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The map label for this gene is aphA [H]

Identifier: 119868765

GI number: 119868765

Start: 2859502

End: 2861085

Strand: Direct

Name: aphA [H]

Synonym: Mkms_2733

Alternate gene names: 119868765

Gene position: 2859502-2861085 (Clockwise)

Preceding gene: 119868764

Following gene: 119868766

Centisome position: 49.84

GC content: 67.05

Gene sequence:

>1584_bases
GTGACGGCCCCCGCCCGCCGGCGGGGAGGCCAGTTGACGGTGCAGGGCTGGTTGAACGTCGTGCTGGCCGTGATGGGAAT
CCTGGTGCTGGCCGGCGCGTTCGCCGGAGCGATCCTGATGAACCGCACGGACGCGGTGTCGCGCGAACTGATCGAAGAGA
TCCAACCGTCTCGGGTGGCGGCCTACCGGTTGCAGGCCGCCCTGCGCGATCAGGAGACGGCGGTACGGGGTTACGCGATC
GCCGCCGACGAACAGTTCCTCGAGCCGTACTACGAGGGGCAGCAGACCGAACGGGAAGCGGCCGAGGAGATCCGCGAACA
CGTCGGTGACCACGCCAACCTGATCGCCGATCTGGATGCGGTCGAACAGGCCACCGCCGAGTGGCGCGCGAACTACGCCG
AGCCGTTCATCCGGAGCGTGGGCCCGGGCGCCCCCGTCGACAACGACCTGGTGCAACGCGGTAAGGAGCGCTTCGACAAC
ATCCGCGCGCTGTTCCACGTGCAGAACGTCGACCTCGCGGCGGCGCGCACCGCCGGGGTCAAGGAACTGGACGAGGTGCG
CGGATGGCGCGACCGCGTCCTCGCCGGCATCATCGTCACGTTCTTCGTGACCGCCTTGGCGCTGGCGATCCTGGCTCGCA
GCGCGCTGGTGCGCCCGCTGTCGGCACTGGCCGCGTCGTGCCGCCGCATCACCGAGGGGCATTTCGACGAGCGGATCGTG
GCCCAAGGGCCGCGTGACGTGCGGAGCATGGCGTCGGACGTCGAGGACATGCGACAACGGATCGTGGAGGAACTCGAGGC
GTCGCGGGCGGCCCGTGAGCAACTCGACGAACAGGCCGTCGAGTTGCGCCGGTCGAACGCCGAGCTGGAGCAGTTCGCCT
ATGTCGCCTCGCATGACCTGCAGGAACCGCTGCGCAAGGTGGCCTCGTTCTGTCAGCTGCTCGAGAAGCGCTACGGCGAC
AAACTCGACGAGCGCGGCGTCGAGTACATCAAGTACGCCGTCGACGGTGCCAAACGGATGCAGGTGCTCATCAACGACCT
GCTGACCTTCTCGCGCGTCGGACGCCTCAGTGCCGCACACACCGACGTCGAACTCGACGAGGCGCTCGACGCCGCGGTGT
CGAATCTCGAAACCTCCATCGAGGAGTCCGGCGCCGAGATCGTGCGCCCCGAAGAGCCGTTACCCCAGGTCCTGGGTGAT
CCGACGCTGCTGACGATGCTGTGGCAGAACCTGATCGGCAACGCGGTGAAGTTCCGGAAACCGGACACCACGCCCCGGAT
CGTGATCGAATGCCAGCGCGGCACCGACGACCGGGACGGCCAGTGGGTGTTCACCGTGTCGGACAACGGCATCGGCATCG
CCGAGGAGTTCTCCCAGAAGGTGTTCGTCATCTTCCAGCGGCTGCACGGGCGCGAGGCCTACAGCGGCACCGGCATCGGG
CTGGCGCTGTGCAAGAAGATCGTCGAGTACCACGGCGGCTCCATCTGGATCGACAACACCTACACCGAAGGCACCCGGTT
CCGCATGACCCTTCCGGTCGCCGTCCACGAACAACCCGAAGTGGTTCTGGAAGGAGCCCAATGA

Upstream 100 bases:

>100_bases
CCCAGTTCGTCGAGGCGCTGATCGACCGCGCCGAGGACCGCGCCCGACGGCACGGTGGACTGACCGACGACATCGCGGTA
GTCCGCGTGGAGCGCACCAC

Downstream 100 bases:

>100_bases
TGACACCCTCGACGAGGCCCATCGACGTTCTGCTCATCGAGGACGACCCGGGAGACGAGCTGATCACCCGCGAGGCGTTC
GAGCACAACAAGATCAGCAA

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MTAPARRRGGQLTVQGWLNVVLAVMGILVLAGAFAGAILMNRTDAVSRELIEEIQPSRVAAYRLQAALRDQETAVRGYAI
AADEQFLEPYYEGQQTEREAAEEIREHVGDHANLIADLDAVEQATAEWRANYAEPFIRSVGPGAPVDNDLVQRGKERFDN
IRALFHVQNVDLAAARTAGVKELDEVRGWRDRVLAGIIVTFFVTALALAILARSALVRPLSALAASCRRITEGHFDERIV
AQGPRDVRSMASDVEDMRQRIVEELEASRAAREQLDEQAVELRRSNAELEQFAYVASHDLQEPLRKVASFCQLLEKRYGD
KLDERGVEYIKYAVDGAKRMQVLINDLLTFSRVGRLSAAHTDVELDEALDAAVSNLETSIEESGAEIVRPEEPLPQVLGD
PTLLTMLWQNLIGNAVKFRKPDTTPRIVIECQRGTDDRDGQWVFTVSDNGIGIAEEFSQKVFVIFQRLHGREAYSGTGIG
LALCKKIVEYHGGSIWIDNTYTEGTRFRMTLPVAVHEQPEVVLEGAQ

Sequences:

>Translated_527_residues
MTAPARRRGGQLTVQGWLNVVLAVMGILVLAGAFAGAILMNRTDAVSRELIEEIQPSRVAAYRLQAALRDQETAVRGYAI
AADEQFLEPYYEGQQTEREAAEEIREHVGDHANLIADLDAVEQATAEWRANYAEPFIRSVGPGAPVDNDLVQRGKERFDN
IRALFHVQNVDLAAARTAGVKELDEVRGWRDRVLAGIIVTFFVTALALAILARSALVRPLSALAASCRRITEGHFDERIV
AQGPRDVRSMASDVEDMRQRIVEELEASRAAREQLDEQAVELRRSNAELEQFAYVASHDLQEPLRKVASFCQLLEKRYGD
KLDERGVEYIKYAVDGAKRMQVLINDLLTFSRVGRLSAAHTDVELDEALDAAVSNLETSIEESGAEIVRPEEPLPQVLGD
PTLLTMLWQNLIGNAVKFRKPDTTPRIVIECQRGTDDRDGQWVFTVSDNGIGIAEEFSQKVFVIFQRLHGREAYSGTGIG
LALCKKIVEYHGGSIWIDNTYTEGTRFRMTLPVAVHEQPEVVLEGAQ
>Mature_526_residues
TAPARRRGGQLTVQGWLNVVLAVMGILVLAGAFAGAILMNRTDAVSRELIEEIQPSRVAAYRLQAALRDQETAVRGYAIA
ADEQFLEPYYEGQQTEREAAEEIREHVGDHANLIADLDAVEQATAEWRANYAEPFIRSVGPGAPVDNDLVQRGKERFDNI
RALFHVQNVDLAAARTAGVKELDEVRGWRDRVLAGIIVTFFVTALALAILARSALVRPLSALAASCRRITEGHFDERIVA
QGPRDVRSMASDVEDMRQRIVEELEASRAAREQLDEQAVELRRSNAELEQFAYVASHDLQEPLRKVASFCQLLEKRYGDK
LDERGVEYIKYAVDGAKRMQVLINDLLTFSRVGRLSAAHTDVELDEALDAAVSNLETSIEESGAEIVRPEEPLPQVLGDP
TLLTMLWQNLIGNAVKFRKPDTTPRIVIECQRGTDDRDGQWVFTVSDNGIGIAEEFSQKVFVIFQRLHGREAYSGTGIGL
ALCKKIVEYHGGSIWIDNTYTEGTRFRMTLPVAVHEQPEVVLEGAQ

