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The map label for this gene is mtr [H]

Identifier: 119868149

GI number: 119868149

Start: 2235117

End: 2236529

Strand: Reverse

Name: mtr [H]

Synonym: Mkms_2113

Alternate gene names: 119868149

Gene position: 2236529-2235117 (Counterclockwise)

Preceding gene: 119868150

Following gene: 119868138

Centisome position: 38.98

GC content: 68.37

Gene sequence:

>1413_bases
ATGGCGCACTTCGATATCGCGATCATCGGAACGGGGTCGGGCAACACGATTCTCGACGAGCGCTACGTCGACAAGCGGGT
CGCCGTCTGCGAGCAGGGCGTCTTCGGCGGCACCTGTCTCAACGTCGGCTGCATCCCGACGAAGATGTTCGTCTACTCGG
CCGGCATCGCCCAGAACGTCGGGGACTCAGCGCGTTTCGGCATCGACGCCCGGATCGACGGGGTCCGCTGGAGCGACATC
GTGTCGCGGGTGTTCGGCCGGATCGACCCGTTGGCCACCGGCGGCGAGCACTACCGGCGTGCCACGCCCAACGTCGAGGT
GTTCGCCAGCCACACCCGCTTCGCCGATGTGCTGCGCGACGGCCGGTACCGGTTACGCACCGAGGACGGTGACGAGTTCA
CCGCCGACCAGGTCGTGATCGCCGCCGGGTCGCGGGCGACGGTGCCGCCGGCGATCTCCGACTGCGGCGTGCAGTACCAC
ACCAGTGACACGATCATGCGGTTGCCGGAACTGCCCGAGCACATCATCATCGCCGGCGGTGGGTATGTCGCCGCGGAGTT
CGCCCACATCTTCTCGTCGCTGGGCTCGCGGGTGACGATCGTCATCCGCGGCACGGCCATGCTCGCCCACGCCGACGACA
CGGTCTGCGAGCGCTTCACCGACATCGCGGGCAAGAAGTGGGAGATCCGCAGCCGCCGCAACATCATCGGCGGCTCCACC
GACGAGTCGGGCGTCACCCTCAACCTCGACGACGGGTCCGCGCTGCACGGGGACGTGCTACTGGTCGCCACCGGCCGGGT
GCCCAACGGGGACCGCCTCGATGCGCACCTGGCGGGCGTGGCGGTCGAGGACGGTCTGGTGCGCGTCGACGAATACCAGC
GGACCACCGCGCGCAACGTCTTCGCATTGGGCGACGTCTGCTCGCCGTATCAGCTCAAGCATGTCGCGAATCACGAAGCG
CGGGTGGTCAAGAACAATCTGCTCGTCGACTGGGACGACACCGATGCGCTGATGCCGGCCAACCACAGCAACGTGCCGTC
GGCGGTGTTCACCGAACCGCAGATCGCCTGCGTCGGGCTCACCGAGAACGAGGCGCGCGCACGGGGCCACCGGATCAGGA
CCAAGGTCCAGGACTACGGCGACGTGGCCTACGGGTGGGCGATGGAGGACACCGAGGCGTTCGCGAAACTCATCGTCGAT
GACGACACCGGGCTGCTGCTCGGTGCGCACATCATGGGCCACCAGGCGTCGTCGATCATCCAGCCCCTCGTCCAGGCCAT
GGCGTTCGGGCTGCCCGCCCAGGACATGGCGCGCGGCCAGTACTGGATTCACCCCGCGCTGCCCGAGGTGGTGGAGAACG
CGCTGCTGGCCCTCTGCGGTGAGCCGCCGTGGCCACCGGCACGGCGGCACTGA

Upstream 100 bases:

>100_bases
CACTCGCCGAGCCACGGCGGGCGGCCTACGGTGAACTGGATCGCTGGCTGGACTGGTATCTGGGTGAGGGTTCGAACACC
ATGCGACGGGGGTTATAAGT

Downstream 100 bases:

>100_bases
GGTTTTCGGCCTTCTCCGACTTGCGTAACGCAGTGGCGGCTCCGGACGCGATTTTCCGCCCCAGCGTTACGCAAACCGTG
CACCGGCTGTCACGACGGCC

Product: mycothione reductase

Products: NA

Alternate protein names: Mycothiol-disulfide reductase; NADPH-dependent mycothione reductase [H]

Number of amino acids: Translated: 470; Mature: 469

Protein sequence:

