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The map label for this gene is hsaA [H]

Identifier: 119868682

GI number: 119868682

Start: 2781188

End: 2782366

Strand: Direct

Name: hsaA [H]

Synonym: Mkms_2649

Alternate gene names: 119868682

Gene position: 2781188-2782366 (Clockwise)

Preceding gene: 119868681

Following gene: 119868683

Centisome position: 48.48

GC content: 64.89

Gene sequence:

>1179_bases
ATGACCGTGACCACTCAACGAACCAGCACCCTCGCCGATCGCGTGCGAGACATCCTGCCGGGCATCTCGGCCCGTGCCGA
CGAAGCAGAACGGATCCGCAAGGTTCCGGTGCAGAACGTCGACGCGCTGCGGGAGATCGGATTCTTCCGCGCCTTCGTGC
CCGCCAAGTACGACGGTCTGTCGGTCTTGCCGTCCGAATTCGGTGAGGCCACCCGTGTGCTCGCCACCGCCTGCCCGTCC
ACCGCGTGGGCGTGCGGCCTGATGGCTGTCCACGCCCACACGGTCGCGAATTACAGCCCCGTGCTGCAGGAAGAGGTGTG
GGGGTCCGACCCGGACACTTTGATCTGCTCATCGGTCGCCCCGATGGGTCAGCCGACGAAGGTCGACGGCGGTATCCGCT
TGACCGGCGACTTCAGCTGGTCCAGCGGCTCCGAGCATGCGCACTGGATCATCGTCGGAATGATGATGCCCGGGTCGAGC
GAAGCGCCTGAGCCGCATTTTGCCATCGTTCCGCGCAGCGACTTCGAGATCAAAGACACCTGGTTCGCCATGGGCTTGAA
AGGCACGGGCAGCCAGGACATCTCGATCAAAGATGTCTTCGTGCCCGAGTATCGTCTGGAAACGCTGATCAGCCTCAACA
TCGGGACTGCGACGGGATTCGGCACCCATGACGCACCGGTCTACCGGTTGCCCTGGCAACCGGTCTTCGCGCTGAACTTC
TCCGCTGTGAACCTCGGCGCCAGCGAGGCGTTGCGCGATCTCTACCCCGCGCGGCTGTCGACCAGGGTCCGCGCGTACAC
CGGCGCGAAGGTCGGAGAGACCGCGCCGGCTCTGATGCGCCTGGCCGAATCCACCCATGAGCTCGATGCCGCCCGGTCCC
TACTCGAAAGTGACTGGCGGGCTATGGATTCGCGCGCCAACTCCACCGACCCGACAACGCCGGACGAGATGGCGGGCTGG
CGGAGCAATCAGGCTTACATCACCCGGTTGGCGGTGCGTGCGGCCGATCGGCTCTTCGATGCATCCGGCGGATCTGCGGT
CCGCGACGAGAACCCCATGCAGCGGTACTGGCGGGATCTGCACACCGGTGCCGCTCATACCTATAGCGATTACGACATCG
CCGCGCAGGTCTACGGTGCTCATCTGGCAGCCGTGCAGCCGCAAGAGGGGCTTTTCTAG

Upstream 100 bases:

>100_bases
ATTCCCGTCACCGTGCTTCTGTTCACTGGCTGGGCCTTGTTGGCCGCCTCCTGACCCCTCGACCCCTCGCGACACCACAA
GCCTTGGAAAGGTTTTCGCC

Downstream 100 bases:

>100_bases
CCATGAAGATAGCAACCGTACTGGCCGCGGGCCGTCCCGTGGTGACTGCGCTCGGTCCGGCTGAGCAGTTGGTCAACGTC
GCCCGGCTGCTCAGCTTGCC

Product: acyl-CoA dehydrogenase type 2

Products: NA

Alternate protein names: 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione 4-hydroxylase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MTVTTQRTSTLADRVRDILPGISARADEAERIRKVPVQNVDALREIGFFRAFVPAKYDGLSVLPSEFGEATRVLATACPS
TAWACGLMAVHAHTVANYSPVLQEEVWGSDPDTLICSSVAPMGQPTKVDGGIRLTGDFSWSSGSEHAHWIIVGMMMPGSS
EAPEPHFAIVPRSDFEIKDTWFAMGLKGTGSQDISIKDVFVPEYRLETLISLNIGTATGFGTHDAPVYRLPWQPVFALNF
SAVNLGASEALRDLYPARLSTRVRAYTGAKVGETAPALMRLAESTHELDAARSLLESDWRAMDSRANSTDPTTPDEMAGW
RSNQAYITRLAVRAADRLFDASGGSAVRDENPMQRYWRDLHTGAAHTYSDYDIAAQVYGAHLAAVQPQEGLF

Sequences:

>Translated_392_residues
MTVTTQRTSTLADRVRDILPGISARADEAERIRKVPVQNVDALREIGFFRAFVPAKYDGLSVLPSEFGEATRVLATACPS
TAWACGLMAVHAHTVANYSPVLQEEVWGSDPDTLICSSVAPMGQPTKVDGGIRLTGDFSWSSGSEHAHWIIVGMMMPGSS
EAPEPHFAIVPRSDFEIKDTWFAMGLKGTGSQDISIKDVFVPEYRLETLISLNIGTATGFGTHDAPVYRLPWQPVFALNF
SAVNLGASEALRDLYPARLSTRVRAYTGAKVGETAPALMRLAESTHELDAARSLLESDWRAMDSRANSTDPTTPDEMAGW
RSNQAYITRLAVRAADRLFDASGGSAVRDENPMQRYWRDLHTGAAHTYSDYDIAAQVYGAHLAAVQPQEGLF
>Mature_391_residues
TVTTQRTSTLADRVRDILPGISARADEAERIRKVPVQNVDALREIGFFRAFVPAKYDGLSVLPSEFGEATRVLATACPST
AWACGLMAVHAHTVANYSPVLQEEVWGSDPDTLICSSVAPMGQPTKVDGGIRLTGDFSWSSGSEHAHWIIVGMMMPGSSE
APEPHFAIVPRSDFEIKDTWFAMGLKGTGSQDISIKDVFVPEYRLETLISLNIGTATGFGTHDAPVYRLPWQPVFALNFS
AVNLGASEALRDLYPARLSTRVRAYTGAKVGETAPALMRLAESTHELDAARSLLESDWRAMDSRANSTDPTTPDEMAGWR
SNQAYITRLAVRAADRLFDASGGSAVRDENPMQRYWRDLHTGAAHTYSDYDIAAQVYGAHLAAVQPQEGLF

Specific function: Catalyzes the o-hydroxylation of 3-hydroxy-9,10- seconandrost-1,3,5(10)-triene-9,17-dione (3-HSA) to 3,4-dihydroxy- 9,10-seconandrost-1,3,5(10)-triene-9,17-dione (3,4-DHSA) in the catabolism of cholesterol. Also catalyzes the o-hydroxylation of a range of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FADH(2)-utilizing monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013107
- InterPro:   IPR006092
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF08028 Acyl-CoA_dh_2; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 42767; Mature: 42636

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTTQRTSTLADRVRDILPGISARADEAERIRKVPVQNVDALREIGFFRAFVPAKYDGL
CCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCC
SVLPSEFGEATRVLATACPSTAWACGLMAVHAHTVANYSPVLQEEVWGSDPDTLICSSVA
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEECCCC
PMGQPTKVDGGIRLTGDFSWSSGSEHAHWIIVGMMMPGSSEAPEPHFAIVPRSDFEIKDT
CCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEECCCCCCCCCE
WFAMGLKGTGSQDISIKDVFVPEYRLETLISLNIGTATGFGTHDAPVYRLPWQPVFALNF
EEEEECCCCCCCCCEEEEEECCCHHEEEEEEEECCCCCCCCCCCCCEEECCCCCEEEEEE
SAVNLGASEALRDLYPARLSTRVRAYTGAKVGETAPALMRLAESTHELDAARSLLESDWR
EEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMDSRANSTDPTTPDEMAGWRSNQAYITRLAVRAADRLFDASGGSAVRDENPMQRYWRDL
HHHCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
HTGAAHTYSDYDIAAQVYGAHLAAVQPQEGLF
HCCCCCCCCCHHHHHHHHHHHHEEECCCCCCC
>Mature Secondary Structure 
TVTTQRTSTLADRVRDILPGISARADEAERIRKVPVQNVDALREIGFFRAFVPAKYDGL
CCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCC
SVLPSEFGEATRVLATACPSTAWACGLMAVHAHTVANYSPVLQEEVWGSDPDTLICSSVA
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEEECCCC
PMGQPTKVDGGIRLTGDFSWSSGSEHAHWIIVGMMMPGSSEAPEPHFAIVPRSDFEIKDT
CCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEECCCCCCCCCE
WFAMGLKGTGSQDISIKDVFVPEYRLETLISLNIGTATGFGTHDAPVYRLPWQPVFALNF
EEEEECCCCCCCCCEEEEEECCCHHEEEEEEEECCCCCCCCCCCCCEEECCCCCEEEEEE
SAVNLGASEALRDLYPARLSTRVRAYTGAKVGETAPALMRLAESTHELDAARSLLESDWR
EEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMDSRANSTDPTTPDEMAGWRSNQAYITRLAVRAADRLFDASGGSAVRDENPMQRYWRDL
HHHCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
HTGAAHTYSDYDIAAQVYGAHLAAVQPQEGLF
HCCCCCCCCCHHHHHHHHHHHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]