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The map label for this gene is gyaR [H]

Identifier: 119868085

GI number: 119868085

Start: 2171811

End: 2172776

Strand: Reverse

Name: gyaR [H]

Synonym: Mkms_2048

Alternate gene names: 119868085

Gene position: 2172776-2171811 (Counterclockwise)

Preceding gene: 119868090

Following gene: 119868084

Centisome position: 37.87

GC content: 73.08

Gene sequence:

>966_bases
ATGACGACCCCGGCCGGACACGTGTACGTGTCGCGGCTGCTCACCGACGGCGCCATGGAGCGGCTGCGGCGGCTCGACCG
GCCCCTGCGCGTCGGCGGCGAGGACCCGCCCACCCGAGACGAGCTCGCGGCCGGGTTCACCGGGGCCTGCGCGGCGGTGG
TCACGCTGACCGAACGGGTCGACGCCGAAATACTCGACGCCGCAGGCGACGGGCTGCGGGTGGTGGCCAACGTCGCCGTC
GGCTACGACAACATCGACGTCGCGGCGGCGCACGCCGCGGGGGTGACCGTCACCAACACCCCGGGTGTGCTCGACAACGC
CACCGCCGACCACACGTTCGCGCTGATCCTCGCCGTCACGCGCCGCGTCGTCGACGGCGACCGGTTCCTGCGCTCGCGCC
GGCCGTGGATCTGGGGGCCCCGCATGCTCACCGGGCTCGACGTCAGCGCGGGCGCCACGCTGGGGATCCTGGGCTACGGC
CGCATCGGCAGGGCGGTCGCGCGGCGGGCCCGCGCCTTCGACATGACGGTGCTGGCCACCTCACGCCGCCGCACCTCCGG
AGCCGACGACGATGTCTGGTTCGTCGACACCGACACCCTGCTGGCCGACAGTGACGTCGTCTGCGTGCTGACGCCGCTCA
CCCCCGAGACCCGCCACCTGATCGACGCCGCGGCGCTCGACCGCATGAAATCGACCGCTTACCTGGTCAACACCGCGCGC
GGCGGGGTCGTCGACGAGTCCGCGCTGATCGACGCGCTGCGCGCCGGGCGTATCGGTGGCGCCGCGCTGGATGTATTCGA
GAATGAACCCCATGTCAACCCCGCACTGCTCGACGCCCCCAACCTCGTCCTCACACCGCACATCGCCAGTGCCGGTGAGG
CGACCCGCGACGCGATGGGCGTCCTCGCCGTCGACAACGTCGCAGCCGTGCTCGCCGGCCGGCCCGCGCTGACCCCGGTC
CGATGA

Upstream 100 bases:

>100_bases
GGTGGCACACCCATCCTGCCTCATGCGGGGCGCCCGGTGTGGCAGGGGCGGTCGAATTCACCCCGGCGACCGGTCCCGCC
GCGCATTAGGGTCTGACCTC

Downstream 100 bases:

>100_bases
AAATCGTTCTCGCACCGGACTCTTTCAAGGAGTCCATGAGCGCCGCGCAGGCCATCGCCGCCATGCGCGACGGCGTACGC
GCCGCCCTTCCGGACGCCGA

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MTTPAGHVYVSRLLTDGAMERLRRLDRPLRVGGEDPPTRDELAAGFTGACAAVVTLTERVDAEILDAAGDGLRVVANVAV
GYDNIDVAAAHAAGVTVTNTPGVLDNATADHTFALILAVTRRVVDGDRFLRSRRPWIWGPRMLTGLDVSAGATLGILGYG
RIGRAVARRARAFDMTVLATSRRRTSGADDDVWFVDTDTLLADSDVVCVLTPLTPETRHLIDAAALDRMKSTAYLVNTAR
GGVVDESALIDALRAGRIGGAALDVFENEPHVNPALLDAPNLVLTPHIASAGEATRDAMGVLAVDNVAAVLAGRPALTPV
R

Sequences:

>Translated_321_residues
MTTPAGHVYVSRLLTDGAMERLRRLDRPLRVGGEDPPTRDELAAGFTGACAAVVTLTERVDAEILDAAGDGLRVVANVAV
GYDNIDVAAAHAAGVTVTNTPGVLDNATADHTFALILAVTRRVVDGDRFLRSRRPWIWGPRMLTGLDVSAGATLGILGYG
RIGRAVARRARAFDMTVLATSRRRTSGADDDVWFVDTDTLLADSDVVCVLTPLTPETRHLIDAAALDRMKSTAYLVNTAR
GGVVDESALIDALRAGRIGGAALDVFENEPHVNPALLDAPNLVLTPHIASAGEATRDAMGVLAVDNVAAVLAGRPALTPV
R
>Mature_320_residues
TTPAGHVYVSRLLTDGAMERLRRLDRPLRVGGEDPPTRDELAAGFTGACAAVVTLTERVDAEILDAAGDGLRVVANVAVG
YDNIDVAAAHAAGVTVTNTPGVLDNATADHTFALILAVTRRVVDGDRFLRSRRPWIWGPRMLTGLDVSAGATLGILGYGR
IGRAVARRARAFDMTVLATSRRRTSGADDDVWFVDTDTLLADSDVVCVLTPLTPETRHLIDAAALDRMKSTAYLVNTARG
GVVDESALIDALRAGRIGGAALDVFENEPHVNPALLDAPNLVLTPHIASAGEATRDAMGVLAVDNVAAVLAGRPALTPVR

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=286, Percent_Identity=37.4125874125874, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI4557497, Length=269, Percent_Identity=39.0334572490706, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI61743967, Length=269, Percent_Identity=39.0334572490706, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI145580578, Length=269, Percent_Identity=38.6617100371747, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI4557499, Length=269, Percent_Identity=38.6617100371747, Blast_Score=145, Evalue=7e-35,
Organism=Homo sapiens, GI145580575, Length=276, Percent_Identity=37.3188405797101, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI23308577, Length=290, Percent_Identity=31.3793103448276, Blast_Score=137, Evalue=1e-32,
Organism=Escherichia coli, GI87082289, Length=312, Percent_Identity=40.7051282051282, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1787645, Length=200, Percent_Identity=35, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1789279, Length=239, Percent_Identity=29.2887029288703, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87081824, Length=163, Percent_Identity=35.5828220858896, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788660, Length=258, Percent_Identity=29.8449612403101, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=301, Percent_Identity=31.8936877076412, Blast_Score=144, Evalue=6e-35,
Organism=Caenorhabditis elegans, GI25147481, Length=275, Percent_Identity=33.0909090909091, Blast_Score=125, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6324055, Length=275, Percent_Identity=36, Blast_Score=153, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6322116, Length=276, Percent_Identity=30.4347826086957, Blast_Score=116, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6320925, Length=266, Percent_Identity=30.8270676691729, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324964, Length=225, Percent_Identity=27.5555555555556, Blast_Score=76, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=174, Percent_Identity=30.4597701149425, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=164, Percent_Identity=27.4390243902439, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28571528, Length=312, Percent_Identity=39.4230769230769, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI28574286, Length=309, Percent_Identity=38.1877022653722, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI45552429, Length=290, Percent_Identity=38.2758620689655, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI28574284, Length=290, Percent_Identity=38.2758620689655, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24585514, Length=290, Percent_Identity=38.2758620689655, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI28574282, Length=290, Percent_Identity=38.2758620689655, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI45551003, Length=290, Percent_Identity=38.2758620689655, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24585516, Length=306, Percent_Identity=33.9869281045752, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI19921140, Length=279, Percent_Identity=34.7670250896057, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24646446, Length=251, Percent_Identity=38.6454183266932, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24646448, Length=251, Percent_Identity=38.6454183266932, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24646452, Length=251, Percent_Identity=38.6454183266932, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24646450, Length=251, Percent_Identity=38.6454183266932, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI62472511, Length=251, Percent_Identity=38.6454183266932, Blast_Score=144, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 33781; Mature: 33650

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPAGHVYVSRLLTDGAMERLRRLDRPLRVGGEDPPTRDELAAGFTGACAAVVTLTERV
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHH
DAEILDAAGDGLRVVANVAVGYDNIDVAAAHAAGVTVTNTPGVLDNATADHTFALILAVT
CHHHHHCCCCCEEEEEEEEECCCCCCEEEHHHCCEEEECCCCCCCCCCCHHHHHHHHHHH
RRVVDGDRFLRSRRPWIWGPRMLTGLDVSAGATLGILGYGRIGRAVARRARAFDMTVLAT
HHHHCHHHHHHHCCCCEECCCEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHEEEEEEE
SRRRTSGADDDVWFVDTDTLLADSDVVCVLTPLTPETRHLIDAAALDRMKSTAYLVNTAR
CCCCCCCCCCCEEEEECCCEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHEEEEECCC
GGVVDESALIDALRAGRIGGAALDVFENEPHVNPALLDAPNLVLTPHIASAGEATRDAMG
CCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEECCCCEEEECCCCCCCCHHHHHHC
VLAVDNVAAVLAGRPALTPVR
EEEHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TTPAGHVYVSRLLTDGAMERLRRLDRPLRVGGEDPPTRDELAAGFTGACAAVVTLTERV
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHH
DAEILDAAGDGLRVVANVAVGYDNIDVAAAHAAGVTVTNTPGVLDNATADHTFALILAVT
CHHHHHCCCCCEEEEEEEEECCCCCCEEEHHHCCEEEECCCCCCCCCCCHHHHHHHHHHH
RRVVDGDRFLRSRRPWIWGPRMLTGLDVSAGATLGILGYGRIGRAVARRARAFDMTVLAT
HHHHCHHHHHHHCCCCEECCCEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHEEEEEEE
SRRRTSGADDDVWFVDTDTLLADSDVVCVLTPLTPETRHLIDAAALDRMKSTAYLVNTAR
CCCCCCCCCCCEEEEECCCEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHEEEEECCC
GGVVDESALIDALRAGRIGGAALDVFENEPHVNPALLDAPNLVLTPHIASAGEATRDAMG
CCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEECCCCEEEECCCCCCCCHHHHHHC
VLAVDNVAAVLAGRPALTPVR
EEEHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA