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The map label for this gene is fklB [H]

Identifier: 119868732

GI number: 119868732

Start: 2824074

End: 2824580

Strand: Direct

Name: fklB [H]

Synonym: Mkms_2699

Alternate gene names: 119868732

Gene position: 2824074-2824580 (Clockwise)

Preceding gene: 119868728

Following gene: 119868734

Centisome position: 49.22

GC content: 71.4

Gene sequence:

>507_bases
ATGGCCGACCTGCTCCCACCTTCGGCGCCCGTGACGTCGGCGGCGGCGAGTACGTGCCCCACGGCGGCGCCGGCCGACGG
CGAACCTGAGTGGACCTTCTCCGGCGCCACCGGCAGCGTCTCGGTCACCGGATCCACCGATGCGGCGGCGCCCGCCGTCG
AGGTACAGGCCCCGTTCAGCGTGACCGAGACCCAGGTGCACACGCTCAAGGCCGGCGACGGCCCGGTCGTCGCGGAGACG
GCCGCAGTCACCGTCTGCTACATGGGTGTCAACGGACGCGACGGCTCGGTGTTCGACAGCAGCTACGAACGGGGTGAACC
GGTCGACTTCCCGCTCGACGGCGTCGTGCCGGGCTTCCAGAAGGCCATCGCGGGCCAGAAGGTGGGGTCCACCGTCGCGG
TCGCCATGACGTCCGCCGACGGCTACCCCGAGGGCCAGCCCGCGGCGGGTATCCAGCCCGGCGACTCGCTCGTGTTCGCG
ATCAAGATCCTCGACGCCTCGGGATAA

Upstream 100 bases:

>100_bases
CTGTGCCGCGTCGTTGGTCGTGACGCTCGCCGCGTGCGGTTCGGACACAGAGACGGCGTCGACGAGTTCGTCGGCCAGCA
CGTCCGCCAGCACGTCGGCC

Downstream 100 bases:

>100_bases
CGGCTACTGCGCGTAGTCCACGCTCAACCAACGGGCCGGGCGCATCCGGATGGCGATCGACGTGGGTGTCAGATTCTGGT
CGGTGAAGGTGTTTCCCGCT

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: FKBP22; PPIase; Rotamase [H]

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MADLLPPSAPVTSAAASTCPTAAPADGEPEWTFSGATGSVSVTGSTDAAAPAVEVQAPFSVTETQVHTLKAGDGPVVAET
AAVTVCYMGVNGRDGSVFDSSYERGEPVDFPLDGVVPGFQKAIAGQKVGSTVAVAMTSADGYPEGQPAAGIQPGDSLVFA
IKILDASG

Sequences:

>Translated_168_residues
MADLLPPSAPVTSAAASTCPTAAPADGEPEWTFSGATGSVSVTGSTDAAAPAVEVQAPFSVTETQVHTLKAGDGPVVAET
AAVTVCYMGVNGRDGSVFDSSYERGEPVDFPLDGVVPGFQKAIAGQKVGSTVAVAMTSADGYPEGQPAAGIQPGDSLVFA
IKILDASG
>Mature_167_residues
ADLLPPSAPVTSAAASTCPTAAPADGEPEWTFSGATGSVSVTGSTDAAAPAVEVQAPFSVTETQVHTLKAGDGPVVAETA
AVTVCYMGVNGRDGSVFDSSYERGEPVDFPLDGVVPGFQKAIAGQKVGSTVAVAMTSADGYPEGQPAAGIQPGDSLVFAI
KILDASG

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm. Periplasm. Note=According to PubMed:7610040 it is periplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI87082390, Length=101, Percent_Identity=38.6138613861386, Blast_Score=69, Evalue=1e-13,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 16616; Mature: 16485

Theoretical pI: Translated: 3.79; Mature: 3.79

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLLPPSAPVTSAAASTCPTAAPADGEPEWTFSGATGSVSVTGSTDAAAPAVEVQAPFS
CCCCCCCCCCCCCHHHCCCCCCCCCCCCCCEEECCCCCEEEEECCCCCCCCEEEEECCCC
VTETQVHTLKAGDGPVVAETAAVTVCYMGVNGRDGSVFDSSYERGEPVDFPLDGVVPGFQ
CCCEEEEEEECCCCCEEEECEEEEEEEECCCCCCCCEECCCCCCCCCCCCCCCCCCCCHH
KAIAGQKVGSTVAVAMTSADGYPEGQPAAGIQPGDSLVFAIKILDASG
HHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEECCC
>Mature Secondary Structure 
ADLLPPSAPVTSAAASTCPTAAPADGEPEWTFSGATGSVSVTGSTDAAAPAVEVQAPFS
CCCCCCCCCCCCHHHCCCCCCCCCCCCCCEEECCCCCEEEEECCCCCCCCEEEEECCCC
VTETQVHTLKAGDGPVVAETAAVTVCYMGVNGRDGSVFDSSYERGEPVDFPLDGVVPGFQ
CCCEEEEEEECCCCCEEEECEEEEEEEECCCCCCCCEECCCCCCCCCCCCCCCCCCCCHH
KAIAGQKVGSTVAVAMTSADGYPEGQPAAGIQPGDSLVFAIKILDASG
HHHCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 8703024; 9298646 [H]