>470_residues
MAHFDIAIIGTGSGNTILDERYVDKRVAVCEQGVFGGTCLNVGCIPTKMFVYSAGIAQNVGDSARFGIDARIDGVRWSDI
VSRVFGRIDPLATGGEHYRRATPNVEVFASHTRFADVLRDGRYRLRTEDGDEFTADQVVIAAGSRATVPPAISDCGVQYH
TSDTIMRLPELPEHIIIAGGGYVAAEFAHIFSSLGSRVTIVIRGTAMLAHADDTVCERFTDIAGKKWEIRSRRNIIGGST
DESGVTLNLDDGSALHGDVLLVATGRVPNGDRLDAHLAGVAVEDGLVRVDEYQRTTARNVFALGDVCSPYQLKHVANHEA
RVVKNNLLVDWDDTDALMPANHSNVPSAVFTEPQIACVGLTENEARARGHRIRTKVQDYGDVAYGWAMEDTEAFAKLIVD
DDTGLLLGAHIMGHQASSIIQPLVQAMAFGLPAQDMARGQYWIHPALPEVVENALLALCGEPPWPPARRH

Sequences:

>Translated_470_residues
MAHFDIAIIGTGSGNTILDERYVDKRVAVCEQGVFGGTCLNVGCIPTKMFVYSAGIAQNVGDSARFGIDARIDGVRWSDI
VSRVFGRIDPLATGGEHYRRATPNVEVFASHTRFADVLRDGRYRLRTEDGDEFTADQVVIAAGSRATVPPAISDCGVQYH
TSDTIMRLPELPEHIIIAGGGYVAAEFAHIFSSLGSRVTIVIRGTAMLAHADDTVCERFTDIAGKKWEIRSRRNIIGGST
DESGVTLNLDDGSALHGDVLLVATGRVPNGDRLDAHLAGVAVEDGLVRVDEYQRTTARNVFALGDVCSPYQLKHVANHEA
RVVKNNLLVDWDDTDALMPANHSNVPSAVFTEPQIACVGLTENEARARGHRIRTKVQDYGDVAYGWAMEDTEAFAKLIVD
DDTGLLLGAHIMGHQASSIIQPLVQAMAFGLPAQDMARGQYWIHPALPEVVENALLALCGEPPWPPARRH
>Mature_469_residues
AHFDIAIIGTGSGNTILDERYVDKRVAVCEQGVFGGTCLNVGCIPTKMFVYSAGIAQNVGDSARFGIDARIDGVRWSDIV
SRVFGRIDPLATGGEHYRRATPNVEVFASHTRFADVLRDGRYRLRTEDGDEFTADQVVIAAGSRATVPPAISDCGVQYHT
SDTIMRLPELPEHIIIAGGGYVAAEFAHIFSSLGSRVTIVIRGTAMLAHADDTVCERFTDIAGKKWEIRSRRNIIGGSTD
ESGVTLNLDDGSALHGDVLLVATGRVPNGDRLDAHLAGVAVEDGLVRVDEYQRTTARNVFALGDVCSPYQLKHVANHEAR
VVKNNLLVDWDDTDALMPANHSNVPSAVFTEPQIACVGLTENEARARGHRIRTKVQDYGDVAYGWAMEDTEAFAKLIVDD
DTGLLLGAHIMGHQASSIIQPLVQAMAFGLPAQDMARGQYWIHPALPEVVENALLALCGEPPWPPARRH

Specific function: Catalyzes the NAD(P)H-dependent reduction of mycothione (the oxidized disulfide form of mycothiol) to mycothiol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=446, Percent_Identity=26.9058295964126, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI91199540, Length=475, Percent_Identity=25.4736842105263, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI291045266, Length=440, Percent_Identity=26.1363636363636, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI22035672, Length=440, Percent_Identity=27.2727272727273, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI148277065, Length=450, Percent_Identity=23.5555555555556, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI33519430, Length=450, Percent_Identity=23.5555555555556, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI33519428, Length=450, Percent_Identity=23.5555555555556, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI33519426, Length=450, Percent_Identity=23.5555555555556, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI148277071, Length=450, Percent_Identity=23.5555555555556, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI291045268, Length=436, Percent_Identity=23.8532110091743, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786307, Length=471, Percent_Identity=28.6624203821656, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1789915, Length=433, Percent_Identity=29.0993071593533, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI87081717, Length=470, Percent_Identity=30, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI87082354, Length=429, Percent_Identity=25.8741258741259, Blast_Score=112, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI32565766, Length=481, Percent_Identity=27.8586278586279, Blast_Score=141, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI71983429, Length=350, Percent_Identity=28, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71983419, Length=350, Percent_Identity=28, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17557007, Length=480, Percent_Identity=26.0416666666667, Blast_Score=113, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6325166, Length=452, Percent_Identity=26.5486725663717, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6321091, Length=451, Percent_Identity=27.9379157427938, Blast_Score=129, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6325240, Length=495, Percent_Identity=24.040404040404, Blast_Score=90, Evalue=9e-19,
Organism=Drosophila melanogaster, GI21358499, Length=480, Percent_Identity=25.8333333333333, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI17737741, Length=482, Percent_Identity=25.5186721991701, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24640549, Length=446, Percent_Identity=26.457399103139, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24640553, Length=446, Percent_Identity=26.457399103139, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24640551, Length=446, Percent_Identity=26.457399103139, Blast_Score=86, Evalue=5e-17,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017817
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.15 [H]

