPAGQVDVTAPVTIDGLSYIAPDDPAMPMYRVIANNRQPVALRDLMIQPVRSGYIGDGHQPDPALVPPTGAQ
AVPDVDVDQVYLPVRDGVARCQLYRPRAAPADEQLPVIVYYHGGGFTVGVSEDCDFLARKLAFTNSALVVSANYRSAPEF
MFPTPLDDAFDVYRWVTVNAELVGGDATRVAVAGDSAGSNFAAALALRARDEHARVPDAVVMLGAMPDFHFERWDSFRAQ
APRGIVYDMAFAGFIRGAYVGPTPWDHPWVSPIEGDLTGYPLTVITAGTHDPIVDSARAFGERIRAAGGQTVEYFPAGMP
HGYYFFPGVHAEEDVAYEIVAEVLAKPFRR
>Mature_350_residues
MIPAALRCVPAGQVDVTAPVTIDGLSYIAPDDPAMPMYRVIANNRQPVALRDLMIQPVRSGYIGDGHQPDPALVPPTGAQ
AVPDVDVDQVYLPVRDGVARCQLYRPRAAPADEQLPVIVYYHGGGFTVGVSEDCDFLARKLAFTNSALVVSANYRSAPEF
MFPTPLDDAFDVYRWVTVNAELVGGDATRVAVAGDSAGSNFAAALALRARDEHARVPDAVVMLGAMPDFHFERWDSFRAQ
APRGIVYDMAFAGFIRGAYVGPTPWDHPWVSPIEGDLTGYPLTVITAGTHDPIVDSARAFGERIRAAGGQTVEYFPAGMP
HGYYFFPGVHAEEDVAYEIVAEVLAKPFRR

Specific function: Lactone hydrolase that is required for the degradation of monocyclic monoterpenes such as menthol and carvone. Catalyzes the ring opening of lactones formed during degradation of monocyclic monoterpenes. Can hydrolyze epsilon-caprolactone, the lactone der

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21328446, Length=117, Percent_Identity=37.6068376068376, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI206597554, Length=151, Percent_Identity=33.112582781457, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI68299767, Length=110, Percent_Identity=37.2727272727273, Blast_Score=69, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24656084, Length=106, Percent_Identity=35.8490566037736, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24656076, Length=106, Percent_Identity=35.8490566037736, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI20130169, Length=106, Percent_Identity=35.8490566037736, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.83 [H]

Molecular weight: Translated: 37922; Mature: 37922

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPAALRCVPAGQVDVTAPVTIDGLSYIAPDDPAMPMYRVIANNRQPVALRDLMIQPVRS
CCCCCEEEECCCCEEEECCEEECCCEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHC
GYIGDGHQPDPALVPPTGAQAVPDVDVDQVYLPVRDGVARCQLYRPRAAPADEQLPVIVY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCEEEE
YHGGGFTVGVSEDCDFLARKLAFTNSALVVSANYRSAPEFMFPTPLDDAFDVYRWVTVNA
ECCCCEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHEEEEEEEEE
ELVGGDATRVAVAGDSAGSNFAAALALRARDEHARVPDAVVMLGAMPDFHFERWDSFRAQ
EEECCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHC
APRGIVYDMAFAGFIRGAYVGPTPWDHPWVSPIEGDLTGYPLTVITAGTHDPIVDSARAF
CCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHH
GERIRAAGGQTVEYFPAGMPHGYYFFPGVHAEEDVAYEIVAEVLAKPFRR
HHHHHHCCCCEEEECCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIPAALRCVPAGQVDVTAPVTIDGLSYIAPDDPAMPMYRVIANNRQPVALRDLMIQPVRS
CCCCCEEEECCCCEEEECCEEECCCEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHC
GYIGDGHQPDPALVPPTGAQAVPDVDVDQVYLPVRDGVARCQLYRPRAAPADEQLPVIVY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCEEEE
YHGGGFTVGVSEDCDFLARKLAFTNSALVVSANYRSAPEFMFPTPLDDAFDVYRWVTVNA
ECCCCEEEECCCCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCHHHHEEEEEEEEE
ELVGGDATRVAVAGDSAGSNFAAALALRARDEHARVPDAVVMLGAMPDFHFERWDSFRAQ
EEECCCCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHHHHC
APRGIVYDMAFAGFIRGAYVGPTPWDHPWVSPIEGDLTGYPLTVITAGTHDPIVDSARAF
CCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHH
GERIRAAGGQTVEYFPAGMPHGYYFFPGVHAEEDVAYEIVAEVLAKPFRR
HHHHHHCCCCEEEECCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA