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The map label for this gene is mmsB [H]

Identifier: 119868666

GI number: 119868666

Start: 2763131

End: 2764027

Strand: Reverse

Name: mmsB [H]

Synonym: Mkms_2631

Alternate gene names: 119868666

Gene position: 2764027-2763131 (Counterclockwise)

Preceding gene: 119868668

Following gene: 119868664

Centisome position: 48.18

GC content: 68.78

Gene sequence:

>897_bases
GTGGACATCGGATTCATCGGTCTGGGCCACATGGGCTTCGAGATGGCCGGTCGGCTGATCGACGCCGGTTACGCCGTGAC
CGTGTACGACACCCGGCGCGAGCCGATCGACGAACTGGTCGGACGCGGTGCGGCCGCGGCGTCGTCCCCGAAGGACACCG
CCGCCCGCGCCGAAACGGTGATGGCCAGCCTGCCCTCGCTGCAGGCCTCGATCGAGGTCGCCACCGGCCCCGACGGCGTC
ATCCAGGGTCACCGCGTCAAACGGTTCGTCGACCTGTCGACGGTCGGCGCCCCGACCGCCGAGCGCACCGCGGCGCTGCT
CGCCGAACGCGGTGTCGCCCAGATCGACTGCCCGGTCTCCGGCGGTGTGGGCGGCGCCCGGAACGGCACGCTGGCGATGA
TGGTGTCGGGTCCGCACGACCACGTCGACAGTGTGCGTCCCGCGCTCGACGTGTTCGGCCGGGTGTTCTTCATCGGCGAG
AAGGCCGGGTCCGCGCAGACCATGAAACTCGCCAACAACCTGCTCGCCGCAACGACACTCGCGGCAACCGCCGAGGCCGT
GGTGCTCGGCGTGAAGGCCGGGCTCGATCCCGCGGTCATGATCGACGTCTTCAACGCCGGCTCGGGAGCGACCCACGCGA
GCCGCGACAAGTTCCCCCGCGCCGTCCTTCCCCGCACCTTCGACTTCGGCTTCGCCACCGGCTTGATGGTCAAGGACGTC
CGGCTCTGTCTGGAACAGGTTGCCGAACTGGGTCTTTCACTCGACATTGCACAGGCCGTCGCTCTAGTCTGGGAGGCGAC
TATCGACGCGACCGGTCCGGATTCGGACTTCACCTCGGTGATCAAACCCATCGAAGAAGCCGCCGGAGTCATCGTCGGAG
ACCCCGGCGGCCCCTGA

Upstream 100 bases:

>100_bases
TCCTCCAGGTCGCGGTTTACGCCGGTGTGCCGGCAGCCGTCGACAGCTTCCGGATCGCCCGGGAGGTCTTCCACGAATTC
GACACGGAGTAGACCGCGCC

Downstream 100 bases:

>100_bases
TCCATCAGTGCTGCGGCACGCCCGTGTACTCCGGATTGGGCGGCACCGACAACGCCACCCCGATCCGGTTCGTCGCGCCG
ATGAACGCGGCAATCGAGAT

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MDIGFIGLGHMGFEMAGRLIDAGYAVTVYDTRREPIDELVGRGAAAASSPKDTAARAETVMASLPSLQASIEVATGPDGV
IQGHRVKRFVDLSTVGAPTAERTAALLAERGVAQIDCPVSGGVGGARNGTLAMMVSGPHDHVDSVRPALDVFGRVFFIGE
KAGSAQTMKLANNLLAATTLAATAEAVVLGVKAGLDPAVMIDVFNAGSGATHASRDKFPRAVLPRTFDFGFATGLMVKDV
RLCLEQVAELGLSLDIAQAVALVWEATIDATGPDSDFTSVIKPIEEAAGVIVGDPGGP

Sequences:

>Translated_298_residues
MDIGFIGLGHMGFEMAGRLIDAGYAVTVYDTRREPIDELVGRGAAAASSPKDTAARAETVMASLPSLQASIEVATGPDGV
IQGHRVKRFVDLSTVGAPTAERTAALLAERGVAQIDCPVSGGVGGARNGTLAMMVSGPHDHVDSVRPALDVFGRVFFIGE
KAGSAQTMKLANNLLAATTLAATAEAVVLGVKAGLDPAVMIDVFNAGSGATHASRDKFPRAVLPRTFDFGFATGLMVKDV
RLCLEQVAELGLSLDIAQAVALVWEATIDATGPDSDFTSVIKPIEEAAGVIVGDPGGP
>Mature_298_residues
MDIGFIGLGHMGFEMAGRLIDAGYAVTVYDTRREPIDELVGRGAAAASSPKDTAARAETVMASLPSLQASIEVATGPDGV
IQGHRVKRFVDLSTVGAPTAERTAALLAERGVAQIDCPVSGGVGGARNGTLAMMVSGPHDHVDSVRPALDVFGRVFFIGE
KAGSAQTMKLANNLLAATTLAATAEAVVLGVKAGLDPAVMIDVFNAGSGATHASRDKFPRAVLPRTFDFGFATGLMVKDV
RLCLEQVAELGLSLDIAQAVALVWEATIDATGPDSDFTSVIKPIEEAAGVIVGDPGGP

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=296, Percent_Identity=30.7432432432432, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI40556376, Length=282, Percent_Identity=27.6595744680851, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI145693186, Length=269, Percent_Identity=33.8289962825279, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1786719, Length=289, Percent_Identity=30.7958477508651, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1790315, Length=289, Percent_Identity=26.9896193771626, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789092, Length=283, Percent_Identity=29.3286219081272, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17557316, Length=247, Percent_Identity=31.5789473684211, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24655230, Length=250, Percent_Identity=32.4, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI19922568, Length=250, Percent_Identity=32.4, Blast_Score=122, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 30610; Mature: 30610

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIGFIGLGHMGFEMAGRLIDAGYAVTVYDTRREPIDELVGRGAAAASSPKDTAARAETV
CCEEEEEECCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHCCCCCCCCCCHHHHHHHHHH
MASLPSLQASIEVATGPDGVIQGHRVKRFVDLSTVGAPTAERTAALLAERGVAQIDCPVS
HHHCCCCCEEEEEECCCCCCCCCCHHHHEEEHHHCCCCCHHHHHHHHHHCCCEEEECCCC
GGVGGARNGTLAMMVSGPHDHVDSVRPALDVFGRVFFIGEKAGSAQTMKLANNLLAATTL
CCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHH
AATAEAVVLGVKAGLDPAVMIDVFNAGSGATHASRDKFPRAVLPRTFDFGFATGLMVKDV
HHHHHHHEEEHHCCCCCEEEEEEECCCCCCCCCHHHCCCHHHCCCCCCCHHHHHHHHHHH
RLCLEQVAELGLSLDIAQAVALVWEATIDATGPDSDFTSVIKPIEEAAGVIVGDPGGP
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEEEECCCCC
>Mature Secondary Structure
MDIGFIGLGHMGFEMAGRLIDAGYAVTVYDTRREPIDELVGRGAAAASSPKDTAARAETV
CCEEEEEECCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHCCCCCCCCCCHHHHHHHHHH
MASLPSLQASIEVATGPDGVIQGHRVKRFVDLSTVGAPTAERTAALLAERGVAQIDCPVS
HHHCCCCCEEEEEECCCCCCCCCCHHHHEEEHHHCCCCCHHHHHHHHHHCCCEEEECCCC
GGVGGARNGTLAMMVSGPHDHVDSVRPALDVFGRVFFIGEKAGSAQTMKLANNLLAATTL
CCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCEEEEEECCCCCHHHHHHHHHHHHHHHH
AATAEAVVLGVKAGLDPAVMIDVFNAGSGATHASRDKFPRAVLPRTFDFGFATGLMVKDV
HHHHHHHEEEHHCCCCCEEEEEEECCCCCCCCCHHHCCCHHHCCCCCCCHHHHHHHHHHH
RLCLEQVAELGLSLDIAQAVALVWEATIDATGPDSDFTSVIKPIEEAAGVIVGDPGGP
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1339433; 10984043 [H]