Molecular weight: Translated: 50957; Mature: 50826

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHFDIAIIGTGSGNTILDERYVDKRVAVCEQGVFGGTCLNVGCIPTKMFVYSAGIAQNV
CCEEEEEEEECCCCCCEEHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHEEECCHHHCC
GDSARFGIDARIDGVRWSDIVSRVFGRIDPLATGGEHYRRATPNVEVFASHTRFADVLRD
CCCHHCCCEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHCCCCEEEEECHHHHHHHHHC
GRYRLRTEDGDEFTADQVVIAAGSRATVPPAISDCGVQYHTSDTIMRLPELPEHIIIAGG
CCEEEECCCCCCCCCCEEEEEECCCCCCCCCHHHCCCEEECCCHHHCCCCCCCEEEEECC
GYVAAEFAHIFSSLGSRVTIVIRGTAMLAHADDTVCERFTDIAGKKWEIRSRRNIIGGST
CHHHHHHHHHHHHCCCEEEEEEECCEEEEECCHHHHHHHHHHCCCEEEECCCCCCCCCCC
DESGVTLNLDDGSALHGDVLLVATGRVPNGDRLDAHLAGVAVEDGLVRVDEYQRTTARNV
CCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCEEEEEEECCCEEEEHHHHHHHHCCE
FALGDVCSPYQLKHVANHEARVVKNNLLVDWDDTDALMPANHSNVPSAVFTEPQIACVGL
EEECCCCCCHHHHHHCCCCCEEEECCEEEEECCCCCCCCCCCCCCCCEEECCCCEEEEEC
TENEARARGHRIRTKVQDYGDVAYGWAMEDTEAFAKLIVDDDTGLLLGAHIMGHQASSII
CCCHHHHCCHHHHHHHHHCCCEEEEEECCHHHHHHEEEEECCCCEEEEHHHHCCCHHHHH
QPLVQAMAFGLPAQDMARGQYWIHPALPEVVENALLALCGEPPWPPARRH
HHHHHHHHCCCCHHHHHCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AHFDIAIIGTGSGNTILDERYVDKRVAVCEQGVFGGTCLNVGCIPTKMFVYSAGIAQNV
CEEEEEEEECCCCCCEEHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHEEECCHHHCC
GDSARFGIDARIDGVRWSDIVSRVFGRIDPLATGGEHYRRATPNVEVFASHTRFADVLRD
CCCHHCCCEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHCCCCEEEEECHHHHHHHHHC
GRYRLRTEDGDEFTADQVVIAAGSRATVPPAISDCGVQYHTSDTIMRLPELPEHIIIAGG
CCEEEECCCCCCCCCCEEEEEECCCCCCCCCHHHCCCEEECCCHHHCCCCCCCEEEEECC
GYVAAEFAHIFSSLGSRVTIVIRGTAMLAHADDTVCERFTDIAGKKWEIRSRRNIIGGST
CHHHHHHHHHHHHCCCEEEEEEECCEEEEECCHHHHHHHHHHCCCEEEECCCCCCCCCCC
DESGVTLNLDDGSALHGDVLLVATGRVPNGDRLDAHLAGVAVEDGLVRVDEYQRTTARNV
CCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCEEEEEEECCCEEEEHHHHHHHHCCE
FALGDVCSPYQLKHVANHEARVVKNNLLVDWDDTDALMPANHSNVPSAVFTEPQIACVGL
EEECCCCCCHHHHHHCCCCCEEEECCEEEEECCCCCCCCCCCCCCCCEEECCCCEEEEEC
TENEARARGHRIRTKVQDYGDVAYGWAMEDTEAFAKLIVDDDTGLLLGAHIMGHQASSII
CCCHHHHCCHHHHHHHHHCCCEEEEEECCHHHHHHEEEEECCCCEEEEHHHHCCCHHHHH
QPLVQAMAFGLPAQDMARGQYWIHPALPEVVENALLALCGEPPWPPARRH
HHHHHHHHCCCCHHHHHCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]