Click here to switch to the map view.

The map label for this gene is gabT [H]

Identifier: 119868357

GI number: 119868357

Start: 2430431

End: 2431771

Strand: Reverse

Name: gabT [H]

Synonym: Mkms_2321

Alternate gene names: 119868357

Gene position: 2431771-2430431 (Counterclockwise)

Preceding gene: 119868364

Following gene: 119868356

Centisome position: 42.39

GC content: 69.28

Gene sequence:

>1341_bases
GTGAGCACCCTCGAGCAGAGCCGCCACCTCGCCACGGCCATCCCCGGCCCGAAGTCGCAGCAGCTCATCGACCGCAAGGC
CGCCGCCGTCTCACGCGGTGTCGGCACCACGATGCCGGTGTACGCGGCGCGCGCCCAGGGCGGCATCGTCGAGGACGTCG
ACGGTAACCGGCTGATCGACCTGGGCTCGGGTATCGCGGTCACCACGATCGGCAACGCGGCCCCCCGCGTCGTGGAGGCC
GTCGCCGCGCAGGCCGGGCGGTTCACCCACACCTGTTTCATGGTCACGCCGTACGAGGGGTACGTGGCGGTCGCCGAGGC
GCTCAACCGGCTCACCCCCGGTAGCGGCGAGAAACGCTCGGCGCTGTTCAACTCCGGTTCGGAGGCCGTCGAGAACGCCG
TCAAGATCGCCAGGTCCTACACCCACAAATCCGCGGTGGTGTCCTTCGACCACGCCTACCACGGTCGCACCAACCTGACC
ATGGCGCTGACCGCCAAGGTGATGCCCTACAAGCACGGGTTCGGACCGTTCGCGCCGGAGATCTACCGCGCGCCGCTCTC
CTACCCCTTCCGCGACGCCGAATTCGGTAAGGAACTGGCGACCGACGGCGAACTGGCCGCCCGCCGGGCGATCGATGTGA
TGGACAAGCAGGTCGGCGCCGACAATCTGGCCGCGGTGATCATCGAACCGATCCAGGGCGAGGGTGGTTTCATCGTCCCG
GCGGAAGGCTTCCTGCCCACCCTGCTCGACTGGTGCCGCCGCAACGACGTCGTGTTCATCGCCGACGAGGTGCAGACCGG
ATTCGCCCGCACCGGGCGGATGTTCGCGTGTGAGCACGAAGGCATCGAACCCGACCTCATCGTGACGGCCAAGGGCATCG
CCGACGGTATGCCGTTGTCCGCGGTGACGGGCCGCGCCGAGATCATGGACTCTCCGCACGTGTCGGGCCTCGGCGGCACC
TACGGCGGCAACCCGGTCGCCTGCGCGGCGGCACTGGCCACCATCGAGACCATCGAATCCGAGAACCTGGTCGAACGCGC
CGCGGCGATCGGGGCGTTGATGAAGGACCGGCTGGGTCGGCTGCAGGCCGAGGACGACCGCATCGGCGACGTGCGCGGAC
GCGGCGCCATGATCGCGGTGGAGCTGGTGAAACCGGGCACCACCGAACCGGACGCCGCCCTGGCCAAGGCGCTGGCCGCC
GGCGCGCACACCGCCGGGGTGATCGTGCTGACGTGCGGCACGTACGGCAACGTGTTGCGTTTCCTACCGCCGTTGGCCAT
CAGCGACGAGTTGCTCGACGAAGGGCTCGACGTGGTGGCCGGTCTCCTGCGCGACCTCTGA

Upstream 100 bases:

>100_bases
CTCCCCCGACGGTCGTTTCCGGCCGCACATCACCGTGGTGCCGACTAGGCTCGTGCGTGCCCGGAATCGCCGCCACCCCA
TGTGACGCAGGAGTCTTGAC

Downstream 100 bases:

>100_bases
CAGACAAGGAGCACTACATGACAACGGTCAAGAACTTCATCGGCGGCGAACTCGTCGACTCCGTCTCCGGCGCCACGATG
CCGCTGGTGGATCCGTCCAC

Product: 4-aminobutyrate aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MSTLEQSRHLATAIPGPKSQQLIDRKAAAVSRGVGTTMPVYAARAQGGIVEDVDGNRLIDLGSGIAVTTIGNAAPRVVEA
VAAQAGRFTHTCFMVTPYEGYVAVAEALNRLTPGSGEKRSALFNSGSEAVENAVKIARSYTHKSAVVSFDHAYHGRTNLT
MALTAKVMPYKHGFGPFAPEIYRAPLSYPFRDAEFGKELATDGELAARRAIDVMDKQVGADNLAAVIIEPIQGEGGFIVP
AEGFLPTLLDWCRRNDVVFIADEVQTGFARTGRMFACEHEGIEPDLIVTAKGIADGMPLSAVTGRAEIMDSPHVSGLGGT
YGGNPVACAAALATIETIESENLVERAAAIGALMKDRLGRLQAEDDRIGDVRGRGAMIAVELVKPGTTEPDAALAKALAA
GAHTAGVIVLTCGTYGNVLRFLPPLAISDELLDEGLDVVAGLLRDL

Sequences:

>Translated_446_residues
MSTLEQSRHLATAIPGPKSQQLIDRKAAAVSRGVGTTMPVYAARAQGGIVEDVDGNRLIDLGSGIAVTTIGNAAPRVVEA
VAAQAGRFTHTCFMVTPYEGYVAVAEALNRLTPGSGEKRSALFNSGSEAVENAVKIARSYTHKSAVVSFDHAYHGRTNLT
MALTAKVMPYKHGFGPFAPEIYRAPLSYPFRDAEFGKELATDGELAARRAIDVMDKQVGADNLAAVIIEPIQGEGGFIVP
AEGFLPTLLDWCRRNDVVFIADEVQTGFARTGRMFACEHEGIEPDLIVTAKGIADGMPLSAVTGRAEIMDSPHVSGLGGT
YGGNPVACAAALATIETIESENLVERAAAIGALMKDRLGRLQAEDDRIGDVRGRGAMIAVELVKPGTTEPDAALAKALAA
GAHTAGVIVLTCGTYGNVLRFLPPLAISDELLDEGLDVVAGLLRDL
>Mature_445_residues
STLEQSRHLATAIPGPKSQQLIDRKAAAVSRGVGTTMPVYAARAQGGIVEDVDGNRLIDLGSGIAVTTIGNAAPRVVEAV
AAQAGRFTHTCFMVTPYEGYVAVAEALNRLTPGSGEKRSALFNSGSEAVENAVKIARSYTHKSAVVSFDHAYHGRTNLTM
ALTAKVMPYKHGFGPFAPEIYRAPLSYPFRDAEFGKELATDGELAARRAIDVMDKQVGADNLAAVIIEPIQGEGGFIVPA
EGFLPTLLDWCRRNDVVFIADEVQTGFARTGRMFACEHEGIEPDLIVTAKGIADGMPLSAVTGRAEIMDSPHVSGLGGTY
GGNPVACAAALATIETIESENLVERAAAIGALMKDRLGRLQAEDDRIGDVRGRGAMIAVELVKPGTTEPDAALAKALAAG
AHTAGVIVLTCGTYGNVLRFLPPLAISDELLDEGLDVVAGLLRDL