Specific function: Photoreceptor which exists in two forms that are reversibly interconvertible by light:the R form that absorbs maximally in the red region of the spectrum and the FR form that absorbs maximally in the far-red region [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=366, Percent_Identity=25.4098360655738, Blast_Score=96, Evalue=5e-21,
Organism=Escherichia coli, GI48994928, Length=246, Percent_Identity=27.2357723577236, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87081816, Length=357, Percent_Identity=24.0896358543417, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1786912, Length=223, Percent_Identity=29.1479820627803, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790346, Length=279, Percent_Identity=25.089605734767, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI145693157, Length=256, Percent_Identity=26.171875, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788713, Length=236, Percent_Identity=25, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790551, Length=330, Percent_Identity=24.5454545454545, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788549, Length=244, Percent_Identity=25, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786783, Length=290, Percent_Identity=26.551724137931, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1786600, Length=305, Percent_Identity=24.9180327868852, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR013654
- InterPro:   IPR016132
- InterPro:   IPR001294
- InterPro:   IPR013515
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF01590 GAF; PF02518 HATPase_c; PF00512 HisKA; PF08446 PAS_2; PF00360 Phytochrome [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 58631; Mature: 58500

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPARRRGGQLTVQGWLNVVLAVMGILVLAGAFAGAILMNRTDAVSRELIEEIQPSRVA
CCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHH
AYRLQAALRDQETAVRGYAIAADEQFLEPYYEGQQTEREAAEEIREHVGDHANLIADLDA
HHHHHHHHHHHHHHHHCEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHH
VEQATAEWRANYAEPFIRSVGPGAPVDNDLVQRGKERFDNIRALFHVQNVDLAAARTAGV
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCH
KELDEVRGWRDRVLAGIIVTFFVTALALAILARSALVRPLSALAASCRRITEGHFDERIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
AQGPRDVRSMASDVEDMRQRIVEELEASRAAREQLDEQAVELRRSNAELEQFAYVASHDL
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
QEPLRKVASFCQLLEKRYGDKLDERGVEYIKYAVDGAKRMQVLINDLLTFSRVGRLSAAH
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TDVELDEALDAAVSNLETSIEESGAEIVRPEEPLPQVLGDPTLLTMLWQNLIGNAVKFRK
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHCCCEECCC
PDTTPRIVIECQRGTDDRDGQWVFTVSDNGIGIAEEFSQKVFVIFQRLHGREAYSGTGIG
CCCCCEEEEEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHH
LALCKKIVEYHGGSIWIDNTYTEGTRFRMTLPVAVHEQPEVVLEGAQ
HHHHHHHHHHCCCEEEECCCCCCCCEEEEEECEEECCCCCCCCCCCC
>Mature Secondary Structure 
TAPARRRGGQLTVQGWLNVVLAVMGILVLAGAFAGAILMNRTDAVSRELIEEIQPSRVA
CCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHH
AYRLQAALRDQETAVRGYAIAADEQFLEPYYEGQQTEREAAEEIREHVGDHANLIADLDA
HHHHHHHHHHHHHHHHCEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHH
VEQATAEWRANYAEPFIRSVGPGAPVDNDLVQRGKERFDNIRALFHVQNVDLAAARTAGV
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCH
KELDEVRGWRDRVLAGIIVTFFVTALALAILARSALVRPLSALAASCRRITEGHFDERIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
AQGPRDVRSMASDVEDMRQRIVEELEASRAAREQLDEQAVELRRSNAELEQFAYVASHDL
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
QEPLRKVASFCQLLEKRYGDKLDERGVEYIKYAVDGAKRMQVLINDLLTFSRVGRLSAAH
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TDVELDEALDAAVSNLETSIEESGAEIVRPEEPLPQVLGDPTLLTMLWQNLIGNAVKFRK
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHCCCEECCC
PDTTPRIVIECQRGTDDRDGQWVFTVSDNGIGIAEEFSQKVFVIFQRLHGREAYSGTGIG
CCCCCEEEEEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHH
LALCKKIVEYHGGSIWIDNTYTEGTRFRMTLPVAVHEQPEVVLEGAQ
HHHHHHHHHHCCCEEEECCCCCCCCEEEEEECEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]