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=417, Percent_Identity=29.9760191846523, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI13994255, Length=415, Percent_Identity=31.8072289156626, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI37574042, Length=430, Percent_Identity=30, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI24119277, Length=423, Percent_Identity=31.2056737588652, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI284507298, Length=327, Percent_Identity=32.1100917431193, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI226442705, Length=430, Percent_Identity=30, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI226442709, Length=399, Percent_Identity=30.3258145363409, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI188536080, Length=472, Percent_Identity=26.9067796610169, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI38679950, Length=472, Percent_Identity=26.9067796610169, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI38679946, Length=472, Percent_Identity=26.9067796610169, Blast_Score=124, Evalue=2e-28,
Organism=Escherichia coli, GI1789016, Length=423, Percent_Identity=44.2080378250591, Blast_Score=357, Evalue=1e-100,
Organism=Escherichia coli, GI1787560, Length=428, Percent_Identity=44.8598130841121, Blast_Score=352, Evalue=3e-98,
Organism=Escherichia coli, GI1789759, Length=416, Percent_Identity=34.1346153846154, Blast_Score=202, Evalue=3e-53,
Organism=Escherichia coli, GI1788044, Length=417, Percent_Identity=34.2925659472422, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI145693181, Length=391, Percent_Identity=35.0383631713555, Blast_Score=187, Evalue=8e-49,
Organism=Escherichia coli, GI1786991, Length=415, Percent_Identity=29.6385542168675, Blast_Score=118, Evalue=7e-28,
Organism=Escherichia coli, GI1786349, Length=311, Percent_Identity=31.5112540192926, Blast_Score=114, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25144271, Length=443, Percent_Identity=29.1196388261851, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71992977, Length=438, Percent_Identity=33.7899543378995, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI32564660, Length=420, Percent_Identity=32.8571428571429, Blast_Score=187, Evalue=8e-48,
Organism=Caenorhabditis elegans, GI25144274, Length=305, Percent_Identity=30.8196721311475, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17541228, Length=479, Percent_Identity=26.9311064718163, Blast_Score=134, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6324432, Length=402, Percent_Identity=31.592039800995, Blast_Score=189, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6323470, Length=417, Percent_Identity=30.4556354916067, Blast_Score=181, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6324386, Length=480, Percent_Identity=25.625, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6321456, Length=478, Percent_Identity=25.5230125523013, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21357415, Length=417, Percent_Identity=29.4964028776978, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI21356575, Length=413, Percent_Identity=33.6561743341404, Blast_Score=180, Evalue=2e-45,
Organism=Drosophila melanogaster, GI28574759, Length=424, Percent_Identity=32.0754716981132, Blast_Score=171, Evalue=7e-43,
Organism=Drosophila melanogaster, GI161085790, Length=423, Percent_Identity=31.6784869976359, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI281366494, Length=477, Percent_Identity=25.9958071278826, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24667139, Length=477, Percent_Identity=25.9958071278826, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24667143, Length=477, Percent_Identity=25.9958071278826, Blast_Score=100, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 46864; Mature: 46733

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTLEQSRHLATAIPGPKSQQLIDRKAAAVSRGVGTTMPVYAARAQGGIVEDVDGNRLID
CCCHHHHCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEECCCCCEEEE
LGSGIAVTTIGNAAPRVVEAVAAQAGRFTHTCFMVTPYEGYVAVAEALNRLTPGSGEKRS
ECCCEEEEEECCCHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHCCCCCCCHHH
ALFNSGSEAVENAVKIARSYTHKSAVVSFDHAYHGRTNLTMALTAKVMPYKHGFGPFAPE
HHHCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCEEEEEEEEECCCCCCCCCCCHH
IYRAPLSYPFRDAEFGKELATDGELAARRAIDVMDKQVGADNLAAVIIEPIQGEGGFIVP
HHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCEEEE
AEGFLPTLLDWCRRNDVVFIADEVQTGFARTGRMFACEHEGIEPDLIVTAKGIADGMPLS
CCCCHHHHHHHHCCCCEEEEECCHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCCCCH
AVTGRAEIMDSPHVSGLGGTYGGNPVACAAALATIETIESENLVERAAAIGALMKDRLGR
HHCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LQAEDDRIGDVRGRGAMIAVELVKPGTTEPDAALAKALAAGAHTAGVIVLTCGTYGNVLR
CCCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEECCCHHHHHH
FLPPLAISDELLDEGLDVVAGLLRDL
HCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STLEQSRHLATAIPGPKSQQLIDRKAAAVSRGVGTTMPVYAARAQGGIVEDVDGNRLID
CCHHHHCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCEEECCCCCEEEE
LGSGIAVTTIGNAAPRVVEAVAAQAGRFTHTCFMVTPYEGYVAVAEALNRLTPGSGEKRS
ECCCEEEEEECCCHHHHHHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHCCCCCCCHHH
ALFNSGSEAVENAVKIARSYTHKSAVVSFDHAYHGRTNLTMALTAKVMPYKHGFGPFAPE
HHHCCCHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCEEEEEEEEECCCCCCCCCCCHH
IYRAPLSYPFRDAEFGKELATDGELAARRAIDVMDKQVGADNLAAVIIEPIQGEGGFIVP
HHHCCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCEEEE
AEGFLPTLLDWCRRNDVVFIADEVQTGFARTGRMFACEHEGIEPDLIVTAKGIADGMPLS
CCCCHHHHHHHHCCCCEEEEECCHHHHHHHCCCEEEECCCCCCCCEEEEECCCCCCCCCH
AVTGRAEIMDSPHVSGLGGTYGGNPVACAAALATIETIESENLVERAAAIGALMKDRLGR
HHCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LQAEDDRIGDVRGRGAMIAVELVKPGTTEPDAALAKALAAGAHTAGVIVLTCGTYGNVLR
CCCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEECCCHHHHHH
FLPPLAISDELLDEGLDVVAGLLRDL
HCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]